Kaposi's sarcoma in different populations in South Africa. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Kaposi's sarcoma in different populations in South Africa.

S Afr Med J. 1987 May 16;71(10):615-9. Unique Identifier : AIDSLINE MED/87206496
Phillips JI; Sher R

Abstract: Patients with Kaposi's sarcoma (13 black and 5 white heterosexuals and 2 homosexuals with the acquired immunodeficiency syndrome (AIDS)) were investigated clinically, histologically, serologically and immunologically. Clinically, lymph node involvement was present in 9 of the 13 black heterosexuals, but was not seen in the other two groups. Oedema, which was seen in 13 of the 14 black patients, was only present in 1 white patient. The lesions were of the nodular cutaneous type except in the AIDS patients who presented with plaque-like lesions. Whereas all non-AIDS patients were negative for HTLV-III antibodies, both AIDS patients were positive and showed a marked cell-mediated immune (CMI) deficiency. Only 1 heterosexual white and 4 heterosexual black patients had some degree of CMI deficiency. South Africans with Kaposi's sarcoma do not have significant underlying immunodeficiency or associated opportunistic infections. No serological or electron microscopic evidence was found to support the aetiological role of cytomegalovirus in Kaposi's sarcoma. The findings suggest that the cell of origin of this tumour is the vascular endothelial cell.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Adult Aged Blacks Female Homosexuality Human Male Middle Age Sarcoma, Kaposi's/DRUG THERAPY/*IMMUNOLOGY/PATHOLOGY South Africa Support, Non-U.S. Gov't Whites JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complicationsadultagedblacksfemalehomosexualityhumanmalemiddleagesarcoma,kaposi's/drugtherapy/KWDimmunology/pathologysouthafricasupport,non-uKWDsKWDgov'twhitesjournalarticle
870830
M8780234

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1987. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1987. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .