Atlanta, Ga. : Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, [1985] ii, 100 p. : ill Unique Identifier : AIDSLINE CAT/8706483
Prog Cancer Res Ther; 32:87-94 1985. Unique Identifier : AIDSLINE ICDB/87632834
Westermark B; Johnsson A; Betsholtz C; Wasteson A; Heldin C-H; Dept. of Pathology, Univ. of Uppsala, Akademiska Hosp., S-751 85; Uppsala, Sweden
Platelet-derived growth factor (PDGF) and its structure, function, and relationship with the transforming gene product of simian sarcoma virus are discussed under the following headings: the subunit composition of PDGF, amino acid sequence of PDGF; structural and functional relationship between p28sis and PDGF; and ex
The human T-cell leukemia (lymphotropic) virus (HTLV) family is reviewed under the following headings: background, isolation of HTLV (a T-cell growth factor or interleukin-2; isolation of HTLV-I; isolation of HTLV-II; isolation of HTLV-III), biological effects of HTLV (transformation of fresh human T lymphocytes by
Health Prog. 1987 May;68(4):58-63. Unique Identifier : AIDSLINE AHA/87195148
Dunphy R
In helping persons with AIDS recognize and understand their spiritual needs, it is beneficial to distinguish between spirituality and organized religion. Spirituality is concerned with meaning, hope, self-identity and self-worth, and forgiveness and reconciliation and is determined by the way persons structure their r
Between February 1983 and April 1986 we studied peripheral blood and bone marrow samples from 20 patients with human immunodeficiency virus (HIV) related disease. 14 patients had AIDS, three had ARC, two had PGL and one had ITP as a sole manifestation of HIV related disease. Peripheral blood abnormalities included mar
A study was made to evaluate the leukocyte aggregation test (LAT) in patients at risk for acquired immunodeficiency syndrome (AIDS) and with confirmed AIDS using tuberculin, streptococcus and candida as recall antigens. These patients were selected on the basis of their well known absence of delayed hypersensitivity,
Ribavirin is a broad-spectrum antiviral drug that has in vitro activity against human immunodeficiency virus. To determine the kinetics of ribavirin, 17 symptom-free homosexual men with lymphadenopathy were studied. Single doses of ribavirin, 600, 1200, or 2400 mg, were given orally or intravenously. The plasma ribavi
To assess the role of open lung biopsy in patients with the acquired immunodeficiency syndrome (AIDS), we retrospectively reviewed the cases of 42 patients with AIDS who underwent this procedure for the diagnosis of pulmonary infiltrates. Four patients had no preceding bronchoscopy because the severity of the respirat
To determine attitudes and practices associated with gastrointestinal endoscopy in patients with acquired immune deficiency syndrome (AIDS), we surveyed the chiefs of gastroenterology at 196 medical centers in the United States . The response rate was 61% overall and 100% from New York
Antibody responses after immunization with 23-valent pneumococcal polysaccharide and trivalent influenza virus vaccines were evaluated in 30 adults with hemophilia and in 17 healthy controls. The 30 patients with hemophilia included 13 who were human immunodeficiency virus (HIV) antibody positive with acquired immune
JAMA. 1987 May 15;257(19):2609-11. Unique Identifier : AIDSLINE MED/87199124
Baker JL; Kelen GD; Sivertson KT; Quinn TC
To determine the prevalence of unsuspected human immunodeficiency virus (HIV) infection in critically ill emergency patients, we examined the anonymous serum samples of 203 critically ill or severely injured patients with no history of HIV infection. We found that six (3%) were seropositive for HIV antibody by both en
Adolescents are a group at high risk for exposure to acquired immunodeficiency syndrome (AIDS). Results of a random-sample survey of 860 adolescents 16 to 19 years of age, in Massachusetts indicate that many adolescents are still misinformed or confused about AIDS and AIDS transmission. Of the adolescent respondents,
A 32-year-old patient with acquired immune deficiency syndrome (AIDS) was evaluated for bilateral visual loss accompanied by uveitis, vitritis and retinochoroiditis. Diagnostic vitrectomy was performed on the right eye, and the diagnosis of ocular toxoplasmosis made. Central nervous system involvement was suggested by
There are several causes of hepatic granulomas, infective and non-infective. Modern technology, including monoclonal antibody techniques and histochemistry, has shed light on the morphology of the sarcoid granuloma. There are numerous causes of hepatic granulomas, both infective and non-infective. The causes are liste
From a personal series of 16 cases, the authors report in this article the various arguments in favor of a vertical or neonatal transmission of HIV. The risk of contamination when the mother is sero-HIV positive seems to be 50 to 60 p. cent, for most teams.
S Afr Med J. 1987 May 16;71(10):615-9. Unique Identifier : AIDSLINE MED/87206496
Phillips JI; Sher R
Patients with Kaposi s sarcoma (13 black and 5 white heterosexuals and 2 homosexuals with the acquired immunodeficiency syndrome (AIDS)) were investigated clinically, histologically, serologically and immunologically. Clinically, lymph node involvement was present in 9 of the 13 black heterosexuals, but was not seen i
Histologic sections from the testes of 32 autopsied patients with acquired immune deficiency syndrome (AIDS) were examined. Almost invariably the testes displayed decreased spermatogenesis, and 20 of the 32 cases showed marked hypospermatogenesis with Sertoli cells predominantly lining the tubules. Although the semini
Wien Klin Wochenschr. 1987 Feb 20;99(4):120-3. Unique Identifier : AIDSLINE MED/87207995
Steger G; Dittrich C; Eichler HG; Flener R; Moser K
Two patients with AIDS and histologically confirmed Kaposi s sarcoma were treated with 3 X 10(6) U/m2 interferon alpha 2C (rIFN alpha 2C) subcutaneously three times a week. In both cases remissions (7 weeks and more than 9 months) of the tumour lesions were achieved and in one case pretherapeutic moderate thrombocytop
Jakobsen J; Diemer NH; Gaub J; Brun B; Helweg-Larsen S
The case is reported of a 46-year-old homosexual LAV/HTLV III seropositive man in whom progressive multifocal leukoencephalopathy was the first and only clinical manifestation of AIDS. The severity and extension of neurological disturbances in AIDS are discussed.
The presence of HIV (human immunodeficiency virus) particles in the tear fluid, on the conjunctival surface or in the contact lenses of patients with chronic HIV infection has made it necessary to establish better for guide-lines for decontamination of instruments during ophthalmological procedures. The methods are no
Peripheral blood lymphocyte subsets were quantified by immunofluorescence in nine patients undergoing open heart surgery for coronary artery, valvular, and congenital heart disease. Compared with normal preoperative values, all patients developed an absolute lymphopenia, a reduction in T4 (helper) lymphocytes, and a s
Am J Hematol. 1987 May;25(1):107-13. Unique Identifier : AIDSLINE MED/87210082
Wissel PS; Sordillo P; Anderson KE; Sassa S; Savillo RL; Kappas A
Three male subjects with cutaneous symptoms and biochemical signs typical of porphyria cutanea tarda (PCT) developed acquired immune deficiency syndrome (AIDS). All three were in a classic high risk group for the latter disease and developed a typical progressive illness. Two patients succumbed to opportunistic infect
Am J Med. 1987 May;82(5):1021-6. Unique Identifier : AIDSLINE MED/87210260
Schottstaedt MW; Hurd ER; Stone MJ
Cutaneous Kaposi s sarcoma developed eight months after initiation of prednisone treatment in a 58-year-old man with systemic rheumatoid disease (rheumatoid arthritis, Felty s syndrome, rheumatoid vasculitis, and myositis). This patient did not have the acquired immune deficiency syndrome. Review of the literature sug
Am J Med. 1987 May;82(5):900-6. Unique Identifier : AIDSLINE MED/87210288
Witt DJ; Craven DE; McCabe WR
Sixty-four episodes of bacterial infection were identified over a 44-month period in 16 of 28 patients with the acquired immune deficiency syndrome (AIDS) and 14 of 31 patients with AIDS-related complex. Nineteen of the 30 infected patients were parenteral drug abusers, 10 were from Caribbean Islands and had no identi
Am J Med. 1987 May;82(5):907-14. Unique Identifier : AIDSLINE MED/87210289
Haverkos HW
Toxoplasma encephalitis has been reported as a life-threatening opportunistic infection among patients with the acquired immune deficiency syndrome. The TE Study Group was established to address clinical questions about Toxoplasma encephalitis by retrospectively reviewing available data. The medical centers selected w
Am J Public Health. 1987 Jun;77(6):729-30. Unique Identifier : AIDSLINE MED/87210745
Graves EJ; Moien M
Data from the National Hospital Discharge Survey on hospitalizations for acquired immunodeficiency syndrome (AIDS) were analyzed for 1984-85. During 1984, an estimated 10,000 discharges from short-stay hospitals had a diagnosis of AIDS. In 1985, this figure more than doubled to 23,000. Ninety-seven percent of all AIDS
Ann Dermatol Venereol. 1987;114(2):185-202. Unique Identifier : AIDSLINE MED/87211658
Janier M; Couderc LJ; Morel P; Vignon MD; Laroche L; D'Agay MF; Rabian C; Palangie A; Harzic M; Bellanger J; et al
We report 31 cases of AIDS-Kaposi s sarcoma (KS) studied at the Hopital Saint-Louis, Paris, France , from January 1983 to January 1986. Twenty-nine cases were cutaneous KS and 2 were lymph-node KS. Twenty-eight patients were homosexual or bisexual males, 1 was a woman with transfusi
Five male patients with the persistent generalized lymphadenopathy syndrome also had a sicca complex. Salivary gland biopsy specimens showed diffuse lymphocytic infiltration of the glandular parenchyma. Serum autoantibodies and rheumatoid factor were not detected. All patients had IgG antibodies to human immunodeficie
A detailed clinicopathologic analysis of 52 cases of fatal infectious mononucleosis was performed. Fever, rash, generalized lymphadenopathy, hepatosplenomegaly, and blood cytopenias were the characteristic findings. Epstein-Barr virus infection was documented in 44 of the 52 patients. A triphasic process evolved in th
Nocardial cerebral abscess is an unusual neurologic manifestation of the acquired immunodeficiency syndrome. A 20-year-old woman with the acquired immunodeficiency syndrome presented with headache and fever. Nocardia asteroides was cultured from a stereotaxic brain biopsy specimen. Despite antibiotic therapy to which
Aviat Space Environ Med. 1987 Mar;58(3):227-36. Unique Identifier : AIDSLINE MED/87212989
Kakitsuba N; Bondi KR
We studied the physics of heat transfer from the human body under conditions of low air velocity (LAV) (less than 0.1 m.s-1). For 1 ATA, we calculated values of the evaporative heat transfer coefficient (he, kcal.m-2.h-1.mm Hg-1) of 5.24 and 5.37 where ambient temperature/relative humidities were 38 degrees C/70% and
Cell. 1987 May 8;49(3):307-19. Unique Identifier : AIDSLINE GENBANK/Y00295
Hirsch V; Riedel N; Mullins JI
Nucleotide sequence analysis of the 3 portion of the genome of simian T-lymphotropic virus type 3 from African green monkeys (STLV-3agm) reveals that it has the same general genome structure as the human immunodeficiency virus (HIV-1), the etiologic agent of AIDS. Short segments of strong amino acid homology and simi
Acquired immune deficiency syndrome (AIDS) is caused by an RNA retrovirus (HIV-1) and is readily transmitted heterosexually. The viral receptor is a differentiation antigen on the surface of a class of immunologically active cells including T helper lymphocytes, some macrophages and antigen presenting cells. HIV may
This paper reviews and analyzes the sensitivity of HTLV-III to various agents. The finding of HTLV-III in tears, the conjunctiva, and the cornea indicates the remote possibility that acquired immunodeficiency syndrome (AIDS) can be spread by instruments in contact with the eye, specifically trial contact lenses. Commo
