[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1985] 48 p (Literature search / National Library of Medicine ; no. 85-20) Unique Identifier : AIDSLINE CAT/8704764
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1986] 38 p (Literature search / National Library of Medicine ; no. 86-3) Unique Identifier : AIDSLINE CAT/8704765
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1986] 32 p (Literature search / National Library of Medicine ; no. 86-6) Unique Identifier : AIDSLINE CAT/8704879
Patrias K; Parker C; Antibody Testing on Public Health
Notes some of the psychosocial aspects of AID patients and offers general guidelines for caregivers in dealing with the factors of impact, regression, acknowledgment, and reconstruction. Identifies the main tools of ministry as those of presence, affirmation, and listening. Challenges the church to go beyond society s
Flint KC; Hudspith BN; Chiensong-Popou R; Tedder R; James DG; Johnson NM
Superficial immunological similarities between sarcoidosis and AIDS led to this radioimmunoassay survey of serum antibodies to HTLV III virus in 17 patients with active sarcoidosis, 8 with peripheral lymphadenopathy. Serum antibodies were negative in all patients with sarcoidosis.
We compared two different techniques in the preparation of slides for the demonstration of Pneumocystis carinii in lung tissue of a patient died for AIDS. The impressions were prepared by imprinting the autopsy tissue surfaces on glass slides, while the concentrates were prepared by a partial homogenization and subseq
Infection with the human immunodeficiency virus (HIV) leads to selective depletion of the helper/inducer lymphocyte subset and a subsequent state of acquired cellular immunodeficiency. Simultaneously, evidence of B-cell hyper-activity may exist. A subset of patients infected with HIV demonstrates a syndrome of persist
Bereavement after diagnosing AIDS or other HIV disease, psychological symptoms secondary to brain disease and the social consequences of having AIDS all interact to produce a devastating illness where the patient may be intensely grieving, demented and totally rejected by all of society.
A 38-yr-old homosexual man developed fever, diarrhea, and weight loss. An upper gastrointestinal examination revealed terminal ileitis, and stains of stool revealed acid-fast bacilli that were subsequently identified as Mycobacterium avium-intracellulare. Antimycobacterial therapy was associated with weight gain and l
Lymphohistiocytosis (LH) is defined by a widespread infiltrate of non-malignant lymphocytes and macrophages, involving principally the liver, spleen and central nervous system and associated with a severe lymphoid atrophy. For this histological study, 38 juvenile cases of LH were selected and reviewed. Morphological a
Recruiting gay and bisexual men into AIDS-related research and education programs will become increasingly common as federal, state and local funds become available. The Pitt Men s Study, a study of the natural history of Human Immunodeficiency Virus (HIV) infection, developed a recruitment strategy based on marketing
J Community Health. 1986 Winter;11(4):233-43. Unique Identifier : AIDSLINE MED/87166856
Siegel K; Grodsky PB; Herman A
Until an effective treatment or vaccine for AIDS is developed, the principal strategy for controlling its spread will remain persuading at-risk and diseased populations to modify behaviors implicated in the transmission of the disease. In the case of homosexual and bisexual men the risk-reduction or safe-sex brochure
Maintaining optimal nutrition in the pediatric patient with Acquired Immune Deficiency Syndrome (AIDS) is challenging, but it may be one of the most effective therapies. Patients experience numerous complications that compromise nutritional status. Infection, fever, diarrhea, feeding problems, and decreased intake all
Int J Lepr Other Mycobact Dis. 1987 Mar;55(1):109-15. Unique Identifier : AIDSLINE MED/87167941
Baskin GB; Gormus BJ; Martin LN; Wolf RH; Murphey-Corb M; Walsh GP; Binford CH; Meyers WM; Malaty R
A 6-month-old male rhesus monkey (Macaca mulatta) was inoculated intravenously and intracutaneously with Mycobacterium leprae obtained from a naturally infected mangabey monkey. The animal developed generalized lepromatous leprosy, and was killed for pathological examination 56 months after inoculation. Lesions were o
A serial section study was executed on a lymph node from a case of AIDS (acquired immune deficiency syndrome) to determine the true three-dimensional morphology and mode of genesis of tubular confronting cisternae which are found in the lymphocytes in this condition. Serial sections from over a hundred such structures
An analysis of 1819 cases of acquired immunodeficiency syndrome (AIDS) in women reported between 1981 and 1986 showed that the majority of women with AIDS were intravenous drug users. The second most common risk group was heterosexual contact with a person at risk for AIDS. The proportion of women with AIDS in this ri
Huang KL; Ruben FL; Rinaldo CR Jr; Kingsley L; Lyter DW; Ho M
We conducted a study to assess the effect of human immunodeficiency virus (HIV) infection on humoral immunity. Fifty-five homosexual men and 19 heterosexual men had four- to six-week postimmunization antibody responses measured to trivalent influenza vaccine and 23-valent pneumococcal vaccine. The homosexual men were
The risk of contracting acquired immune deficiency syndrome (AIDS) is a concern to otolaryngologists and other health care workers. Failure to appreciate this valid concern is dangerous, but overestimating it may be equally injurious to the delivery of good patient care. We review the data on antibody titers and recov
Between January 1982 and December 1986, among the 750 patients with the acquired immunodeficiency syndrome (AIDS) who were treated at two adjacent hospitals in New York City, 78 (10.4 percent) needed evaluation for renal disorders. Reversible acute renal failure due to nephrotoxic injury, ischemic injury, or both was
de la Monte SM; Ho DD; Schooley RT; Hirsch MS; Richardson EP Jr
Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subac
Evans Blue, an anionic dye which has been found to inhibit the replication of human immunodeficiency virus, proved also inhibitory to the DNA polymerases alpha and beta. The mode of inhibition was competitive with respect to the template X primer, and noncompetitive with respect to the deoxynucleoside triphosphate sub
Pathol Res Pract. 1986 Dec;181(6):755-60. Unique Identifier : AIDSLINE MED/87175193
Schiaffino E; Bestetti-Bosisio M; Toia G; Onida L; Riboli P; Schmid C
Lymph node biopsies from 16 cases of intravenous drug addicts with lymphadenopathy syndrome (LAS) have been examined at the electron microscope. The main ultrastructural alterations observed in the lymphocytes, dendritic reticulum cells and endothelial cells were tubulo-reticular structures (TRS), test tube and ring s
The chest radiographs and postmortem pathologic findings in 24 patients with acquired immunodeficiency syndrome (AIDS) and autopsy-proved intrathoracic Kaposi sarcoma were reviewed. Premortem radiographic visualization of pulmonary lesions of Kaposi sarcoma depended on the extent of involvement and the presence of con
A patient with AIDS developed local complications of BCG vaccination and disseminated chickenpox with severe pneumonia. This cas suggests that AIDS patients should not receive BCG vaccination and that adults with severe chickenpox should be investigated for LAV/HTLV III virus carriage.
Three cases of febrile pharyngitis were recorded retrospectively in a cluster of 5 men and 1 woman linked by sexual contact to a human immunodeficiency virus (HIV) carrier. In all 3 patients, a progression into clinical HIV disease was noted during an observation period of 20-25 months. The febrile pharyngitis develop
AIDS is a rapidly growing epidemic in Kigali, Rwanda . To understand the level of public awareness of AIDS in that city, 33 informants (15 men and 18 women) were interviewed during September, 1985. Most (66.7%) said that they first heard of the disease only within the previous eight
S Afr Med J. 1987 Mar 21;71(6):394-6. Unique Identifier : AIDSLINE MED/87178482
Welsh NH; Swartz J; Martin C; Salmenson BD; James SH; Zwi S
Increasing numbers of patients with the acquired immunodeficiency syndrome (AIDS) are being reported. In the US literature the eye complications have been well documented but because so few cases of AIDS have been reported in South Africa , the retinal complications are largely unk
Sex Transm Dis. 1987 Jan-Mar;14(1):54-7. Unique Identifier : AIDSLINE MED/87178562
Robinson EN Jr; Latham RH
A 27-year-old man presented with a history of acquired immunodeficiency syndrome and the new onset of weakness and numbness of the lower extremities. During the course of a prolonged and extensive evaluation fraught with iatrogenic complications, it was discovered that his complaints were fabricated and his history of
The flexible fiberoptic sigmoidoscope has gained widespread acceptance as a diagnostic tool in the detection and diagnosis of colorectal disease. Since its introduction nearly a decade ago, studies have thus far indicated that in the hands of experienced physicians, flexible sigmoidoscopy is a safe procedure affording
Am J Gastroenterol. 1987 Apr;82(4):338-41. Unique Identifier : AIDSLINE MED/87181604
Baskin DH; Lax JD; Barenberg D
Bacteremic infection with Shigella species is extremely rare in adults. We report five cases of Shigella bacteremia in adult men that occurred at our hospital over a 2-yr period. Four of these cases occurred in patients with the acquired immune deficiency syndrome. The fifth patient had evidence of cell-mediated immun
Am J Gastroenterol. 1987 Apr;82(4):378-81. Unique Identifier : AIDSLINE MED/87181617
Meltzer SJ; Rotterdam HZ; Korelitz BI
Kaposi s sarcoma is a well-known manifestation of the acquired immune deficiency syndrome. Involvement of the gastrointestinal tract, including the colon, by this tumor usually causes no gastrointestinal symptoms. However, Kaposi s sarcoma has never been reported in association with ulcerative colitis in patients with
Am J Public Health. 1987 May;77(5):578-81. Unique Identifier : AIDSLINE MED/87182144
Martin JL
A sample of 745 gay men, ages 20 to 65, were interviewed in 1985 as part of an effort to determine the impact of the AIDS (acquired immunodeficiency syndrome) epidemic on the non-ill but at-risk community. Measured in terms of the number of different sexual partners, sexual activity was reported to have declined by 78
An Esp Pediatr. 1987 Feb;26(2):118-20. Unique Identifier : AIDSLINE MED/87182677
Negreira Cepeda S; Ramos Amador JT; Albert Pinole JL; Garcia-Penuela Negron MD; Fuertes Ortiz A; Nogales Espert A
Recently some cases of AIDS and AIDS-related disorders in children have been published. Some of them had received blood transfusions, others were secondary to AIDS in the mother (vertical transmission). Authors report a case of an 18-month old male infant who became seriously ill when he was 13-month old, and which pr
Since exposure to blood products occurs on a daily basis during hemapheresis, the acquired immunodeficiency syndrome (AIDS) epidemic has a serious impact both for patients undergoing apheresis procedures as well as for health professionals working in the field. We studied serum samples from 110 patients who underwent
Human immunodeficiency virus (HIV) has been identified in patients with AIDS in their circulating and tissue lymphocytes and in their monocyte-macrophages, an arm of the cell-mediated immune system. We report our findings of HIV in brain biopsies. Virus was detected in oligodendroglial and astroglial cells. Virus was
Nature. 1987 Mar 26-Apr 1;326(6111):343-5. Unique Identifier : AIDSLINE MED/87172980
Rees M
Extrapolation from short-term data is risky, but the development of AIDS among those infected with HIV by blood transfusions, if properly described by a normal distribution, suggests a 15-year mean incubation and a high incidence of disease among carriers of the virus.
To assess the epidemiology and natural history of persistent generalized lymphadenopathy (PGL) and subclinical immunodeficiency in relation to serologic evidence of lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV-III) infection, 109 homosexual men with PGL, 47 homosexual men without lymp
Sex Transm Dis. 1987 Jan-Mar;14(1):48-51. Unique Identifier : AIDSLINE MED/87178560
Rabkin CS; Thomas PA; Jaffe HW; Schultz S
To determine whether HTLV-III/LAV is transmitted to men by heterosexual contact and whether contact with prostitutes plays a role in such transmission, a serosurvey was conducted in clinics for sexually transmitted diseases in New York City. Two hundred ninety-five male heterosexual nonusers of intravenous drugs were
Two African infants born in Belgium , dying from the acquired immune deficiency syndrome are reported. The first patient was a premature baby girl born to healthy parents. However, her asymptomatic mother was found to have polyclonal hypergammaglobulinaemia, a reversed T-helper/T-s
Pitchenik AE; Burr J; Suarez M; Fertel D; Gonzalez G; Moas C
The incidence of tuberculosis has recently risen in Southeast Florida. In order to determine the number and proportion of tuberculosis cases and the characteristics of tuberculosis that might be related to human T-cell lymphotrophic virus-III (HTLV-III) infection, all patients seen by the Dade County Florida Public He
Ann Intern Med. 1987 May;106(5):692-5. Unique Identifier : AIDSLINE MED/87182698
Hollander H; Levy JA
Infectious human immunodeficiency virus (HIV) was recovered from 30 of 48 cerebrospinal fluid specimens from seropositive persons with and without neurologic symptoms or disease. Of 16 patients with only neurologic problems or other HIV-related conditions, but not the acquired immunodeficiency syndrome (AIDS), 11 had
After short review of literature about psychopathological findings in AIDS the history of three homosexual patients is reported. The clinical picture was characterised by complaints of restricted memory function and concentration increasing in the course of several months. In two patients a polyneuropathysyndrome coul
A random sample of 541 dentists in California was surveyed to determine the dentists attitudes toward AIDS and their role in relation to AIDS, their knowledge about AIDS, their behaviors in regard to screening for AIDS, and their use of infection-control measures. The survey results showed that dentists believe they
Marquart KH; Muller HA; Hartter P; Oku JC; Ayuko WO
The authors report a case of a lymphadenopathic type of Kaposi s sarcoma in a Ugandan boy aged 2 years and 1 month who was seropositive for antibodies to lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV-III).
Klin Wochenschr. 1987 Jan 5;65(1):22-6. Unique Identifier : AIDSLINE MED/87170916
Paschelke G; Altvater-Kremer G; Meyer WD; Kremer H
To date, long-term intravenous drug users studied at regional European centers of illicit drug use have had a high number of LAV/HTLV-III infections. Among 200 patients remanded by court or referred from prison to a special clinic in northern Germany for young delinquent drug abus
Plasma samples of patients with angioimmunoblastic lymphadenopathy (AIBL) were tested for anti-HTLV antibodies and for interferon content. Out of 12 patients 4 had antibodies to HTL-III. Two of these plasma samples contained antibodies reacting with HTLV-I and HTLV-II, too. Activated interferon (IFN) system was found
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2469-73. Unique Identifier : AIDSLINE MED/87175695
Dahlberg JE; Mitsuya H; Blam SB; Broder S; Aaronson SA
Certain dideoxynucleosides have been shown to markedly inhibit the infectivity of human T-lymphotropic virus type III/lymphadenopathy-associated virus, the causative agent of acquired immunodeficiency syndrome (AIDS). Our present studies demonstrate that these drugs are broad spectrum antiretroviral agents capable of
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2479-83. Unique Identifier : AIDSLINE MED/87175697
Palker TJ; Matthews TJ; Clark ME; Cianciolo GJ; Randall RR; Langlois AJ; White GC; Safai B; Snyderman R; Bolognesi DP; et al
A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Ar
To objectively evaluate the fetal acquired immunodeficiency syndrome, we have developed a scoring system based on the presence of the characteristic features that we have previously reported. Using this scoring system, 37 children seropositive for the human immunodeficiency virus were classified into three groups: dys
Both recombinant alpha A interferon and azidothymidine inhibit the replication of human immunodeficiency virus in peripheral blood mononuclear cells. Combinations of recombinant alpha A interferon and azidothymidine at concentrations that are easily achievable in patients synergistically inhibit human immunodeficiency
Ishii Y; Kokai Y; Yamaguchi A; Tsubota H; Kikuchi K
We have generated a battery of monoclonal antibodies (MAbs) that distinguish different antigen molecules present in human B cells. Two antigen systems, termed L26 and L27, respectively, were expressed in most surface immunoglobulin-positive B cells and thus showed pan-B cell specificity. Two other antigens (L22 and L3
Boll Ist Sieroter Milan. 1986;65(5):354-6. Unique Identifier : AIDSLINE MED/87157144
Corridori S; Barbarini G; Trespi G; Chiesa A; Campisi D
The authors are herewith reporting the results of an immunological screening performed on 15 drug addicts presenting serological positivity for anti HTLV III (Elisa and WB). The study has been carried out determining populations and subpopulations of lymphocytes (T3, T4, T8 and T4/T8) and performing cutaneus tests wit
FEBS Lett. 1987 Mar 9;213(1):133-7. Unique Identifier : AIDSLINE MED/87162456
Dewhurst S; Stevenson M; Volsky DJ
Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibo
Monoclonal antibodies against Pneumocystis carinii (PC) antigenic epitopes resistant to denaturing procedures were developed by immunization of mice with isolated parasites and a urea extract of infected human lung tissue. Paraffin sections of infected lung tissue were used as antigen in the screening for reactive clo
S Afr Med J. 1987 Mar 7;71(5):289-93. Unique Identifier : AIDSLINE MED/87178441
Pincus PS; Hurwitz MD; Kallenbach JM; Abramowitz JA; Zwi S
Pneumocystis carinii pneumonia is today an opportunistic infection of major importance, occurring in immunosuppressed patients. Twelve cases of P. carinii pneumonia were seen by the Pulmonology Unit in Johannesburg between November 1984 and December 1985. The clinical presentation, laboratory and radiographic features
Z Geburtshilfe Perinatol. 1986 Nov-Dec;190(6):279-81. Unique Identifier : AIDSLINE MED/87180118
von Kries R; Muller JE; Distler W; Bruster H; Wahn V
The clinical course of AIDS in a child of a HTLV III virus infected drug addicted mother is reported. Aged 7 month the baby died from Pneumocystis carinii pneumonia. The clinical course prior to the final lethal infection was remarkably uneventful. Immunological controls revealed strikingly high immunoglobulin values,
Aust N Z J Med. 1986 Dec;16(6):749-56. Unique Identifier : AIDSLINE MED/87184320
Tindall B; Cooper DA; Burcham J; Gold J; Penny R
The Sydney AIDS Project is a prospective immunoepidemiological study of 911 homosexual and bisexual men enrolled between February 1984 and January 1985. Clinical, immunological, and serological studies are performed on these subjects every six months. At enrollment, 39.9% of subjects were seropositive for antibodies t
Recent changes in sexual habits have likely contributed to the emergence of a new sexually transmissible agent, acquired immune deficiency syndrome (AIDS) virus. This virus may have been present in central Africa as early as 1959; however, frequent infection did not produce an epidemic until the late 1970 s. Migration
Klecker RW Jr; Collins JM; Yarchoan R; Thomas R; Jenkins JF; Broder S; Myers CE
We investigated the clinical pharmacokinetics of azidothymidine (N3TdR) as part of a phase I/II trial in the treatment of acquired immunodeficiency syndrome and related diseases. During the 6-week course of therapy, drug levels in plasma, cerebrospinal fluid, and urine were determined by HLPC. The plasma half-life of
FEBS Lett. 1987 Mar 9;213(1):138-43. Unique Identifier : AIDSLINE MED/87162457
Dewhurst S; Bresser J; Stevenson M; Sakai K; Evinger-Hodges MJ; Volsky DJ
Three human brain-derived cell lines (including two of astrocytic origin) were exposed in vitro to the human immunodeficiency virus (HIV), the etiologic agent of immunodeficiency in AIDS. In all three lines, HIV transcripts were detected by in situ hybridisation in 20-30% of cells 48 h after infection. Synthesis of vi
The antigenic characteristics of rat Pneumocystis carinii obtained from infected lungs and grown in tissue culture were compared with the properties of human P. carinii obtained from the lungs of AIDS and non-AIDS patients by the immunoblotting technique, using different sources of antibody. Major immunoreactive bands
Avarol and avarone are two antimitotic and antimutagenic agents that preferentially inhibit proliferation of T-cell leukemia lines in vitro. This report shows that these compounds have a dose-dependent inhibitory effect on the replication of the etiologic agent of acquired immune deficiency syndrome (AIDS), human T-ly
Neuroepidemiology is that branch of chronic disease epidemiology dealing with disorders that affect the nervous system. The potential for neurological involvement in the diagnosis and pathogenesis of Acquired Immune Deficiency Syndrome (AIDS) has recently been noted. The following review outlines the spectrum of neuro
Acalculous inflammation of the biliary tract is a recently reported complication of the acquired immunodeficiency syndrome (AIDS). In a 33-month period, nine men with AIDS were evaluated because of right upper quadrant and/or epigastric pain, jaundice, or abnormal liver function test results. Each patient underwent ul
To study the possible role of plastic embedding in the surgical pathologic diagnosis of Pneumocystis carinii pneumonia, bronchial biopsy specimens from five patients with AIDS were examined using 0.9 micron thick methacrylate sections stained with silver methenamine borate and counterstained with toluidine blue. This
A radioaerosol clearance test was used to detect lung injury in 12 patients with acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii pneumonia documented by bronchoscopy. The clearance of 99mTc-DTPA was elevated over most regions of interest in all of these patients. In each of 7 subjects who responded
Ann Intern Med. 1987 May;106(5):671-6. Unique Identifier : AIDSLINE MED/87182694
Burke DS; Brandt BL; Redfield RR; Lee TH; Thorn RM; Beltz GA; Hung CH
To detect human immunodeficiency virus (HIV) antibodies in a simple enzyme-linked immunoassay (CBre3-EIA), we used an Escherichia coli-expressed polypeptide antigen, representing the carboxy-terminal third of the external membrane glycoprotein gene fused with the amino-terminal half of the transmembrane glycoprotein g
Ann Intern Med. 1987 May;106(5):714-8. Unique Identifier : AIDSLINE MED/87182705
Pearson RD; Hewlett EL
The widespread emergence of chloroquine-resistant Plasmodium falciparum led to the formulation of an effective, fixed combination of two antimalarial agents, pyrimethamine and the long-acting sulfonamide sulfadoxine, for prophylaxis and treatment. These drugs act at sequential steps to inhibit the formation of tetrahy
Elwell LP; Ferone R; Freeman GA; Fyfe JA; Hill JA; Ray PH; Richards CA; Singer SC; Knick VB; Rideout JL; et al
The thymidine analog 3 -azido-3 -deoxythymidine (BW A509U; azidothymidine [ AZT ]) had potent bactericidal activity against many members of the family Enterobacteriaceae, including strains of Escherichia coli, Salmonella typhimurium, Klebsiella pneumoni
Lymphokines represent a new group of substances that have engendered increasing interest in the context of cancer therapy. They are products of the lymphoid system that can now be produced in pure form as a consequence of advances in gene cloning technology. alpha-Interferon has been tested in clinical trials for seve
To date, 16 cases of AIDS have been officially reported in Japan : 8 of them were hemophiliacs and the others were male homosexuals. We had two hemophiliacs with AIDS, and describe these cases in this paper. One was a 48-year-old man with hemophilia B and the other was a 62-year-old
Zeng Y; Fan J; Zhang Q; Wang PC; Tang DJ; Zhon SC; Zheng XW; Liu DP
Using ELISA, Western blots and immunofluorescence techniques, we identified seropositivity for lymphadenopathy-associated virus/human lymphotropic virus-III (LAV/HTLV-III) in 4 of 18 hemophiliacs and 1 AIDS patient. The four seropositive patients had received factor VIII prepared by Armour Company. The hemophiliacs ar
The routes of transmission of human immunodeficiency virus (HIV) can be divided into two categories, 1. sexual transmission (male-to-male, male-to-female and female-to-male) and 2. parenteral transmission by blood or blood products. Among 488 Japanese hemophiliacs, 165 (33.8%) were seropositive and were infected by th
Serum specimens from 252 recipients of factor VIII and/or factor IX (237 hemophiliacs and 15 nonhemophiliacs), 99 blood transfusion recipients, 269 chronic diseases, and 366 healthy subjects (included blood donors, hospital personnel and family members of hemophiliacs) were tested for reactivity to lymphadenopathy-ass
Br Med J (Clin Res Ed). 1987 Feb 21;294(6570):495-6. Unique Identifier : AIDSLINE MED/87158179
Srivastava AC; Pinching AJ; Adler MW; Robertson R; Higgs R
Dr A C Srivastava has written to us to describe a case that raises the suggestion that people infected with the human immuno-deficiency virus (HIV) should carry identity cards. We asked two physicians, a general practitioner working with patients with the acquired immune deficiency syndrome (AIDS), and a general pract
Plaeger-Marshall S; Spina CA; Giorgi JV; Mitsuyasu R; Wolfe P; Gottlieb M; Beall G
Testing of cytotoxic function using a panel of natural killer (NK)-sensitive target cells, including a unique herpes simplex virus-infected Raji-cell target, was performed in conjunction with phenotypic cell analysis by dual-color flow cytometry to characterize the NK system. Subjects included in the study were at ris
A further histopathological complication of atypical mycobacterial infection in acquired immune deficiency syndrome (AIDS) is reported. Positive reactivity between mycobacterial antibodies within a polyclonal antiserum and mycobacteria within tissues resulted in false positivity with this reagent to factor VIII relate
To determine the potential immunotherapeutic role of interferon-gamma (IFN-gamma) as a mononuclear phagocyte-activating agent, we examined the effector cell function of peripheral blood monocytes from healthy donors and acquired immunodeficiency syndrome (AIDS) patients after either in vitro and/or in vivo treatment w
Since the first patients with acquired immune deficiency syndrome (AIDS) were seen in 1981, the disease has been recognized as an epidemic, now considered a major health threat. This article reviews, on the basis of the literature and personal observations of 120 human immune deficiency virus (HIV) infected patients,
Funke I; Hahn A; Rieber EP; Weiss E; Riethmuller G
The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamu
Kornfeld H; Riedel N; Viglianti GA; Hirsch V; Mullins JI
Although much is now known of the strain variation among the type-1 human immunodeficiency virus (HIV-1), which is the cause of AIDS (acquired immune deficiency syndrome) in the United States , Europe, and Central Africa, much less is yet known about a second group of viruses that have
Public Health Rep. 1987 Mar-Apr;102(2):224-31. Unique Identifier : AIDSLINE MED/87176317
Mays VM; Cochran SD
Approximately 25 percent of persons diagnosed with acquired immunodeficiency syndrome (AIDS) have been black. This paper examines three areas of concern when focusing on AIDS in the black population: differences from whites in patterns of transmission of the infection, cultural factors that may affect health education
The speed of research into the pathogenesis of AIDS is breathtaking, and it is now possible to review potential therapeutic approaches against the AIDS virus. This review concentrates upon antiviral drugs and vaccine development.
Nicholson JK; Jones BM; Echenberg DF; Spira TJ; McDougal JS
In a previous study of asymptomatic homosexual men, we found that CD8+ T-cell levels were higher in homosexual men infected with the human immunodeficiency virus (HIV) than in uninfected homosexual men because of higher numbers of CD8+ T cells that do not express the Leu15 marker, a phenotype associated with cytotoxic
To determine whether abnormalities of cell-mediated immunity are associated with chronic hepatitis B virus infection or with homosexuality, we studied 15 homo- and 11 heterosexual men with chronic hepatitis B virus infection, as well as 11 homo- and 16 heterosexual apparently healthy men. T lymphocyte subsets, natural
Twenty homosexual men who reported having sexual contact with homosexual men who had the acquired immunodeficiency syndrome (AIDS) or the AIDS-related complex were examined to determine their clinical status, immunologic profiles, and the presence of antibody to the human T-cell lymphotropic virus type III (HTLV-III).
Wien Klin Wochenschr. 1987 Jan 9;99(1):18-20. Unique Identifier : AIDSLINE MED/87179927
Eberhartinger C; Simader R
The case report is presented of a patient belonging to a group at high risk for the development of AIDS who suffered from an acute mononucleosis-like illness coincident with seroconversion.
XLP was first described in 1975, when EBV was still focused on as an immediate oncogenic agent, but with some uncertainties raised by the absence of EBV in most non-endemic Burkitt lymphoma. The discovery of XLP refreshingly evidenced and popularized the concept, EBV pathogenicity (oncogenicity) in immunocompromised h
Okano M; Osato T; Koizumi S; Imai S; Aya T; Fujiwara S; Mizuno F; Sakiyama Y; Matsumoto S; Sugawara O; et al
Lymphomas occurred in 3 of 16 Japanese patients with ataxia telangiectasia (AT) and Wiskott-Aldrich syndrome (WAS). The patients had a persistently reactivated Epstein-Barr virus (EBV) infection with a remarkable decrease in virus-specific cellular immunity. In these patients, the B lymphocytes were more sensitive to
Okano M; Sakiyama Y; Matsumoto S; Mizuno F; Osato T
A chronic active Epstein-Barr virus (EBV) infection with no significant underlying diseases was evidenced in 7 Japanese children and adolescents. In these patients, massive EBV-positive polyclonal lymphoproliferation occurred with extremely high EBV antibody titers.
