A comparison of leukocyte aggregation, leukocyte migration and skin reactivity to recall antigens in patients with AIDS.

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

A comparison of leukocyte aggregation, leukocyte migration and skin reactivity to recall antigens in patients with AIDS.

Clin Exp Immunol. 1986 Dec;66(3):574-81. Unique Identifier : AIDSLINE MED/87188434
Rouveix B; Groult F; Pocidalo JJ

Abstract: A study was made to evaluate the leukocyte aggregation test (LAT) in patients at risk for acquired immunodeficiency syndrome (AIDS) and with confirmed AIDS using tuberculin, streptococcus and candida as recall antigens. These patients were selected on the basis of their well known absence of delayed hypersensitivity, a fact which should avoid false positive tests. Antigen-induced human peripheral blood leukocyte aggregation was measured quantitatively. The results obtained have been compared with the leukocyte migration inhibition test (LMIT) in patient and control groups. Among the 46 patients, less than 7% were positive for the LAT, whereas more than 50% were LMIT positive (P less than 0.001). These results suggest that there are fewer false positive reactions with LAT which can therefore be considered as a reliable method for assessing CMI in human. Furthermore, a negative LAT correlated well with negative delayed skin tests in more than 90% of the patients for the three antigens. These patients had either an AIDS or an advanced AIDS-related complex (ARC). In only eight of the patients was there a discrepancy in the results of the two tests. A positive LAT and a negative skin test were seen in three cases lacking opportunistic infections (OI), whereas a negative LAT and a positive skin test were found in patients with or without OI. In the latter, a negative LAT could indicate a more advanced stage of disease and hence a poor prognosis.

Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/IMMUNOLOGY Adult AIDS-Related Complex/DIAGNOSIS/IMMUNOLOGY Cell Aggregation Cell Migration Inhibition Comparative Study Female Human Hypersensitivity, Delayed/IMMUNOLOGY Leukocytes/*IMMUNOLOGY Male Middle Age Prognosis *Skin Tests Support, Non-U.S. Gov't JOURNAL ARTICLE

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