Preparations of human peripheral blood dendritic cells have been infected with human immunodeficiency virus (HIV). After 5 days in culture they were examined by electron microscopy. Virus was observed budding from the plasma membrane of dendritic cells and mature virions were observed on the cell surface. In addition,
Romano N; Portera M; Vitale F; Russo Alesi D; Torregrossa MV; Perrera G
The new human retroviruses HTLV III/LAV, implicated as the causative agent of AIDS, have been isolated from peripheral blood lymphocytes of 5 of 13 drugs abusers with acquired immunodeficiency syndrome-related complex (ARC). In one patient the virus was also found in cell-free plasma. No HTLV III/LAV was detected in o
We tested the Wellcozyme anti-HTLV III kit on: 600 blood donors fresh sera, simultaneously tested by Elavia (Diagnostics Pasteur) or Vironostika (Organon); 20 plasmas, known to be anti-HIV negative; 22 sera, already labelled, and a panel of 10 specimens from the Retrovirus study group of the French National Society of
Science. 1987 May 15;236(4803):819-22. Unique Identifier : AIDSLINE MED/87206194
Koyanagi Y; Miles S; Mitsuyasu RT; Merrill JE; Vinters HV; Chen IS
Human immunodeficiency virus (HIV) is the causative agent of the acquired immune deficiency syndrome (AIDS). A large number of AIDS patients show evidence of neurologic involvement, known as AIDS-related subacute encephalopathy, which has been correlated with the presence of HIV in the brain. In this study, two geneti
The authors compared cases of acquired immunodeficiency syndrome (AIDS) diagnosed in San Francisco, California, during 1983-1984 with human immuno-deficiency virus (HIV) antibody-negative neighborhood and clinic controls, looking for risk factors for clinical AIDS. They also compared antibody-positive with antibody-ne
Am J Med. 1987 May;82(5):1027-30. Unique Identifier : AIDSLINE MED/87210261
Gupta S; Imam A
An HTLV-III/LAV antibody-positive homosexual man in whom disseminated malignant melanoma developed is described. Immunologic analysis revealed an increase in suppressor/cytotoxic phenotype (Leu-2-positive) T cells, depressed proliferative response to mitogens, decreased proportions of T cells with interleukin-2 recept
Am J Public Health. 1987 Jun;77(6):685-9. Unique Identifier : AIDSLINE MED/87210735
Winkelstein W Jr; Samuel M; Padian NS; Wiley JA; Lang W; Anderson RE; Levy JA
The prevalence and incidence of infection by the human immunodeficiency virus (HIV) has been under study in a cohort of 1,034 single men recruited by area probability sampling from a six kilometer square area of San Francisco where the epidemic of acquired immunodeficiency syndrome (AIDS) has been most severe. Prevale
Appl Environ Microbiol. 1987 Apr;53(4):708-9. Unique Identifier : AIDSLINE MED/87211954
Martin LS; Loskoski SL; McDougal JS
Neutral buffered Formalin, a fixative used in most pathology laboratories, was found to inactivate human T-lymphotropic virus type III/lymphadenopathy-associated virus. Preparations containing this virus with infectivity titers of greater than 10(5) were treated with 1% or greater neutral buffered Formalin; after trea
Patients with acute leukemia have an impaired ability to produce antibodies to poliovirus in response to inoculation with inactivated vaccine. Reimmunization will, however, produce a relative increase in antibodies equivalent to that of healthy subjects. A child with acute lymphocytic leukemia was hyperimmunized with
A commericially obtained enzyme-linked immunosorbent assay system has been used on an investigative basis since May 1985 for the detection of HTLV-III antibodies in patient sera. Histories, obtained both with the specimen and retrospectively, confirm that the Abbott enzyme immunoassay system is extremely sensitive whe
The results of the first screening in pregnant women for HIV antibodies published in the literature were obtained at the Charlottenburg Gynecological Clinic of the Free University of Berlin, and are communicated here. They indicate that in future it will be questionable whether AIDS should be looked for only among ris
The demonstrated in vitro and in vivo activity of 3 -azido-3 -deoxythymidine (N3dThd) against the infectivity and the cytopathic effect of human immunodeficiency virus has prompted an investigation of the mechanism by which this nucleoside analogue permeates the cell membrane. As with the transport of thymidine, the i
Piot P; Plummer FA; Rey MA; Ngugi EN; Rouzioux C; Ndinya-Achola JO; Veracauteren G; D'Costa LJ; Laga M; Nsanze H; et al
Among 446 sera from prostitutes in Nairobi, the prevalence of antibody to human immunodeficiency virus (HIV) rose from 4% in 1981 to 61% in 1985. None of 118 men with chancroid seen in 1980 had antibody to HIV compared with 15% of 107 such men in 1985. Among pregnant women, 2.0% were seropositive in 1985 versus none o
Ho DD; Sarngadharan MG; Hirsch MS; Schooley RT; Rota TR; Kennedy RC; Chanh TC; Sato VL
Serum neutralizing antibodies against the human immunodeficiency virus were frequently detected in infected individuals, and low or absent serum neutralizing titers correlated with poor prognosis. Multiple diverse human immunodeficiency virus isolates were found to exhibit similar susceptibility to neutralization by a
We recently reported the isolation of a new retrovirus, termed human immunodeficiency virus type 2 (HIV-2), from two West African patients with the acquired immunodeficiency syndrome (AIDS). This virus is related to but distinct from the well-characterized AIDS retrovirus, human immunodeficiency virus type 1 (HIV-1).
N Engl J Med. 1987 May 21;316(21):1339-42. Unique Identifier : AIDSLINE MED/87201777
Goedert JJ
Because of the lethality of the HIV epidemic, rational and scientifically defined standards of sex that preclude the spread of sexually transmitted diseases are required. In the context of an HIV-antibody test that has been documented to be extremely sensitive and specific, standards for truly safe sex can be defined.
Oral manifestations in AIDS, in AIDS-related complex, and in patients with antibodies to the AIDS-causing virus, human immunodeficiency virus (HIV), have been described previously. One of these manifestations, oral hairy leukoplakia, is apparently specifically associated with HIV infection and has until recently been
Thomas PA; Lubin K; Milberg J; Reiss R; Getchell J; Enlow R
The virus or viruses (human immunodeficiency virus) associated with the acquired immunodeficiency syndrome may be transmitted in utero or perinatally from an infected mother to her baby. Infected adults may remain asymptomatic for months to years, during which time a mother could transmit the virus. It is not known to
Proc Natl Acad Sci U S A. 1987 May;84(10):3526-30. Unique Identifier : AIDSLINE MED/87204170
Cheng-Mayer C; Rutka JT; Rosenblum ML; McHugh T; Stites DP; Levy JA
Six isolates of the human immunodeficiency virus (HIV) showed differences in their ability to productively infect glioma-derived cell lines and early-passage human brain cell cultures. Susceptibility to HIV infection correlated well with the expression of the astrocyte marker glial fibrillary acidic protein. The CD4 m
Proc Natl Acad Sci U S A. 1987 May;84(9):2951-5. Unique Identifier : AIDSLINE MED/87204245
Naylor PH; Naylor CW; Badamchian M; Wada S; Goldstein AL; Wang SS; Sun DK; Thornton AH; Sarin PS
We have reported that an antiserum prepared against thymosin alpha 1 [which shares a region of homology with the p17 protein of the acquired immunodeficiency syndrome (AIDS)-associated human immunodeficiency virus] effectively neutralized the AIDS virus and prevented its replication in H9 cells. Using HPLC and immunob
Antigens of human (HIV) or simian immunodeficiency viruses (SIV) were identified with polyclonal or monoclonal antibodies and avidin-biotin complex (ABC) immunohistochemistry in fixed surgical pathology and autopsy specimens of humans or monkeys with the acquired immunodeficiency syndrome. With B-5 fixative, viral ant
Ann Neurol. 1987 Apr;21(4):397-401. Unique Identifier : AIDSLINE MED/87211797
Epstein LG; Goudsmit J; Paul DA; Morrison SH; Connor EM; Oleske JM; Holland B
The retrovirus that causes acquired immune deficiency syndrome (AIDS) is now designated the human immunodeficiency virus (HIV). The cerebrospinal fluid (CSF) of 27 children with HIV infection was assayed for intra-blood-brain barrier (IBBB) synthesis of HIV-specific antibodies and for the presence of HIV antigen. In t
Crit Care Med. 1987 May;15(5):503-5. Unique Identifier : AIDSLINE MED/87189093
Mallory DL; Parrillo JE; Bailey KR; Akin GL; Brenner M; Lane HC; Fauci AS; Masur H
Intramuscular (im) pentamidine isethionate can cause substantial local pain and inflammation at the injection site. This drug is being used more frequently in recent years to treat Pneumocystis pneumonia, particularly in patients with acquired immunodeficiency syndrome. Clinicians began administering it iv despite war
Thirty-one Chinese patients with peripheral T cell lymphoma (PTCL) were reviewed. Using the modified Japanese Lymphoma Group classification, there were nine (29%) of the pleomorphic type, 16 (52%) immunoblastic lymphadenopathy (IBL)-like, two (7%) T-zone lymphoma, and one (3%) Lennert s lymphoepithelioid type. Three (
Serologic and immunologic studies were performed in 38 African and 60 US patients with acquired immunodeficiency syndrome (AIDS), 100 African and 100 US heterosexual men and women, and 100 US homosexual men to examine the potential role of infectious agents in human immunodeficiency virus (HIV) infection. There were n
The prevalence of HIV antibodies in various groups at risk was studied in 1,546 persons in Zurich. The prevalence was 17% (39/236) in homosexual men, 7% (13/180) in bisexual men, and 45% (14/31) and 42% (22/53) in female and male intravenous drug abusers, respectively. Heterosexual transmission appeared to be the rout
Proc Natl Acad Sci U S A. 1987 May;84(10):3395-9. Unique Identifier : AIDSLINE MED/87204143
Ashida ER; Scofield VL
Human sperm and blood cells were cocultured in vitro to determine whether specific interactions occur between gametes and blood cells. Evidence for cell type-specific sperm binding and penetration of lymphocytes is presented together with findings that suggest that either or both events involve major histocompatibilit
Am J Epidemiol. 1987 Jun;125(6):1048-57. Unique Identifier : AIDSLINE MED/87210064
van Griensven GJ; Tielman RA; Goudsmit J; van der Noordaa J; de Wolf F; de Vroome EM; Coutinho RA
As part of the prospective AIDS study in Amsterdam, blood samples were collected from 741 healthy homosexual men with multiple sexual partners, between October 1984 and May 1985. Samples were analyzed for the presence of antibodies to the human immunodeficiency virus (anti-HIV). Anti-HIV was demonstrated in 233 (31%)
Am J Trop Med Hyg. 1987 May;36(3):509-16. Unique Identifier : AIDSLINE MED/87210790
Wanke C; Tuazon CU; Kovacs A; Dina T; Davis DO; Barton N; Katz D; Lunde M; Levy C; Conley FK; et al
Although Toxoplasma gondii is the most commonly recognized cause of central nervous system mass lesions in patients with acquired immune deficiency syndrome, published investigations have provided little information about criteria for diagnosis of toxoplasmosis or the response to therapy. In this series the method of
Shoeman RL; Young D; Pottathil R; Victor J; Conroy RR; Crowl RM; Coleman T; Heimer E; Lai CY; Ganguly K; et al
Diagnostic reagents for detection of human immunodeficiency virus (HIV) exposure with improved reliability may be provided by viral encoded proteins produced by recombinant DNA techniques or by synthetic peptides corresponding to appropriate viral epitopes. We have expressed at high levels in E. coli a gag gene segmen
Urinary tract infection caused by nontyphoid salmonella is rare. A case is described in a patient with acquired immunodeficiency syndrome who had multiple recurrences. A review of cases in which salmonella involved the urinary tract indicates that this infection usually occurs in patients who are structurally or immun
Pentamidine isethionate, an aromatic diamidine, is an antiprotozoal agent proven to decrease mortality from Pneumocystis carinii pneumonia in debilitated infants and immunodeficient adults and children. Like the combination antimicrobial agent co-trimoxazole, pentamidine has been shown in retrospective studies to reso
Immunol Lett. 1987 Feb;14(3):191-5. Unique Identifier : AIDSLINE MED/87192894
