Karpas A; Dept. of Hematological Medicine, Univ. of Cambridge Clinical; Sch., Hills Road, Cambridge CB2 2QL, England
Results of long-term culture experiments and seroepidemiological studies are discussed in relation to adult T-cell leukemia viruses (ATLV)/human T-cell leukemia virus (HTLV), and the diseases attributed to these viruses. Topics include T-cell hairy cell leukemia, acquired immunodeficiency syndrome (AIDS), lymphadenopa
Manzari V; Collalti E; Gradilone A; Frati L; III Cattedra di Patologia Generale, Instituto di Biopatologia; Umana, Universita degli Studi La Sapienza, 00161 Roma, Italy
Characteristics of the human T-cell leukemia/lymphoma virus (HTLV) as revealed by electron microscopy, restriction enzyme analysis and seroepidemiological studies, are discussed. By electron microscopy, human T-cell leukemia/lymphoma virus (HTLV) appears to be a typical C retrovirus. HTLV can be grouped by its behavio
Immunity to Cancer. Reif AE, Mitchell MS, eds. New York, Academic Press, p. 323-45, 1985.. Unique Identifier : AIDSLINE ICDB/86627013
Stutman O; Memorial Sloan-Kettering Cancer Center, New York, NY
Immunological surveillance (IS) is discussed under the following headings: definitions, generality of IS, the tumor-host interaction, mechanisms, functions of the immune system, IS against contagious invaders, and IS and natural killer (NK) activity. IS has been defined as the immunological mechanism by which potentia
Immunity to Cancer. Reif AE, Mitchell MS, eds. New York, Academic Press, p. 347-61, 1985.. Unique Identifier : AIDSLINE ICDB/86627014
Fahey JL; Taylor J; Afrasiabi R; Weaver M; Mitsuyasu R; Center for Interdisciplinary Res. in Immunology and Disease,; Dept. of Microbiology and Immunology, UCLA Sch. of Medicine, Los; Angeles, CA 90024
Kaposi sarcoma (KS) was a rare disease in North America and Europe with prevalence of 0.01-0.06 per 100,000 prior to the epidemic of acquired immune deficiency syndrome (AIDS). The original epidemiologic description of AIDS included, at the beginning, only individuals with evidence of opportunistic infections or KS. T
Immunity to Cancer. Reif AE, Mitchell MS, eds. New York, Academic Press, p. 605-17, 1985.. Unique Identifier : AIDSLINE ICDB/86627036
Gardner MB; Pedersen N; Marx P; Henrickson R; Luciw P; Gilden R; Dept. of Medical Pathology, Sch. of Medicine, Univ. of; California, Davis, CA
Vaccine prevention of virus-induced animal tumors has provided convincing evidence that this would be the best way to attack such tumors in man. The animal model systems in which vaccine control of virus-induced tumors has been accomplished are briefly reviewed and new vaccine approaches against feline leukemia virus
Hinuma Y; Dept. of Prevention and Therapeutics, Inst. for Virus Res., Kyoto; Univ., Sakyo-Ku Kyoto, 606 Japan
Adult T-cell leukemia/lymphoma virus (ATLV) is reviewed under the following headings: the relation of ATLV to adult T-cell leukemia/lymphoma (ATL), biologic and immunologic properties of ATLV, epidemiology of ATLV, diversity of clinical features in ATLV infection or ATL, the relationship between ATLV and human T-cell
More than 14,000 cases of AIDS have been reported to the Centers for Disease Control as of October 1985. Two to five times that number of people were reported to have the AIDS-related conditions. An additional 12,000 cases of AIDS will have been reported by mid-year. In light of these statistics, an ever increasing nu
Health Matrix. 1986 Summer;4(2):14-7. Unique Identifier : AIDSLINE AHA/87008197
Lewis BF; Galea RP
I think AIDS is the worst disease in the world, and the fact that two people I used to get high with a couple of years ago are now dying puts fear in me. But, I ve talked about it honestly and openly and realize worrying about getting sick won t do a thing to prevent it. All I can do is pray. Is there anything more th
Health Matrix. 1986 Summer;4(2):3-13. Unique Identifier : AIDSLINE AHA/87008202
Gostin L
Acquired immune deficiency syndrome (AIDS) poses the greatest threat to public health of any communicable disease in contemporary times. Efforts to reduce the spread of this disease have become the United States top priority on the health scene. The following article examines the current medical data on the etiology,
Acquired immunodeficiency deficiency syndrome (AIDS) is atopic that currently grips the attention of many people in this country. How many surgical technologists have taken the time to study this subject and learn how we should respond? This article briefly reviews the microbiology and the transmission of AIDS, as wel
AIDS Res. 1983-84;1(4):231-6. Unique Identifier : AIDSLINE MED/87000001
Goudsmit J; Tersmette T; Kabel P; Miedema F; Melief C
Thirty-nine homosexual males, 11 of whom suffered from AIDS and 13 from Lymphadenopathy Syndrome (LAS), 18 healthy hemophiliacs and 12 healthy blood donors, not belonging to any AIDS risk group, were tested for IgG antibodies to Human T-lymphotropic retrovirus type III (HTLV-III) by indirect immunofluorescence. All te
Peripheral blood lymphocytes from male individuals at risk for AIDS were cultured in the presence of interleukin-2. Approximately 90% of cultures originating from pre-AIDS and AIDS patients were retrovirus-positive as detected by the reverse transcriptase (RT) assay and confirmed by electron microscopy. Prolonged incu
AIDS Res. 1983-84;1(4):275-97. Unique Identifier : AIDSLINE MED/87000006
Bayer R; Levine C; Murray TH
The identification of Acquired Immune Deficiency syndrome (AIDS) three years ago has created a crisis of confidence. Persons with AIDS and others who might be research subjects recognize that research is essential to understand, treat, and prevent this devastating disease, yet they are concerned that information divul
A collaborative study of sera from men in New York City with AIDS and at risk for AIDS, by investigators in Omaha, Cambridge and Kyoto, has failed to identify antibodies to human T cell leukemia virus I (HTLV-I).
AIDS Res. 1986 Summer;2(3):191-209. Unique Identifier : AIDSLINE MED/87000013
Patt YZ; Mansell PW; Reuben JM; Claghorn L; Li S; Gehan E; Hersh EM
Azimexon, a 2-cyan-aziridinyl immune modulator, was given at a dose of 250 mg/m2/day for 10 days IV to 12 patients with AIDS and 16 with AIDS related complex (ARC). A decrease in total number of AIDS related symptoms from 43 to 24 and in mean number from 2.6 to 1.5 was observed among ARC patients (p less than .01). Th
AIDS Res. 1986 Summer;2(3):231-4. Unique Identifier : AIDSLINE MED/87000017
Gould IA; Belok LC; Handwerger S
A forty-two year-old male homosexual with the acquired immunodeficiency syndrome (AIDS) developed Listeria monocytogenes septicemia and meningitis. The gastrointestinal tract was the likely portal of entry. The patient was treated with intravenous ampicillin with complete and permanent resolution of his listerial infe
AIDS Res. 1986 Summer;2(3):253-8. Unique Identifier : AIDSLINE MED/87000020
Bausell RB; Damrosch S; Parks P; Soeken K
A telephone interview of 1256 adults age 18 and over was conducted using a random digit dialing procedure. Participants were queried about their perceptions of being at risk for contracting the acquired immune deficiency syndrome (AIDS), optimism-pessimism about the controllability of the epidemic, whether they take s
Synergistic combinations of achievable serum levels of amikacin, rifampin, and ethambutol were tested for their ability to inhibit growth of Mycobacterium avium-intracellulare strains isolated from seven patients with acquired immune deficiency syndrome. Even when the isolates were very resistant to the individual ant
From Jan 1, 1981 to Oct 31, 1984, 24 of 280 (8.6 percent) patients with acquired immunodeficiency syndrome (AIDS) had tuberculosis. No patient with both AIDS and tuberculosis was Haitian. In 15 patients, tuberculosis was diagnosed prior to or concomitant with the diagnosis of AIDS. Twelve patients (50 percent) had Myc
Kazlow PG; Shah K; Benkov KJ; Dische R; LeLeiko NS
Oral Candida and Candida esophagitis are common findings in patients with the acquired immune deficiency syndrome. The intestinal protozoan, Cryptosporidium, is known to cause gastrointestinal symptoms in these patients. We report a 2-yr-old child with acquired immune deficiency syndrome, who had oral candidiasis, dys
The increasing infection of young pregnant women with the LAV/HTLV-III virus means that AIDS is now also becoming a problem for the gynecologist. This article reports on findings in 6 women, four of whom have borne a child. The three children examined to date are infected, with one of the children manifesting a lympha
Four cases of exaggerated scabies are described in patients who were immunodeficient secondary to human T-lymphotropic virus type III (HTLV-III) infection. As in classical scabies, these patients had a pruritic dermatitis but lacked the usual distribution of the eruption. The rash was initially misdiagnosed in all fou
The authors are studying from a personal case revealing an AIDS, and from bibliographical cases, the treated evolution of toxoplasmic encephalitis in immuno-depressed patients and the elements of the diagnosis. They are insisting on the interest of the brain biopsy, and on the importance of the inflammatory brain oede
Stat Med. 1986 Jul-Aug;5(4):355-62. Unique Identifier : AIDSLINE MED/87018395
Kaplan JE; Schonberger LB; Lui KJ
In the first seven cases of transfusion-associated acquired immunodeficiency syndrome (TA-AIDS) with completion of blood donor investigations, there was identification of at least one person (a high-risk donor--HRD) in each donor set who might have transmitted the disease. Using three definitions of an HRD, we estimat
Science. 1986 Oct 31;234(4776):566-74. Unique Identifier : AIDSLINE GENBANK/M14220
Gurney ME; Heinrich SP; Lee MR; Yin HS
A novel 56,000-dalton growth factor found in mouse salivary gland was purified, molecularly cloned, and expressed in monkey COS cells. The protein is a neurotrophic factor and also, surprisingly, a lymphokine product of lectin-stimulated T cells. The factor was therefore named neuroleukin. Neuroleukin promotes the sur
Mild-to-profound anemia, thrombocytopenia, and rarely neutropenia have been observed in patients with the acquired immune deficiency syndrome (AIDS). To investigate a possible immune mechanism, blood samples from 28 hospitalized AIDS patients, four asymptomatic homosexual men, four homosexual men with the AIDS-related
A rare care is presented of recurrent dysuria and urinary obstruction due to cryptococcal prostatitis in a thirty-six-year-old male with acquired immune deficiency syndrome. Although there are a handful of reports in the world literature of patients with cryptococcal prostatitis, this appears to be the first case repo
Sherman L; Gazit A; Yaniv A; Dahlberg JE; Tronick SR
The nucleotide sequence of the long terminal repeat (LTR) of caprine arthritis encephalitis virus (CAEV), a prototype lentivirus was determined. 6-bp directly repeated host cell sequences flank the 376-bp proviral LTRs. By comparison with other retroviral sequences, the CAEV LTR likely contains U3, R and U5 regions 20
Hausser D; Villars S; Burnand B; Glauser MP; Gutzwiller F
Objective information for the groups exposed to the disease and the public in general is the only step that is currently possible in the prevention of AIDS. A certain number of information and support actions have been developed as a consequence of the appearance of AIDS in Switze
Herpes genitalis is commonly seen by the obstetrician-gynecologist. Prolonged persistence of herpes is unusual and may herald an underlying disorder. A case of chronic primary herpes is presented, in which the diagnosis of acquired immunodeficiency syndrome was delayed because of a low degree of suspicion.
Am J Public Health. 1986 Nov;76(11):1325-30. Unique Identifier : AIDSLINE MED/87023518
Arno PS
Community-based organizations in San Francisco have played a key role in providing social support services and public health information to those affected by acquired immune deficiency syndrome (AIDS). These services have helped minimize the economic impact of the epidemic by reducing the level and expense of hospital
Am J Surg. 1986 Oct;152(4):403-6. Unique Identifier : AIDSLINE MED/87023593
Helsper J; Formenti S; Levine A
Initial manifestation of AIDS in the head and neck region occurs frequently. The purpose of this report has been to alert the head and neck surgeon to the occurrence of AIDS-related lesions, their clinical characteristics, and disease outcome. Incomplete recognition of these disorders may delay appropriate diagnostic
Ann Med Interne (Paris). 1986;137(3):251-3. Unique Identifier : AIDSLINE MED/87024206
Singer DR; Venning MC; Lockwood CM; Pusey CD
We report the clinical features and outcome of 16 patients with cryoglobulinaemia. Two patients with Type I cryoglobulinaemia both had IgG kappa monoclonal paraproteins. Nine of 10 with Type II disease had monoclonal IgM kappa and polyclonal IgG; one had monoclonal IgG kappa and polyclonal IgG in the cryoglobulin. Und
Ann Med Psychol (Paris). 1986 Jan;144(1):94-102. Unique Identifier : AIDSLINE MED/87024222
Rager P; Benezech M; Bourgeois M
From hundred diagnostic evaluations according to D.S.M.-III classification, the authors bring to light the frequency of psychiatric disorders among the prisoners. Substance use disorder (axis 1) and antisocial personality (axis 2) are the more frequent diagnosis and they are often associated. Schizophrenic disorders a
Ann Ophthalmol. 1986 Sep;18(9):260-1. Unique Identifier : AIDSLINE MED/87024226
Zaidman GW
A 33-year-old homosexual patient with acquired immune deficiency syndrome (AIDS) developed sudden unilateral loss of vision. Slit-lamp and funduscopic examination of the affected eye was completely within normal limits. The patient, however, had a Marcus Gunn pupil, decreased color vision, and a large central scotoma
There is widespread concern amongst laboratory workers over the risks of exposure to human T cell lymphotrophic virus III [HTLV III] and the possibility of the subsequent development of the acquired immune deficiency syndrome [AIDS]. HTLV III is thermolabile and is completely inactivated by heating at 56 degrees C for
A 49-year-old bisexual man with generalized lymphadenopathy and antihuman T lymphocyte virus, type III, (HTLV-III) antibodies presented with recurrent, unilateral amaurosis fugax. A temporal artery biopsy specimen showed eosinophilic vasculitis. The patient then developed acquired immunodeficiency syndrome with Kaposi
Feinberg MB; Jarrett RF; Aldovini A; Gallo RC; Wong-Staal F
The African green monkey nonlymphoid cell line cos-1 produces infectious HTLV-III virus following transfection with biologically active molecular clones of HTLV-III. Transfected cos-1 cells produce large amounts of viral RNA and protein. We have used this rapid transfection system to study the regulatory functions and
Le Tourneau A; Audouin J; Diebold J; Marche C; Tricottet V; Reynes M
The detection of LAV- or HTLV III-type viral particles in lymph node germinal centers from patients with the persistent lymphadenopathy syndrome (LAS) or the acquired immunodeficiency syndrome (AIDS)-related complex (ARC) is an important diagnostic factor in the prodromal stages of AIDS. These particles, the morpholog
Harada S; Purtilo DT; Koyanagi Y; Sonnabend J; Yamamoto N
A sensitive assay for neutralizing antibodies (NA) against AIDS-related viruses (HTLV-III and LAV) was developed, using human T-cell lymphotropic virus type-I (HTLV-I)-bearing and HTLV-III-susceptible MT-4 cells. NA to HTLV-III in 21 patients with acquired immune deficiency syndrome (AIDS), 10 individuals with AIDS-re
The principle and technical design of a simple UV sterilization device for applanation tonometer bodies is described. Time-dose relations effective against HTLV-III-LAV are given.
The retrovirus human T cell lymphotropic virus type III (HTLV-III) can cause no symptoms at all, a syndrome of vague symptoms such as fever and fatigue, or full-blown acquired immune deficiency syndrome (AIDS). Serologic tests for antibodies to HTLV-III are available for identifying the virus; tests for T lymphocyte s
In March 1985 an ELISA test for serum antibodies to human T-cell leukemia/lymphotropic virus type III (HTLV-III) was licensed for use in screening commercial blood products. Controversy over the appropriate use and interpretation of this test continues, and some public health officials in the
Virology. 1986 Oct 30;154(2):249-58. Unique Identifier : AIDSLINE MED/87020732
Harada S; Koyanagi Y; Nakashima H; Kobayashi N; Yamamoto N
The incubation of Molt-4/HTLV-III cells, human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV)-producer cell line, with more than 0.5 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 2 to 4 days stimulated virus-induced cell killing which resulted in a high production of HTLV-III
A 42-year-old homosexual man without evidence of immune deficiency developed cerebral granulomatous angiitis in association with the isolation of human T-lymphotropic virus type III (HTLV-III) from brain tissue and cerebrospinal fluid. This syndrome may be an additional neurological sequela of HTLV-III infection.
In a group of homosexual men in Vancouver studied prospectively since November 1982, 26 cases of acquired immune deficiency syndrome (AIDS) have arisen. To identify behavioural, clinical and laboratory findings that might predict the development of AIDS in people with antibody to human immunodeficiency virus (HIV), we
Monoclonal antibodies can be used in sandwich enzyme-linked immunosorbent assays to measure viral antigens. Such an assay was developed to detect the core protein, p24, of human T-cell lymphotropic virus type III and lymphadenopathy-associated virus, etiologic agents of the acquired immunodeficiency syndrome (AIDS). A
Nature. 1986 Oct 2-8;323(6087):467-9. Unique Identifier : AIDSLINE MED/87014811
Ruprecht RM; O'Brien LG; Rossoni LD; Nusinoff-Lehrman S
The retroviruses human T-cell lymphotrophic virus-I (HTLV-I) and HTLV-III/LAV (lymphadenopathy-associated virus) are clearly linked to human diseases. Patients with HTLV-I-positive neoplasms may respond transiently to traditional chemotherapy, but are not cured. For patients with acquired immune deficiency syndrome (A
This report describes the neurologic manifestations of 36 children with human immunodeficiency virus (HIV) infection. In this cohort, in 16 of 21 children with acquired immunodeficiency syndrome (AIDS), three of 12 children with AIDS-related complex, and one of three asymptomatic seropositive children, a progressive e
Proc Natl Acad Sci U S A. 1986 Oct;83(20):7935-7. Unique Identifier : AIDSLINE MED/87017061
Levy JA; Pan LZ; Beth-Giraldo E; Kaminsky LS; Henle G; Henle W; Giraldo G
Three different assays for detection of antibodies to the human immunodeficiency virus (HIV) were conducted on 677 sera obtained from 1964 to 1975 from male and female children and adults in Uganda and other countries in Africa. Several sera were collected from individuals with Kap
Loeb I; Jonkheer T; Philippart P; Chaikh A; Levy J
The authors describe the case of a little girl from Zaire presenting a proven HTLVIII infection. The interest of this observation lies in the fact that the clinical symptoms, leading to this diagnosis, fall within the competence of stomatology.
Ann Intern Med. 1986 Nov;105(5):679-82. Unique Identifier : AIDSLINE MED/87024140
Fallon T Jr; Abell E; Kingsley L; Ho M; Winkelstein A; Jensen F; Rinaldo C Jr
Physical examination by a single clinician showed that 17 of 51 asymptomatic homosexual men and 19 of 26 men with persistent lymphadenopathy had linear telangiectasias in a broad, crescent distribution across the chest. The telangiectasias were commonly associated with erythema in the same distribution. Of the 36 men
AIDS Res. 1986 Summer;2(3):227-30. Unique Identifier : AIDSLINE MED/87000016
Tirelli U; Vaccher E; Carbone A; Volpe R; De Paoli P; Santini G; Monfardini S
Persistent generalized lymphadenopathy (PGL) is the most frequent AIDS related manifestation in homosexual men. From May 1984 to March 1985, 45 (38%) out of 117 intravenous (iv) drug abusers evaluated had PGL. Thirty-two were males and 13 females (median age 25 years). All patients referred to the frequent sharing of
In a group of 61 patients admitted to New England Deaconess Hospital, Boston, with a diagnosis of acquired immune deficiency syndrome (AIDS), 25 were found to have Kaposi s sarcoma involving the skin and mucous membranes. Of these 25 patients, eight had lesions involving the respiratory system. Radiographically, patie
Spontaneous pneumothorax is a rare complication of pneumonia. Three cases of spontaneous pneumothorax in patients with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome are described. Two patients had bronchopleural fistulas. Local subpleural necrosis was felt to be the cause of the pneumothorax. P
Functional analyses of peripheral blood leukocytes (PBL) from high risk HTLV-III antibody-negative and antibody-positive donors, as well as from patients with acquired immune deficiency syndrome (AIDS), lymphadenopathy syndrome (LAS), and AIDS-related complex (ARC) were performed by the in vitro generation of cytotoxi
Med Hypotheses. 1986 Aug;20(4):421-7. Unique Identifier : AIDSLINE MED/87014175
Sharpe RJ; Schweizer RT
The acquired immunodeficiency syndrome (AIDS) is caused by the LAV/HTLV-III virus. The incubation period for AIDS is prolonged and on the order of years. We hypothesize that during this prolonged incubation period the LAV/HTLV-III virus is replicating very slowly and is present in extremely low concentrations. The con
We reviewed the clinical records and chest radiographs of all patients admitted to our institution between 1982 and 1984 who had pulmonary disease and who were later proved to have acquired immunodeficiency syndrome (AIDS) (95 patients). Diffuse parenchymal lung disease was the most common finding. These infiltrates w
South Med J. 1986 Oct;79(10):1315-6. Unique Identifier : AIDSLINE MED/87019120
Kelly AR; Sutker WL
For unknown reasons, manifestations of even heavy opportunistic infection in AIDS patients may be chronic and subtle. We have presented the second fully reported case of an AIDS patient with symptomatic Pneumocystis carinii pneumonia in whom the usual screening tests of blood gases and chest roentgenography were norma
Tumori. 1986 Aug 31;72(4):365-74. Unique Identifier : AIDSLINE MED/87020262
Contu L; Carcassi C; La Nasa G; Zurrida SM; Sirigu F; Del Giacco S; Cerimele D; Longinotti M; Pitzus F
We report a case of classical Kaposi s sarcoma (KS) in a patient affected by B-cell chronic lymphocytic leukemia for 2 years and who had not received any antiblastic treatment. At the ultrastructural analysis the leukemic cell showed rather immature features, and the immunologic phenotype (absence of detectable cytopl
Virology. 1986 Oct 30;154(2):395-400. Unique Identifier : AIDSLINE MED/87020746
Rasheed S; Gottlieb AA; Garry RF
Extensive cell killing and cytopathology were observed within 24 hr after exposure of a clonal cell line of human T-4 lymphocytes (RH9) to culture supernatants containing human immunodeficiency virus (HIV). Ultraviolet-irradiated HIV-containing culture fluids were also capable of killing RH9 cells and of inducing spec
Z Erkr Atmungsorgane. 1986;167(1-2):12-7. Unique Identifier : AIDSLINE MED/87021250
Renovanz HD
AIDS represents a virus-induced disturbance of the cell-determined immunity which is seen in ever increasing numbers of cases even in Europe. AIDS occurs in certain risk groups. Clinically the first symptoms of the disease which are seen are pulmonary, bouts of fever, unproductive coughing, dyspnoea whilst dullness, b
The radiographic appearance of gastrointestinal Kaposi s sarcoma in patients with AIDS has been described previously, but little attention has been paid to pharyngeal involvement. This study compared the radiographic findings of pharyngeal Kaposi s sarcoma in eight patients with AIDS and dysphagia to those of visual i
The radiologic studies of 200 consecutive AIDS patients with neurologic symptoms were evaluated to determine their diagnostic specificity and prognostic value. Of 81 patients with initially normal CT scans, four (5%) later developed progressive neurologic illness. Of 75 patients with CT evidence of diffuse cerebral at
The ever-increasing number of patients with acquired immunodeficiency syndrome (AIDS) will involve more surgeons in their diagnosis and treatment. The surgeon should be aware of the cause of AIDS, mode of transmission, method of diagnosis, usual cutaneous and abdominal manifestations, complications needing operative p
AIDS Res. 1986 Summer;2(3):211-8. Unique Identifier : AIDSLINE MED/87000014
Bottone EJ; Toma M; Johansson BE; Wormser GP
Ten isolates of Cryptococcus neoformans recovered from individual patients with the acquired immunodeficiency syndrome (AIDS) were studied in conjunction with three other isolates from non-AIDS patients. On primary culture nine out of ten of the AIDS isolates grew as nonmucoid, dry, pasty colonies resembling those pro
AIDS Res. 1986 Summer;2(3):219-25. Unique Identifier : AIDSLINE MED/87000015
Bottone EJ; Wormser GP
Cryptococcus neoformans recovered from the cerebrospinal fluid (CSF) of eight patients, seven with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC), were studied to assess the relationship between degree of encapsulation noted in fresh CSF with that observed after animal passage. We further
Cancer Res. 1986 Nov;46(11):5457-68. Unique Identifier : AIDSLINE MED/87002143
Levy JA
I have attempted to illustrate the many different properties of retroviruses and their presence in a wide variety of animal species including humans. Since the turn of this century, progress in the field of retrovirology has been noteworthy and many new and important scientific observations have been made (Table 7). A
A novel, highly quantitative transient expression assay based on the human interleukin-2 ( IL-2 ) gene was used to examine the trans-activation of the Human Immunodeficiency Virus (HIV/HTLV-III/LAV/ARV) long terminal repeat (LTR) in a range of eukaryotic cell lines. In t
Hosp Community Psychiatry. 1986 Oct;37(10):1001-6. Unique Identifier : AIDSLINE MED/87006528
Perry SW; Markowitz J
Although the medical and psychosocial problems posed by acquired immune deficiency syndrome (AIDS) are unique, interventions to treat AIDS-related psychiatric disorders are currently available. The depression, delirium, and denial that occur in medically hospitalized patients with AIDS respond to standard psychotherap
Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c
HLA A, B, C, typing have been done in 39 patients with clinically and histologically documented classical Kaposi s sarcoma. Thirty three were also typed for HLA DR antigens. Twenty seven were males, 12 were females and three ethnic groups were represented: european caucasoids 41%, north african caucasoids 38.5% and ne
Schweiz Med Wochenschr. 1986 Aug 23;116(34):1119-26. Unique Identifier : AIDSLINE MED/87018754
Cottier H; Hess MW; Walti ER
This is a short overview concerning possible relationships between immunodeficiency and cancerogenesis/leukemogenesis. Following introductory remarks on concomitant and sinecomitant antitumor immunity, various factors/mechanisms that could influence tumor-host-interactions are discussed, in particular properties of ne
Alpha interferon has been the most widely studied biologic response modifier for the treatment of Kaposi s sarcoma (KS) associated with acquired immune deficiency syndrome (AIDS). At San Francisco General Hospital s AIDS Clinic, three sequential trials of recombinant interferon alfa-2b (Intron A) were conducted betwee
Cloning and expression in E. coli cells of a fragment of the env gene of HTLV-III virus is described. This fragment coding for from 294 to 757 aminoacid residue of virus protein was cloned in plasmid pUC 18. Conditions are described contributing to the regulated functioning of Lac-promoter allowing the expression of p
Am J Med. 1986 Oct;81(4):579-83. Unique Identifier : AIDSLINE MED/87023099
Goldsmith JC; Dewhurst S; Hedenskog M; Casareale D; Volsky DJ
Twenty-eight patients from the Nebraska Regional Hemophilia Center were studied for the prevalence and titers of antibodies to lymphadenopathy-associated virus/human T cell lymphotropic virus type III (LAV/HTLV-III) and for clinical symptoms of possible progression to the acquired immune deficiency syndrome (AIDS). Te
Ann Intern Med. 1986 Nov;105(5):730-6. Unique Identifier : AIDSLINE MED/87024152
Conte JE Jr
Infection with the human immunodeficiency virus (HIV) (formerly HTLV-III/LAV) is transmitted by sexual contact, by blood and blood products, and perinatally. There is no evidence for casual transmission. The risk to health care workers is low but appropriate infection control precautions should be taken. Specimens sho
Ann Neurol. 1986 Sep;20(3):289-95. Unique Identifier : AIDSLINE MED/87024404
Gabuzda DH; Ho DD; de la Monte SM; Hirsch MS; Rota TR; Sobel RA
Human T-cell lymphotropic virus type III (HTLV-III) has been isolated from neural tissues and cerebrospinal fluid (CSF) of patients with neurological syndromes associated with the acquired immune deficiency syndrome (AIDS) and the virus may be directly involved in the pathogenesis of the syndromes. To detect HTLV-III
Multinucleated giant cells that are characteristic of the encephalomyelopathy of acquired immunodeficiency syndrome are stained by a lectin histochemical method. The particular lectin used, Ricinus communis agglutinin I, has been shown to bind to endogenous microglial cells in human brain, as well as to endothelial ce
Human immunodeficiency virus (HIV), the retrovirus that causes the acquired immunodeficiency syndrome, is cytopathic for CD4+ T cells and binds to these cells via a complex of the 110,000 m.w. viral-envelope glycoprotein, gp110, and the CD4 molecule. We treated virus with several physical, chemical, and enzymic agents
There is much interest in developing vaccines against acquired immune deficiency syndrome (AIDS), which is caused by a retrovirus termed human immunodeficiency virus (HIV). Isolates of this virus include human T-lymphotropic virus type III (HTLV-III), lymphadenopathy-associated virus (LAV), and AIDS-associated retrovi
The psychiatric, psychosocial, and ethical considerations in the design and evaluation of health care programs for AIDS patients and others with HIV infection are described in this article. The responsibilities of health care providers are considered in the context of the history and epidemiology of AIDS, previous res
In 1982 only 20 cases of AIDS were recognized in the Chicago area. Today 383 cases are known. The Howard Brown Memorial Clinic provides the 120 surviving individuals and their loved ones with comprehensive and coordinated services ranging from financial assistance to significant other support groups.
The ombudsman position was created at the Gay Men s Health Crisis (GMHC) in New York to link AIDS patients with the health care system. The department, which has served 3,400 clients since 1982, handles complaints and problems relating to such areas as ambulatory care, home attendant care, and advocacy for improved pa
Infectivity of human T-cell lymphotropic virus, Type III (HTLV-III) was inactivated by heat more rapidly if in liquid medium than if lyophilized and more rapidly at 60 degrees than 56 degrees C. When HTLV-III was added to factor VIII suspension, then lyophilized and heated at 60 degrees C for 2 hours or longer there w
Biochem Biophys Res Commun. 1986 Aug 29;139(1):367-74. Unique Identifier : AIDSLINE MED/87025726
Weigent DA; Hoeprich PD; Bost KL; Brunck TK; Reiher WE 3d; Blalock JE
A region of human interleukin-2 ( IL-2 ) which was predicted to be a contact point with its receptor was used to locate a homologous region in the envelope protein of human T-lymphotropic retrovirus (HTLV-III). This homologous six amino acid peptide from the carboxy (C)-
AIDS Res. 1986 Summer;2(3):183-90. Unique Identifier : AIDSLINE MED/87000012
Reiss RF; Rubinstein P; Friedman-Kien A; Laubenstein LJ; Ciavarella D; Smith J; Walker M
Intensive plasma exchange was performed in seven male homosexual patients with AIDS and Kaposi s sarcoma. Serial 1.2 plasma volume exchange procedures were performed three times a week for six weeks. In five of the patients, plasma replacement included gamma globulin in the form of plasma (two patients), or an IV IgG
AIDS Res. 1986 Summer;2(3):235-47. Unique Identifier : AIDSLINE MED/87000018
Inada Y; Lange M; McKinley GF; Sonnabend JA; Fonville TW; Kanemitsu T; Tanaka M; Clark WS
Circulating immune complexes (CICs) are common in patients with the acquired immunodeficiency syndrome (AIDS) as in anemia. In our previous reports, we observed that the deposition of CICs on erythrocytes via C3b receptors (CR1) resulted in a defective CIC clearing system of erythrocytes and in high membrane osmotic f
Tausk FA; McCutchan A; Spechko P; Schreiber RD; Gigli I
We studied levels of erythrocyte C3b receptors (E-CR1) and correlated them to the level of circulating immune complexes (CIC) and complement activation in patients with or at risk for acquired immunodeficiency syndrome (AIDS). A significant reduction was found in patients with AIDS (185 +/- 93 CR1/cell), AIDS-related
Functional and phenotypical parameters demonstrated significant aberrations in both prodromal males and patients with the acquired immune deficiency syndrome (AIDS). Impaired B-cell functions as quantitated by Staphylococcus aureas Cowan Strain I (SAC) and pokeweed mitogen (PWM)-induced blastogenesis, intracytoplasmic
A new case of lymphocytic interstitial pneumonitis developed in the course of a persistent generalized lymphadenopathy syndrome is reported. The patient was a 30-year old Haitian woman with only her ethnic risk factor. Broncho-alveolar lavage showed high cellularity with mostly major lymphocytosis (76%) and a fall of
A system has been developed for expression of surface protein (SP) of the virus of acquired immune deficiency syndrome (AIDS) in E. coli. For this purpose, cloning and substitution of a fragment of SP gene of HTLV-III virus under control of PL-promoter of phage lambda was carried out using pre-modified plasmid vector
Am J Med. 1986 Oct;81(4):584-90. Unique Identifier : AIDSLINE MED/87023100
Rush TJ; Betts RF; Saxinger C; Cowell SA; Ryan DH; Yang CC; Steigbigel RT
The cause of the abnormal T lymphocyte subsets reported in healthy homosexual men is not known. Frequent sexually transmitted infections including human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) are possible causes. To determine if the T lymphocyte subsets were abnormal in this
Cutaneous delayed-type hypersensitivity was measured using the Multitest CMI in a group of 97 patients with hemophilia who were enrolled in the New England Area Comprehensive Clinic. The Multitest CMI is a multipuncture system that dispenses seven test antigens including tetanus, diphtheria, Streptococcus, Proteus, tu
AIDS Res. 1986 Summer;2(3):175-81. Unique Identifier : AIDSLINE MED/87000011
Fiala M; Cone LA; Chang CM; Mocarski ES
Cytomegalovirus ( CMV ) viremia was studied in 15 homosexual patients [two healthy, nine with the acquired immune deficiency syndrome (AIDS), five with the AIDS-related complex (ARC)], in one patient with transfusion-related AIDS, and in four individuals with canc
AIDS Res. 1986 Summer;2(3):249-52. Unique Identifier : AIDSLINE MED/87000019
Bakeman R; Lumb JR; Smith DW
Analysis of the AIDS case data for the United States reported to the Centers for Disease Control reveals quite different risk group profiles for minorities and for whites. A much higher percentage of minority male AIDS cases are heterosexual, the ratio of bisexual to homosexual cases i
The haematological and immunological characteristics of 34 healthy anti-HTLV-I antibody-positive individuals (HTLV-I carriers) in southwestern Japan were examined. No significant difference was noted between carriers and the controls in counts of RBC, WBC and the absolute number of
Cell. 1986 Oct 10;47(1):29-35. Unique Identifier : AIDSLINE MED/87002489
Okamoto T; Wong-Staal F
Human T cell lymphotropic viruses (HTLV s) differ from most other retroviruses based on the presence of trans-regulatory genes for virus expression. In this study, using an in vitro cell-free transcription system, we demonstrate that nuclear extracts obtained from cells infected with HTLV-III (human immunodeficiency v
Interleukin-2 ( IL-2 ) is a lymphokine synthesized by T cells following activation. Resting T cells do not express IL-2 receptors, but receptors are rapidly expressed on T cells following interaction of the antigen-specific T-cell-receptor complex with appropriately proc
Ataxia telangiectasia (AT) is a primary immunodeficiency syndrome characterized by oculocutaneous telangiectasia, ataxia, recurrent infection and development of malignancies. Epstein-Barr virus (EBV) is a B-cell lymphocytotropic virus which causes infectious mononucleosis and is also highly associated with Burkitt s l
Gomori s methenamine silver and the periodic acid--Schiff reaction stain cytoplasmic but not intranuclear cytomegalovirus inclusions. The biochemical basis of these staining qualities is discussed, and the staining characteristics are correlated with supporting ultrastructural obse
Immunol Lett. 1986 Aug;13(1-2):19-24. Unique Identifier : AIDSLINE MED/87006872
Lee TH; Essex M; Klein E; Klein G
Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA
Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, fro
We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 1 1/2 yr for relationships between cytomegalovirus ( CMV ) and human T-lymphotropic virus type III (HTLV-III) infections. CMV was most frequently isolated
Ernberg I; Bjorkholm M; Zech L; Sandstedt B; Szigeti R; Andersson J; Henle W; Klein G
A Burkitt-like lymphoma/leukemia confined to bone marrow was detected in a human T cell leukemia virus (HTLV)-III/LAV- and Epstein-Barr virus (EBV)-seropositive homosexual man. The tumor cells were EBNA-positive and contained at least 22 EBV genomes per cell. They were totally immunoglobin negative, but showed other m
Rotbart HA; Levin MJ; Jones JF; Hayward AR; Allan J; McLane MF; Essex M
Three Native American children with severe combined immunodeficiency developed noma, a necrotizing gingivostomatitis not previously reported in this country. The similarity between the clinical findings and those observed in monkeys with simian AIDS prompted us to evaluate our patients and their families for human ret
Bryant ML; Gardner MB; Marx PA; Maul DH; Lerche NW; Osborn KG; Lowenstine LJ; Bodgen A; Arthur LO; Hunter E
The Mason- Pfizer monkey virus (MPMV) was reisolated from a cryopreserved sample of the original MPMV-containing rhesus breast carcinoma, and complete integrated MPMV provirus was detected in chromosomal DNA of this tumor. Reanalysis of the in vivo pathogenicity and molecul
The authors report on a baby born on August 25, 1984 with a birthweight of 1100 g. Her parents used drugs intravenously and her mother had anti-HTLV III antibody. In the clinical course an immune deficiency syndrome with pathologic reduction of T4:T8 (T-helper: T-suppressor cells) was apparent. The child had no anti-H
Klin Wochenschr. 1986 Aug 15;64(16):760-6. Unique Identifier : AIDSLINE MED/87012948
Kramer HJ; Baecker A; Weiler E; Liddiard C
An endogenous inhibitor of sodium transport and of the Na-K-ATPase enzyme was previously detected in the small molecular weight postsalt fraction SIV of serum from saline-loaded rats after gel filtration on Sephadex G-25. In addition, a natriuretic factor present in this fraction of urine from salt-loaded subjects was
Del Mistro A; De Rossi A; Aldovini A; Salmi R; Chieco-Bianchi L
In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2
Raffoux C; David V; Couderc LJ; Rabian C; Clauvel JP; Seligmann M; Colombani J
HLA-A B and DR typing were performed in 77 patients with AIDS related complex (ARC)--69 lymphadenopathy associated syndrome and 8 thrombocytopenic purpura LAV/HTLV III related--and 21 symptom free homosexual males. A significant increase in the frequency of HLA DR5 antigen was observed in patients with ARC mainly in p
Mann JM; Francis H; Davachi F; Baudoux P; Quinn TC; Nzilambi N; Bosenge N; Colebunders RL; Kabote N; Piot P; et al
Seroprevalence to human immunodeficiency virus (HIV) was determined among 368 children 2 to 14 years of age who were admitted to the pediatric service at Mama Yemo Hospital in Kinshasa, Zaire . Forty (11%) of these patients and only one (1%) of 92 healthy siblings of these patients
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7192-6. Unique Identifier : AIDSLINE MED/87016913
Giam CZ; Nerenberg M; Khoury G; Jay G
Human T-cell leukemia virus type I (HTLV-I), a virus associated with adult T-cell leukemia, contains a long open reading frame (LOR) in the 3 end of its genome between the env region and the 3 long terminal repeat (LTR). This open reading frame encodes a 40-kDa protein (designated p40x) that has been implicated as a
Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated
Am J Gastroenterol. 1986 Oct;81(10):944-50. Unique Identifier : AIDSLINE MED/87022936
Hinnant KL; Rotterdam HZ; Bell ET; Tapper ML
Alimentary tract cytomegalovirus ( CMV ) infections of 24 patients were reviewed, including 19 with the acquired immune deficiency syndrome. CMV inclusion bodies (CMV-IB) were calibrated per mm2 of tissue. CMV-IB counts were co
Am J Hematol. 1986 Nov;23(3):239-45. Unique Identifier : AIDSLINE MED/87022977
McGrath KM; Spelman D; Barnett M; Kellner S
One hundred fifty-eight hemophilia A, B, and von Willebrand disease (VWD) patients treated with clotting factor concentrates from a single manufacturer were tested for antibody to the human T-lymphotropic virus type III (HTLV-III). Antibody was detected in 63% and 40% of those with severe hemophilia A and B, respectiv
Am J Hematol. 1986 Nov;23(3):295-305. Unique Identifier : AIDSLINE MED/87022984
Gomperts ED
A considerable body of data has accumulated on the viral inactivated clotting factor concentrates. This information strongly indicates considerable safety and expected efficacy of these products. Probably most procedures are capable of inactivating large amounts of the LAV/HTLV-III virus, but there is considerable var
Carson LF; Twiggs LB; Fukushima M; Ostrow RS; Faras AJ; Okagaki T
Immunologic evaluations of women with genital neoplasia-papilloma syndrome demonstrated the presence of subclinical immunodeficiency when compared with results in 20 control women. All patients with genital neoplasia-papilloma syndrome were previously found to have human papillomavirus deoxyribonucleic acid in genital
Twenty-six strains of the Mycobacterium avium complex isolated from persons with AIDS were examined for plasmid content. The strains were of serotypes 4, 8, 4/6, and 4/8. Plasmid content was determined by agarose gel electrophoresis. All 26 strains carried small plasmids (9 to 15 Mdal), with 11 strains carrying 1 smal
Biochem Biophys Res Commun. 1986 Aug 29;139(1):129-35. Unique Identifier : AIDSLINE GENBANK/M13810
Nam SH; Hatanaka M
We determined the nucleotide sequence of a region between the gag and pol genes of a replication-competent proviral clone of a human T-cell leukemia virus type I (HTLV-I) from MT-2 cells. This region overlapping the gag and pol genes contains an open reading frame with a different phase from others. The deduced amino
Biochem Biophys Res Commun. 1986 Aug 29;139(1):353-60. Unique Identifier : AIDSLINE MED/87025724
Noma T; Nakamura T; Maeda M; Okada M; Taniguchi Y; Tagaya Y; Yaoita Y; Yodoi J; Honjo T
IL-1 alpha cDNA clone was isolated from a T cell line infected by the human T lymphotropic retrovirus type-I (HTLV-I/ATLV). We found significant amounts of mRNA hybridizing to IL-1 alpha cDNA not only in HTLV-I-transformed T cells but also in Epstein-Barr Virus-transformed B cells. A part of
Cancer. 1986 Nov 15;58(10):2244-50. Unique Identifier : AIDSLINE MED/87001888
Sadamori N; Nishino K; Kusano M; Tomonaga Y; Tagawa M; Yao E; Sasagawa I; Nakamura H; Ichimaru M
The chromosomes of leukemic blood cells in eight Japanese patients with acute adult T-cell leukemia (ATL) were examined by a direct method or short-term culture method without any mitogens. Six patients showed a chromosome 14 anomaly with a break at band q11-13: inv(14)(q11q32) in two patients, t(11;14)(p13;q13) in on
J Immunol. 1986 Nov 1;137(9):2945-51. Unique Identifier : AIDSLINE MED/87009972
Copeland TD; Tsai WP; Kim YD; Oroszlan S
Three peptides corresponding to selected regions of the env gene products of human T cell leukemia virus type I were synthesized by solid-phase Merrifield techniques. The sequence of peptide designated SP-65 was identical to the predicted C-terminal 12 residues of the transmembrane protein p21env, and peptide SP-74 wa
Mann JM; Francis H; Davachi F; Baudoux P; Quinn TC; Nzilambi N; Bosenge N; Colebunders RL; Piot P; Kabote N; et al
A prevalence study of antibody to human immunodeficiency virus (HIV) was conducted in Kinshasa, Zaire , among 258 children 2-24 months old who were in hospital, 191 children 1-20 months old who were attending a well-child clinic, and their mothers. 8% of the mothers of both groups
Frazer IH; Medley G; Crapper RM; Brown TC; Mackay IR
Cells from the anorectal mucosa of 61 homosexual men were examined microscopically for evidence of papillomavirus infection and dysplastic changes. There was cytological evidence of dysplasia with concomitant features of human papillomavirus (HPV) infection on at least one occasion in 24 men and of papillomavirus infe
Asjo B; Morfeldt-Manson L; Albert J; Biberfeld G; Karlsson A; Lidman K; Fenyo EM
T-lymphotropic viruses were isolated from 31 patients with different clinical manifestations of human immunodeficiency virus (HIV) infection. Lymphocyte cultures from patients with the acquired immunodeficiency syndrome (AIDS) or pre-AIDS yielded virus rapidly, as indicated by high levels of reverse transcriptase (RT)
Mann JM; Bila K; Colebunders RL; Kalemba K; Khonde N; Bosenge N; Nzilambi N; Malonga M; Jansegers L; Francis H; et al
The natural history of human immunodeficiency virus (HIV) infection in Zaire was determined by identifying in October, 1984, 125 seropositive hospital personnel without signs or symptoms and 145 age and sex matched seronegative controls from the same population. Between July, 1985
Etiology of and pathogenetic mechanisms in multiple sclerosis are still badly known; therapy is thus uncertain and poorly active. Many recent studies have nevertheless shown a weak but clear association with HLA-DR2, as the possible role of a HTLV-related virus. Infection of genetically sensitive (DR2 positive) childr
Schweiz Med Wochenschr. 1986 Aug 23;116(34):1126-33. Unique Identifier : AIDSLINE MED/87018755
Schupbach J
Retroviruses are known to cause a variety of naturally occurring disorders in animals. These include various types of cancer, immune deficiencies, and degenerative and autoimmune disorders. In man, retroviruses are the causal agents of adult T-cell leukemia/lymphoma and AIDS. In addition, serologic evidence suggests t
Science. 1986 Oct 31;234(4776):596-601. Unique Identifier : AIDSLINE MED/87018841
Salahuddin SZ; Ablashi DV; Markham PD; Josephs SF; Sturzenegger S; Kaplan M; Halligan G; Biberfeld P; Wong-Staal F; Kramarsky B; et al
A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals: two HTLV-III seropositive patients from the United States (one with AIDS-related lymphoma and one with dermatopathic lymphadenopathy), three HTLV-III seronegative patients fr
The etiologic agent for acquired immune deficiency syndrome (AIDS) has been identified as human T lymphotropic virus type III (HTLV-III). Its distinguishing characteristics and putative receptor, the T4 molecule, are discussed. The Western Blot method has been applied to assess the presence of antibody to HTLV-III in
A total of 1,333 persons in 627 families were surveyed for presence of antibody to adult T-cell leukemia-associated antigen (anti-ATLA). Each person was classified according to the anti-ATLA status (positive for sample 1, negative for sample 2) of the head of household of his or her family. In sample 1, the sex- and a
Am J Pathol. 1986 Sep;124(3):537-58. Unique Identifier : AIDSLINE MED/87023300
Anders KH; Guerra WF; Tomiyasu U; Verity MA; Vinters HV
The central nervous system (CNS) has been examined at autopsy in 89 patients who died of the acquired immune deficiency syndrome (AIDS), including 14 patients who died primarily of neurologic complications of the disease. A total of 66 brains (74%) showed significant pathologic abnormalities, with opportunistic infect
Dodd RC; Winkler CF; Williams ME; Bunn PA; Gray TK
Hypercalcemia is a frequent complication in patients with adult T-cell lymphoma. We measured serum calcitriol (1,25-dihydroxyvitamin D3) levels in five hypercalcemic patients with adult T-cell lymphoma and compared the values with those of five patients with mycosis fungoides, a T-cell neoplasm not associated with hyp
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