Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
OVERVIEW OF SIMIAN AIDS
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 131-44, 1986.. Unique Identifier : AIDSLINE ICDB/87629271 Marx PA; California Primate Res. Center, Univ. of California Davis, Davis,; CA
Abstract:
Simian acquired immune deficiency syndrome (SAIDS) is an AIDS-like disease that occurs in rhesus monkeys (Macaca mulatta) at the California Primate Research Center. The current outbreak is characterized by persistent lymphadenopathy and opportunistic infections such as noma (necrotizing gingivitis), generalized cytomegalovirus infections, and candidiasis. No lymphomas or CNS diseases have occurred during the 9-yr history of this current outbreak. This is a spontaneous disease which has developed in six or seven species of the macaque genus of Old World monkeys. In all cases, a type D retrovirus has been associated with the disease. Of the type D retroviruses, Mason-Pfizer monkey virus (MPMV) has been known for the longest period of time; it is the prototype of D retrovirus and was first found in a rhesus monkey with a breast carcinoma. The SAIDS group of viruses includes SAIDS/D (New England), SAIDS/D (California), SAIDS/D (Washington), and SAIDS/D (Oregon). The subtypes of viruses that are associated with particular species are summarized in a table. In Macaca mulatta, there is SAIDS-like disease definitely associated with experimentally inoculated MPMV. MPMV does not appear to be naturally occurring in captive macaque populations in the United States; it may be that MPMV was a 'one-time only' recombinant that arose in the rhesus monkey that had the breast carcinoma. Two type D endogenous viruses have been found, one in the squirrel monkey (Saimiri sciureus), and another in the Langur monkey (Presbytis obscurus). Neither is associated with disease. SAIDS retrovirus type 1 (SAIDS/D California) is associated with SAIDS in the rhesus monkey at the California Primate Research Center. A similar virus is found in the Taiwanese-rock macaque (Macaca cyclopis) and the crab-eating macaque (Macaca fascicularis). SAIDS retrovirus type 2 (Oregon isolate of SAIDS) is associated with SAIDS plus retroperitoneal fibromatosis in the Celebes macaque (Macaca nigra) at the Oregon Primate Research Center; a similar agent is present in pig-tailed macaque (Macaca nemestrina). (8 Refs)
Keywords: Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MICROBIOLOGY/ TRANSMISSION/*VETERINARY Animal Carrier State/VETERINARY Disease Outbreaks/*VETERINARY Macaca Monkey Diseases/*MICROBIOLOGY Retroviridae/CLASSIFICATION/GROWTH & DEVELOPMENT/*ISOLATION & PURIF/ULTRASTRUCTURE Serotyping United States Virus Cultivation MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