Kazatchkine MD; Jouvin MH; Wilson JG; Fischer E; Fischer A
Genetic deficiencies of complement receptors have recently been described. CR1 expression is reduced on erythrocytes, leucocytes and podocytes of many patients with systemic lupus erythematosus because of both genetic and acquired mechanisms. CR1 deficiency is also found in AIDS and AIDS-related syndromes and correlat
1,834 serum samples from high-risk subjects were tested for anti-HTLV-III/LAV antibody by using the enzyme immuno assay (EIA) of Abbott (A), or the EIA of Abbott and Pasteur (P), or those two EIA plus Western blot analysis (WB). 983 samples were negative in A, 766 were strongly positive when tested in duplicate with b
Kennedy RC; Dreesman GR; Chanh TC; Boswell RN; Allan JS; Lee TH; Essex M; Sparrow JT; Ho DD; Kanda P
A polyamide-based solid-phase support containing an acid-stable p-(oxymethyl)benzoic acid handle to anchor the COOH-terminal amino acid was utilized in the production of synthetic peptides analogous to amino acid sequences 503-532 from the human immunodeficiency virus (HIV) envelope glycoprotein. The resin-bound pepti
There was 100% agreement between the results of indirect immunofluorescence (IF) and Western blot testing when these methods were used to detect antibodies to the human immunodeficiency virus in sera from 25 patients with acquired immune deficiency syndrome (AIDS), 20 patients with AIDS-related complex, 186 subjects a
The antibody response to human immunodeficiency virus (HIV) after primary infection was monitored in eight homosexual men with the acute mononucleosis-like illness associated with seroconversion. Multiple sera from each subject, taken at frequent intervals after onset of acute illness, were tested for antibody to HIV
The ultrastructure and distribution of some viral and cellular antigens was examined in lymphoid C91/PL and fibroblastic HOS/PL cells infected with human T-cell leukaemia virus type I. Tubuloreticular structures in the endoplasmic reticulum, characteristic of virus-infected or interferon-treated cells, were found in b
Coded cadaveric sera from 35 patients with acquired immunodeficiency syndrome (AIDS), from 45 cadavers at high risk of human immunodeficiency virus (HIV) infection, and from 262 cadavers without known signs or risk of AIDS were assessed using three commercially available enzyme-linked immunosorbent assays (ELISA) kits
This report reviews the use of trimethoprim-sulfamethoxazole (TMP-SMZ) in individuals with Pneumocystis carinii pneumonitis (PCP) and the acquired immunodeficiency syndrome (AIDS). Before AIDS, TMP-SMZ was at least as effective as pentamidine in pediatric and adult populations and was notably less toxic. In a study pr
Du Pont De Nemours perfected a new enzyme immunoassay for the screening of anti-HIV 1 antibodies, characterized by its rapidity: 2 hours of incubation, when the normal procedure needed 3 hours 30 minutes of incubation. We tested with the normal procedure and the shortened one 4,025 randomly selected blood donors. 55 s
Regions of the gag-pol gene of human immunodeficiency virus (HIV), the causative agent of AIDS, have been cloned into the polyhedrin gene of the baculovirus Autographa californica nuclear polyhedrosis virus. When these recombinant viruses were used to infect insect cells, the cells produced gag-related proteins which
386 sera were examined with three commercially available ELISAs for antibodies to HTLV-III. Western Blot and an indirect immunofluorescence assay were performed on sera showing a positive reaction in one or more ELISAs as confirmatory assay. 299 sera reacted negatively in all ELISAs, 48 were positive in all ELISAs and
Lai-Goldman M; McBride JH; Howanitz PJ; Rodgerson DO; Miles JA; Peter JB
The authors tested 15 immune serum globulin pharmaceutical preparations for antibody reactivity to human T cell lymphotrophic virus type III (HTLV-III) by the Abbott immunoenzymometric assay (IEMA). Although no evidence of HTLV-III infectivity has appeared after injection of similar preparations into humans, the autho
Am J Med. 1987 May;82(5):1035-8. Unique Identifier : AIDSLINE MED/87210263
Kalin MF; Poretsky L; Seres DS; Zumoff B
Four patients with the acquired immune deficiency syndrome (AIDS) and persistent unexplained hyperkalemia were studied. Testing with cosyntropin (0.25 mg intravenously) revealed normal baseline and stimulated cortisol levels and adequate aldosterone stimulation. The baseline aldosterone level was low for the degree of
Am J Psychiatry. 1987 May;144(5):551-6. Unique Identifier : AIDSLINE MED/87210669
Faulstich ME
Acquired immune deficiency syndrome (AIDS) has neuropsychiatric and psychopathological complications: anxiety, depressive symptoms, and suicidal ideation are common. Patients may express anger toward ineffective medical care and perceived public discrimination, guilt about sexual practices or drug abuse, reactions to
ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transpla
Biochem Pharmacol. 1987 May 1;36(9):1489-94. Unique Identifier : AIDSLINE MED/87213393
Muller WE; Sobel C; Diehl-Seifert B; Maidhof A; Schroder HC
The effect of the antileukemic and anti-HIV agent avarol on the lymphoid system was studied both in vitro and in vivo. Radioactively labelled avarol ([3H]-dihydroavarol) was found to accumulate in vitro in the cytoplasmic compartment primarily of T-lymphocytes and not of B-lymphocytes. Avarol increased significantly t
Patients with thalassemia who receive multiple blood transfusions are at risk for the acquired immunodeficiency syndrome. Peripheral blood lymphocyte subpopulations were studied in 22 multitransfused thalassemic patients; 10 patients were without splenectomy and 12 were studied after splenectomy. Both groups were nega
Thirty five homosexual men (17 positive for antibody to the human immunodeficiency virus (HIV) and 18 consistently negative) were vaccinated against hepatitis B virus infection. Eight of the 17 seropositive patients failed to develop detectable hepatitis B surface antibody within three months of the third injection co
Hattori T; Sagawa K; Matsushita S; Koito A; Suto H; Matsuoka M; Yokoyama M; Takatsuki K
VAK3, VAK4 and VAK5 monoclonal antibodies (mAbs) were raised by using disrupted purified human immunodeficiency virus (HIV) as an antigen. These mAbs exclusively reacted with an HIV-infected cell line, H9/HIV, and did not react with human T cell lymphotropic virus (HTLV)-I or -II infected cell lines. Strip radioimmuno
Ten percent of acquired immune deficiency syndrome (AIDS) cases are in persons over 50 years of age with 25% of these cases in persons over 60, and 4% in persons over 70 years of age. If the present age distribution holds, there will be 27,000 AIDS cases in persons over 50, and 1100 cases in persons over 70 years of a
J Immunol. 1987 May 15;138(10):3415-8. Unique Identifier : AIDSLINE MED/87196363
Evans LA; McHugh TM; Stites DP; Levy JA
Isolates of HIV showed distinct differences in the ability to replicate in continuous human hematopoietic cell lines. Moreover, although all PMC cultures obtained from healthy individuals could be infected with HIV, considerable variation in the amount of virus released from different PMC cultures was observed. These
Proc Natl Acad Sci U S A. 1987 May;84(9):2693-7. Unique Identifier : AIDSLINE MED/87204197
McClure MA; Johnson MS; Doolittle RF
An anomalous sequence in certain lentiviruses was found to be related to a region in a completely different part of the simian retrovirus type I (SRV-I) and its close relative, the hamster intracisternal A particle (IAP-H18). The segment is not present in the human immunodeficiency virus (HIV), which is also a lentivi
Proc Natl Acad Sci U S A. 1987 May;84(9):2985-9. Unique Identifier : AIDSLINE MED/87204252
Montefiori DC; Mitchell WM
The biological response modifier r(I)n.r(C12-U)n, referred to here as mismatched double-stranded (ds) RNA, was examined for antihuman immunodeficiency virus (HIV) activity in vitro because of its known antiviral activity and ability to induce interferon (IFN) in other biological systems [Carter, W. A., Strayer, D. R.,
Marcos MR; Gaspar ML; de la Hera A; Toribio ML; Marquez C; Millan I; Martinez-A C
T lymphocytes (CD3+) without expression of CD4/CD8 surface antigens have recently been described in the thymus and peripheral lymphoid organs. We have conducted a retrospective analysis of the literature, seeking quantitative variations in this T-cell subset in normal heterosexual controls, and in risk, pre-AIDS, and
Clapham PR; Weiss RA; Dalgleish AG; Exley M; Whitby D; Hogg N
The monocytic leukemic cell line U937 can be infected with human immunodeficiency virus type 1 (HIV-1) to become permanently infected virus producers. Uninfected U937 cells express T4 (CD4) antigen and form syncytia when mixed with HIV-1 producing cells. Anti-T4 monoclonal antibodies block syncytium formation indicati
The capacity of the peripheral blood lymphocytes (PBL) to generate an antibody response in vitro T cell-dependent antigen ovalbumin was studied in 12 severe hemophilia patients who were otherwise in good health. PBL from four of 12 patients were not capable of generating such a response after stimulation in vitro, whe
To our knowledge, bilateral syphilitic optic neuritis has not been reported in conjunction with AIDS. We document a case of a bisexual man with AIDS whose vision deteriorated overnight from 20/20 in both eyes to total bilateral blindness as a result of syphilitic retrobulbar neuritis. The implications and management o
A sensitive enhancing system was developed for detecting low density cell surface antigen by flow cytometry. The system termed the super avidin-biotin system (SABS) uses biotinylated antibody, phycoerythrin-streptavidin (StreptA-PE), biotinylated goat anti-streptavidin antibody, and StreptA-PE. CR1 complement recept
The lung is involved in more than 50 per cent of patients with the acquired immune deficiency syndrome (AIDS), and pulmonary abnormalities can be easily investigated using the bronchoalveolar lavage (BAL). Besides providing information on the type of infecting microorganism, BAL has been used to characterize immunocom
S Afr Med J. 1987 May 2;71(9):567-9. Unique Identifier : AIDSLINE MED/87206524
Nicholson NA; Karabus CD; Beatty DW; Becker WB
A majority of haemophiliacs who have received large-pool plasma products within the past 5 years have been exposed to the putative agent of the acquired immunodeficiency syndrome (AIDS)--HIV. It is not known what the risk of infection is among patients in South Africa . A study was
Am J Gastroenterol. 1987 May;82(5):427-31. Unique Identifier : AIDSLINE MED/87210023
Budhraja M; Levendoglu H; Kocka F; Mangkornkanok M; Sherer R
Enteric infections, chronic diarrhea frequently with no obvious etiology, and weight loss cause major morbidity and mortality in acquired immune deficiency syndrome (AIDS). Alterations in mucosal immunity may explain the increased incidence of enteric infections, and contamination of the upper small intestine with bac
Duvic M; Reisman M; Finley V; Rapini R; DiLuzio NR; Mansell PW
Six of 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex receiving intravenous infusions of soluble glucan (beta-1-3 polyglucose) developed a keratoderma of the palms and soles. The eruption began during the first two weeks of therapy and resolved two to four weeks after its discontinu
The in vitro transformation of normal T-lymphocytes by human T-cell leukemia/lymphoma virus (HTLV-I) is possible utilizing cocultivation techniques. We now report on a quantitative assay for HTLV-I transformation. Transformed cell lines were produced by cocultivation of either preactivated (phytohemagglutinin and T-ce
A luminescence assay was adapted for detection of peroxidase-labelled secondary antibodies, which react specifically with antibodies to human immunodeficiency virus on Western blots. This method is about one hundred times more sensitive than either commercial enzyme-linked immunosorbent assay or the chromogenic peroxi
Pathological changes in the liver have been described in patients with acquired immune deficiency syndrome; however, lesions of the bile ducts have not been noted. We report 2 patients with intrahepatic bile duct abnormalities, one having sclerosing cholangitis of the large ducts. We discuss the possibility that these
Antilymphocyte antibodies have been demonstrated in autoimmune diseases, acute viral infections, and acquired immune deficiency syndrome (AIDS) by using either the conventional microlymphocytotoxicity or the double fluorescence technique. In the present study, we used both methods to detect the antilymphocyte antibodi
Adenovirus type 35 (Ad35) is an uncommon group B adenovirus that has been isolated nearly exclusively from immunosuppressed hosts. In our series of 46 patients with Ad35 isolates, 36 had AIDS or AIDS-related complex (ARC), seven patients were immunocompromised because of other diseases, and three patients were normal.
J Med Chem. 1987 May;30(5):862-6. Unique Identifier : AIDSLINE MED/87198605
Kim CH; Marquez VE; Broder S; Mitsuya H; Driscoll JS
5-Substituted 2 ,3 -dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV-III/LAV (HIV) virus, the causative agent of acquired immunodeficiency syndrome (AIDS). These analogues were designed to be more lipophilic
A complex pattern of gene expression was found for visna virus in a highly permissive cell culture system in vitro. In addition to the genomic RNA (9.4 kilobases [kb]), five other mRNAs were detected. The three large RNA transcripts (5.0 kb and a doublet at 4.3 kb) arise by a single splicing event joining 5 sequences
Kannagi M; Kiyotaki M; King NW; Lord CI; Letvin NL
The human immunodeficiency virus (HIV) and the closely related simian immunodeficiency virus (SIV) induce profound immune dysfunction in primate species. The present studies show that cell populations infected in vitro with SIV exhibit increases in major histocompatibility complex (MHC) class II antigen expression. Ce
Four strains of human immunodeficiency virus (HIV) manifest consistent differences in biologic behavior after infection of the X50-7 line of human umbilical cord lymphocytes immortalized by Epstein-Barr virus (EBV). Some dilutions of the first strain examined, human T-cell lymphotropic virus type III B, which is deriv
Human immunodeficiency virus (HIV) has been associated with acquired immunodeficiency syndrome and related disorders. Assays to detect antibodies to HIV proteins have been developed and used to screen sera for the identification of individuals who have been exposed to the virus. Although these serological tests have s
Wahren B; Morfeldt-Mansson L; Biberfeld G; Moberg L; Sonnerborg A; Ljungman P; Werner A; Kurth R; Gallo R; Bolognesi D
The human immunodeficiency virus (HIV)-specific lymphocyte proliferation response was determined for 40 persons at different stages of HIV infection. The specific response to purified HIV virion antigens from strain HTLV-IIIB was poor, occurred in only 9 of the 40 subjects, was not improved with the addition of interl
Med Microbiol Immunol (Berl). 1987;176(2):53-64. Unique Identifier : AIDSLINE MED/87201266
Olsen RG; Tarr MJ; Mathes LE; Whisler R; Du Plessis D; Schulz EJ; Blakeslee JR
We present evidence that systemic lupus erythematosus (SLE) patients, but not other mixed connective tissue disease patients, have been exposed to a retrovirus similar or identical to known human T-lymphotropic viruses (HTLV). Serological studies demonstrated a high incidence of seropositivity in SLE patients to HTLV-
An Epstein-Barr virus-transformed B-cell line derived from a patient with severe combined immunodeficiency who died of a lymphoreticular malignancy has been characterized. The line derived from bone marrow cultures and designated DV-1 shows surface and cytoplasmic IgM and staining with fluorescent monoclonal antibodie
Science. 1987 May 15;236(4803):827-31. Unique Identifier : AIDSLINE MED/87206196
Kanki PJ; M'Boup S; Ricard D; Barin F; Denis F; Boye C; Sangare L; Travers K; Albaum M; Marlink R; et al
A new human T-lymphotropic virus (HTLV-4) was recently described in healthy people from Senegal . This virus has many properties in common with members of the human T-lymphotropic viruses, particularly the human immunodeficiency virus or HIV, the etiologic agent of acquired immune
Science. 1987 May 15;236(4803):837-40. Unique Identifier : AIDSLINE MED/87206199
Knight DM; Flomerfelt FA; Ghrayeb J
The art/trs transactivator protein of human immunodeficiency virus (HIV) was expressed in mammalian cells as a 19-kilodalton protein that was immunoreactive with sera from HIV-infected patients. Separate plasmids encoding the art/trs protein, the tat protein, or the envelope glycoprotein gp120 were used to demonstrate
d'Onofrio G; Mancini S; Tamburrini E; Mango G; Ortona L
Using the automated hematologic analyzer Technicon H6000, which classifies leukocytes by their size and peroxidase activity, the authors have observed in nine patients with full-blown acquired immune deficiency syndrome (AIDS) a consistent increase in peroxidase content of circulating neutrophils. The increase in pero
Annu Rev Med. 1987;38:195-209. Unique Identifier : AIDSLINE MED/87211816
Jones JF; Straus SE
The Epstein-Barr virus (EBV) has been associated with classic infectious mononucleosis, Burkitt s lymphoma, nasopharyngeal carcinoma, and B-cell lymphomas in primary and secondary immunodeficiency disease. The availability of specific serologic diagnosis of EBV, rather than dependence on heterophile antibody positivit
Lupton GP; James WD; Redfield RR; Brown C; Rodman OG
Oral hairy leukoplakia (HL) is a newly described lesion occurring principally on the lateral borders of the tongue in immunosuppressed homosexual men infected with human T-cell lymphotropic virus type III (HTLV-III). Clinically, HL appears as a slightly raised, poorly demarcated lesion with a corrugated or hairy surfa
Weintrub PS; Sullender WM; Lombard C; Link MP; Arvin A
A 4 1/2-year-old boy with acute myelomonocytic leukemia developed fever, neutropenia, and a prolonged respiratory illness while receiving maintenance chemotherapy. An open lung biopsy specimen demonstrated a giant cell pneumonia with intracytoplasmic and probable intranuclear viral inclusions of the paramyxovirus type
Three classes of proteins (mol wts 70k, 64k and 45k) having the characteristics of interleukin 2 receptor were detected in phytohemagglutinin-activated human lymphocytes using two monoclonal antibodies which recognize distinct epitopes on the receptor. It was shown that at least portions of these proteins were phospho
Pasqualetti D; Cafaro A; Gastaldi R; Lopez M; Malagnino F; Manzari V; De Rossi G
A patient with Chronic Lymphocytic Leukemia (CLL) characterized by an expansion of helper phenotype mature T lymphocytes is here described. The phenotype of these cells was OKT3+, OKT4+, Leu 9+, 5/9+, OKT8-, Tac- and functional studies showed a strong helper activity on B cell differentiation; an in vivo presence of a
