London ; New York : Croom Helm ; New York, NY : Published in the USA by Croom Helm in association with Methuen, c1988 x, 92 p. : ill Unique Identifier : AIDSLINE CAT/8711047
Cancer in Children. Clinical Management. Second Edition. Voute PA et al, eds. Current Treatment of Cancer, New York, Springer-Verlag, p. 176-84, 1986.. Unique Identifier : AIDSLINE ICDB/87637339
Nesbit ME; Univ. of Minnesota, Dept. of Pediatrics, Box 484 Mayo Clinic; Bldg., 430 Delaware Street S.E., Minneapolis, MN 55455
Histiocytosis X (Langerhans cell histiocytosis, LCH) in children is reviewed, including histopathology, characteristics and treatment of localized and generalized disease, and differential diagnosis among various disease entities that are difficult to distinguish from LCH (histiocytic medullary reticulosis, malignant
The expression of proviruses is determined by complex interactions between cellular and viral components. Previously, provirus transcription was thought to reflect only the capacity of host cell transcription factors to recognize the LTR-promoter of a virus, with chromosomal position effects influencing the response a
The problem: Current research indicated that 10 to 20 percent of AIDS-related complex (ARC) patients progress to a diagnosis of AIDS. This is particularly alarming when considering the possibility that there are approximately 170,000 Americans with an ARC diagnosis. The major concern of this study was to investigate t
Cancer in Children. Clinical Management. Second Edition. Voute PA et al, eds. Current Treatment of Cancer, New York, Springer-Verlag, p. 152-63, 1986.. Unique Identifier : AIDSLINE ICDB/87637337
Amylon MD; Link MP; Murphy SB; Stanford Univ. Medical Center, Children's Hosp. at Stanford,; Stanford, CA 94305
The epidemiology, etiology, clinical presentation, staging and prognosis, tumor biology, and treatment of T cell lymphoblastic, lymphoblastic non-T cell, large cell (histiocytic), and other rare non-Hodgkin s lymphomas in children are discussed with emphasis on the first of these entities. Maturational stages of norma
Mason- Pfizer monkey virus (M-PMV) is the prototype of the D-type retroviruses. The DNA provirus of M-PMV has been shown to be 8.1 kilobase pairs in length, and has long terminal repeats that are 350 base pairs in length. DNA fragments representing the LTR-gag and env regio
Human T-cell leukemia virus type I (HTLV-I) has been associated with the etiology of adult T-cell leukemia/lymphoma (ATL), an aggressive mature T-cell proliferative disorder. Antiviral antibodies with specificity for both structural and non-structural HTLV-I polypeptides were detected previously in sera of ATL patient
Hosp Mater Manage. 1987 Aug;12(8):7-9. Unique Identifier : AIDSLINE AHA/87308448
Dixon RH Jr
As the AIDS virus spreads into the general population, protecting the public, health workers and patients from possible infection becomes increasingly important. The Surgeon General recommends testing all surgery patients for the presence of AIDS prior to surgery; however, it is often impossible to complete these test
Fed Regist. 1987 Aug 28;52(167):32540-4. Unique Identifier : AIDSLINE AHA/87300902
This rule amends the Med Examination of Aliens regulations (42 CFR Part 34) by substituting human immunodeficiency virus (HIV) infection for acquired immunodeficiency syndrome (AIDS) on the list of dangerous contagious diseases and by expanding the scope of the medical examination to include serologic tests for HIV in
According to the 15 autopsies performed at the Department of Pathological Anatomy, Escola Paulista de Medicina, Sao Paulo, Brazil , it was confirmed that acquired immunodeficiency syndrome (AIDS) occurs preferably in young homosexual males, who die in a short period of time of the d
The clinical and histologic features of five homosexual men with acquired immunodeficiency syndrome (AIDS) who developed extranodal non-Hodgkin s lymphomas of the head and neck region are presented. The primary sites of these malignant neoplasms include the larynx, palate, alveolar ridge, nasal vestibule, and skin ove
Murphy MF; Metcalfe P; Waters AH; Carne CA; Weller IV; Linch DC; Smith A
The incidence of lymphopenia, thrombocytopenia and neutropenia was studied in 105 homosexual men with HIV infection. Lymphopenia was common in patients with AIDS (75%), but its incidence in PGL (24%) was not significantly different from that in asymptomatic anti-HIV positive (15%) homosexual men. Neutropenia and throm
The Pompidou Group was set up in 1971 to provide a forum for exchanging views and concerting action in Western Europe in response to the growing drugs problem. Until 1979 it had no formal status, but in 1980 the Group became part of the Council of Europe with member States being free to choose whether to join or not.
Louie E; Borkowsky W; Klesius PH; Haynes TB; Gordon S; Bonk S; Lawrence HS
Cryptosporidia are intestinal protozoans long known to cause diarrhea in humans, especially those with acquired immune deficiency syndrome (AIDS). When transfer factor prepared from calves which possessed delayed-type hypersensitivity to Eimeria bovis was given to nonimmune calves and mice it conferred protection agai
Acute infection with human immunodeficiency virus (HIV-1) may give rise to a febrile illness with distinctive clinical features. Oral and cutaneous involvement may be prominent. Two cases are reported that illustrate this syndrome, and the importance of its early recognition is emphasized.
