Bristol-Myers Cancer Symp; 7:1-209 1985. Unique Identifier : AIDSLINE ICDB/87627471
Anonymous; No affiliation given
Proceedings of the Seventh Bristol-Myers Symposium on Cancer Research are reported under the following headings: genetics, cell differentiation, and cancer; synthesis of adenoviral DNA with purified proteins; left-handed Z-DNA and chromatin; factors involved in elongation and termination of bacterial and mammalian tra
Results from the human B lymphocyte portion of the Second International Workshop on Human Leukocyte Differentiation Antigens, held in Boston, Massachusetts, 17-20 September 1984, are presented. Studies employing the 52 B cell/leukemia panel antibodies are presented under the following headings: serological specificity
Using an enzyme-linked immunosorbent assay (ELISA) technique, the B cell/leukemia panel of murine monoclonal antibodies (mAbs) from the Second International Workshop on Human Leukocyte Differentiation Antigens was screened against 18 undifferentiated lymphoma (UL) cell lines (African Burkitt s lymphoma, 6; American Bu
Anderson KC; Boyd AW; Fisher DC; Daley JF; Schlossman SF; Nadler LM; Div. of Tumor Immunology, Dana-Farber Cancer Inst., Dept. of; Medicine, Harvard Medical Sch., Boston, MA 02115
Dual-fluorochrome staining and flow cytometry were used to identify two B cell populations in normal peripheral blood, lymph node, spleen, and tonsil, and in lymph node tissue from patients (pts) with acquired immunodeficiency syndrome (AIDS, 8) or AIDS-related complex (ARC, 9). The majority of B cells identified coex
Bristol-Myers Cancer Symp; 7:183-202 1985. Unique Identifier : AIDSLINE ICDB/87627485
Gallo RC; Ratner L; Popovic M; Salahuddin SZ; Sarngadharan MG; Wong-Staal F; Shaw G; Hahn B; Reitz M; Robert-Guroff M; et al; Lab. of Tumor Cell Biology, NCI, Bethesda, MD
Studies illustrating the disparate effects of the various human T cell leukemia (lymphotropic) viruses (HTLVs) are reviewed together with recent investigations concerning acquired immune deficiency syndrome (AIDS) under the following headings: transformation of T cells by HTLV-I and HTLV-II; possible mechanisms of HTL
Health Trends. 1986 Aug;18(3):63-6. Unique Identifier : AIDSLINE AHA/87030184
Jones KE
AIDS is a highly emotive subject. From the outset the problem was tackled openly, looking at it from a professional and a public point of view. Initially the programme was intended only to protect staff and manage patients effectively. It rapidly expanded to delivery an educational message, which deals with all aspect
Health Policy. 1986;6(3):259-67. Unique Identifier : AIDSLINE AHA/87033415
Lee PR; Arno PS
The response of the U.S. government to the AIDS epidemic is reviewed within the context of health policy making in the U.S.A. in general and the reduced role of the federal government in domestic social programs in particular. This review involves multiple levels of government, the relationship of government to the pr
Papaevangelou G; Roumeliotou-Karayannis A; Kallinikos G; Politou K
There is no evidence up to now that the currently available plasma hepatitis B vaccine transmits the agent of AIDS. To support further the safety of this vaccine we examined 137 vaccinees for the presence of antibodies to LAV/HTLV-III. Three groups had received Merck, Sharp and Dohme hepatitis B vaccine (two groups of
Rossi P; Carbonari M; Bonomo R; Galli M; Manconi PE; Scarpati B; Scano G; Gaetano C; Ensoli B; Aiuti F
An epidemiological survey on the presence of serum antibodies to human T lymphotropic retrovirus III (HTLV-III) is reported. The study was carried out on people living in large as well as small cities in different Italian regions. Serum samples of 21 patients with AIDS, 402 with ARCS, and 920 from individuals at risk
The first case, to our knowledge, of cervicofacial actinomycosis arising in a patient with evidence of infection by the human T-cell lymphotrophic virus type III, the causal agent of the acquired immunodeficiency syndrome, is reported. Clinical uncertainty often exists in cases of actinomycosis due to the relative rar
In a patient with AIDS, marked uptake of Ga-67 in the stomach walls initially was regarded with a high degree of suspicion for gastric involvement. Results of subsequent intragastric tests, including biopsy and culture, proved negative. Caution should be exercised when considering further costly and/or invasive proced
The charts of 340 patients with Acquired Immunodeficiency Syndrome (AIDS), AIDS-related complex (ARC), or AIDS-prodrome (AIDS-P), treated between January 1982 and April 1986 at the Roosevelt Division of the St. Luke s-Roosevelt Hospital Center, were reviewed. The incidence of anorectal disease was 34 percent. Fifty-tw
Dtsch Med Wochenschr. 1986 Oct 17;111(42):1599-602. Unique Identifier : AIDSLINE MED/87029939
Klein E; Trautmann M; Hoffmann HG
Ten patients - two with Salmonella septicaemia associated with AIDS; one each Salmonella excretors in the convalescence stage and with Salmonella osteomyelitis; three with abdominal typhoid, and three with Salmonella enteritis - were treated with the gyrase inhibitor ciprofloxacin. The drug was given for 3-33 days, at
The AIDS crisis poses a special challenge for American health care, which depends heavily on private insurance to pay medical bills. Can we provide adequate health care to all who need it and still meet the financial requirements of the private health insurance industry? More insurance carriers are turning to antibody
Mycobacterium avium is a cause of nontuberculous chronic granulomatous infections which is attracting increased attention as a frequent opportunistic pathogen in acquired immunodeficiency syndrome. Some important aspects of its human pathogenicity were investigated by using cultured human macrophages infected with it.
Kannagi M; Kiyotaki M; Desrosiers RC; Reimann KA; King NW; Waldron LM; Letvin NL
The T cell tropic retrovirus of macaque monkeys simian T lymphotropic virus type III (STLV-III) has morphologic, growth, and antigenic properties indicating that it is related to human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), the etiologic agent of the acquired immune deficie
The authors evaluated the impact of a continuing education program on the AIDS-related competencies of primary care physicians in Los Angeles County. In the fall of 1984, telephone interviews were conducted with a random sample of general internists and family and general practitioners. Interviews were completed with
Over a period of 23 months, 30 cases of cryptococcosis have been studied in Bujumbura ( Burundi ). Through them, epidemiological and clinical aspects have been underlined, and attempts have been made to establish links between cryptococcosis and A.I.D.S., which is significantly freq
Med Trop (Mars). 1986 Jul-Sep;46(3):257-60. Unique Identifier : AIDSLINE MED/87038690
Lesbordes JL; Meunier DM; Georges-Courbot MC
Among the 155 cases of A.I.D.S. observed by the authors in Bangui (C.A.R.) from April 1985 to February 1986, 49 patients (31.6%) were carriers of mycosis. 42 candidosis, 5 cryptococcosis, 2 aspergillosis were found; the authors describe the clinical aspects, the localizations and the methods of diagnosis.
Toxoplasmosis is an infection frequently observed in patients with acquired immunodeficiency syndrome. Its first manifestations usually are cerebromeningal symptoms, but others may occur. A pulmonary lesion is sometimes present; it is discovered at post-mortem examination in most cases. The authors report a case of pu
Schweiz Med Wochenschr. 1986 Oct 4;116(40):1358-66. Unique Identifier : AIDSLINE MED/87042708
Bengoa JM; Widgren S
The gastrointestinal manifestations seen in acquired immune deficiency syndrome (AIDS) are discussed based on the observation of 14 patients with a positive serology for LAV/HTLV III antibody. AIDS was confirmed in 8 cases and AIDS related complex (ARC) in 6 cases. Risk groups included 6 homosexuals, 6 drug abusers an
Science. 1986 Nov 21;234(4779):951-5. Unique Identifier : AIDSLINE MED/87042781
Glass RI
Epidemiology has evolved from its historic origins as the study of major epidemics and vital statistics to a contemporary focus on the study of the distribution and determinants of health and disease in humans. This evolution reflects changes in the patterns of diseases and deaths that have occurred in our time and ha
Cerebral CT scannings were performed in 19 homosexual men with the acquired immunodeficiency syndrome (AIDS). Nearly half of them (9 patients) had cortical atrophy. Three patients with toxoplasmosis had cerebral pathology, in two of them with ring enhancement while the third had an ill-defined nonspecific lesion with
With the advent of fluorochrome-labeled monoclonal antibodies, it has now become possible to eliminate the removal of unbound antibodies during immunophenotypic analysis of lymphoid cells by flow cytometry. Suspensions of mononuclear cells from healthy controls and fluoresceinated monoclonal antibodies may be introduc
Cardiac abnormalities have been reported in 25% to 73% of adult patients with acquired immunodeficiency syndrome (AIDS). We are reporting the clinical course of a child with congenital AIDS who developed similar cardiac complications. He presented with congestive heart failure three months after the diagnosis of AIDS.
Am J Gastroenterol. 1986 Nov;81(11):1073-5. Unique Identifier : AIDSLINE MED/87046005
Balthazar EJ; Reich CB; Pachter HL
The etiology, radiographic diagnosis, and surgical management of small bowel intussusception in adults have been well documented in the literature. It has been shown that unlike the intussusceptions seen in infants, the adult variety is in most cases associated with a focal pathological process and that surgical reduc
Am J Psychiatry. 1986 Nov;143(11):1440-2. Unique Identifier : AIDSLINE MED/87046490
Flavin DK; Franklin JE; Frances RJ
Three alcohol-dependent homosexual men with suicidal ideation and behavior consciously attempted to contract the acquired immune deficiency syndrome (AIDS) as a means of committing suicide. The authors briefly examine the interrelationship among alcoholism and substance abuse, homosexuality, suicidal behavior, and AID
Am J Public Health. 1986 Dec;76(12):1443-5. Unique Identifier : AIDSLINE MED/87046560
DiClemente RJ; Zorn J; Temoshok L
To assess adolescents knowledge, attitudes, and beliefs about AIDS in San Francisco, data were obtained from 1,326 adolescents. There was marked variability in knowledge across informational items, particularly about the precautionary measures to be taken during sexual intercourse which may reduce the risk of infecti
Am J Surg. 1986 Nov;152(5):483-6. Unique Identifier : AIDSLINE MED/87046606
Toy PT; Stehling LC; Strauss RG; Esposito B; Huling D; Poole L; Sears R
In January 1983, blood banks encouraged the use of autologous blood for transfusion in elective surgical patients due to the advent of transfusion-associated AIDS. Since autologous blood does not transmit hepatitis and other viruses and does not cause alloimmunization, it should be utilized whenever possible. To deter
Wachter RM; Luce JM; Turner J; Volberding P; Hopewell PC
Eighty-two patients with the acquired immunodeficiency syndrome (AIDS) were admitted to the intensive care units (ICUs) at San Francisco General Hospital (SFGH) between March 1981 and December 1985. Of these patients, 69% died in the hospital, as did 87% of patients who required mechanical ventilation because of Pneum
Pichot F; Bader B; Laurian Y; Alvin P; Tardieu M; Tchernia G; Larrieu MJ; Courtecuisse V
In an adolescent with hemophilia B, the diagnosis of AIDS was established in face of cachexia, orodigestive candidiasis, associated with lymphopenia, major decrease in T4/T8 ratio with marked decrease in T helper cells and presence of LAV-antibodies. The patient died rapidly from a cerebral infection due to Toxoplasma
Di Carlo EF; Amberson JB; Metroka CE; Ballard P; Moore A; Mouradian JA
Malignant lymphomas occurring in 29 homosexual men and one thalassemic woman with the acquired immunodeficiency syndrome or the acquired immunodeficiency syndrome-related complex are reported using a working formulation for non-Hodgkin s lymphomas (NHLs). The patients ages ranged from 25 to 59 years, with an average
Bratt G; von Krogh G; Moberg L; Karlsson A; Putkonen PO; Biberfeld G; Bottiger M; Sandstrom E
In a health screening project for gay men in Stockholm, delayed cutaneous hypersensitivity was tested in 710 men by a commercial kit (Multitest, Merieux) containing seven recall antigens and related to past hepatitis B virus (HBV) infection, various life style factors, the lymphadenopathy syndrome (LAS), and antibodie
The Acquired Immune Deficiency Syndrome (AIDS) has been aptly termed the plague of the 80s. Over 19,000 people in less than five years have contracted this incurable viral disease. We have reviewed and summarized the literature in regards to characteristics and epidemiology of the virus, ocular and systemic manifestat
J Immunol. 1986 Nov 15;137(10):3306-9. Unique Identifier : AIDSLINE MED/87034962
Robert-Guroff M; Reitz MS Jr; Robey WG; Gallo RC
Transmission and culture of parental virus (HTLV-III) from H9 cells transfected with the cloned isolate (lambda HXB-2D) in human serum possessing HTLV-III neutralizing antibody selected for a variant that was not neutralized by the selecting serum but was neutralized by another antibody-positive serum Control virus, s
A majority of pediatric patients and rare adult patients with the acquired immunodeficiency syndrome (AIDS) develop a chronic respiratory disorder referred to as lymphocytic interstitial pneumonitis (LIP). Efforts to identify an infectious agent responsible for this process so far have failed. In this study, frozen se
Patients with the acquired immunodeficiency syndrome (AIDS) are subject to a spectrum of central nervous system (CNS) disorders. Recent evidence implicates the human T-cell lymphotropic virus type III (HTLV-III) in the pathogenesis of some of these illnesses, although, the cells infected by the virus have yet to be id
Am J Med. 1986 Nov;81(5):898-900. Unique Identifier : AIDSLINE MED/87046085
Duncan ED; Miller HJ; McKeever WP
Non-Hodgkin s lymphoma of the small intestine developed in a 66-year-old woman who was the wife of a man with transfusion-related acquired immune deficiency syndrome (AIDS). Antibody to the human T lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) was present in her serum, and the virus was
Can Med Assoc J. 1986 Nov 15;135(10):1091-6. Unique Identifier : AIDSLINE MED/87027916
Johnson BJ; Soskolne CL
Given the increasing endemicity of human immunodeficiency virus (HIV), the agent implicated in the causation of acquired immune deficiency syndrome (AIDS), in numerous sizeable subgroups of society, hospitals can expect increasing exposure to the legal implications presented by patients with AIDS. This paper reviews t
JAMA. 1986 Nov 7;256(17):2381-3. Unique Identifier : AIDSLINE MED/87037103
Dalakas MC; Pezeshkpour GH; Gravell M; Sever JL
Two homosexual men were initially seen with polymyositis as the only manifestation of the acquired immunodeficiency syndrome (AIDS) retrovirus infection. They developed AIDS-related complex a few weeks later and typical AIDS two to six months after onset of muscle weakness. By use of anti-human T-cell lymphotropic vir
Aust N Z J Med. 1986 Jun;16(3):397-401. Unique Identifier : AIDSLINE MED/87048538
March LM; Webb J; Eckstein RP
A 60 year old woman developed generalised erythema nodosum-like lesions together with hectic fever, lymphadenopathy, and hepatitis. Biopsies revealed lobular panniculitis with a benign histiocytic infiltrate and prominent phagocytosis in subcutaneous sites, lymph nodes, and bone marrow. All immunological, serological,
Purified streptococcal mitogens (SMs) including erythrogenic exotoxin were compared with phytohemagglutinin (PHA) for their ability to sustain lymphadenopathy-associated virus (LAV) replication after the stimulation of normal human peripheral blood mononuclear cells and purified CD4+ and CD8+ T cells infected with LAV
Schulof RS; Simon GL; Sztein MB; Parenti DM; DiGioia RA; Courtless JW; Orenstein JM; Kessler CM; Kind PD; Schlesselman S; et al
Forty-two male homosexuals and/or hemophiliacs with depressed helper/suppressor T-cell ratios were treated with one of three different doses of thymosin fraction 5 (TF5, 30, 60, and 120 mg), or a single dose of thymosin Alpha One (TA1, 600 micrograms), by daily subcutaneous (SQ) administration for 10 weeks, followed t
Terwilliger E; Sodroski JG; Rosen CA; Haseltine WA
Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3 orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3
JAMA. 1986 Nov 7;256(17):2365-71. Unique Identifier : AIDSLINE MED/87037100
Gartner S; Markovits P; Markovitz DM; Betts RF; Popovic M
Primary cultures from a brain biopsy specimen of a human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) seropositive patient with progressive dementia contained small numbers of monocytoid cells and showed reverse transcriptase activity that pers
JAMA. 1986 Nov 7;256(17):2383-5. Unique Identifier : AIDSLINE MED/87037104
Zuger A; Wolf BZ; el-Sadr W; Simberkoff MS; Rahal JJ
Severe hemorrhagic pancreatitis developed in a patient with the acquired immunodeficiency syndrome (AIDS) during pentamidine isethionate treatment for Pneumocystis carinii pneumonia. Despite prompt withdrawal of administration of the drug, the patient died of complications of pancreatitis. Pentamidine is known to be t
In an effort to evaluate data on genomic relatedness among the various human immunodeficiency viruses (HIVs), we have molecularly cloned a virus isolate designated HIV (CDC-451). Preliminary characterization of the HIV (CDC-451) clone indicated that the restriction enzyme map was distinct from those of other known HIV
Science. 1986 Nov 21;234(4779):970-4. Unique Identifier : AIDSLINE MED/87042784
Kozel NJ; Adams EH
Issues regarding the use of epidemiology in drug abuse research are discussed and systems for monitoring national trends and identifying risk factors are described. Data indicate a general decline in marijuana use among youth, a cohort aging effect among heroin and marijuana users, and increased prevalence and health
Science. 1986 Nov 21;234(4779):988-92. Unique Identifier : AIDSLINE GENBANK/K03455
Wright CM; Felber BK; Paskalis H; Pavlakis GN
The human T-lymphotropic retrovirus HTLV-III/LAV encodes a trans-activator that increases viral gene expression. We expressed this trans-activator in animal cells and studied its structural and functional characteristics. The putative trans-activator protein was immunoprecipitated from overproducing stable cell lines
South Med J. 1986 Nov;79(11):1363-5. Unique Identifier : AIDSLINE MED/87042962
Chuang MT; Rosen MJ; Teirstein AS; Brown LK; Padilla ML; Tow TW
Seventy-seven patients with acquired immune deficiency syndrome (AIDS) and suspected of having Pneumocystis carinii pneumonia (PCP) had flexible bronchoscopy. The diagnosis was established in 52 of the 54 patients (96%) who proved to have PCP. There was one false-positive result. The remaining 22 patients and the pati
Barrio JL; Suarez M; Rodriguez JL; Saldana MJ; Pitchenik AE
Among 150 cases of microscopically proved Pneumocystis carinii pneumonia secondary to the acquired immunodeficiency syndrome (AIDS) seen by our pulmonary service from January 1982 to January 1986, P. carinii presented roentgenographically as a solitary pulmonary nodule in 2 patients (1.3%). It was the sole cause of th
Pneumocystis carinii pneumonia is a clinically, roentgenologically, and serologically uncharacteristic pneumonia of the immunodeficient patient and is caused by the opportunistic parasite Pneumocystis which is most likely a protozoon. The untreated disease is lethal. The epidemiologic, clinic, and histologic features
Int J Addict. 1986 Apr-May;21(4-5):509-37. Unique Identifier : AIDSLINE MED/87032537
Israelstam S; Lambert S
There is very little literature in the area of homosexuals and alcohol but since the 1960s some work on the alcohol use of homosexuals has begun to surface. Most studies focus on the male but there are some studies of lesbians. The gay bar seems to be the best starting point for such studies as it is so central to gay
Moss A; Osmond D; Bacchetti P; Gerberding J; Levy J; Carlson J; Casavant C
The occupational risk of acquiring acquired immunodeficiency syndrome (AIDS) virus infection in health workers exposed to AIDS patients and specimens was assessed by a serologic study at San Francisco General Hospital and collaborating research laboratories. A total of 101 medical workers without risk factors for AIDS
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7. Unique Identifier : AIDSLINE MED/87041451
Furman PA; Fyfe JA; St Clair MH; Weinhold K; Rideout JL; Freeman GA; Lehrman SN; Bolognesi DP; Broder S; Mitsuya H; et al
The thymidine analog 3 -azido-3 -deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo, R. C., Bolognesi, D., Barry, D. W. & Broder, S. (1985)
Antibody to Human Immunodeficiency Virus (HIV) was detected by an enzyme immunoassay (Genetic Systems LAV EIA) in low risk populations from five geographically distinct sites. The assay used virus (LAV) grown in the T-cell line CEM. In blood and plasma donor populations, 0.4 percent of the samples were initially react
A confidential self-administered questionnaire was given to all donors prior to blood donation (n = 95,917). The questionnaire describes acquired immunodeficiency syndrome (AIDS) high-risk groups and requires the donor to designate his blood for either laboratory purposes or for transfusion. Six-hundred and twenty-sev
Kleinman S; Anton-Guirigis H; Culver BD; Taylor TH; Prince HE; Kaplan HS
We have evaluated the western blot (WB) test for distinguishing anti-HTLV III ELISA-positive donors who have likely been exposed to HTLV III from those that are false positives. Of 1,955 donors, 26 were positive for anti-HTLV III by ELISA testing. Only 6 (23%) were positive by WB: 5 of these 6 were male homosexuals wi
Interferon inhibitory activity was found in the plasma of 11 of 14 patients with the acquired immune deficiency syndrome (AIDS). This was not seen in 75 normal persons, including six whose specimens were randomly and blindly interspersed among the patient samples. Plasma from a single patient with the AIDS prodrome (A
Am J Med Sci. 1986 Nov;292(5):328-34. Unique Identifier : AIDSLINE MED/87046120
Santangelo WC; Krejs GJ
The increasing frequency of acquired immunodeficiency syndrome (AIDS) mandates that all physicians be aware of the diverse nature of problems that affect this group of patients. The gastrointestinal tract is involved in approximately 50% of patients with AIDS, although not all are symptomatic. Common problems include
Ann Med Interne (Paris). 1986;137(4):338-41. Unique Identifier : AIDSLINE MED/87047220
Bricaire F; Haas C; Patri B
Tuberculosis is one of the opportunist infections which may complicate the course of many immunodepressive conditions generally those affecting cell-mediated immunity as the Koch bacillus is an organism which develops intracellularly provoking the activation of the cellular type of defence reaction. Recently, patients
The first case of AIDS associated with blood transfusion was described in 1982. Over the following two years great advances were made in the understanding and prevention of this new hazard associated with blood transfusion, culminating in 1985 with the introduction of a screening test for blood donation.
Serum samples from 6015 African subjects without symptoms of the acquired immune deficiency syndrome (AIDS) or contact with the disease were examined for antibodies to the human immunodeficiency virus by a combination of an enzyme linked immunosorbent assay and radioimmunoprecipitation (2567 samples) or by immunofluor
In a series of 25 patients with suspected pneumonia related to the acquired immune deficiency syndrome (AIDS) the first 12 underwent routine fibreoptic bronchoscopy and bronchoalveolar lavage with or without transbronchial biopsy before treatment. Eight were found to have Pneumocystis carinii pneumonia and had typical
The cell mediated immune response was evaluated in vivo in 29 patients with clinically severe haemophilia by means of the dinitrochlorobenzene skin test. All patients had a response below the median normal value, and in 19 the response was on or below the lower limit of the normal range. There was no difference in ski
C R Acad Sci III. 1986;303(8):303-6. Unique Identifier : AIDSLINE MED/87027641
Becker JL; Hazan U; Nugeyre MT; Rey F; Spire B; Barre-Sinoussi F; Georges A; Teulieres L; Chermann JC
The etiological agent of AIDS known as HIV has been shown to bind on different insect cell lines including Drosophila, Mosquito, Ceratitis; and his DNA to be integrated in the cellular genome, but no expression of the viral genome was detected in those cells. None of the human lymphocytes markers is expressed at the s
Cell. 1986 Nov 7;47(3):333-48. Unique Identifier : AIDSLINE MED/87028225
Maddon PJ; Dalgleish AG; McDougal JS; Clapham PR; Weiss RA; Axel R
The isolation of clones encoding the human surface protein T4, and the expression of the T4 gene in new cellular environments, have enabled us to examine the role of this protein in the pathogenesis of AIDS. Our studies support a mechanism of AIDS virus infection that initially involves the specific interaction of the
Immunol Lett. 1986 Oct;13(4):179-84. Unique Identifier : AIDSLINE MED/87032187
Sethi KK; Naher H
A sensitive monoclonal antibody based ELISA was used to detect cell-free interleukin-2 receptor (IL-2R) in the body fluids of patients with acquired immune deficiency syndrome (AIDS), a variety of other disease conditions and a control group of apparently healthy (heterosexual and homosexual) males. Two of the 25 cont
Disseminated mycobacterial infections are commonly seen in acquired immunodeficiency syndrome (AIDS) patients, and laboratory culture is the best method for diagnosing these infections. In addition to conventional agar media, we used BACTEC 12A (Johnston Laboratories, Inc., Towson, Md.) broth medium for culture. More
Formation of syncytia, with progression to cell death, is a characteristic feature of in vitro cultures of susceptible cells infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). Viral antigen-positive multinucleated giant cells have also been observed in histological secti
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8734-8. Unique Identifier : AIDSLINE MED/87041526
Hammer SM; Gillis JM; Groopman JE; Rose RM
The ability of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and gamma interferon (IFN-gamma) to modify human immunodeficiency virus (HIV; also called HTLV-III/LAV) infection in the monocytic cell line U-937 was examined. When added to persistently infected cell cultures, GM-CSF at 30-300
The acute phase protein serum amyloid A (SAA) and C-reactive protein (CRP) were measured in a group of 30 homo- and bisexual males with AIDS, 31 males with AIDS-related complex (ARC) and 23 healthy male homosexual controls (HC) in Copenhagen. The mean values of SAA and CRP were significantly higher in the AIDS group c
Science. 1986 Nov 28;234(4780):1120-3. Unique Identifier : AIDSLINE MED/87042802
Sattentau QJ; Dalgleish AG; Weiss RA; Beverley PC
The CD4 (or T4) surface antigen of human T lymphocytes is an important part of the receptor for the human immunodeficiency virus (HIV). After binding to the receptor, the HIV may enter the T cell and induce the formation of syncytia. In an attempt to identify the receptor site more closely, monoclonal antibodies (Mab
Cells infected with the human immunodeficiency virus (HIV) show decreased expression of the 58-kilodalton T4 (CD4) antigen on their surface. In this study, the effect of HIV infection on the synthesis of T4 messenger RNA (mRNA) and protein products was evaluated in T-cell lines. Metabolically labeled lysates from the
The retrovirus LAV/HTLV III, highly likely to be responsible for the acquired immunodeficiency syndrome (AIDS) in some recipients of blood products, can be inactivated by chemical and/or heat treatment, so the use of virus-inactivated factor VIII and factor IX preparations for treating hemophilia A and B has become im
Aust N Z J Med. 1986 Jun;16(3):402-4. Unique Identifier : AIDSLINE MED/87048539
Thomas MA; Ibels LS; Wells JV; Isbister JP; Cooper DA; McMahon C
A 29 year old homosexual male presented with acute renal failure caused by acute myeloma. Subsequent investigation demonstrated antibody to the AIDS-associated virus human T-cell lymphotropic virus III, (HTLV-III/LAV/ARV). The association between lymphadenopathy syndrome and multiple myeloma is discussed.
Human T-lymphotropic virus type III (HTLV-III) is a recently discovered retrovirus with tropism and cytotoxicity for the OKT4+ lymphocytes that are depleted in the acquired immune deficiency syndrome (AIDS). In addition to the frequent detection of HTLV-III in patients with AIDS and related syndromes, seroepidemiologi
Int J Cancer. 1986 Nov 15;38(5):657-9. Unique Identifier : AIDSLINE MED/87032507
Fouchard M; Reveil B; Mbayo K; Lurhuma A; Sarin PS; Gallo RC; Zagury D
The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-
Longitudinal immune studies of patients with hemophilia A were begun in 1982 by the Regional Hemophilia Center in St. Louis, Missouri. Serum samples collected from 74 participants between 1982 and 1985 were analyzed for antibody to human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV).
The infectious pathogens and associated cellular reactions in 75 pulmonary cytological specimens obtained largely by fiberoptic bronchoscopy from 36 patients with the acquired immune deficiency syndrome are described and correlated with the biopsy specimens. An opportunistic pathogen was diagnosed in 33% of cytologica
Over a 2-yr period, 1982-1984, 181 pulmonary cytology specimens were obtained from 45 patients clinically suspected of having AIDS in an attempt to identify the various organisms and the cytologic atypias present in pulmonary cells. Cytologic correlations with autopsy findings were available for 28 of these cases (62%
Ribavirin, a broad spectrum, non-interferon-inducing virustatic chemotherapeutic agent, demonstrates activity against a wide range of RNA and DNA viruses, including the retrovirus known to cause the acquired immune deficiency syndrome. The drug s proposed mechanism of action, as well as pharmacokinetics are discussed,
Although semen is a particularly rich source of cytomegalovirus ( CMV ) and is useful for monitoring CMV shedding, its culturing is associated with extensive monolayer toxicity, isolation failures, and lengthy detection times.
Archibald DW; Zon LI; Groopman JE; Allan JS; McLane MF; Essex ME
Of 45 individuals seropositive for human T cell lymphotropic virus type III/lymphadenopathy-associated virus, 45 were found to have detectable salivary antibodies to viral antigens by a radioimmunoprecipitation assay. The results also showed that a Western blot assay for salivary antibodies may be possible. The feasib
The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoproliferative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An e
In the brains and spinal cords of 153 adult patients dying with acquired immunodeficiency syndrome (AIDS) at New York and Memorial Hospitals a subacute encephalitis with multinucleated cells was present in 28% of all patients. This encephalitis was characterized by multinucleated cells primarily located in the white m
Sera from 37 adult Nigerian men with Kaposi s sarcoma (KS), 30 contemporaneous controls bearing primary cell carcinoma of the liver (PCL), and 150 healthy non-tumour-bearing negative controls were tested for antibody to human T-cell lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) by enzyme-
Caprine arthritis-encephalitis virus (CAEV) and visna virus are pathogenic lentiviruses of goats and sheep which share morphologic features and sequence homology with human T-cell lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immune deficiency syndrome. The nucleotide sequence of the CAEV
Human T-cell leukemia virus type I (HTLV-I) contains the pX sequence which codes for the trans-activator of the long terminal repeat (LTR) and is thus postulated to be associated with leukemogenesis in adult T-cell leukemia. Overlapping open reading frames (ORF) in the pX sequence were recently found to code for p27x-
Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed ne
Benveniste RE; Arthur LO; Tsai CC; Sowder R; Copeland TD; Henderson LE; Oroszlan S
A retrovirus has been isolated on the human T-cell line HuT 78 after cocultivation of a lymph node from a pig-tailed macaque (Macaca nemestrina) that had died with malignant lymphoma in 1982 at the University of Washington primate center. This isolate, designated MnIV (WPRC-1) (M. nemestrina immunodeficiency virus, Wa
The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa
Human sequences that are related to the mouse mammary tumor virus (MuMTV) genome were cloned from breast tumor cell DNA. Of 100 recombinants, only 1 hybridized with two different probes from separate regions of the MuMTV genome (gag-pol and long terminal repeat [LTR]). This sequence, NMWV 4, was shown to have a provir
Lightfoote MM; Coligan JE; Folks TM; Fauci AS; Martin MA; Venkatesan S
Automated N-terminal microsequencing of immune affinity-purified acquired immunodeficiency syndrome retrovirus polypeptides from infected cells was used to locate the N termini of 64-, 51-, and 34-kilodalton (kDa) polypeptides within the pol open reading frame (ORF) of the proviral DNA. The 64- and 51-kDa proteins had
We report on a patient with cytomegaloviral epididymitis and the acquired immune deficiency syndrome. The diagnosis was suggested by epididymitis that was refractory to antibiotics, and by isolation of cytomegalovirus from the urine and semen. The definitive diagnosis was made with
Quesada JR; Reuben J; Hopfer RL; Mundon FK; Hersh EM
Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus ( CMV ) and human T-cell lymphotrophic viruses (HTLV). Eighty-three p
Kawasaki disease (KD) is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. Large epidemics have been described in Japan and the United States and the number of
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8112-6. Unique Identifier : AIDSLINE MED/87041410
Shimotohno K; Takano M; Teruuchi T; Miwa M
The cis-acting regulatory sequence of transcription from long terminal repeats (LTRs) of human T-cell leukemia virus type I and type II (HTLV-I and HTLV-II), which is essential for action of the virally encoded trans-acting transcriptional factor(s) designated pX(s), in HTLV-I and -II was identified. Deletion of most
Science. 1986 Nov 21;234(4779):955-63. Unique Identifier : AIDSLINE MED/87042782
Quinn TC; Mann JM; Curran JW; Piot P
Cases of the acquired immune deficiency syndrome (AIDS) have been reported in countries throughout the world. Initial surveillance studies in Central Africa suggest an annual incidence of AIDS of 550 to 1000 cases per million adults. The male to female ratio of cases is 1:1, with age- and sex-specific rates greater in
De Rossi A; Gallo P; Tavolato B; Callegaro L; Chieco-Bianchi L
In order to confirm the findings on the presence of antibodies against human T-lymphotropic retroviruses in subjects affected by multiple sclerosis we studied paired serum and CSF samples from 32 MS patients. Both ELISA and Western blot procedures were employed to detect antibodies against HTLV-I and LAV/HTLV-III anti
Am J Gastroenterol. 1986 Nov;81(11):1068-72. Unique Identifier : AIDSLINE MED/87046004
Agha FP; Nostrant TT; Abrams GD; Mazanec M; Van Moll L; Gumucio JJ
A 29-year old white homosexual man with acquired immune deficiency syndrome presented initially with right upper quadrant pain and progressive cholestasis. Diffuse mucosal irregularities were seen at endoscopic retrograde cholangiography. Histopathological examination of the gallbladder and wedge liver biopsy showed e
Am J Pathol. 1986 Oct;125(1):173-81. Unique Identifier : AIDSLINE MED/87046304
Lairmore MD; Rosadio RH; DeMartini JC
For examination of the characteristics of lentivirus-induced pulmonary disease in an animal model, neonatal lambs were given intratracheal injections of high-and low-passage ovine lentivirus (OvLV) isolates. In 6 of 6 lambs inoculated with low-passage OvLV or OvLV from lung lavage fluid, lesions of lymphoid interstiti
Biochem Biophys Res Commun. 1986 Oct 30;140(2):735-42. Unique Identifier : AIDSLINE MED/87048831
Balzarini J; Pauwels R; Herdewijn P; De Clercq E; Cooney DA; Kang GJ; Dalal M; Johns DG; Broder S
2 ,3 -Dideoxycytidinene (ddeCyd), the 2 ,3 -unsaturated derivative of 2 ,3 -dideoxycytidine (ddCyd) is, like ddCyd itself, a potent and selective inhibitor of HTLV-III/LAV in vitro. This conclusion is based on the relatively high ratio of effective antiviral dose (0.3 microM) versus cell growth inhibitory concentratio
The numbers of neutrophils and platelets and the serum calcium (Ca) levels were examined in 12 patients with lymphoma-type adult T cell leukemia (ATL) and 35 patients with leukemic-type ATL. The same parameters were also studied in 17 patients with non-Hodgkin s lymphoma and 22 pat
Mitsuya H; Jarrett RF; Cossman J; Cohen OJ; Kao CS; Guo HG; Reitz MS; Broder S
Human T lymphotropic virus-I (HTLV-I)-specific T cell lines were established and cloned. K5, an OKT8+ clone bearing multiple proviral integration sites, retained its HTLV-I-specific cytotoxicity and a normal dependence on interleukin 2 ( IL-2 ), indicating that there is
Of 315 patients from Scandinavia and West Germany with cutaneous T cell lymphoma, thirty-six (11.4%) had specific antibodies reactive against human T cell lymphotropic virus type I (HTLV-I). Among the HTLV-I antibody-positive patients, one had Sezary syndrome; five, mycosis fungoi
A cutaneous maculopapular eruption has been previously described in humans infected with HTLV-III/LAV, the etiologic agent of acquired immunodeficiency syndrome. In this study, rhesus monkeys were prospectively examined after infection with an HTLV-III-like virus (STLV-III) to ascertain the incidence and clinical cour
In an investigation of the mode of transmission of adult T cell leukemia virus (ATLV) in family settings, 275 male and 444 female subjects positive for antibody to ATLV-associated antigen (anti-ATLA) were studied. Their children were surveyed for anti-ATLA status. None of the 82 children of a positive father and a neg
This article provides an overview of the range of neurological manifestations that have been described in association with human immunodeficiency virus (HIV) infection. The transmission of acquired immunodeficiency syndrome (AIDS) and the precautions personnel must take when having contact with patients with AIDS are
Thirteen patients with hematological neoplasms were treated with Bestrabucil (100 mg/day po, total dose 700-9,900 mg), which is the benzoate of an estradiol-chlorambucil conjugate. The diseases from which they suffered consisted of T-cell leukemia (3), lymphoma (3), myeloma (5) and essential thrombocytosis (2). Althou
Lancet. 1986 Nov 15;2(8516):1113-5. Unique Identifier : AIDSLINE MED/87038422
Melbye M; Njelesani EK; Bayley A; Mukelabai K; Manuwele JK; Bowa FJ; Clayden SA; Levin A; Blattner WA; Weiss RA; et al
In a hospital-based survey in Lusaka, Zambia , 189 (17.5%) of 1078 subjects had antibodies against the human immunodeficiency virus (HIV). The prevalence of antibodies was low in subjects aged less than 20 or greater than 60 years; in men the peak prevalence (32.9%) occurred in thos
Lancet. 1986 Nov 22;2(8517):1187-9. Unique Identifier : AIDSLINE MED/87038481
Scorza Smeraldi R; Fabio G; Lazzarin A; Eisera NB; Moroni M; Zanussi C
To investigate the contribution of genetic susceptibility to infection with human immunodeficiency virus, 50 subjects with lymphadenopathy syndrome (LAS) and 7 subjects with acquired immunodeficiency syndrome (AIDS) and Kaposi s sarcoma were typed for HLA A, B, C, and DR antigens. The frequency of B35 was significantl
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8744-8. Unique Identifier : AIDSLINE MED/87041528
Oseroff AR; Ohuoha D; Hasan T; Bommer JC; Yarmush ML
Selective in vitro photodestruction of HPB-ALL human T-cell leukemia cells was accomplished using the photosensitizer chlorin e6 coupled through dextran molecules to an anti-T-cell monoclonal antibody (mAb), anti-Leu-1. Conjugates with mAb/chlorin molar ratios as high as 1:36 retained mAb binding activity, and the abs
The prevalence of antibodies to human T-cell leukaemia virus type I in Africa ranges from 2% to 21% according to the geographical area surveyed. Most studies suggest that the background infection rate in children is low. In paediatric patients with malignant disease in the Witwatersrand area the prevalence is low (1%)
The prevalence of antibodies to human immunodeficiency virus (HIV = LAV/HTLV-III) in a rural population from the Ifakara area in southeastern Tanzania was investigated. Sera from 286 individuals collected from 1982 to 1984 in connection with a study on liver disorders were tested
Am J Med Sci. 1986 Nov;292(5):325-7. Unique Identifier : AIDSLINE MED/87046119
Yim M; Hayashi T; Yanagihara E; Kadin M; Nakamura J
Adult T-cell leukemia (ATL) is a disease found endemic in Southern Japan and the Caribbean basin. The human T-cell leukemia virus I (HTLV-I) has been implicated epidemiologically as the causative agent in this disease. This paper describes the identification of this disease in Hawai
We describe spinal myoclonus in a 35-year-old homosexual man with concurrent human T-cell lymphotropic virus type III/lymphadenopathy--associated virus (HTLV III/LAV) infection of the central nervous system as indicated by intra-blood-brain barrier synthesis of HTLV III/LAV-specific IgG. The spinal myoclonus was chara
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