PLATELET-DERIVED GROWTH FACTOR: COMMENTS ON THE STRUCTURAL AND FUNCTIONAL RELATIONSHIP WITH THE TRANSFORMING PROTEIN OF SIMIAN SARCOMA VIRUS NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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PLATELET-DERIVED GROWTH FACTOR: COMMENTS ON THE STRUCTURAL AND FUNCTIONAL RELATIONSHIP WITH THE TRANSFORMING PROTEIN OF SIMIAN SARCOMA VIRUS

Prog Cancer Res Ther; 32:87-94 1985. Unique Identifier : AIDSLINE ICDB/87632834
Westermark B; Johnsson A; Betsholtz C; Wasteson A; Heldin C-H; Dept. of Pathology, Univ. of Uppsala, Akademiska Hosp., S-751 85; Uppsala, Sweden

Abstract: Platelet-derived growth factor (PDGF) and its structure, function, and relationship with the transforming gene product of simian sarcoma virus are discussed under the following headings: the subunit composition of PDGF, amino acid sequence of PDGF; structural and functional relationship between p28sis and PDGF; and expression of the c-sis gene in human tumor cells. Using a 32P-labeled c-sis probe, the authors recently identified c-sis transcripts on Northern blots of polyA+ RNA isolated from human osteosarcoma cell line U-2 OS and other sarcoma and glioma lines. It is conceivable that an undue expression of the c-sis gene and synthesis of PDGF leads to an autocrine stimulation of growth of these tumor cells; it is noted in this connection that gliomas and sarcomas are derived from PDGF-responsive tissues. However, expression of c-sis is not a constant feature of gliomas and sarcomas, indicating that the undue expression of c-sis and PDGF production may represent only one of several mechanisms of constitutive mitogenesis in glioma and sarcoma cells. (26 Refs)
Keywords: Amino Acid Sequence Cell Line *Cell Transformation, Neoplastic *Cell Transformation, Viral Chromosomes, Human, Pair 22 Gene Expression Regulation Human Neoplasms/GENETICS Nucleotide Mapping *Oncogenes Platelet-Derived Growth Factor/*GENETICS/ISOLATION & PURIF Sarcoma Viruses, Simian/*GENETICS Structure-Activity Relationship Translation, Genetic MEETING PAPER

KWDaminoacidsequencecelllineKWDcelltransformation,neoplasticKWDcelltransformation,viralchromosomes,human,pair22geneexpressionregulationhumanneoplasms/geneticsnucleotidemappingKWDoncogenesplatelet-derivedgrowthfactor/KWDgenetics/isolation&purifsarcomaviruses,simian/KWDgeneticsstructure-activityrelationshiptranslation,geneticmeetingpaper
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Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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