Differential inhibitory effects of Evans blue on various DNA polymerases. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Differential inhibitory effects of Evans blue on various DNA polymerases.

Nucleic Acids Symp Ser. 1986;(17):183-6. Unique Identifier : AIDSLINE MED/87174880
Nakane H; Balzarini J; De Clercq E; Ono K

Abstract: Evans Blue, an anionic dye which has been found to inhibit the replication of human immunodeficiency virus, proved also inhibitory to the DNA polymerases alpha and beta. The mode of inhibition was competitive with respect to the template X primer, and noncompetitive with respect to the deoxynucleoside triphosphate substrates. The inhibitory effect of Evans Blue on DNA polymerases is discussed in relation to that of suramin.
Keywords: Azo Compounds/*PHARMACOLOGY DNA Polymerase I/*ANTAGONISTS & INHIB DNA Polymerase II/*ANTAGONISTS & INHIB Evans Blue/*PHARMACOLOGY Human Kinetics KB Cells Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDazocompounds/KWDpharmacologydnapolymerasei/KWDantagonists&inhibdnapolymeraseii/KWDantagonists&inhibevansblue/KWDpharmacologyhumankineticskbcellssupport,non-uKWDsKWDgov'tjournalarticle
870730
M8770274

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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