Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
MALIGNANT LYMPHOMA IN HOMOSEXUAL MEN: RELATIONSHIP TO ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS)
Dev Oncol; 32:251-60 1985. Unique Identifier : AIDSLINE ICDB/87629334 Muggia FM; Dancis A; Odajnyk C; Raphael B; Wernz JC; Krigel RL; Laubenstein LJ; Knowles DM; Rita and Stanley H. Kaplan Cancer Center, New York Univ., New; York, NY
Abstract:
The definition of acquired immune deficiency syndrome (AIDS) has encompassed the diagnosis of opportunistic infection (OI) or Kaposi's sarcoma (KS) arising in certain populations without any previously known immunologic defects. Malignancies other than KS, particularly lymphomas, are known to complicate a variety of genetically determined or induced immunodeficiency states. The changing incidence of lymphomas during the current AIDS epidemic and the various pathologic and clinical features that are emerging are discussed, focusing on the specific features which characterize the emergence of lymphomas in relation to immunodeficiency and viral oncogenes. Eighteen homosexual men with lymphoma were encountered from March 1982 to December 1983: four had Hodgkin's disease (HD) and 14 had non-Hodgkin's lymphoma (NHL). The patients (pts) with NHL fell within three groups: immunoblastic (4 pts), Burkitt's (BL; 4), and miscellaneous types (6), including one unclassified primary brain lymphoma. The median age of these pts was 39 (range 20-74 yr). Over the initial 4-yr period beginning in 1976, only 10 single men with the diagnosis of high or intermediate grade lymphomas were identified and no pt with KS, CNS lymphomas or BL were noted. During the 2 yr in which the current group of homosexual men was studied and identified, 23 other male pts were diagnosed with high or intermediate grade lymphoma. The concomitant occurrence of KS with NHL was observed in four instances, and with HD in one instance, an association noted in the classic descriptions of KS and in KS-complicating renal transplantation. One of four pts with immunoblastic lymphomas presented initially with OI, thus fulfilling the AIDS criteria. The remaining three had pre-AIDS manifestations and one also had a subsequent OI. Two BL pts presented de novo with no AIDS or pre-AIDS symptoms; and two other BL pts had the pre-AIDS hallmark of lymphadenopathy. Six other pts with a variety of NHL diagnoses included four pts with KS and lymphadenopathy who subsequently were documented to have a lymphoplasmacytoid lymphoma of the bone marrow and large bowel, a small cleaved lymphoma of the bone marrow, a large uncleaved lymphoma in ascitic fluid, and a large cleaved lymphoma of the lung, respectively. (41 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Burkitt's Lymphoma/COMPLICATIONS Epidemiologic Methods *Homosexuality Human Lymphoma/COMPLICATIONS/*EPIDEMIOLOGY/PATHOLOGY Male New York City Risk Sarcoma, Kaposi's/COMPLICATIONS United States MEETING PAPER
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
