ADULT T-CELL LEUKEMIA VIRUS, THE PRESENT PICTURE NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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ADULT T-CELL LEUKEMIA VIRUS, THE PRESENT PICTURE

Serono Symp Publ Raven Press; 20:435-50 1985. Unique Identifier : AIDSLINE ICDB/86626936
Hinuma Y; Dept. of Prevention and Therapeutics, Inst. for Virus Res., Kyoto; Univ., Sakyo-Ku Kyoto, 606 Japan

Abstract: Adult T-cell leukemia/lymphoma virus (ATLV) is reviewed under the following headings: the relation of ATLV to adult T-cell leukemia/lymphoma (ATL), biologic and immunologic properties of ATLV, epidemiology of ATLV, diversity of clinical features in ATLV infection or ATL, the relationship between ATLV and human T-cell leukemia virus (HTLV), and ATLV-like agents in monkeys. Human leukemia virus (HULV) is proposed as a better term for the virus denoted by the names ATLV and HTLV. Although ATLV has been characterized extensively within the last few years, further studies are appropriate, as follows: analysis of genes and proteins of ATLV as well as immunologic studies, which may disclose the mechanism of oncogenesis by ATLV; world-wide epidemiological studies involving antibody detection and detection of viral genome in cells by cloned probes of ATLV, which most likely will elucidate the ecology of ATLV; and elucidation of the exact routes of ATLV transmission to aid in establishment of plans to prevent infection of man. Certain immunological treatments linked to ATLV specificity, such as monoclonal antibodies or killer T cells, may prove effective in treating ATL. (74 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Adolescence Adult Animal Antibodies, Viral/ANALYSIS Antigens, Viral/ANALYSIS Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Human HTLV-BLV Viruses/IMMUNOLOGY/PATHOGENICITY Leukemia/IMMUNOLOGY/*MICROBIOLOGY Lymphoma/MICROBIOLOGY Macaca Middle Age Retroviridae Infections/IMMUNOLOGY/*MICROBIOLOGY MEETING PAPER


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Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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