Red cell autoantibodies in patients with acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Red cell autoantibodies in patients with acquired immune deficiency syndrome.

Transfusion. 1986 Sep-Oct;26(5):405-9. Unique Identifier : AIDSLINE MED/87020112
McGinniss MH; Macher AM; Rook AH; Alter HJ

Abstract: Mild-to-profound anemia, thrombocytopenia, and rarely neutropenia have been observed in patients with the acquired immune deficiency syndrome (AIDS). To investigate a possible immune mechanism, blood samples from 28 hospitalized AIDS patients, four asymptomatic homosexual men, four homosexual men with the AIDS-related lymphadenopathy syndrome, 30 hospitalized patients with diseases other than AIDS, and 60 blood donors were tested for the presence of atypical red cell antibodies. Eighteen AIDS patients (64%) had anti-i, nine (32%) had autoanti-U, and 12 (43%) had a positive direct antiglobulin test. One asymptomatic homosexual man and three homosexual men with lymphadenopathy also had anti-i. In contrast, of the 30 patients with diseases other than AIDS and 60 donors, none had anti-U or a positive direct antiglobulin test. One patient with sickle cell disease had anti-i. The mean hemoglobin level of AIDS patients with anti-i or anti-U was significantly lower than the mean hemoglobin level of patients who did not have those antibodies.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Autoantibodies/*ANALYSIS Erythrocytes/*IMMUNOLOGY Human Male Opportunistic Infections/BLOOD Sarcoma, Kaposi's/BLOOD JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyautoantibodies/KWDanalysiserythrocytes/KWDimmunologyhumanmaleopportunisticinfections/bloodsarcoma,kaposi's/bloodjournalarticle
870130
M8710203

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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