All physicians share a responsibility for educating the public in the expanding risks of sexually transmitted diseases, and in the vital importance of safe sexual practices. Both the public health implications of undiagnosed STDs and the adverse social consequences of an incorrect diagnosis emphasize the need to compr
Nolla-Salas J; Ricart C; D'Olhaberriague L; Gali F; Lamarca J
We describe a case of central nervous system (CNS) toxoplasmosis in a patient with acquired immunodeficiency syndrome (AIDS). Supratentorial hydrocephalus as a result of aqueductal collapse was the only abnormal finding on computed tomography scan. Toxoplasma gondii is the most common pathogen organism in high-risk AI
Opportunistic infections and neoplasias, which led to the identification and characterisation of AIDS, are the most common manifestations of this disease. The present review gives a comprehensive presentation of the current knowledge on the opportunistic infectious agents concerned and on the resulting clinical pictur
Watkins EB; Findlay P; Gelmann E; Lane HC; Zabell A
The oropharynx and hypopharynx are common sites of involvement in AIDS patients with mucocutaneous Kaposi s sarcoma. The radiotherapist is often asked to intervene with these patients due to problems with pain, difficulty in swallowing, or impending airway obstruction. We have noted an unexpected decrease in normal ti
Specific DNA probes (Gen-Probe Corp., San Diego, Calif.) for Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium tuberculosis were compared with conventional methods for the identification of isolates of the Mycobacterium avium complex. A total of 56 isolates of M. avium complex were recovered from 34
J Nerv Ment Dis. 1987 Aug;175(8):496-9. Unique Identifier : AIDSLINE MED/87310430
Treiber FA; Shaw D; Malcolm R
Eight nurses and four physicians involved in the care of an acquired immune deficiency syndrome (AIDS) patient and a matched, non-AIDS patient responded to three self-report measures that assessed the psychological distress associated with working with each patient. While working with the AIDS patient the physicians a
Fifty consecutive AIDS autopsy cases were evaluated. All subjects showed one or more opportunistic infections and malignancies included in the AIDS case definition with cytomegalovirus and Kaposi s sarcoma being most prevalent. Mycobacterial and cryptococcal infections occurred onl
The costs which were incurred by patients for hospital-based care during the time from the diagnosis of the acquired immunodeficiency syndrome (AIDS) to death, range from pounds 6838 in London, England, to US$147,000 in Atlanta, USA. In 1986, a study was undertaken in Sydney to calculate the costs of the hospital-base
Beliefs about the spread of the human immunodeficiency virus were determined among a community sample (n = 178:98 women; 80 men) of Australians. In order to reduce the statements to manageable clusters, a principal components analysis was computed which was followed by Varimax rotation for eigenvalues that were greate
Twenty-three patients with low natural killer syndrome (LNKS), 7 males and 16 females, are reported here. These LNKS patients had an age range from 14 to 77 years, with a median of 36.5 years. LNKS is a newly proposed category of immune disorders, being characteristically diagnosed by lowered NK cell activity against
The behaviour of gallium scintigraphy in a group of 15 drug addicts suffering from LAS is examined. The examination was positive in 11 patients with no pleuro-pulmonary lesions that could be demonstrated by clinical or radiological examination. This is in line with similar observations in AIDS cases and may reflect th
The Centers for Disease Control (CDC) has recorded 35,900 cases of acquired immunodeficiency syndrome (AIDS) in the United States , including 2447 infected females, as of May 25, 1987. These cases include 503 children under the age of 13, of whom 80% were thought to have been affected t
In an attempt to study the incidence of hand infections in dental personnel, a standardized survey was submitted to 715 dental professionals and hygienists throughout the state of Nebraska. Of those surveyed, 508 responded (71 percent). Ninety-eight of the 508 respondents reported an infection (19.29 percent). The rat
The postmortem histopathologic findings of eyes from two patients with acquired immunodeficiency syndrome (AIDS) are presented. Both patients had succumbed to multiple opportunistic infections. All of the eyes demonstrated calcified cotton-wool patches of the retina. To date, there have been no prior descriptions of c
Gudesblatt M; Gerber O; Vaillancourt PD; Bronster D
We report eight patients with cryptococcal meningitis and a cerebrospinal fluid characterized by few or no white blood cells and chemistries that may be near normal. In four of these patients, only testing for cryptococcal antigen allowed the initial diagnosis. Seven of the patients had a certain diagnosis of AIDS. Si
The envelope of the human immunodeficiency virus type 1 (HIV-1) plays a central role in the process of virus entry into the host cell and in the cytopathicity of the virus for lymphocytes bearing the CD4 molecule. Mutations that affect the ability of the envelope glycoprotein to form syncytia in CD4+ cells can be divi
The benefits of blood transfusion must be considered and evaluated in terms of risk factors relating to the adverse effects of transfusion. Transfusions may result in either serious or troublesome complications. Although the risk of transfusion-associated acquired immune deficiency syndrome (AIDS) is of paramount conc
Am J Gastroenterol. 1987 Sep;82(9):859-64. Unique Identifier : AIDSLINE MED/87323160
Colebunders R; Francis H; Mann JM; Bila KM; Izaley L; Kimputu L; Behets F; Van der Groen G; Quinn TC; Curran JW; et al
Ninety-eight (40%) of 243 acquired immune deficiency syndrome inpatients at Mama Yemo Hospital, Kinshasa, Zaire , presented with a history of diarrhea for at least 1 month. To determine the predictive value of persistent diarrhea for human immune deficiency virus (HIV) infection, 1
Am J Gastroenterol. 1987 Sep;82(9):894-5. Unique Identifier : AIDSLINE MED/87323169
Lustbader I; Sherman A
Gastrointestinal involvement by Kaposi s sarcoma in patients with cutaneous or lymph node involvement is common. Since the advent of the acquired immune deficiency syndrome in 1981, primary gastrointestinal involvement, i.e., without skin or lymph node involvement, has not been adequately documented. We describe a pat
Am J Epidemiol. 1987 Oct;126(4):578-86. Unique Identifier : AIDSLINE MED/87323182
Biggar RJ; Horm J; Goedert JJ; Melbye M
Using a proportional morbidity analysis method, the authors examined changes in the risk of malignancy among never-married men 20-49 years old (a surrogate population for homosexual men) in a high AIDS-risk area (City of San Francisco) and other lower AIDS-risk areas. This approach easily detected increases in Kaposi
Tuberculosis has been reported previously in patients with acquired immunodeficiency syndrome who are at increased risk of prior infection with Mycobacterium tuberculosis. We performed a population-based study of AIDS and tuberculosis in San Francisco using the Tuberculosis and AIDS Registries of the San Francisco Dep
An Esp Pediatr. 1987 Jun;26(6):439-43. Unique Identifier : AIDSLINE MED/87324532
Matamoros N; Ciria L; Julia MR; Herrera M; Henales V; Labay M
We report here the first paediatric immunodeficiency acquired syndrome (AIDS) in Spain , acquired by vertical-transmission and a second infant case with the same transmission and classified as AIDS related complex. We also mention the incidence and characteristics, of the neonatal po
A 37-year-old homosexual man was evaluated for a one-week history of hematochezia. Results of a physical examination were remarkable only for grossly bloody stool. Sigmoidoscopy to 30 cm showed a friable mucosa compatible with an acute colitis, and a rectal biopsy specimen demonstrated an increased plasma cell infiltr
AIDS Res Hum Retroviruses. 1987 Summer;3(2):157-63. Unique Identifier : AIDSLINE MED/87299206
Wendler I; Bienzle U; Hunsmann G
The capacity to neutralize the human immunodeficiency virus (HIV) in vitro was examined in 52 sera obtained from 23 seropositive individuals in addition to 7 negative control sera. Neutralization was measured as the activity of a serum to protect MT-4 cells against the cytopathic effect of HTLV-IIIB. Virus neutralizat
The simian T-lymphotropic virus type III (STLV-III[AGM]) is a retrovirus in wild African green monkeys which is serologically related to the human T-lymphotropic virus type III (HTLV-III/LAV-1/HIV) and other related human retroviruses. The long terminal repeats (LTR) contained in clones of viral DNA of (STLV-III[AGM])
Caspari G; Beyer J; Schunter F; Knuver-Hopf J; Schmitt H
Anti-HIV test results of the Red Cross Blood Transfusion Service of Lower Saxony from 1 June 1985 to 31 July 1986 inclusive were analysed retrospectively. Nine out of 70,936 donors who had not donated blood before 1 June 1985 (first-time donors) and 9 out of 261,231 donors who had donated blood before this date (repea
Suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS). Ninety-eight patients with AIDS manifest as opportunistic infections (n = 38), AIDS with Kaposi s sarcoma (n = 38), AIDS-related c
HIV-infections can be transferred by blood and blood products, semen or organ transplants. For this reason, the WHO recommended a screening of all donors of blood, semen, tissues and organs. Those who belong to high-risk groups should be excluded from donations. If this recommendation should be also applied to cialit
Wodak A; Dolan K; Imrie AA; Gold J; Wolk J; Whyte BM; Cooper DA
The sharing of needles and syringes by intravenous drug abusers has been recognized as a critical factor in the transmission of the human immunodeficiency virus (HIV). In an attempt to reduce the sharing of needles and syringes among intravenous drug abusers, a pilot sterile needle-and-syringe exchange programme was e
Am Fam Physician. 1987 Sep;36(3):197-204. Unique Identifier : AIDSLINE MED/87322903
Lange WR; Dax EM
Screening international travelers for human immunodeficiency virus (HIV) antibodies does little to prevent the spread of the acquired immune deficiency syndrome. Individuals who are seropositive for HIV antibodies and wish to travel abroad will be subject to varying restrictions, depending on the severity of their ill
Am J Epidemiol. 1987 Oct;126(4):568-77. Unique Identifier : AIDSLINE MED/87323181
Chmiel JS; Detels R; Kaslow RA; Van Raden M; Kingsley LA; Brookmeyer R
Interviews regarding medical history, life-style, specific drug taking and sexual activities, and physical examinations were administered to 4,955 homosexual men who volunteered for the Multicenter AIDS Cohort Study in Baltimore, Chicago, Los Angeles, and Pittsburgh. Overall, the prevalence of antibodies to human immu
Ann Fr Anesth Reanim. 1987;6(4):356-8. Unique Identifier : AIDSLINE MED/87324346
Roussel LJ; Moisant L; Delhotellerie C; Merot S; Pesce A
A case is reported of autoimmune thrombocytopenic purpura in a narcotics addict with antibodies against human immune deficiency virus (HIV). Three points need stressing: 1) HIV is a new viral cause of autoimmune thrombocytopenic purpura, the first report of which dates from 1985; 2) this bleeding diathesis may be seen
AIDS Res Hum Retroviruses. 1987 Spring;3(1):33-9. Unique Identifier : AIDSLINE GENBANK/K03455
Wong-Staal F; Chanda PK; Ghrayeb J
Human T-lymphotropic virus type III (HTLV-III/LAV) has been shown to contain at least four extra genes in addition to the three essential genes (gag, pol, env) for replication of most retroviruses. These genes are expressed by complex splicing mechanisms and utilization of overlapping reading frames. We now demonstrat
Int Dent J. 1987 Jun;37(2):108-13. Unique Identifier : AIDSLINE MED/87306897
Silverman S Jr
In spite of attempts to modify homosexual behaviour and the sharing of contaminated needles by drug abusers, AIDS virus infections continue to spread throughout the world. The potential for transmission, the lack of a vaccine and effective treatment, and the lethal nature of the disease cause great alarm and influence
Int Dent J. 1987 Jun;37(2):98-107. Unique Identifier : AIDSLINE MED/87306908
Wall C
The AIDS epidemic has caused widespread concern in the community and there has been a corresponding impact on dentistry. Dentists have seen themselves as vulnerable due to frequent exposure to blood and to the salivary pool, which may possibly be infective, either inherently or by reason of blood contamination. The fe
Smith RS; Naso RB; Rosen J; Whalley A; Hom YL; Hoey K; Kennedy CJ; McCutchan JA; Spector SA; Richman DD
Detection of antibodies to human immunodeficiency virus (HIV) by enzyme-linked immunosorbent assay (ELISA) is the accepted method to screen blood products at risk to transmit infection. The presence of antibodies to HIV in 565 serum specimens from 274 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-rel
Nara PL; Robey WG; Arthur LO; Asher DM; Wolff AV; Gibbs CJ Jr; Gajdusek DC; Fischinger PJ
Persistent infection by human immunodeficiency virus (HIV-1) in the chimpanzee may be valuable for immunopathologic and potential vaccine evaluation. Two HIV strains, the tissue culture-derived human T-cell lymphotropic virus type IIIB (HTLV-IIIB) and in vivo serially passaged lymphadenopathy-associated virus type 1 (
The effectiveness of a mandatory premarital screening program was examined as a means of curtailing the spread of the human immunodeficiency virus (HIV) infection in the United States . The epidemiology of the HIV, the technical characteristics of tests for antibodies to HIV, and the lo
Proc Natl Acad Sci U S A. 1987 Sep;84(18):6364-8. Unique Identifier : AIDSLINE MED/87317652
Hauber J; Perkins A; Heimer EP; Cullen BR
Human immunodeficiency virus encodes a gene product termed tat that is able to activate viral gene expression when present in trans. The mechanism of action of the tat gene product appears to be bimodal, resulting in both an increase in the steady-state level of viral mRNA and the enhanced translation of that RNA. In
Sixty-one paired sera and cerebrospinal fluid (CSF) specimens were tested for the presence of human T-cell lymphotropic virus/lymphadenopathy-associated virus (HTLV-III) antibodies. Of 16 sera negative for HTLV-III antibodies by enzyme-linked immunosorbent assay (ELISA), the corresponding CSF results were also negativ
Ann Intern Med. 1987 Oct;107(4):502-5. Unique Identifier : AIDSLINE MED/87324556
Gill PS; Rarick M; Brynes RK; Causey D; Loureiro C; Levine AM
Four patients with the acquired immunodeficiency syndrome, and a history of Pneumocystis carinii pneumonia developed severe pancytopenia (hemoglobin, less than 85 g/L; granulocytes, less than or equal to 0.5 X 10(9)/L; platelets, less than or equal to 30 X 10(9)/L) 12 to 17 weeks after the initiation of azidothymidine
AIDS Res Hum Retroviruses. 1987 Spring;3(1):87-94. Unique Identifier : AIDSLINE MED/87299198
Lyerly HK; Cohen OJ; Weinhold KJ
Tetanus toxoid (TT) reactive CD4+ cells were infected with HTLV-IIIB and exposed to TT at various times throughout a 7-day interval. Acute infection per se failed to produce overt cytopathology. However, exposure of infected cells to TT resulted in a rapid loss of cell viability, an increase in viral p24 expression, a
AIDS Res Hum Retroviruses. 1987 Summer;3(2):147-55. Unique Identifier : AIDSLINE MED/87299205
Ratner L; Polmar SH; Paul N; Ruddle N
Conditioned media from human immunodeficiency virus type I (HIV-1) infected cells were tested for cytotoxic cell-derived factors. The assay used a murine fibroblast cell line which is sensitive to the effects of tumor necrosis factors, but nonpermissive for HIV-1 replication. Cytotoxic activity was detected in culture
HIV-infected and noninfected H9-cell cultures were incubated with two antibodies (Biochrom, DuPont) against p24gag antigen (capsid) of HIV: the antibodies show a positive reaction against p24 antigen in the Western blot. The antibody-labeled cells were examined by fluorescence-activated cell sorting (FACS) and by micr
J Med Virol. 1987 Aug;22(4):299-306. Unique Identifier : AIDSLINE MED/87310407
Conte D; Ferroni P; Lorini GP; Aimo GP; Mandelli C; Cesana M; Brunelli L; Bignotti GC; Bianchi PA; Zanetti AR
Three hundred and two intravenous drug addicts (IVDA) from five towns in Northeastern Italy were studied. Of the males, 37/249 (14.8%) were homosexuals and of the females, 29/53 (54.7%) were prostitutes; 118 (39.0%) were alcoholics. AST levels were abnormal in 31.8%, ALT in 45.7%, G
Gill PS; Levine AM; Krailo M; Rarick MU; Loureiro C; Deyton L; Meyer P; Rasheed S
Twenty-two consecutive patients with high-grade, B-cell lymphomas related to the acquired immunodeficiency syndrome (AIDS) were accrued onto two sequential phase II studies, consisting of a standard regimen (M-BACOD, group no. 1, N = 13), or a novel, intensive regimen (group no. 2, N = 9), which included high-dose cyt
Diagnosis of infection with the human immunodeficiency virus (HIV) relies on the demonstration of antibody to this virus. Occasionally, the combined analysis of sera using ELISA and western blot reveals false-positive results. We have compared a newly developed test to detect antibodies to the core (anti-p24) and surf
Frazer IH; Mackay IR; Crapper RM; Jones B; Gust ID; Sarngadharan MG; Campbell DC; Ungar B
A prospective study on 100 homosexual male volunteers was designed to examine immunological function in relation to sexual activity and infection with the human T cell lymphotropic virus Type III (HTLV-III). Complete data were available for 71 men. In a comparison with 100 age-matched heterosexual men, the study group
During a 10-month period in 1985 and 1986, three cases of acquired immunodeficiency syndrome (AIDS) and a rapidly progressive fatal cardiomyopathy were encountered. All three patients originally presented with common opportunistic infections and later experienced marked congestive heart failure associated with echocar
Forty-one patients with primary Kaposi s sarcoma (KS) have been evaluated clinically, histologically and immunologically at the time of diagnosis. There was no correlation between histological and immunological features. Moreover, the disease did not appear to be related to particular HLA phenotypes. The T4/T8 ratio w
During a prospective immunologic study of 130 homosexual men, the authors looked for the presence of paraprotein bands in serum by electrophoresis. Antibody to the human immunodeficiency virus (HIV) was present in 65 of the 130 men, the lymphadenopathy syndrome (LAS) in 26, and the acquired immune deficiency syndrome
Ann Intern Med. 1987 Oct;107(4):495-8. Unique Identifier : AIDSLINE MED/87324554
Conte JE Jr; Hollander H; Golden JA
Study Objective: To evaluate inhaled or reduced-dose intravenous pentamidine for the treatment of patients with mild Pneumocystis carinii pneumonia. Design: Open, nonrandomized pilot study; measurement of pentamidine concentrations in plasma and bronchoalveolar lavage fluid. Patients: Of 22 men with mild P. carinii pn
The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate-Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltr
Lin KT; Huang SH; Kao CL; Huang KM; Yu JC; Hung TP; Chou MY; Liu WT; Fang CT; Kuo YT
The first case of AIDS positively identified in a non-foreigner in Taiwan was a 25-year-old unmarried male who had practiced homosexuality for ten years. The patient began to have abdominal pain accompanied with loose stools and wei
Sera from 47 individuals repeatedly reactive in one screening ELISA system (designated as ELISA-A) for antibodies against human immunodeficiency virus (HIV) were evaluated by a second ELISA system (designated as ELISA-B) as well as by the Western blot technique. Both ELISA systems and the Western blot were positive in
Boll Ist Sieroter Milan. 1987;66(1):9-13. Unique Identifier : AIDSLINE MED/87299060
Lazzarin A; Crocchiolo P; Galli M; Uberti Foppa C; Caredda F; Re T; Moroni M
Sera collected between 1978 and 1985 from 716 parenteral drug-addicts admitted to our Clinic with viral hepatitis were tested for antibodies to HTLV III. None of the patients was showing symptoms suggestive of LAV/HTLV III infection at the time of sera collection. Positivity for HTLV III antibody was found and confirm
AIDS Res Hum Retroviruses. 1987 Spring;3(1):71-85. Unique Identifier : AIDSLINE MED/87299197
Groopman JE; Benz PM; Ferriani R; Mayer K; Allan JD; Weymouth LA
To determine the clinical significance of human neutralizing antibodies to the human immunodeficiency virus (HIV), we measured serum neutralization in patients with different clinical outcomes following HIV infection. Serum neutralization titers ranged from less than 1:5 to 1:100. The neutralization response after HIV
AIDS Res Hum Retroviruses. 1987 Spring;3(1):95-105. Unique Identifier : AIDSLINE MED/87299199
Kenealy W; Reed D; Cybulski R; Tribe D; Taylor P; Stevens C; Matthews T; Petteway S
Recombinant proteins representing gag and env amino acid sequences of the Human Immunodeficiency Virus (HIV) (HTLV-IIIb) were produced in Escherichia coli and used to analyze sera for the presence of antibodies to HIV. ENV-9 is a protein representing the carboxy terminus of gp120 and part of gp41 which is highly immun
AIDS Res Hum Retroviruses. 1987 Summer;3(2):165-76. Unique Identifier : AIDSLINE MED/87299207
Chiodi F; Bredberg-Raden U; Biberfeld G; Bottiger B; Albert J; Asjo B; Fenyo EM; Norrby E
The sensitivity and specificity of radioimmunoprecipitation assay (RIPA) and Western blot (WB) test were compared by use of a collection of 183 sera, representing different categories of individuals, noninfected or infected with the human immunodeficiency virus (HIV). The sera were subdivided on the basis of their rea
The epidemiology of HIV infection emphasizes the need to be able to identify and communicate with female prostitutes as a group. Health education, screening and the prevention of STD in female prostitutes remains an essential priority for the well-being of the prostitutes, their clients and the health of society. Howe
Antibodies against HIV-2 were tested by indirect immunofluorescence in over 2000 sera from Africa and the Federal Republic of Germany . The specificity of the test for HIV-2 was established by absorption of the sera with HIV-1 infected cells. Antibodies against HIV-2 were found in
Data are presented that male homosexuals with chronic lymphadenopathy and reduced numbers of T4-antigen-bearing cells have an increased incidence of activated T8-antigen-bearing cells. Evidence suggesting an increase in activated T cells in these subjects includes an increase in incidence of T10-antigen-bearing cells,
A gelatin particle agglutination assay was compared with indirect immunofluorescence by using 663 serum samples from acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related complex patients and asymptomatic male homosexuals in the United States and from hemoph
J Med Virol. 1987 Aug;22(4):357-63. Unique Identifier : AIDSLINE MED/87310413
Paul DA; Falk LA; Kessler HA; Chase RM; Blaauw B; Chudwin DS; Landay AL
An enzyme immunoassay (EIA) has been developed which detects antigen(s) (Ag) of the human immunodeficiency virus (HIV) in the serum of patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), and patients at high risk for HIV infection. The test has a sensitivity of approximately 50 pg/
Pekovic DD; Gornitsky M; Ajdukovic D; Dupuy JM; Chausseau JP; Michaud J; Lapointe N; Gilmore N; Tsoukas C; Zwadlo G; et al
