ANIMAL MODELS OF RETROVIRUS INFECTION AND THEIR RELATIONSHIP TO AIDS NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


ANIMAL MODELS OF RETROVIRUS INFECTION AND THEIR RELATIONSHIP TO AIDS

Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, 470 p., 1986.. Unique Identifier : AIDSLINE ICDB/87629262
Anonymous; No affiliation given

Abstract: The acquired immune deficiency syndrome (AIDS) has reached epidemic proportions since it was first recognized in 1981. The number of patients diagnosed as suffering from AIDS doubles every 15 mo. AIDS is a fatal syndrome that may become apparent months to years after infection with the underlying causative retrovirus, HTLV-III/LAV (human T cell lymphotropic virus type III/lymphadenopathy-associated virus), and leaves its victims to die from opportunistic diseases, months to years after diagnosis. In an attempt to understand, control, treat, and prevent this human syndrome, this book compares AIDS to related retrovirus diseases in selected animals. The book is divided into five sections: virology of retrovirus model systems, pathogenesis of retrovirus infection, host immunity and retrovirus disease, vaccines and immunotherapy, and human AIDS in the chimpanzee. The animal models reviewed include the feline, simian, ovine, murine, equine, and bovine systems. Similarities and differences between human and animal retroviruses, opportunistic diseases related to virus infection, and the treatment of these diseases are discussed. Problems associated with development of a vaccine for AIDS also are discussed, using as a model the only marketed retrovirus vaccine, one developed for feline leukemia virus in cats.
Keywords: *Acquired Immunodeficiency Syndrome Animal *Disease Models, Animal Human *Retroviridae Infections MONOGRAPH

KWDacquiredimmunodeficiencysyndromeanimalKWDdiseasemodels,animalhumanKWDretroviridaeinfectionsmonograph
870430
M8740292

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1987. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1987. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .