Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus.

Br Med J (Clin Res Ed). 1986 Oct 18;293(6553):978-80. Unique Identifier : AIDSLINE MED/87027364
Madhok R; Gracie A; Lowe GD; Burnett A; Froebel K; Follett E; Forbes CD

Abstract: The cell mediated immune response was evaluated in vivo in 29 patients with clinically severe haemophilia by means of the dinitrochlorobenzene skin test. All patients had a response below the median normal value, and in 19 the response was on or below the lower limit of the normal range. There was no difference in skin response between patients positive and negative for the human immunodeficiency virus (HIV; formerly known as human T cell lymphotropic virus III or lymphadenopathy associated virus). In the whole group, and in seronegative patients (n = 17), there was an inverse relation between exposure to clotting factor and skin response. In seropositive patients (n = 12) no such association was apparent. This study shows that clotting factor concentrate impairs the cell mediated immune response to a new antigen in the absence of infection with HIV.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY Blood Coagulation Factors/IMMUNOLOGY/THERAPEUTIC USE Dinitrochlorobenzene/DIAGNOSTIC USE Hemophilia/COMPLICATIONS/*IMMUNOLOGY Human Immunity, Cellular Immunosuppressive Agents/IMMUNOLOGY Skin Tests Support, Non-U.S. Gov't T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDimmunologybloodcoagulationfactors/immunology/therapeuticusedinitrochlorobenzene/diagnosticusehemophilia/complications/KWDimmunologyhumanimmunity,cellularimmunosuppressiveagents/immunologyskintestssupport,non-uKWDsKWDgov'tt-lymphocytes/classificationjournalarticle
870228
M8720099

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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