Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
SIMIAN ACQUIRED IMMUNE DEFICIENCY SYNDROME
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 155-8, 1986.. Unique Identifier : AIDSLINE ICDB/87629273 Sever J; Natl. Inst. of Neurological and Communicative Disorders and; Stroke, NIH, Bethesda, MD
Abstract:
Simian acquired immune deficiency syndrome (SAIDS) (California) can be transmitted by tissue homogenates, plasma, and serum or by the retrovirus grown in a variety of tissue cultures. Electron microscopy (EM) studies of the morphologies of the retroviruses associated with SAIDS and AIDS provided evidence that the cores of these retroviruses are cylindrical in shape. The insight gained from such morphological studies was applied to screening various tissue specimens from animals and man for the presence of similar retroviruses. In a study of transmission of SAIDS, animals were inoculated with a pool of serum from an animal with advanced SAIDS. Virus was isolated in vitro from the saliva of one recipient animal 14 wk after inoculation and in terminal SAIDS. In another study, a normal animal developed SAIDS 17 wk after it was caged with an animal inoculated with SAIDS virus; SAIDS virus was also isolated in tissue culture from the saliva of this animal. In addition, samples of saliva and urine studied by EM showed characteristic virus particles with typical SAIDS retrovirus morphology. SAIDS virus was also isolated from the urine of diseased animals and was isolated from animals in both early and late stages of disease. SAIDS was transmitted to healthy rhesus monkeys by inoculating them with saliva from diseased animals. Thus, transmission was successful using either the tissue culture-passed virus isolated from urine or the virus taken directly from saliva. When EM was used to study samples from human patients (pts) with AIDS, characteristic bar-shaped viruses were observed in thin sections of parotid glands, prostates, and testes taken from AIDS pts at autopsy.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/TRANSMISSION/ *VETERINARY Animal Human HIV/ISOLATION & PURIF/ULTRASTRUCTURE Macaca mulatta Male Microscopy, Electron Monkey Diseases/MICROBIOLOGY/*TRANSMISSION Parotid Gland/MICROBIOLOGY Prostate/MICROBIOLOGY Retroviridae/ISOLATION & PURIF/*ULTRASTRUCTURE Saliva/MICROBIOLOGY Testis/MICROBIOLOGY Urine/MICROBIOLOGY MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
