Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons.

Science. 1986 Oct 31;234(4776):566-74. Unique Identifier : AIDSLINE GENBANK/M14220
Gurney ME; Heinrich SP; Lee MR; Yin HS

Abstract: A novel 56,000-dalton growth factor found in mouse salivary gland was purified, molecularly cloned, and expressed in monkey COS cells. The protein is a neurotrophic factor and also, surprisingly, a lymphokine product of lectin-stimulated T cells. The factor was therefore named neuroleukin. Neuroleukin promotes the survival in culture of a subpopulation of embryonic spinal neurons that probably includes skeletal motor neurons. Neuroleukin also supports the survival of cultured sensory neurons that are insensitive to nerve growth factor, but has no effect on sympathetic or parasympathetic neurons. The amino acid sequence of neuroleukin is partly homologous to a highly conserved region of the external envelope protein of HTLV-III/LAV, the retrovirus that causes acquired immune deficiency syndrome.
Keywords: Amino Acid Sequence Animal Cells, Cultured Chick Embryo Cloning, Molecular DNA/GENETICS Growth Substances/GENETICS/*PHYSIOLOGY Lymphokines/GENETICS/*PHYSIOLOGY Male Mice Mice, Inbred BALB C Motor Neurons/DRUG EFFECTS Muscles/INNERVATION Nerve Growth Factors/GENETICS/ISOLATION & PURIF/*PHYSIOLOGY Neurons/DRUG EFFECTS Neurons, Afferent/DRUG EFFECTS Salivary Glands/METABOLISM Spinal Cord/CYTOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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