LONG-TERM CULTURE OF LEUKAEMIC CELLS AND THE EXPRESSION OF NEW VIRUSES: POSSIBLE ROLE IN LEUKAEMOGENESIS

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

LONG-TERM CULTURE OF LEUKAEMIC CELLS AND THE EXPRESSION OF NEW VIRUSES: POSSIBLE ROLE IN LEUKAEMOGENESIS

Serono Symp Publ Raven Press; 20:409-29 1985. Unique Identifier : AIDSLINE ICDB/86626934
Karpas A; Dept. of Hematological Medicine, Univ. of Cambridge Clinical; Sch., Hills Road, Cambridge CB2 2QL, England

Abstract: Results of long-term culture experiments and seroepidemiological studies are discussed in relation to adult T-cell leukemia viruses (ATLV)/human T-cell leukemia virus (HTLV), and the diseases attributed to these viruses. Topics include T-cell hairy cell leukemia, acquired immunodeficiency syndrome (AIDS), lymphadenopathy-associated virus, and adult T-cell leukemia (ATL). Retroviruses have been isolated from adult T-cell leukemia cells; they are probably involved in the development of this disease. Sera from neither Japanese (0/12) nor British (0/11) patients (pts) with mycosis fungoides and Sezary syndrome (MF/SS) had antibodies to ATLV/HTLV-I, suggesting that the black pts originally described as having MF/SS really had ATL. Although ATLV/HTLV are exogenous viruses, transmission appears to be at a low level of infectivity. The largest epidemiological study for antibodies to ATLV/HTLV failed to find any positive cases in over 4,000 sera, supporting the idea that so far retroviruses are involved only with ATL of Japanese and some blacks of African origin. In a study of 108 homosexuals, no HTLV-I (ATLV) serum-positive individuals were found, regardless of whether they had AIDS, suggesting that the virus involved in AIDS does not belong to the same group of viruses. The failure to detect cross-reacting antibodies to ATLV in AIDS pts rules out a similarity of the causative agents of these two diseases. It can be concluded that T-cell leukemia viruses are involved in the development of adult T-cell leukemia in the Japanese (ATLV) and blacks of African origin (HTLV), but that at least ATLV is neither involved in other lymphoid malignancies, including MF/SS, nor in AIDS. (61 Refs)

Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Cell Line Herpesvirus 4, Human/PATHOGENICITY Human HTLV-BLV Viruses/PATHOGENICITY Inclusion Bodies, Viral/ULTRASTRUCTURE Leukemia/*MICROBIOLOGY Leukemia, Hairy Cell/MICROBIOLOGY Microscopy, Electron Retroviridae/PATHOGENICITY Tumor Virus Infections/*MICROBIOLOGY MEETING PAPER

870130
M8710274

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1987. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1987. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .