Neutralizing antibody prevents type D retrovirus viremia in Celebes black macaques. NLM AIDSLINE Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date.

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Neutralizing antibody prevents type D retrovirus viremia in Celebes black macaques.

Clin Exp Immunol. 1986 Aug;65(2):265-8. Unique Identifier : AIDSLINE MED/87078997
Wilson BJ; Shiigi SM; Zeigler JL; Olson LC; Malley A; Howard CF

Abstract: The Celebes black macaque (Macaca nigra) colony at the Oregon Regional Primate Research Center has a high incidence of simian acquired immunodeficiency syndrome (SAIDS-RF) that may be caused by type D retrovirus type 2 (SRV-2). During the spring and autumn screening of the colony, seven monkeys previously aviremic were found to be viremic on the basis of the Raji co-culture assay. These monkeys and control groups were selected for further study, which included titration of neutralizing antibody activity and immunofluorescent antibody (IFA) activity before and at the time that the animals became viremic. Results indicated that neutralizing antibody was not present before or at the time that monkeys became viremic and that control monkeys who were IFA+ and did not become viremic had high levels of neutralizing antibody. The IFA titre did not change significantly or predictably at the time the animals became viremic.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*VETERINARY Animal Antibodies, Viral/ANALYSIS/*IMMUNOLOGY Antigen-Antibody Complex/IMMUNOLOGY Macaca Monkey Diseases/*IMMUNOLOGY Neutralization Tests Retroviridae/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDveterinaryanimalantibodies,viral/analysis/KWDimmunologyantigen-antibodycomplex/immunologymacacamonkeydiseases/KWDimmunologyneutralizationtestsretroviridae/KWDimmunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
870430
M8740260

Copyright © 1987 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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