The abilities of peripheral blood lymphocytes from 9 patients with adult T-cell leukemia (ATL) and 14 healthy control adults to cause regression of proliferating B-cell foci induced by Epstein-Barr virus (EBV) were examined. Marked regression of EBV-transformed B-cell foci was observed in lymphocytes from all 10 EBV-s
Mizuno F; Osato T; Imai S; Koizumi S; Aya T; Kinoshita T; Hirai N; Hirota M; Ohigashi H; Koshimizu K; et al
The extracts of a certain African plant species, Euphorbia tirucalli, were found to have markedly enhancing effects on the activation of latent Epstein-Barr virus (EBV) genomes in the EBV carrying lymphoblastoid cells and also on EBV-induced transformation of human lymphocytes. The Euphorbia tirucalli was especially n
The mechanisms of chromosomal translocations and its role in Burkitt lymphoma (BL), mouse plasmacytoma (MPC) and rat immunocytoma (RIC) are discussed with particular emphasis on the following questions: 1) Does the cis-relationship between the c-myc oncogene and one of the 3 Ig-loci play a causative role in the genesi
Prevention of EBV-associated lymphoproliferative diseases in immune deficient individuals is preferred; however, standard therapy for the B cell lymphomas has been successful. Chemotherapy must be given cautiously lest further immune compromise result in opportunistic infections. Recently,
The effects of various compounds were studied quantitatively on the growth of human immunodeficiency virus (HIV). For this we used a human T-cell leukemia virus type I carrying cell line, MT-4 which is most permissive for HIV infection. The results are summarized as follows: 1) Prostaglandin E2 and 12-0-tetradecanoylp
Antibodies against Epstein-Barr virus, associated with antibody dependent cytotoxic cell activity, were found to be present in diminished titer in 20 of 22 patients tested with chronic mononucleosis syndrome (CMS). Gamma globulin was shown to improve symptoms in 53% of the patients treated, compared with 32% of placeb
The Epstein-Barr Virus (EBV) has been studied extensively as a human cancer virus. Until recently, however, little was known about the viral genes encoding for different proteins involved in the virus immortalization and replication cycles. Most of the efforts have been directed at those genes expressed in immortalize
An Epstein-Barr virus (EBV)-specific determinant of early antigen (EA) character was found to be associated with intermediate filaments of EBV genome-activated cells. This determinant was defined with a murine monoclonal antibody (MAb) and with human MAb derived from lymphoblastoid cell lines of patients with acute in
Zeng Y; Pi GH; Deng H; Zhang JM; Wang PC; Wolf H; De The G
Since 1978 more than 300,000 sera from normal individuals were screened serologically in NPC high risk areas and prospective studies were carried out. Many patients were diagnosed in early stage. For example, in Wuzhou city, 20,726 persons over 40 years of age were screened; 1,138 persons were found to have IgA VCA an
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL) and a trans-acting viral function was proposed to be involved in ATL development because of the non-specific provirus integration in leukemic cells and the frequent immortalization of helper T-cells by in vitro infection.
Hatanaka M; Sabe H; Tanaka A; Mori K; Siomi H; Nam S; Adachi Y; Itamura S; Hirayoshi K
Human T-lymphocyte cell line termed MT-2 is producing persistently HTLV-I virion and has a strong potential to transform human T-lymphocytes when cocultivated. The virion of HTLV-I (MT-2) was isolated and its RNA was extracted to analyze the gene and gene products of HTLV-I. HTLV (MT-2) virion RNA was translated in a
Boll Ist Sieroter Milan. 1986;65(5):357-60. Unique Identifier : AIDSLINE MED/87157145
Ferrante P; Nardi G; Zanchetta N; Salvioni PM; Pagano A
The prevalence of HTLV III/LAV antibody has been studied in six groups of population: healthy subjects, a virological laboratory staff, prisoners, drug addicts, patients with lymphoadenopathy-associated syndrome (LAS) and patients with AIDS. Prevalences and levels in the same groups of HBsAg and
Cancer Res. 1987 Apr 15;47(8):2077-82. Unique Identifier : AIDSLINE MED/87159273
Oda T; Watanabe S; Sumii H; Nakamura T; Arakaki Y; Shimotohno K
The location of the pX gene products in human T-cell leukemia virus type 1-producing cells, MT-2 and HUT 102, was studied by immunoelectron microscopy using the direct and indirect peroxidase-labeled antibody methods. Fab -peroxidase conjugates were prepared for the direct method with a maleimide compound from antiser
Cross SL; Feinberg MB; Wolf JB; Holbrook NJ; Wong-Staal F; Leonard WJ
We have characterized regulatory regions of the human IL-2 receptor alpha chain (IL2R alpha) promoter. 5 deletion constructs extending to -327 directed CAT expression in HTLV-I-infected T cells, which express IL2R alpha constitutively, and in Jurkat cells, which expre
We constructed a fusion plasmid, pMX-I, by which the major open reading frame, X-I, of the bovine leukemia virus (BLV) X gene was expressed under control of the mouse metallothionein promoter. pMX-I was cotransfected into CV1 monkey kidney cells together with another construct containing the BLV long terminal repeat (
Tissues from patients with Laron dwarfism are resistant to the actions of endogenous or exogenous GH. As a result, insulin-like growth factor I (IGF-I) levels are low, possibly contributing to the severe growth deficiency that occurs in patients with this syndrome. In this study, we found that erythroid progenitor cel
Mann DL; Lasane F; Popovic M; Arthur LO; Robey WG; Blattner WA; Newman MJ
The addition of inactivated preparations of purified human T cell lymphotropic virus (HTLV-III) was found to inhibit normal human lymphocyte phytohemagglutinin (PHA)-induced blastogenesis but had no effect on concanavalin A (Con A), pokeweek mitogen, or allogeneic stimulation. The inhibition was concentration-dependen
We investigated Epstein-Barr virus (EBV)-specific T cell responses in homosexual men with, and at risk for, AIDS. We studied healthy laboratory workers, healthy homosexual men, and patients with AIDS-related complex or AIDS. The cytotoxic activity, absolute number of T4 lymphocytes, and interleukin-2 (
Three interleukin 2 ( IL-2 )-independent human T cell lines transformed with human T cell leukemia virus type I were analyzed for o-phosphotyrosine-containing proteins (Ptyr proteins). Membrane and intracellular immunofluorescence was positive with antibody to Ptyr (Ptyr
The incidence of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) is increasing, and as head and neck manifestations of this entity are common it is important that otolaryngologists have an up-to-date knowledge of this condition. In this paper the epidemiological aspects of the disease are revi
Med Hypotheses. 1987 Jan;22(1):27-33. Unique Identifier : AIDSLINE MED/87172385
Minarovits J; Segesdi J; Kovacs Z; Foldes I
The mechanism of action of LAV/HTLV-III resulting in a pronounced cytopathic effect is still unknown. We demonstrate that the long terminal repeat (LTR) sequence and env gene of LAV/HTLV-III contain regions of 70-80% homology and/or complementarity with regions of small nuclear (sn) RNAs U1 and U2. On this basis, we h
Guyader M; Emerman M; Sonigo P; Clavel F; Montagnier L; Alizon M
Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li
Human immunodeficiency virus (HIV) production from latently infected T lymphocytes can be induced with compounds that activate the cells to secrete lymphokines. The elements in the HIV genome which control activation are not known but expression might be regulated through a variety of DNA elements. The cis-acting cont
The mitogenic or antigenic stimulation of T lymphocytes in the presence of accessory cells results in the synthesis of interleukin-2 ( IL-2 ), which, on interacting with de novo synthesized receptors on the membrane, induces the proliferation and differentiation of T cel
A 34-year-old homosexual man with acquired immune deficiency syndrome developed extraocular muscle deficits, chorioretinitis, and paraplegia without sensory symptoms. EMG showed severe diffuse denervation, but only mildly slowed nerve conduction velocities, in both legs. Meningitis persisted for 6 weeks and was exacer
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2033-7. Unique Identifier : AIDSLINE MED/87175608
Mitsuya H; Jarrett RF; Matsukura M; Di Marzo Veronese F; DeVico AL; Sarngadharan MG; Johns DG; Reitz MS; Broder S
We report that 2 ,3 -dideoxyadenosine and 2 ,3 -dideoxycytidine inhibit retroviral DNA synthesis and mRNA expression in T cells exposed to the virus that causes acquired immunodeficiency syndrome, and afford such cells long-term protection in vitro under conditions of substantial viral excess. Both 2 ,3 -dideoxyadenos
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2317-21. Unique Identifier : AIDSLINE MED/87175665
Yeh HJ; Pierce GF; Deuel TF
The subcellular distribution of v-sis-related protein(s) was analyzed in three simian sarcoma virus (SSV)-transformed cell lines with immunofluorescence and protein A-gold labeling techniques using rabbit polyclonal anti-platelet-derived-growth factor (PDGF) antisera. Antigenically reactive proteins were recognized in
A spectrum of radiologic findings in cytomegalovirus ( CMV ) infection of the alimentary canal seen in 14 patients and correlated with pathologic examinations is described. Twelve patients had acquired immunodeficiency syndrome
Farmerie WG; Loeb DD; Casavant NC; Hutchison CA 3d; Edgell MH; Swanstrom R
The ability to express the genes of pathogenic human viruses, such as the acquired immune deficiency syndrome (AIDS) virus (also called human immunodeficiency virus) in bacterial cells affords the opportunity to study proteins that are ordinarily difficult or inconvenient to obtain in amounts sufficient for detailed a
Wien Klin Wochenschr. 1987 Jan 23;99(2):37-49. Unique Identifier : AIDSLINE MED/87179930
Preis P
Within a very short time the application of molecular biology to cancer research has resulted in an essential change and extension of our knowledge of transformation processes and tumor development. For the first time these mechanisms can be understood in a causal manner and causal cancer therapy seems to be possible
Cytomegalovirus ( CMV ) inclusions were discovered at autopsy in the thyroid follicles in five immunocompromised adults, four of whom had acquired immune deficiency syndrome (AIDS). Although reports of viral infections of the thyroid are uncommon in adults, our ex
Am J Gastroenterol. 1987 Apr;82(4):287-91. Unique Identifier : AIDSLINE MED/87181594
Schiff ER
There are presently available immune globulin preparations of proven efficacy and safety in the prophylaxis of type A and B viral hepatitis. Active vaccines for prevention of type B hepatitis are now available and are safe and effective. None of these preparations has been associated with the development of HTLV-III/L
Freeman WR; Henderly DE; Wan WL; Causey D; Trousdale M; Green RL; Rao NA
Seventeen patients with the acquired immune deficiency syndrome and cytomegalovirus retinitis were treated with the antiviral drug ganciclovir (9-[1,3-dihydroxy-2-propoxy-methyl]-guanine, DHPG). Eight eyes of five patients developed rhegmatogenous retinal detachment after initiatio
Patients with the acquired immune deficiency syndrome (AIDS) with disseminated Mycobacterium avium infection have responded poorly to treatment with rifabutine (Ansamycin) and clofazimine, in spite of the good in vitro response of M. avium to these antimicrobial agents. We compared the ability of these and other antim
The ubiquitous, DNA herpesvirus, EBV, has B cell tropism and the geographically restricted RNA retrovirus, ATLV/HTLV-I has T cell tropism. Clinical descriptions by Burkitt and Takatsuki led to discovery of these viruses which infect silently early in life; however, ATLV is also transmitted to a spouse or by blood tran
Transcription of Epstein Barr virus (EBV) genome during immortalization of tonsil lymphocytes was studied. Cytoplasmic poly(A) RNA was Northern blot hybridized with 32P-labeled cloned EBV fragments. A 5.1 kb band was detected by hybridization with BamHI-H, -F, -K, -A and het fragments. The implication of this finding
Cell-associated transmission of adult T-cell leukemia virus (ATLV/HTLV-I) suggested early in a follow-up study on recipients of blood has been supported with the latest results of an extended follow-up. Approximately 10(8) lymphocytes of blood donors carrying the antibodies against ATLV seemed to be necessary for the
There are two large clusters of HTLV-I/ATLV carriers in the world. One large endemic area could be Africa, but available information is not yet sufficient to prove this. The other definitely large endemic area is Japan . Much smaller endemic areas and sporadic cases of the virus-carr
The acquired immune deficiency syndrome (AIDS) is characterized by severe immunological defects resulting in opportunistic infections and malignancies. A novel human retrovirus, known under the terms of LAV, HTLV-III, ARV or as a human immunodeficiency virus (HIV), has been defined as the infectious agent responsible
Miwa M; Shimotohno K; Takano M; Shima H; Watanabe S; Tosu M; Sekiguchi T; Shimoyama M; Sugimura T
There is a high homology of nucleotide sequence between 3 two-thirds of the X (or pX) regions of human T-cell leukemia virus (HTLV)-I, and of HTLV-II. Monoclonal antibody against p41 coded from X-IV, an open reading frame of X region of HTLV-I, was established. Two proteins coded by Xb, one of the open reading frames
Iakovleva LA; Timanovskaia VV; Indzhiia LV; Lapin BA; Voevodin AF
Inoculation of rabbits with permanent B-cell line cultures obtained from Stumptailed Macaques M. arctoides (MAL) which contain lymphotropic herpesvirus and C-type particles has led to the development of generalized lymphomas. The lymphoma cells had rabbit karyotype and did not contain surface an cytoplasmic immunoglob
Graziani G; Pasqualetti D; Lopez M; D'Onofrio C; Testi AM; Mandelli F; Gallo RC; Bonmassar E
Peripheral mononuclear cells (MNC) collected from 12 healthy donors and 44 leukemic patients at various stages of the disease were tested for natural killer (NK) activity and for their susceptibility to HTLV-I infection in vitro, measured in terms of percentage of p19 positive cells. MNC from leukemic donors at any st
Uemura Y; Kotani S; Yoshimoto S; Fujishita M; Yamashita M; Ohtsuki Y; Taguchi H; Miyoshi I
We studied the mode of natural transmission of human T-cell leukemia virus type I (HTLV-I) in rabbits. Four virus-infected rabbits (2 males and 2 females) were individually mated with 4 noninfected rabbits. Two virus-infected females mated with noninfected males gave birth to 7 offspring, and 2 noninfected females mat
Shimoyama M; Abe T; Miyamoto K; Minato K; Tobinai K; Nagoshi H; Matsunaga M; Nomura T; Tsubota T; Ohnoshi T; et al
Chromosome aberrations and clinical features of three patients with adult T cell leukemia-lymphoma (ATL) not associated with human T cell leukemia virus type I (HTLV-I) are described. From their clinical features, two patients were diagnosed as acute type and one patient was diagnosed as chronic type, which later conv
We describe a cloning-expression vector system for selecting DNA fragments containing open reading frames (ORFs) and expressing them as beta-galactosidase (beta Gal) hybrid fusion proteins. The plasmid vector, pWS50, utilizes the very strong and easily regulated bacteriophage lambda promoter pL, and the efficient tran
J Cancer Res Clin Oncol. 1987;113(2):192-6. Unique Identifier : AIDSLINE MED/87166135
Verma RS; Macera MJ; Krishnamurthy M; Abramson J; Kapelner S; Dosik H
Chromosomal studies were performed on six patients with adult T-cell leukemia (ATL). Structural abnormalities of chromosome 3 were the most common. In one case a complete loss of the short arm of chromosome 10 (10 p-) was noted while in another case a balanced translocation involving chromosome 10p and 4q was found. T
Pollock R; Ames F; Rubio P; Jones J; Reuben J; Wong W; Mavlight G
A large percentage of patients with blood transfusion related AIDS received their transfusion during cardiac surgery requiring cardiopulmonary bypass. We hypothesized that the procedure of cardiopulmonary bypass (CPB) in patients undergoing cardiac surgery might be associated with severe immune dysregulation and hence
Hattori T; Matsuoka M; Chosa T; Yoshiki T; Robert-Guroff M; Takatsuki K
We have examined expression of antigens defined by HT462 monoclonal antibody (mAb), together with other HTLV-I related antigens using phorbol 12-myristate 13-acetate treated leukemic mature T cells. Thirteen patients with adult T-cell leukemia (ATL), 3 patients in remission states of ATL and 5 patients with non-ATL we
Kikukawa-Itamura R; Harada S; Kobayashi N; Hatanaka M; Yamamoto N
Co-cultivation of HTLV-I carrying cells and virus-free lymphoid cells resulted in the cytopathic effect and cytotoxicity of the latter cells. Microscopically, these phenomena were observed as early as 2 h as the appearance of multinuclear giant cells and ballooning cells with striking resemblance with cytopathic chang
Lancet. 1987 Mar 21;1(8534):656-8. Unique Identifier : AIDSLINE MED/87171657
Carne CA; Weller IV; Johnson AM; Loveday C; Pearce F; Hawkins A; Smith A; Williams P; Tedder RS; Adler MW
The prevalence of antibody against human immunodeficiency virus (anti-HIV), which rose among British homosexual/bisexual men attending a London sexually-transmitted-disease clinic from 3.7% (4/107) in March, 1982, to 21% (26/124) in July, 1984, was 18.1% (17/94) in April/May 1985, 24.5% (61/249) in January, 1986, and
Lancet. 1987 Mar 28;1(8535):728-31. Unique Identifier : AIDSLINE MED/87171713
Melbye M; Grossman RJ; Goedert JJ; Eyster ME; Biggar RJ
In a closed internal medicine practice for homosexual men in Central Manhattan herpes zoster developed in 112 men between 1980 and mid-1986. In these patients the incidence of acquired immunodeficiency syndrome (AIDS) was high: Kaplan-Meier survival analysis indicated cumulative incidences of AIDS of 22.8% within 2 ye
Mitchell WM; Montefiori DC; Robinson WE Jr; Strayer DR; Carter WA
Ampligen , a non-toxic, mismatched polymer of double-stranded RNA with antiviral and immunomodulatory activities reduced the concentration of zidovudine (azidothymidine, AZT ; Retrovir , Wellcome) required for inhibitory activity against human immuno
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2015-8. Unique Identifier : AIDSLINE MED/87175604
Skare JC; Milunsky A; Byron KS; Sullivan JL
The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length
For a seroepidemiologic study of adult T-cell leukemia virus (ATLV) infection in Taiwan , the gelatin particle agglutination technique and the indirect immunofluorescence method were used for anti-ATLV titration. Sporadic sero-positi
Aust N Z J Med. 1986 Dec;16(6):823-7. Unique Identifier : AIDSLINE MED/87184336
Dalgleish AG; McElwain T
There have been numerous suggestive but inconclusive reports of a possible infectious etiology for Hodgkin s disease. The discovery of the causative agent of the adult T cell leukemia-lymphoma syndrome suggests that a similar agent to the human T cell leukemia-lymphoma virus may have a causal role in Hodgkin s disease
University Available from the Intergovernmental Health Policy Project, George Washington University, 2100 Pennsylvania Ave., N.W., Washington, D.C. 20037, 202/872-1445, 1985 Nov 27 108 p Unique Identifier : AIDSLINE KIE/22562
This information is designed to support, not replace, the relationship that exists between you and your doctor.