Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
THE PATHOBIOLOGY OF MACAQUE RETROVIRUSES CLOSELY RELATED TO HUMAN T CELL LYMPHOTROPIC VIRUSES
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 223-32, 1986.. Unique Identifier : AIDSLINE ICDB/87629278 Kanki PJ; Hunt RD; Essex ME; Dept. of Cancer Biology, Harvard Sch. of Public Health, Boston,; MA
Abstract:
The macaque monkey is naturally infected with two T lymphotropic retroviruses, one closely related to HTLV-I (human T cell lymphotropic virus type I) and the second more closely related to HTLV-III (human T lymphotropic virus type III); these have been designated STLV-I and STLV-III, respectively. Studies of these primate viruses indicate numerous parallels to the human systems and could provide a relevant model system for the understanding of HTLV viruses and the pathogenesis of their associated diseases. Phytohemagglutinin-stimulated lymphocytes from seropositive macaques showed type C virus particles identical to HTLV-I after 6 days in short-term culture. In cocultivation procedures, the macaque virus was capable of transforming seronegative macaque and human lymphocytes. The HTLV-I-transformed cells exhibited the adult T cell leukemia antigen when tested with the appropriate antisera in a fixed immunofluorescence assay. It appears that the STLV-I virus is very closely related to HTLV-I by major antigen cross-reactivity. It also appears that STLV-I, like its human counterpart, may be associated with a spontaneous lymphoid abnormality. The macaque retrovirus STLV-III has been serologically identified and characterized by radioimmunoprecipitation techniques. Virus-specific proteins of 160 kilodaltons (kD), 120 kD, 55 kD, and 24 kD were identified; all similar in size to the major gag- and env-encoded proteins of HTLV-III. These protein species were similarly recognized by macaque serum samples and human reference serum samples from acquired immune deficiency syndrome (AIDS)-related complex (ARC) and AIDS patients, positive for HTLV-III antibodies. Most of the macaques are apparently free of type D retrovirus, based on repeated unsuccessful isolation attempts and negative serology. The authors hypothesize that the macaque T lymphotropic retroviruses may be etiologically linked to an immunodeficiency syndrome, thus providing an animal model for the study of HTLV-III and the pathogenesis of AIDS. The close relationship of STLV-III to HTLV-III at an antigenic level may provide valuable insight into the development of an AIDS vaccine. (47 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*VETERINARY Animal Genes, Viral HIV/ISOLATION & PURIF HTLV-BLV Infections/MICROBIOLOGY/*VETERINARY HTLV-BLV Viruses/ISOLATION & PURIF Immunologic Techniques Macaca Monkey Diseases/*MICROBIOLOGY Retroviridae/*ISOLATION & PURIF/ULTRASTRUCTURE Retroviridae Proteins/ANALYSIS MONOGRAPH
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Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.
