Peripheral blood and bone marrow abnormalities in patients with HIV related disease. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Peripheral blood and bone marrow abnormalities in patients with HIV related disease.

Br J Haematol. 1987 Mar;65(3):289-94. Unique Identifier : AIDSLINE MED/87185258
Treacy M; Lai L; Costello C; Clark A

Abstract: Between February 1983 and April 1986 we studied peripheral blood and bone marrow samples from 20 patients with human immunodeficiency virus (HIV) related disease. 14 patients had AIDS, three had ARC, two had PGL and one had ITP as a sole manifestation of HIV related disease. Peripheral blood abnormalities included marked anisocytosis and poikilocytosis, rouleaux formation, neutropenia, lymphopenia, monocytopenia, a left shift in the granulocyte series and, in the patients with AIDS, vacuolated monocytes. The most frequent bone marrow abnormalities were reticuloendothelial iron block, dyserythropoiesis, megaloblastic change and erythroid hypoplasia. Excess histiocytes were noted in four marrows, one exhibiting haemophagocytosis. None of the bone marrows showed lymphopenia. Eight of the 20 marrows were difficult or impossible to aspirate. None of the trephine biopsies showed increased reticulin. The causes of these abnormalities are probably multiple and include opportunistic infections, drug therapy, immune mechanisms and possibly direct insult by the HIV virus.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS/PATHOLOGY Adult AIDS-Related Complex/COMPLICATIONS Bone Marrow/*PATHOLOGY Female Hematologic Diseases/*ETIOLOGY Human Leukopenia/ETIOLOGY Lymphopenia/ETIOLOGY Male Middle Age Monocytes/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDcomplications/pathologyadultaids-relatedcomplex/complicationsbonemarrow/KWDpathologyfemalehematologicdiseases/KWDetiologyhumanleukopenia/etiologylymphopenia/etiologymalemiddleagemonocytes/pathologyjournalarticle
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Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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