HIV antigens were searched for in the thymus, lymph nodes, bone marrow, and spleen of AIDS patients, by means of immunofluorescence technique. Human IgG against HIV and monoclonal antibodies against viral gag P24 protein yielded strong cytoplasmic fluorescence of cells in sections of the thymus, lymph nodes and spleen
We describe 2 patients with unrecognized acquired immunodeficiency syndrome who presented with acute urological conditions. One patient had inapparent obstructive anuric renal failure and the other had a testicular mass. The etiology in each case was large cell lymphoma. Recognition of the acquired immunodeficiency sy
The National Association of Public Hospitals and the Association of American Medical Colleges Council of Teaching Hospitals conducted a detailed survey on hospital care to patients with acquired immunodeficiency syndrome (AIDS) in major US public and private teaching institutions in 1985. The 169 hospitals treating p
Kessler HA; Blaauw B; Spear J; Paul DA; Falk LA; Landay A
Early diagnosis of acute human immunodeficiency virus (HIV) infection is difficult because patients may be seronegative for HIV at the time of presentation. We have used a serum HIV antigen (HIV-Ag) enzyme immunoassay (EIA) to diagnose acute HIV infection in four high-risk patients. The clinical syndrome in these four
Med Trop (Mars). 1987 Apr-Jun;47(2):185-8. Unique Identifier : AIDSLINE MED/87314355
Rogerie F; Ott D; Wolff R; Vandepitte J; Lemmens P
A male Rwandese adult with proven A.I.D.S. died from generalized cryptococcosis six months after episodes of recurrent fever with isolation of Salmonella enteritidis from the blood culture. The authors discuss the frequent and precocious appearance of Salmonella septicaemia in patients with A.I.D.S. They propose the i
In many retroviruses the 5 end of the pol gene codes for a protease vital for the processing of the gag polyprotein into the separate core proteins. In some viruses this protease is encoded at the 3 end of the gag gene, or between the gag and pol genes in a different reading frame to either. A sequence, Asp-Thr-Gly,
Malekzadeh MH; Church JA; Siegel SE; Mitchell WG; Opas L; Lieberman E
An 11-year-old boy developed Kaposi s sarcoma and progressive T lymphocyte deficiency 5 years after cadaveric kidney transplantation for end-stage renal disease. He had received 17 individual red blood cell transfusions prior to and during transplantation in 1980. Human immunodeficiency virus (HIV) was cultured from b
Eight hundred sera from a non-risk group and thousand sera from people at risk for acquiring AIDS were tested for the presence of LAV/HTLV-III specific antibodies by ELISA test kits manufactured by Du Pont and Organon. Western Blot analysis was used as a confirmatory test. All Western Blot positive sera were also posi
Thirty-four cases of eosinophilic granulomas, 18 cases of diffuse histiocytosis-X, 2 cases of Letterer-Siwe-like syndrome with immunodeficiency, 4 cases of malignant histiocytosis and virus associated hemophagocytic syndrome were studied. On paraffin section, S100 protein, lysozyme, alpha-1-anti-trypsin, alpha-1-antic
Ann Intern Med. 1987 Oct;107(4):492-5. Unique Identifier : AIDSLINE MED/87324553
Hicks CB; Benson PM; Lupton GP; Tramont EC
Reagin and treponemal antibody tests are highly reliable in diagnosing secondary syphilis. However, patients infected with the human immunodeficiency virus (HIV) respond abnormally to antigenic stimulation and may fail to develop typical serologic responses to infections. We report the case of an HIV-infected man with
Multidisciplinary andrology deals with clinical application and modern technology for the evaluation and differential diagnosis of male infertility with emphasis on morphological, anatomical, biochemical, immunological, hereditary, and microbiological parameters. Little is known about the effects of diet, disease, str
AIDS Res Hum Retroviruses. 1987 Summer;3(2):109-14. Unique Identifier : AIDSLINE MED/87299201
Gottlieb MS; Wolfe PR; Chafey S
A patient with AIDS-related thrombocytopenia (ART) was treated with the new anti-retroviral agent azidothymidine ( AZT , Retrovir, zidovudine) by the intravenous and oral routes for a period of 20 weeks. After a 6 week period of initial treatment, the p
Recombinant human interleukin-2 (rIL-2) was administered to 87 patients with the acquired immune deficiency syndrome (AIDS) to test the hypothesis that this lymphokine would correct the underlying qualitative and quantitative deficiency in cellular immunity. Patients were divided into two groups by the presence or abs
AIDS Res Hum Retroviruses. 1987 Summer;3(2):125-33. Unique Identifier : AIDSLINE MED/87299203
Hartshorn KL; Neumeyer D; Vogt MW; Schooley RT; Hirsch MS
The antiviral activities of various interferon preparations against human immunodeficiency virus (HIV) were evaluated in vitro. Recombinant interferon alpha-A, and beta interferons and leukocyte-derived alpha interferons show similar concentration-dependent antiviral activity. Recombinant and lymphocyte-derived gamma
AIDS Res Hum Retroviruses. 1987 Summer;3(2):135-45. Unique Identifier : AIDSLINE MED/87299204
Crowe S; Mills J; McGrath MS
HIV infection of CD4-bearing lymphocytes alone does not fully explain the immune dysfunction of AIDS. Monocyte/macrophages infected with HIV may serve as a reservoir of HIV, may function abnormally and may transmit infection to other susceptible cells, thus playing a central role in the development of the immunodefici
Br Med J (Clin Res Ed). 1987 Jun 20;294(6587):1595-7. Unique Identifier : AIDSLINE MED/87300508
McEvoy M; Porter K; Mortimer P; Simmons N; Shanson D
In a prospective study of 150 health care workers in the United Kingdom who had been accidentally exposed to the human immunodeficiency virus no evidence of transmission was found. Larger studies in the United States and anecdotal accounts in publicatio
Br Med J (Clin Res Ed). 1987 Jun 27;294(6588):1675-7. Unique Identifier : AIDSLINE MED/87300548
Gillon R
In summary, I have argued that the arguments offered or hinted at in favour of doctors breaking medical confidentiality by passing on information about their patients HIV state to others, including other doctors, when this is against the patient s considered wishes are generally unconvincing. Although in highly exce
Fletcher MA; Baron GC; Ashman MR; Fischl MA; Klimas NG
Whole blood (WB) methods requiring less than 4 ml heparinized peripheral blood were used to define mononuclear cell phenotype, lymphocyte proliferation, and natural cell-mediated cytotoxicity (CYT) in samples from normal controls and patients with immunodeficiency states of acquired immunodeficiency syndrome (AIDS) an
Birkmeyer RC; Diaco R; Hutson DK; Lau HP; Miller WK; Neelkantan NV; Pankratz TJ; Tseng SY; Vickery DK; Yang EK
We have used chromium dioxide magnetic particles as the solid support in developing a series of immunological tests. The high surface area (greater than 40 m2/g) available on the magnetic particles and their easy dispersion throughout a solution allow for rapid and complete capture of the target antigen. The magnetic
A 2.4-kb DNA fragment from the pol region of the human T-cell lymphotropic virus, encoding the protease, reverse transcriptase and a portion of the endonuclease N-terminus was stably introduced into a high-level Bacillus subtilis expression system under inducible control of the Escherichia coli lac regulatory elements
Cord blood samples were collected from 140 Ugandan neonates after vaginal delivery from healthy women and were tested for the presence of HIV antibodies. Two ELISA tests were used: HTLV-III EIA and ELAVIA. Eleven (7.9%) of the 140 samples were positive and 127 were negative by both ELISA tests. The positivity of 11 sa
Int J Immunopharmacol. 1987;9(4):483-8. Unique Identifier : AIDSLINE MED/87307028
Reddy MM; Grieco MH
A monoclonal antibody (anti-Tac) that appears to bind the receptor for interleukin-2 ( IL-2 ) was used to quantitate lymphocytes that express IL-2 receptors (IL-2R) in response to phytohemagglutinin (PHA) stimulation. 62 +/- 4% of the cells expressed IL-2R in response to
The amount of infectious virus released into the culture fluid from human immunodeficiency virus (HIV)-producing MOLT-4 cells (MOLT-4/HIV HTLV-III) was measured as a function of the culture conditions and cell density. After 3 days, the daily yield of infectious virus per cell in the fluid of non-growing cells culture
The effect of neurotropin on human immuno-deficiency virus (HIV) production in a virus-producing MOLT-4 (MOLT-4/HTLV-III) cell line was studied. Culture of the cells for 4 days in the presence of 100 micrograms/ml of neurotropin resulted in a 72% decrease in the number of infectious virus particles released into the c
Bolton V; Pedersen NC; Higgins J; Jennings M; Carlson J
The human immunodeficiency virus (HIV) was isolated from the blood of 192 of 410 seropositive individuals. Original isolations were made in peripheral blood mononuclear cell (PBMC) cultures, and only one-fifth of the HIV isolates could be adapted to replicate in continuous T-cell lines. Of the 192 HIV isolates, 42 had
Adherent cells display an important accessory role on normal T-cell colony formation. Since the in-vitro proliferation of T colony-forming cells (T-CFC) from AIDS patients is extremely impaired we studied the effect of patients adherent cells on T-CFC growth. Patients peripheral blood mononuclear cells (PBMC) were f
Seitz M; Napierski I; Augustin R; Hunstein W; Kirchner H
Tests for lymphoproliferation and interferon induction in normal blood donors and patients with rheumatoid arthritis (RA) were performed in a whole-blood assay. Patients with high inflammatory RA showed significantly reduced lymphoproliferation and interferon gamma production after stimulation with phytohemagglutinin
Mazurier C; de Romeuf C; Parquet-Gernez A; Jorieux S; Goudemand M
We report here the results of our evaluation of the effects of a dry heat treatment (96 h at 68 degrees C) to eliminate LAV/HTLV-III virus on factor VIII (FVIII) and von Willebrand factor (vWf) present in an intermediate-purity concentrate. This thermal inactivation appears to have little effect on FVIII. There is an
A case of an intravenous drug user who, over the course of less than 18 months, was diagnosed as having multiple opportunistic infections, the acquired immunodeficiency syndrome (AIDS) and a non-Hodgkin s lymphoma is presented. Cytogenetic findings on both bone marrow and lymph nod
One hundred forty-five patients were initially seen with Pneumocystis carinii pneumonia (PCP). Of the many features examined, several variables were identified early in the hospitalization for PCP that were associated with poor survival. These included multiple admissions, leukocytoses, elevated serum lactate dehydrog
Cancer. 1987 Oct 1;60(7):1449-53. Unique Identifier : AIDSLINE MED/87301269
Ioachim HL; Weinstein MA; Robbins RD; Sohn N; Lugo PN
Non-Hodgkin s lymphomas with particular clinicopathologic features occur with a high incidence in homosexual men affected by AIDS. More frequently than in the general population, these lymphomas have an extranodal location including the gastrointestinal tract. We have recently observed four cases of AIDS-associated ly
Several parameters of lymphocyte interleukin 2 receptor (IL-2R) expression in response to tetanus toxoid (TT) were monitored using a receptor-specific monoclonal antibody and flow cytometry in patients with acquired immunodeficiency syndrome (AIDS, n = 6), AIDS-related complex (ARC, n = 8), or lymphadenopathy syndrome
Serial determinations of the numbers of peripheral blood T-lymphocyte subpopulations (T-helper/inducer and T-suppressor/cytotoxic cells) were made using monoclonal antibodies in 12 patients with haemophilia who were HIV antibody positive. Eleven patients were clinically severe and one clinically moderate. Follow-up st
Goodman DS; Teplitz ED; Wishner A; Klein RS; Burk PG; Hershenbaum E
Ninety adult patients with acquired immunodeficiency syndrome (AIDS) and 27 with AIDS-related complex were seen consecutively, when available, either as inpatients or in AIDS clinics and given complete cutaneous examinations. Skin disease was common both in patients with AIDS and in those with AIDS-related complex. Th
To examine the relationship between human immunodeficiency virus (HIV) seropositivity and T lymphocyte subsets in a clinically well population, we assayed HIV antibody and analyzed T lymphocyte subsets in 30 people at increased risk for acquired immunodeficiency syndrome (AIDS) who were clinically well. Seventy-six pe
In vitro studies indicate that human immunodeficiency virus (HIV) infections are cytopathic for T4+ peripheral blood lymphocytes and for most continuous lines of T4+ lymphocytes. These cytopathic effects have been largely attributed to the formation of syncytia by HIV-infected cells. We report that HIV infections kill
Ann Intern Med. 1987 Oct;107(4):474-80. Unique Identifier : AIDSLINE MED/87324550
Kaslow RA; Phair JP; Friedman HB; Lyter D; Solomon RE; Dudley J; Polk BF; Blackwelder W
In 1984 a large prospective study of gay and bisexual men was begun to elucidate the natural history of the human immunodeficiency virus (HIV) infection. At two successive semiannual examinations, clinical or hematologic abnormalities were found up to 13 times more often among HIV-seropositive men (n = 1611) than HIV-
Boll Ist Sieroter Milan. 1987;66(1):14-7. Unique Identifier : AIDSLINE MED/87299048
Sala PG; Mazzolini S; Tonutti E; Crucil C; Pitzus E; Bramezza M
Sera from 55 patients with positivity for anti-HTLV III antibodies, including 24 healthy subjects, 29 LAS and 2 AIDS, were examined by means of high resolution agarose gel electrophoresis and immunofixation, in order to evaluate the occurrence of monoclonal-oligoclonal immunoglobulin patterns. Monoclonal-oligoclonal i
A new primate retrovirus, STLV-IIIAGM, has been recently isolated from healthy African green monkeys and is apparently nonpathogenic in its natural host. However, spontaneous infection as well as inoculation of STLV-IIIAGM into macaques induces a disease with clinical features that resemble human AIDS. Independent iso
AIDS Res Hum Retroviruses. 1987 Spring;3(1):3-10. Unique Identifier : AIDSLINE MED/87299193
Albert J; Bredberg U; Chiodi F; Bottiger B; Fenyo EM; Norrby E; Biberfeld G
A new human retrovirus of West African origin (SBL-6669) has been isolated from a patient with immunological and clinical signs of immunodeficiency. Using radioimmunoprecipitation assays (RIPA) and Western blot (WB) tests with human sera, the new virus isolate has been compared with HTLV-IV, LAV-II, and the HTLV-IIIB
The long terminal repeat (LTR) of the AIDS virus (HIV) has been found to contain promoter sequences that are active in uninfected HeLa whole cell and nuclear extracts. Here we report that elements upstream of position -104 (start site +1) do not affect transcriptional activity in vitro whereas sequences between -104 a
To examine the mechanism of lymphocytotoxicity induced by human T-lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV), an in vitro model has been developed. Introduction of an HTLV-III/LAV proviral clone, HXB2, into normal lymphocytes results in the production of virions and cell death. The com
Cancer. 1987 Oct 1;60(7):1459-61. Unique Identifier : AIDSLINE MED/87301271
Presant CA; Gala K; Wiseman C; Kennedy P; Blayney D; Sheibani K; Winberg CD; Rasheed S
A patient with multiple infections whose serum had antibodies to a human immunodeficiency virus (HIV) developed a T-cell lymphoblastic lymphoma (T11+, Leu-1+, Leu-3a+, TdT+, B1-, common ALL-). Antibodies to human T-lymphotropic virus-I (HTLV-I) were absent. T-cell leukemia-lymphoma may be associated with HIV infection
Lasky LA; Nakamura G; Smith DH; Fennie C; Shimasaki C; Patzer E; Berman P; Gregory T; Capon DJ
The primary event in the infection of cells by HIV is the interaction between the viral envelope glycoprotein, gp120, and its cellular receptor, CD4. A recombinant form of gp120 was found to bind to a recombinant CD4 antigen with high affinity. Two gp120-specific murine monoclonal antibodies were able to block the int
In comparison to older children and adults, neonates are immunologically incompetent. They are susceptible to infections caused by a variety of microorganisms, including bacteria, fungi and viruses. These infectious agents may be acquired by neonates either prenatally, during the intrapartum period or postnatally. The
Specific antibody responses against the 2 major subcomponents of EBNA, EBNA1 and EBNA2 were evaluated, in order to study whether this serological study was beneficial compared to classical EBV serology. During this investigation, 491 sera, obtained from blood donors and patients with Burkitt s lymphoma (BL), nasophary
We have examined the activities of Epstein-Barr virus (EBV)-specific memory T-cells of carriers of adult T-cell leukemia (ATL) associated retrovirus (HTLV-I) and non-carriers in an ATL-endemic area, all of whom were EBV-seropositive, by assay of EBV-induced B-cell focus regression. The result showed that immune suppre
The reverse transcriptase polymerase of the human T-cell lymphotropic virus/lymphadenopathy-associated virus has been cloned into an expression vector and expressed in Escherichia coli. Two polypeptides of 66 and 51 kDa molecular mass are detectable in polymerase-expressing bacterial lysates with human patient sera. T
Membreno L; Irony I; Dere W; Klein R; Biglieri EG; Cobb E
Clinical features of adrenal steroid deficiency occur in patients with the acquired immunodeficiency syndrome (AIDS). To determine the frequency of aberrations in peripheral steroid levels in patients with AIDS and AIDS-related complex (ARC) we measured morning recumbent plasma cortisol, deoxycorticosterone, 18-hydrox
Mounting evidence suggests that opiate addiction and stress are associated with impaired cell-mediated immunity. We tested the hypothesis that morphine and the endogenous opioid beta-endorphin (beta-END), a pituitary peptide released in increased concentrations during stress, can suppress the production of the key mac
The Hodgkin-associated Ki-1 antigen was analyzed in different cell lines. In Hodgkin analogous L428 cells, biosynthetically labeled with radioactive amino acids, the Ki-1 antibody precipitated three glycoproteins with 90, 105, and 120 kDa, respectively. Surface-labeling revealed that the two larger components were mem
J Med Virol. 1987 Aug;22(4):375-8. Unique Identifier : AIDSLINE MED/87310415
Reddy D; Okochi K; Woodfield DG; Judd W
Sera from 1,943 individuals from Auckland, New Zealand , were tested for the presence of serum antibodies to human T cell lymphotropic virus I (HTLV I), mainly with an enzyme-linked immunosorbent assay (ELISA) with cell extracts as target antigen. The individuals tested were blo
We have isolated a molecular clone of the full-length integrated provirus of simian acquired immune deficiency syndrome retrovirus serotype 1 (SRV-1) from a fatal case of simian acquired immune deficiency syndrome in a juvenile rhesus macaque. An integrated SRV-1 provirus was cloned, sequenced, and found to contain fo
Riepenhoff-Talty M; Dharakul T; Kowalski E; Michalak S; Ogra PL
Rotaviruses are important pathogens of human infants and the infants of many animal species. The disease produced by these viruses can be described as an acute, self-limiting diarrheal disease, with virus replication localized to the differentiated epithelial enterocytes of the small intestine. Immunologically normal
Adams SE; Dawson KM; Gull K; Kingsman SM; Kingsman AJ
The yeast retrotransposon, Ty, encodes a set of proteins that are assembled into virus-like particles, Ty-VLPs (refs 1, 2). These proteins include Ty-VLP structural proteins, a protease that mediates cleavage of primary translation products and a reverse transcriptase. The major structural components of Ty-VLPs are pr
Norrby E; Biberfeld G; Chiodi F; von Gegerfeldt A; Naucler A; Parks E; Lerner R
Human immunodeficiency virus (HIV) strains can be separated into two types: HIV and HIV-related West African viruses. Site-directed serology using synthetic peptides offers possibilities for the determination of type-specific antibodies. A 22-amino-acid peptide with the sequence Ala-Ile-Glu-Lys-Tyr-Leu-Glu-Asp-Gln-Ala
Cytomegalovirus ( CMV ) infection presenting as a painful palatal gingival ulcer was one of the initial clinical manifestations of the acquired immune deficiency syndrome (AIDS) in a male homosexual patient. The diagnosis of oral CMV infection was established when
This case report documents a perforation of the terminal ileum in a 40-year-old white male homosexual with the acquired immunodeficiency syndrome. The perforation occurred at a site that had severe cytomegalovirus infection and was in close proximity to multiple nodules of Kaposi s
ATL-cell lines producing C-type retroviruses were established by culture of the peripheral blood mononuclear cells from a patient with chronic ATL. These cell lines had the surface feature of inducer/helper T-cells with electron microscopic finding of C-type retrovirus on the cell surface. Chromosome analysis revealed
A retrospective analysis of all testicular tumors treated at our institution over a seven-year period was conducted. Twenty-five of 115 patients were found to have acquired immune deficiency syndrome (AIDS), AIDS-related complexes, or to be at risk for AIDS developing. Non-seminomatous germ cell tumors were more commo
We have prospectively followed for 9-12 months, 246 female health care workers (HCWs): 102 with high exposure (HE), 43 with low exposure (LE), and 101 with no exposure (NE) to AIDS (acquired immunodeficiency syndrome) patients. No HCWs have clinical, serologic, or immunologic evidence of HIV (human immunodeficiency vi
Gartner JG; Murphy MN; Diocee M; deSa DJ; McLain KL
The subject of this investigation was an 11-month-old infant girl who presented with a pathological fracture of the right femur due to a metastasis from an abdominal immunoblastic sarcoma. Her past history included recurrent, intractable bacterial and fungal infections. Investigations of her immune status revealed low
Am J Vet Res. 1987 Aug;48(8):1264-8. Unique Identifier : AIDSLINE MED/87324429
Lopez JW; Woods GT
In calves inoculated with live swine influenza virus (SIV) A/sw/IL/75 (H1N1) intranasally, SIV was isolated for 7 days, and respiratory tract disease was observed. Antibody was detected in serum of inoculated calves from postinoculation day 9, and virus-neutralization antibody was demonstrated on postinoculation days
Jacobson MA; de Miranda P; Cederberg DM; Burnette T; Cobb E; Brodie HR; Mills J
Ganciclovir is a nucleoside analog which inhibits the replication of herpesviruses in vitro and which has been effective by intravenous administration for the treatment of severe cytomegalovirus infection in immunocompromised patients. Because most patients with acquired immunodefi
Data on 54 persons who died of acquired immunodeficiency syndrome were reviewed for lesions of the heart. These persons met the criteria of the Centers for Disease Control (Atlanta) for acquired immunodeficiency syndrome. Pathologic changes were seen in 30 patients (55%). Changes were seen in the endocardium (17%), my
Kahn DG; Garfinkle JM; Klonoff DC; Pembrook LJ; Morrow DJ
We describe an immunosuppressed patient with enteric cryptosporidiosis who developed combined cryptosporidial and cytomegaloviral hepatitis and cholecystitis as well as Enterobacter cloacae cholecystitis. To our knowledge, the presence of Cryptosporidium in a liver biopsy specimen has not previously been reported.
Three patients with the acquired immunodeficiency syndrome (AIDS) had combined infections of the central nervous system, with both herpes simplex virus (HSV) and cytomegalovirus ( CMV ). All three had a diffuse ventriculoenceph
AIDS Res Hum Retroviruses. 1987 Spring;3(1):19-32. Unique Identifier : AIDSLINE MED/87299192
DeFreitas E; Wroblewska Z; Maul G; Sheremata W; Ferrante P; Lavi E; Harper M; di Marzo-Veronese F; Koprowski H
Antibodies reacting with HTLV-I, the etiologic agent of acute T cell leukemia/lymphoma and a transforming agent for T4-positive lymphocytes in vitro, have recently been described in sera of patients with chronic neurologic disease in the absence of lymphoproliferative disorders. The largest number of such cases was de
Ragni MV; Winkelstein A; Kingsley L; Spero JA; Lewis JH
A cohort of 181 patients with hemophilia A (149) and hemophilia B (32) cared for at the Hemophilia Center of Western Pennsylvania was followed to determine human immunodeficiency virus (HIV) seroprevalence, seroconversion rate, and clinical and immunologic correlates of HIV infection. By December 1986, 82 (45%) were H
Cancer. 1987 Oct 1;60(7):1474-8. Unique Identifier : AIDSLINE MED/87301274
Lee SY; Mastushita K; Machida J; Tajiri M; Yamaguchi K; Takatsuki K
Human T-cell leukemia virus Type I (HTLV-I) has been detected in a high proportion of individuals in Kumamoto prefecture (Kyushu) and Okinawa, where adult T-cell leukemia (ATL) is more likely to occur. The seroprevalence of antibody to HTLV-I was evaluated in hemodialysis patients and healthy individuals in the ATL en
Goldstein H; Ambrus JL Jr; Grove JH; Margolick JB; Fauci AS
We have previously described YA2, a human T-cell clone that secretes B-cell differentiation factor (BCDF) but not B-cell growth factor (BCGF). The BCDFs secreted by YA2 and HTLV-I-transformed YA2 (TYA2) were functionally similar in their ability to stimulate Ig secretion by Staphylococcus aureus Cowan strain I-activat
Nakamura H; Hayami M; Ohta Y; Ishikawa K; Tsujimoto H; Kiyokawa T; Yoshida M; Sasagawa A; Honjo S
Protection against human T-cell leukemia virus type-I (HTLV-I) infection in cynomolgus monkeys, achieved by immunizing the animals with env gene products of HTLV-I produced in Escherichia coli, was evaluated. Four monkeys that had been immunized with the env product produced antibody against HTLV-I gp68 and gp46, and
Kinoshita K; Amagasaki T; Hino S; Doi H; Yamanouchi K; Ban N; Momita S; Ikeda S; Kamihira S; Ichimaru M; et al
In order to clarify the natural transmission route of human T-cell leukemia virus type I (HTLV-I) from mother to child, we have followed two groups of children with ages of 1 to 3 years who were nourished either with HTLV-I-infected breast milk, or with non-infected milk from sero-positive, HTLV-I carrier mothers. Tes
Production of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by human T-lymphotropic virus-I (HTLV-I)-infected lymphocytes may be the cause of the hypercalcemia frequently found in HTLV-I-associated adult T-cell lymphoma/leukemia. We examined three HTLV-I-transformed lymphocyte cell lines, two HTLV-II-transformed lymphocyte
The adult T cell leukemia (ATL) is a T cell neoplasm etiologically associated with human T lymphotropic virus type I (HTLV-I) infection. ATL cells often abnormally express interleukin 2 ( IL-2 ) receptors, and ATL patients may show clinical evidence of hypercalcemia, ost
Monoclonal antibodies against human T cell leukemia virus type I (HTLV-I) p24 and p19 were produced and employed in the in vivo expression of HTLV-I in some HTLV-I-related subjects by Western blot analysis. The antigenic determinants of these monoclonal antibodies were different from that of natural human anti-HTLV-I
Lancet. 1987 Aug 29;2(8557):480-3. Unique Identifier : AIDSLINE MED/87313919
Montgomery AB; Debs RJ; Luce JM; Corkery KJ; Turner J; Brunette EN; Lin ET; Hopewell PC
15 patients with first episodes of Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome were treated with only aerosolised pentamidine, which they inhaled for 20 minutes every day for 21 days. 13 of the 15 responded to therapy. Mean PaO2 (mm Hg) and vital capacity (% predicted) were 67.9 and 50.8
Ranki A; Valle SL; Krohn M; Antonen J; Allain JP; Leuther M; Franchini G; Krohn K
Signs of latent HIV infection were sought in stored serum samples collected before overt seroconversion, confirmed by enzyme-linked immunosorbent assay (ELISA), from 9 subjects with human-immunodeficiency-virus (HIV) infection, in serum from 25 seronegative sexual partners of HIV-seropositive men and from 23 other ser
Unusual cutaneous vascular neoplasms distinct from Kaposi s sarcoma were observed in five patients with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 infection. The cutaneous lesions were solitary or multiple papules and nodules. In some patients the lesions also affected intern
Current experience with the safety and efficacy of vaccines in infected children and adults is reviewed to examine the basis for decisions about routine immunisations of children infected with the human immunodeficiency virus (HIV). No adverse reactions to inactivated vaccines have been noted, but complications with l
Nerenberg M; Hinrichs SH; Reynolds RK; Khoury G; Jay G
Human T-lymphotropic virus type 1 (HTLV-1) is a suspected causative agent of adult T-cell leukemia. One of the viral genes encodes a protein (tat) that not only results in transactivation of viral gene expression but may also regulate the expression of certain cellular genes that are important for cell growth. Transge
Hinrichs SH; Nerenberg M; Reynolds RK; Khoury G; Jay G
Human T-lymphotropic virus type 1 (HTLV-1) has been associated with the neurologic disorder tropical spastic paraparesis and possibly with multiple sclerosis. The tat gene of HTLV-1 under control of its own long terminal repeat is capable of inducing tumors in transgenic mice. The morphologic and biologic properties o
Efforts to solve the epidemiologic puzzle of AIDS in Africa are complicated by the presence of multiple human retroviruses. Simple serologic tests that unambiguously distinguish among infections by these retroviruses are essential. To that end, a partially conserved immunoreactive epitope was identified in the transme
The risk of transfusion-associated acquired immunodeficiency syndrome (AIDS) has been difficult to estimate because of the long and variable incubation period. Mathematical modeling suggests there may eventually be 2100 cases among persons aged 13 to 65 who received transfusions between 1978 and 1984. An estimated 12,
Adv Exp Med Biol. 1987;213:129-37. Unique Identifier : AIDSLINE MED/87322693
Waldmann TA
Interleukin-2 ( IL-2 ) is a lymphokine synthesized by T cells following activation. Resting T cells do not express IL-2 receptors, but receptors are rapidly expressed on T cells following interaction of the antigen-specific T-cell receptor complex with appropriately proc
Ann Neurol. 1987 Jul;22(1):67-71. Unique Identifier : AIDSLINE MED/87324799
Lolli F; Fredrikson S; Kam-Hansen S; Link H
The presence of IgG antibodies reacting with purified and disrupted human T-lymphotropic virus type I (HTLV-I) was examined by an indirect enzyme-linked immunosorbent assay (ELISA) in sera from 49 patients with multiple sclerosis (MS), 21 patients with aseptic meningoencephalitis (AM), 12 patients with Guillain-Barre
Gan To Kagaku Ryoho. 1987 Sep;14(9):2792-5. Unique Identifier : AIDSLINE MED/87324973
Okabe K; Toki H; Fujii M; Kiura K; Kamei H
A 68-year-old man was referred to our hospital because of generalized lymphadenopathy. His abnormal findings were hepatomegaly, leukocytosis and elevated serum LDH. Anti-ATLA antibody was positive. As about half of the peripheral lymphocytes reacted to the monoclonal antibody CD25, these cells were considered to be co
The gene encoding the human Interleukin 2 ( IL-2 ) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement f
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