Impairment of polymorphonuclear leucocyte function in patients with acquired immunodeficiency syndrome and with lymphadenopathy syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Impairment of polymorphonuclear leucocyte function in patients with acquired immunodeficiency syndrome and with lymphadenopathy syndrome.

Clin Exp Immunol. 1986 Jul;65(1):105-11. Unique Identifier : AIDSLINE MED/87078968
Lazzarin A; Uberti Foppa C; Galli M; Mantovani A; Poli G; Franzetti F; Novati R

Abstract: Granulocyte functions were studied in 20 patients with acquired immunodeficiency syndrome (AIDS), 20 subjects with lymphadenopathy syndrome (LAS) and 15 symptom-free drug addicts (SFDA). Polymorphonuclear leucocyte (PMNL) phagocytosis and killing of C. albicans appeared normal in homosexual men with AIDS, while drug addicts with AIDS or LAS and SFDA showed a significant defect of these functions as compared to healthy controls. Migration of PMNL in response to a chemoattractant was normal in SFDA, but markedly defective both in LAS and in AIDS patients. In the AIDS group no significant differences were evident between homosexual men and drug addicts. We conclude that defective PMNL phagocytosis and killing, unlike defective migration, are somehow related to drug abuse rather than to infection with the causative agent of the immunodeficiency.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adolescence Adult AIDS-Related Complex/*IMMUNOLOGY Chemotaxis, Leukocyte Female Homosexuality Human Male Neutrophils/*IMMUNOLOGY Phagocytosis Substance Dependence/IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadolescenceadultaids-relatedcomplex/KWDimmunologychemotaxis,leukocytefemalehomosexualityhumanmaleneutrophils/KWDimmunologyphagocytosissubstancedependence/immunologysupport,non-uKWDsKWDgov'tjournalarticle
870430
M8740261

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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