The human T-cell leukemia (HTLV) family of viruses now include two groups of transforming viruses (HTLV-I and HTLV-II) and one group of viruses with immunosuppressive activity but no apparent transforming ability (HTLV-III). Nucleotide sequence analysis of an HTLV-I provirus by Seiki et al [Proc Natl Acad Sci USA 1982
In order to characterize the effects of HIV (human T-lymphotropic virus type III/lymphadenopathy-associated virus) on the immune system, Leu8- and Leu8+ subsets of CD4 and CD8 cells were studied in seropositive homosexually active men without acquired immune deficiency syndrome (AIDS). Controls included both heterosex
J Immunol. 1987 May 15;138(10):3284-9. Unique Identifier : AIDSLINE MED/87196343
Yamashita U; Shirakawa F; Nakamura H
The accessory function for T cell activation and the production of interleukin 1 (IL 1) of adult T cell leukemia (ATL) cell lines were studied in vitro. ATL cell lines such as Hut-102, MT-1, and MT-2 functioned as accessory cells for the stimulation of human T cell proliferative response induced with concanavalin A (C
J Immunol. 1987 May 1;138(9):3069-74. Unique Identifier : AIDSLINE MED/87196440
Arima N; Daitoku Y; Yamamoto Y; Fujimoto K; Ohgaki S; Kojima K; Fukumori J; Matsushita K; Tanaka H; Onoue K
To examine the possibility of heterogeneous mechanisms in the proliferation of adult T cell leukemia (ATL) cells, leukemic cells from 13 patients, nine acute-type and four chronic-type ATL, were examined for the production of interleukin 2 (IL 2) with or without mitogenic stimulation and their response to recombinant
A serological survey of 317 healthy residents of rural Papua New Guinea (PNG) showed a 26% prevalence of antibodies to human T cell leukemia virus type I (HTLV-I). Antibody to HTLV-I was detected in 16% of children less than or equa
JAMA. 1987 May 15;257(19):2604-8. Unique Identifier : AIDSLINE MED/87199123
Bartholomew C; Saxinger WC; Clark JW; Gail M; Dudgeon A; Mahabir B; Hull-Drysdale B; Cleghorn F; Gallo RC; Blattner WA
Risk for human T-cell lymphotropic virus type (HTLV-I) and human immunodeficiency virus (HIV) infection was evaluated in 100 homosexual or bisexual men from Trinidad . High seropositivity for HTLV-I (15% vs 2.4% in the general popula
Lancet. 1987 May 2;1(8540):999-1002. Unique Identifier : AIDSLINE MED/87200423
Eales LJ; Nye KE; Parkin JM; Weber JN; Forster SM; Harris JR; Pinching AJ
The distribution of phenotypes of the group specific component (Gc) was examined in 203 homosexuals at risk of infection or infected by the human immunodeficiency virus and compared with that in 50 randomly selected homosexuals and 122 healthy male heterosexual seronegative controls. 30.2% of patients with the acquire
Lancet. 1987 May 9;1(8541):1073-5. Unique Identifier : AIDSLINE MED/87200436
Anderson RM; Medley GF; Blythe SP; Johnson AM
A mathematical model of the dynamics of transmission of human immunodeficiency virus within the male homosexual population in the United Kingdom demonstrates that even the minimum size of the acquired immunodeficiency syndrome (AIDS) epidemic in the United Kingdom (based upon the assum
As part of a project within the European Community research activities on acquired immunodeficiency syndrome (AIDS), infants born to human-immunodeficiency-virus-seropositive mothers are being followed up from birth. By October, 1986, 71 infants from Padua, Berlin, and Edinburgh had been followed up to a median age of
Lancet. 1987 May 23;1(8543):1168-71. Unique Identifier : AIDSLINE MED/87200523
Borkowsky W; Krasinski K; Paul D; Moore T; Bebenroth D; Chandwani S
Of 85 children with human-immuno-deficiency-virus (HIV) infection based on clinical (opportunistic infection), epidemiological (mother a drug addict or known to be HIV infected), and immunological (helper-T-cell deficiency and impaired proliferative response to pokeweed mitogen) features, 9 were found to lack antibody
Science. 1987 May 29;236(4805):1103-6. Unique Identifier : AIDSLINE MED/87206235
Mann DL; DeSantis P; Mark G; Pfeifer A; Newman M; Gibbs N; Popovic M; Sarngadharan MG; Gallo RC; Clark J; et al
Serum containing antibodies to the human T-lymphotropic virus type I (HTLV-I) has been observed at a higher than expected frequency in patients with B-cell chronic lymphocytic leukemia (CLL) in an area endemic for HTLV-I. An attempt was made to determine whether the cells from patients with this leukemia were HTLV-I a
Hattori T; Ikematsu S; Chosa T; Yamamoto S; Matsuoka M; Fukutake K; Robert-Guroff M; Takatsuki K
Sera from 154 hemophiliacs, including 132 with hemophilia A and 22 with hemophilia B, were examined for antibodies against human T cell lymphotropic virus type III (HTLV-III) and type I by strip radioimmunoassay based on the Western blotting technique. Sixty-two patients lived in Kyushu, a known endemic area of HTLV-I
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 1):1194-202. Unique Identifier : AIDSLINE MED/87212056
Ohno R
Since the late 1970s, 18 clinical studies have been conducted in Japan with various types of human interferon (IFN) for their possible anti-tumor efficacy under the control of the Special Committee for Clinical Application of IFN of the Ministry of Health and Welfare. Objective anti
Roman GC; Schoenberg BS; Madden DL; Sever JL; Hugon J; Ludolph A; Spencer PS
Tropical spastic paraparesis (TSP), a chronic myelopathy of unknown etiology, was studied in the Seychelles . Human T-lymphotropic virus type I (HTLV-I) and human immunodeficiency virus antibodies were determined using an enzyme-linked immunosorbent assay and confirmed with an i
Six patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) were studied by electrophysiologic methods. Upper-limb short-latency somatosensory evoked potentials showed slight delay of the N9-N20 interpeak latency in one of 12 limbs, while the lower-limb short-latency somatosensory evo
Human T-lymphotropic virus type I (HTLV-I), the causative agent of adult T-cell leukemia and non-Hodgkin s lymphoma (ATLL)--or a cross-reacting retrovirus--has been associated with tropical spastic paraparesis in
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