Dev Oncol; 32:251-60 1985. Unique Identifier : AIDSLINE ICDB/87629334
Muggia FM; Dancis A; Odajnyk C; Raphael B; Wernz JC; Krigel RL; Laubenstein LJ; Knowles DM; Rita and Stanley H. Kaplan Cancer Center, New York Univ., New; York, NY
The definition of acquired immune deficiency syndrome (AIDS) has encompassed the diagnosis of opportunistic infection (OI) or Kaposi s sarcoma (KS) arising in certain populations without any previously known immunologic defects. Malignancies other than KS, particularly lymphomas, are known to complicate a variety of g
Dev Oncol; 32:441-54 1985. Unique Identifier : AIDSLINE ICDB/87629355
Gaynor ER; Ultmann JE; Section of Hematology/Oncolgy, Dept. of Medicine, Univ. of; Chicago, Chicago, IL
Although tremendous advances in the understanding of non-Hodgkin s lymphomas (NHL) have been made, therapeutic approaches to some of these diseases have remained relatively stagnant. Advances in the fields of immunology, cytogenetics, molecular biology, and virology are briefly summarized, the current status of therap
San Martin MS; Blasina EN; Abulafia J; Pezzi H; Hospital Gral. de Agudos J.M. Penna., Argentina
A 38-yr-old homosexual male with a history of drug abuse and venereal disease (syphilis and gonorrhea) developed alternating constipation and diarrhea, as well as skin lesions involving the entire body except for the hands and one foot, during a prolonged stay in New York. These symptoms worsened over a 7-mo period, a
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, 470 p., 1986.. Unique Identifier : AIDSLINE ICDB/87629262
Anonymous; No affiliation given
The acquired immune deficiency syndrome (AIDS) has reached epidemic proportions since it was first recognized in 1981. The number of patients diagnosed as suffering from AIDS doubles every 15 mo. AIDS is a fatal syndrome that may become apparent months to years after infection with the underlying causative retrovirus,
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 59-74, 1986.. Unique Identifier : AIDSLINE ICDB/87629266
Hoover EA; Mullins JI; Quackensush SL; Gasper PW; Dept. of Pathology, Colorado State Univ., Fort Collins, CO
Prototype pathogenic feline leukemia virus (FeLV) strains that induce either feline acquired immune deficiency syndrome (AIDS) or aplastic anemia (AA) have been identified by serial in vivo passage in specific pathogen-free (SPF) cats and have recently been molecularly cloned and shown to possess disease-specific path
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 75-93, 1986.. Unique Identifier : AIDSLINE ICDB/87629267
Hardy WD Jr; Lab. of Veterinary Oncology, Memorial Sloan-Kettering Cancer; Center, New York, NY
The etiologic and therapeutic aspects of human and feline acquired immune deficiency syndromes (AIDS) are compared in this chapter. In an introduction, comparisons of human AIDS and feline AIDS (FAIDS) with respect to immune parameters and secondary intercurrent diseases are presented in tables; also, common opportuni
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 107-19, 1986.. Unique Identifier : AIDSLINE ICDB/87629269
Burny A; Bruck C; Cleuter Y; Couez D; Gregoire D; Kettmann R; Mammerickx M; Marbaix G; Portetelle D; Willems L; Dept. of Molecular Biology, Univ. of Brussels, Belgium
This chapter on bovine leukemia virus as an inducer of bovine leukemia is divided into four parts: one quarter deals with molecular biology, tumor induction, and host-virus relationships; one quarter deals with immune responses; and the remainder deals with the relatedness of human T cell lymphotropic virus (HTLV) and
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 131-44, 1986.. Unique Identifier : AIDSLINE ICDB/87629271
Marx PA; California Primate Res. Center, Univ. of California Davis, Davis,; CA
Simian acquired immune deficiency syndrome (SAIDS) is an AIDS-like disease that occurs in rhesus monkeys (Macaca mulatta) at the California Primate Research Center. The current outbreak is characterized by persistent lymphadenopathy and opportunistic infections such as noma (necrotizing gingivitis), generalized
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 155-8, 1986.. Unique Identifier : AIDSLINE ICDB/87629273
Sever J; Natl. Inst. of Neurological and Communicative Disorders and; Stroke, NIH, Bethesda, MD
Simian acquired immune deficiency syndrome (SAIDS) (California) can be transmitted by tissue homogenates, plasma, and serum or by the retrovirus grown in a variety of tissue cultures. Electron microscopy (EM) studies of the morphologies of the retroviruses associated with SAIDS and AIDS provided evidence that the core
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 161-8, 1986.. Unique Identifier : AIDSLINE ICDB/87629274
Francis D; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, GA
There are some unique aspects of acquired immune deficiency syndrome (AIDS) that have made it a markedly difficult disease to understand and treat: it has an extremely long incubation period; it concerns groups of people who are unique in terms of lifestyle; and the politics of AIDS. The pathogenesis of AIDS is discus
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 265-77, 1986.. Unique Identifier : AIDSLINE ICDB/87629281
Montagnier L; Viral Oncology Unit, Institut Pasteur, Paris, France
The discovery of the retrovirus considered to be the causative agent of acquired immune deficiency syndrome (AIDS) in humans has made it possible to detect specific humoral responses against viral antigens and, therefore, to study the seroepidemiology of viral infection. The AIDS virus was first named lymphadenopathy-
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 325-33, 1986.. Unique Identifier : AIDSLINE ICDB/87629285
Madden DL; Budzko D; London WT; Gravell M; Sever J; Henrickson RV; Maul D; Marx P; Gardner M; Natl. Inst. of Neurological and Communicative Disorders and; Stroke, NIH, Bethesda, MD
The pathogenesis of simian acquired immunodeficiency syndrome (SAIDS) was studied in twenty-four, 8-20-mo-old, laboratory-raised, juvenile rhesus monkeys, using tissue homogenates or serum that was known to be highly infectious. SAIDS was diagnosed when four or more of the following signs were observed: anemia, neutro
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 355-66, 1986.. Unique Identifier : AIDSLINE ICDB/87629287
Narayan O; Dept. of Neurology, Johns Hopkins Univ. Sch. of Medicine,; Baltimore, MD
Lentiviruses are nononcogenic retroviruses that cause slowly progressive diseases after unusually long incubation periods. Visna-maedi virus of sheep and caprine-arthritis-encephalitis (CAE) virus of goats are prototypes of this group of agents and cause paralysis, pneumonia, arthritis, and mastitis months to years af
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 403-19, 1986.. Unique Identifier : AIDSLINE ICDB/87629290
Snyder HW Jr; Singhal MC; Ernst NR; Grant CK; Cotter SM; Yoshida LH; Jones FR; Immune Response Program, Pacific Northwest Res. Foundation,; Seattle, WA
The feline leukemia virus (FeLV) is a contagious T cell lymphotropic retrovirus that productively infects lymphoid and myeloid cells in approx 30% of exposed pet cats. After the onset of viremia, death usually results within 3 mo to 3 yr due to degenerative bone marrow disease, leukemia, lymphosarcoma (LSA), or, more
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 443-56, 1986.. Unique Identifier : AIDSLINE ICDB/87629293
Eichberg JW; Lawlor DA; Kennedy RC; Dressman GR; Alter HJ; Saxinger WC; Virology and Immunology Dept., Southwest Foundation for; Biomedical Res., San Antonio, TX
Acquired immune deficiency syndrome (AIDS) is an escalating disease of devastating proportions. An animal model for this disease would have several major benefits, including safety and efficacy testing of potential human T cell lymphotropic virus type III (HTLV-III) vaccines; testing of potential methods of HTLV-III i
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 457-62, 1986.. Unique Identifier : AIDSLINE ICDB/87629294
Gibbs CJ Jr; Gajdusek DC; Epstein LG; Asher DM; Goudsmit J; Lab. of Central Nervous System Studies, Intramural Res. Program,; Natl. Inst. of Neurological and Communicative Disorders and; Stroke, NIH, Bethesda, MD
Acquired immune deficiency syndrome (AIDS) is a slow infection caused by a human T lymphocyte retrovirus (HTLV-III/LAV). Characteristic signs of clinical AIDS include lymphadenopathy, wt loss, severe diarrhea, muscle weakness, neoplasms, and a number of varied opportunistic infections that have in the past complicated
Mechanisms of Host Resistance to Infectious Agents, Tumors, and Allografts. Steinman RM, North RJ, eds. New York, Rockefeller University Press, p. 321-33, 1986.. Unique Identifier : AIDSLINE ICDB/87630026
Murray HW; Div. of Infectious Diseases, Cornell Univ. Medical College, New; York, NY 10021
Studies related to the immunopathogenesis of opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS) are reviewed, including lymphokine-generating capacity of AIDS T-cells (crude lymphokines, interferon-gamma [IFN-gamma], and interleukin-2 [ IL-2
Animal Models of Retrovirus Infection and Their Relationship to AIDS. Salzman LA, ed. Orlando, Florida, Academic Press, p. 223-32, 1986.. Unique Identifier : AIDSLINE ICDB/87629278
Kanki PJ; Hunt RD; Essex ME; Dept. of Cancer Biology, Harvard Sch. of Public Health, Boston,; MA
The macaque monkey is naturally infected with two T lymphotropic retroviruses, one closely related to HTLV-I (human T cell lymphotropic virus type I) and the second more closely related to HTLV-III (human T lymphotropic virus type III); these have been designated STLV-I and STLV-III, respectively. Studies of these pri
The role of therapeutic apheresis was assessed in a number of clinical syndromes associated with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Four groups of patients were studied: AIDS with opportunistic infections, AIDS with Kaposi s sarcoma, AIDS/ARC patients with
Lazzarin A; Uberti Foppa C; Galli M; Mantovani A; Poli G; Franzetti F; Novati R
Granulocyte functions were studied in 20 patients with acquired immunodeficiency syndrome (AIDS), 20 subjects with lymphadenopathy syndrome (LAS) and 15 symptom-free drug addicts (SFDA). Polymorphonuclear leucocyte (PMNL) phagocytosis and killing of C. albicans appeared normal in homosexual men with AIDS, while drug a
Wilson BJ; Shiigi SM; Zeigler JL; Olson LC; Malley A; Howard CF
The Celebes black macaque (Macaca nigra) colony at the Oregon Regional Primate Research Center has a high incidence of simian acquired immunodeficiency syndrome (SAIDS-RF) that may be caused by type D retrovirus type 2 (SRV-2). During the spring and autumn screening of the colony, seven monkeys previously aviremic wer
Detailed analysis of caretaker response to the first infant newly diagnosed with AIDS at a university hospital was done by review of nursing notes for three periods: before diagnosis of AIDS, after diagnosis, and after psychiatric consultation. Five consultation questions were posed, and the findings on investigation
Pulmonary Kaposi s sarcoma is an unusual pre-mortem diagnosis in AIDS patients. During a four-year period, 318 patients with AIDS-associated Kaposi s sarcoma presented to New York University Medical Center; 19 patients were found to have pulmonary involvement. All 19 patients were homosexual men; 18 of these patients
A 37-year-old female patient reported marked weight loss, prolonged alopecia, recurrent infections and watery diarrhoea. Examination revealed Salmonella infection, candidiasis and immunological signs of previous toxoplasmosis. Between 1978 and 1981, the patient had had close sexual relations to a patient with haemophi
Biliary tract dilatation without obstruction may result from sclerosing cholangitis, pyogenic cholangitis, or bile duct surgery. This case report describes a patient with AIDS whose biliary tract dilatation was due to cytomegalovirus infection. Such a diagnosis should now be consid
Mathematical and computer-simulation models of sexually transmitted diseases, which have been used to study gonorrhoea and human papilloma virus transmissions, are applied to the study of AIDS. The problems of adapting the general model to the new problem, within already established principles, are described; and solu
Twenty-eight homosexual men with Kaposi sarcoma as part of the acquired immune deficiency syndrome (AIDS-related KS) and 2 homosexual men without AIDS were examined with abdominal and pelvic computed tomography (CT). Abnormalities of the rectum and perirectal areas were seen in 8 of the 30 patients on CT examination.
Gen Hosp Psychiatry. 1986 Nov;8(6):395-403. Unique Identifier : AIDSLINE MED/87081370
Wolcott DL; Namir S; Fawzy FI; Gottlieb MS; Mitsuyasu RT
High levels of illness-related psychologic distress, marked social stigmatization and loss of social support, and negative internalized feelings towards homosexuality have previously been reported in homosexual men with the diagnosis of acquired immune deficiency syndrome (AIDS). We assessed 50 homosexual or bisexual
The most common histologic pattern observed in lymph node biopsy specimens from homosexual men with the syndrome of persistent generalized lymphadenopathy is that of florid hyperplasia of germinal centers. This change has been characterized as showing large and irregular germinal centers, mantle zone effacement, folli
A computer simulation of the morbidity and mortality rates of the Acquired Immunodeficiency Syndrome in the Federal Republic of Germany was performed. Since sexual intercourse is the main mode of transmission, the population was divided into six groups with different sexual behavi
Using the electron microscopic technique of negative staining, viruses of the herpes group were detected in leukoplakic lesions on the tongue of a bisexual, HTLV-III-/LAV-infected male. Oral hairy leukoplakia was diagnosed, which was the first clinical symptom of on HTLV-III/LAV infection in this patient.
Acquired immune deficiency syndrome was diagnosed in a 43-year-old man, born and living in Congo. The patient presented a disseminated infection caused by mycobacteria which were recovered from blood, jejunal fluid, and duodenal and rectal biopsies. Identification, according to conventional tests and mycolate profile
Mycobacterium haemophilum was isolated from wrist and ankle aspirates as the organism responsible for tenosynovitis in a patient with acquired immune deficiency syndrome. Mycobacterium isolates recovered from synovial fluid were identified as hemin requiring by their failure to grow on subculture unless the medium was
JAMA. 1987 Jan 16;257(3):340-3. Unique Identifier : AIDSLINE MED/87087010
Sitz KV; Keppen M; Johnson DF
Basal cell carcinoma is a common neoplasm that rarely metastasizes. Metastatic basal cell carcinoma has been associated with a deficiency of cellular immunity. Patients with acquired immunodeficiency syndrome, at greater risk for specific neoplasms, may be at greater risk for basal cell carcinoma and subsequent metast
JAMA. 1987 Feb 6;257(5):635-9. Unique Identifier : AIDSLINE MED/87087049
In a study of Haitians in Miami and New York, Creole-speaking interviewers questioned 55 patients with acquired immunodeficiency syndrome (AIDS) (45 men and ten women) and 242 control-persons (164 men and 78 women). One male patient was homosexual, and one female patient had received blood within five years. No one ad
We studied seven patients with AIDS or AIDS-related complex (ARC) and movement disorders. Three had hemichorea-ballismus, two had segmental myoclonus, one had postural tremor with dystonia, and one had paroxysmal dystonia. Besides the hyperkinesias, two patients had parkinsonism, and one had cerebral Whipple s disease
Five cases of Hodgkin s disease in young homosexual men at risk for the acquired immune deficiency syndrome (AIDS) are reported. The mixed cellularity histologic subtype was present in each. Two also showed features of lymphocyte depletion. Four of the five patients had pathologic stage IIIB or IVB disease at presenta
Am J Med. 1986 Dec;81(6):974-8. Unique Identifier : AIDSLINE MED/87097312
Mandell W; Goldberg DM; Neu HC
Five patients with disseminated histoplasmosis are reviewed. Four of five had the acquired immune deficiency syndrome (AIDS) and one was receiving steroid therapy. All were immigrants to the United States from Puerto Rico , the
Am J Med. 1987 Jan;82(1):149-50. Unique Identifier : AIDSLINE MED/87097358
Witt D; McKay D; Schwam L; Goldstein D; Gold J
Disseminated cryptococcosis developed as the first manifestation of the acquired immune deficiency syndrome in a previously healthy Haitian man. Following presentation with a febrile illness that included massive mediastinal and peripheral lymphadenopathy, the patient died of overwhelming pulmonary, visceral, and meni
Am J Med. 1987 Jan;82(1):175-8. Unique Identifier : AIDSLINE MED/87097368
Clairmont GJ; Zon LI; Groopman JE
Hemophilus parainfluenzae, a common upper respiratory tract pathogen, has been reported to cause pharyngitis, epiglottitis, otitis media, conjunctivitis, and pneumonia. Rarely H. parainfluenzae infects the urinary tract, and is believed not to have been previously reported as a cause of prostatitis. A case of H. parai
Am J Med Sci. 1986 Dec;292(6):372-5. Unique Identifier : AIDSLINE MED/87097411
Shenoy CM; Lin JH
Bone marrow aspirates and biopsies from 35 AIDS/AIDS-related complex patients, consisting primarily of intravenous drug abusers, were studied. The most common findings included hypercellularity (86%), plasmacytosis (63%), reticular fibrosis (50%), and lymphocytosis (37%) occasionally admixed with histiocytes. Granuloc
Three infants with the acquired immunodeficiency syndrome (AIDS) are reported. Two cases belong to infants died with AIDS; one of them have as infection source multiple transfusions of blood during the neonatal period and the other case was an haemophilic children transfused several times with commercial factor VIII.
Ann Intern Med. 1987 Feb;106(2):254-6. Unique Identifier : AIDSLINE MED/87098292
Mycobacterial disease is common among patients with the acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. Among all patients with AIDS, the most frequently isolated cause is Mycobacterium avium complex; but in some groups, such as Haitians and intravenous drug users, M. tuberc
Twenty-nine patients at risk of developing acquired immunodeficiency syndrome (AIDS) presented with cognitive, motor, and behavioral dysfunctions characteristic of the AIDS dementia complex, either preceding or in the absence of major systemic opportunistic infections or neoplasms.
Aviat Space Environ Med. 1986 Dec;57(12 Pt 1):1208-14. Unique Identifier : AIDSLINE MED/87099738
Osborn JE
The 1986 Armstrong Lecture--21st in a series of annual lectures named for the late Col. Harry Armstrong, USAF, MC--was delivered April 24 during the Aerospace Medical Association s Annual Scientific Meeting in Nashville, TN, April 20-24. The history of the onset of the AIDS epidemic was reviewed along with pertinent a
Med Hypotheses. 1986 Nov;21(3):253-66. Unique Identifier : AIDSLINE MED/87089175
Da Prato RA; Rothschild J
The AIDS virus is an opportunistic organism which requires a previously immunocompromised host for successful replication. We propose that the primary and as yet unlocalized lesion caused by the AIDS virus involves disruption of physiologically balanced responses to stressors, effectively creating a state of chronic r
Med Hypotheses. 1986 Dec;21(4):421-30. Unique Identifier : AIDSLINE MED/87089193
McKenna JJ; Miles R; Lemen D; Dunford SA; Renirie R
In both African AIDS populations and homosexual populations outside of Africa, a high incidence of syphilis and multiple exposures to infectious diseases results in frequent, often abusive use of antibiotics. Epidemiological evidence exists for chemical immunosuppression resulting from antibiotics and other prescribed
In situ hybridization with a 35S-labeled probe of cryosections from 14 lymph nodes of HTLV-III/LAV-seropositive individuals with lymphadenopathy showed the presence of rare cells containing HTLV-III RNA at levels consistent with virus replication. Positive cells were observed at a frequency of only 1-10 per section. I
We report three homosexual men who developed malaise, fever and a roseola-like exanthema which disappeared over 2 weeks. During 3 months follow-up, all three patients felt well and had no symptoms. HTLV III seroconversion was detected several weeks after the acute HTLV III infection. In two of the three cases the West
EMBO J. 1986 Nov;5(11):3065-71. Unique Identifier : AIDSLINE MED/87080292
Chanh TC; Dreesman GR; Kanda P; Linette GP; Sparrow JT; Ho DD; Kennedy RC
Two synthetic peptides containing amino acid sequences analogous to the envelope glycoprotein of human T-lymphotropic virus (HTLV) type III (HTLV-III) and lymphadenopathy associated virus (LAV) were produced and used to immunize rabbits. The subsequent rabbit antisera neutralized HTLV-III infectivity in vitro. The two
J Med Virol. 1987 Jan;21(1):75-9. Unique Identifier : AIDSLINE MED/87085525
Oldham LJ; Moulsdale HJ; Mortimer PP; Tedder RS; Morgan-Capner P
The sensitivity of nine commercial assays, Western blot, and a newly developed monoclonal antibody-based assay for antibody to human T lymphotropic virus type III/lymphadenopathy associated virus (anti-HTLV III/LAV) were evaluated using a panel of mainly weak-positive sera. In tests on 20 sera three commercial assays
JAMA. 1987 Feb 6;257(5):631-4. Unique Identifier : AIDSLINE MED/87087048
Koenig RE; Pittaluga J; Bogart M; Castro M; Nunez F; Vilorio I; Delvillar L; Calzada M; Levy JA
Few patients with the acquired immunodeficiency syndrome have been reported in the Dominican Republic , although they share the island of Hispaniola with Haiti , which has numerous cases. Prevalence
JAMA. 1987 Feb 6;257(5):640-4. Unique Identifier : AIDSLINE MED/87087050
Fischl MA; Dickinson GM; Scott GB; Klimas N; Fletcher MA; Parks W
Forty-five adults with the acquired immunodeficiency syndrome (AIDS) and their 45 spouses, 109 children, and 29 household contacts were studied for evidence of heterosexual, perinatal, and household spread of human T-cell lymphotropic virus type III (HTLV-III) infection. Of the 45 spouses enrolled, 26 (58%) had antibo
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9278-83. Unique Identifier : AIDSLINE MED/87092236
Fauci AS
A number of current issues exist that must be taken into account in the development of a strategy for dealing with the problem of the acquired immunodeficiency syndrome (AIDS) in the United States and throughout the world. Given the complexity of the problem and the fact that the epide
Am J Public Health. 1987 Feb;77(2):169-72. Unique Identifier : AIDSLINE MED/87097684
Chaisson RE; Moss AR; Onishi R; Osmond D; Carlson JR
To investigate the risk of infection with the human immunodeficiency virus (HIV) in San Francisco, the prevalence of antibodies to HIV was determined in 281 heterosexual intravenous drug users recruited from community-based settings. Ten per cent of subjects had ELISA and Western blot confirmed seropositivity for anti
No speciality is unaffected by the AIDS epidemic, and the obstetric implications of HTLV3 (HIV) infection are not clear. Maternity units should have a protocol for screening and for management of the seropositive patient, but staff should be aware that the risks to themselves in caring for such women are extremely low
Monocyte functions, including interleukin 1 (IL-1) production, have been shown previously to be impaired in acquired immunodeficiency syndrome (AIDS). We have fractionated culture supernatants from unstimulated peripheral blood mononuclear cells (PBMCs) to determine whether the low IL-1 activity in AIDS was due to the
Three patients with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex and lymphocytic interstitial pneumonia are reported. All patients presented with progressive dyspnea, nonproductive cough, fever, anorexia, weight loss, and arterial hypoxemia. Chest roentgenograms exhibited bilateral diffuse re
EMBO J. 1986 Nov;5(11):3051-6. Unique Identifier : AIDSLINE MED/87080290
Certa U; Bannwarth W; Stuber D; Gentz R; Lanzer M; Le Grice S; Guillot F; Wendler I; Hunsmann G; Bujard H; et al
A 240-bp DNA fragment encoding a peptide, designated ENV(80), homologous to a conserved part of the gp41 transmembrane glycoprotein of human immunodeficiency virus (HIV) was chemically synthesized and inserted into different plasmid expression vectors. Escherichia coli transformants containing these plasmid constructs
JAMA. 1987 Jan 16;257(3):326-30. Unique Identifier : AIDSLINE MED/87087006
Lang W; Anderson RE; Perkins H; Grant RM; Lyman D; Winkelstein W Jr; Royce R; Levy JA
Forty-nine percent of homosexual/bisexual men were positive for antibody to the human immunodeficiency virus (HIV) in a population-based probability sample of 1034 single men recruited from San Francisco. All heterosexual men were negative. Among seropositive men, marked lymphadenopathy was present in 29%, and 16% had
JAMA. 1987 Jan 16;257(3):331-4. Unique Identifier : AIDSLINE MED/87087007
Goedert JJ; Biggar RJ; Melbye M; Mann DL; Wilson S; Gail MH; Grossman RJ; DiGioia RA; Sanchez WC; Weiss SH; et al
We prospectively evaluated potential markers and cofactors for the acquired immunodeficiency syndrome (AIDS) in 86 homosexual men who were seropositive for human immunodeficiency virus antibodies. During three years of follow-up, 19 men developed AIDS. Risk of AIDS was clearly predicted by the total number of circulat
Nine patients with the acquired immunodeficiency syndrome (AIDS) were administered four doses of pooled transfer factor obtained from the lymphocytes of three healthy controls and three homosexuals with stable lymphadenopathy and serum antibody to the human immunodeficiency virus. Before receiving transfer factor, all
Med J Aust. 1987 Jan 19;146(2):65-9. Unique Identifier : AIDSLINE MED/87089339
Whyte BM; Gold J; Dobson AJ; Cooper DA
Since 1982, when the first case of acquired immunodeficiency syndrome (AIDS) was diagnosed in Australia , a total of 373 cases has been reported to the NHMRC Special Unit in AIDS Epidemiology and Clinical Research to December 19, 1986. Analysis of the data shows that 70% of cases
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9754-8. Unique Identifier : AIDSLINE MED/87092326
Hirsch V; Riedel N; Kornfeld H; Kanki PJ; Essex M; Mullins JI
Simian T-lymphotropic retroviruses with structural, antigenic, and cytopathic features similar to the etiologic agent of human acquired immunodeficiency syndrome, human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), have been isolated from a variety of primate species including African
All gallium-67 citrate scans obtained in patients with acquired immunodeficiency syndrome (AIDS) at the Clinical Center, National Institutes of Health (Bethesda, Md.) were retrospectively analyzed and correlated with the results of bronchoscopy, chest radiography, and endoscopy. There were 164 scans of 95 patients. Tw
Am J Med. 1987 Jan;82(1):73-8. Unique Identifier : AIDSLINE MED/87097390
Peters SG; Prakash UB
Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic. Underlying diseases included leukemia in 15 patients, lymphoma in nine, nonhematologic malignancies in five, acquired immune deficiency syndrome in two, an various inflammatory diseases treated by corticosteroids in 1
Literature data on etiology, immune disorders, pathological anatomy of the acquired immunodeficiency syndrome (AIDS) was analysed. AIDS is a low-contagious disease, is most likely caused by retrovirus HTLV-III affecting a subpopulation of T-lymphocytes helpers. The disease develops in a small number of persons with an
Boll Ist Sieroter Milan. 1986;65(4):269-76. Unique Identifier : AIDSLINE MED/87076080
Barcellini W; Meroni PL; Lazzarin A; Sguotti C; Parravicini C; Borghi MO; Brucato A; Moroni M; Sirianni MC; Aiuti F; et al
The persistent generalized lymphadenopathy (PGL) in drug addicts displays the same immunological abnormalities previously found in homosexual and haemophiliac men with PGL: impaired in vivo and in vitro T cell functions, inverted T4/T8 ratio in blood and B cell abnormalities. The peripheral blood B-lymphocytes, in fac
Brain biopsy is justified in patients suspected of having encephalitis or viral encephalopathy because those patients are most likely to be helped if a diagnosis is made rapidly and with the greatest certainty possible. Neurosurgeons are occasionally reluctant to undertake brain biopsy because the procedure is diagnos
McHugh TM; Stites DP; Casavant CH; Carlson JR; Yee J; McVay PA; Busch MP; Levy JA
One hundred and eighty-four serum specimens were assayed for antibodies to the human immunodeficiency virus. All specimens were screened with a commercial enzyme immunoassay and confirmed by two indirect immunofluorescence assays. Sera were also assayed by Western blot. Results from sera of 48 healthy heterosexual vol
Mathe G; Blazsek I; Canon C; Gil-Delgado M; Misset JL
Severe impairment of the lymphopoietic cell renewal system is an important etiological factor of cancer development and it may be the consequence of massive radio and/or chemotherapeutic regimens. In a comparative study, we analysed the potential, systemic immunorestoratory capacity of bestatin, a microbial leucil-ami
Inosine pranobex is a synthetic compound formed from the p-acetamido benzoate salt of N-N dimethylamino-2-propanol and inosine in a 3:1 molar ratio. It has been reported to exert antiviral and antitumour activities in vivo which are secondary to an immunomodulating effect, and early results suggest beneficial clinical
The literature on the transmission of human immunodeficiency virus (HIV/HTLV-III/LAV) is reviewed. HIV spreads by vertical transmission and by iatrogenic transmission (transfer of blood or blood-containing products), by infected needles among i.v. drug users and, more rarely, among health care workers, but mainly by s
Int Ophthalmol. 1986 Dec;9(4):247-51. Unique Identifier : AIDSLINE MED/87082561
Kestelyn P; Van de Perre P; Sprecher-Goldberger S
The human T-cell leukemia/lymphotropic virus type III (HTLV-III) has been isolated from aqueous humor in two patients with perivasculitis of the peripheral retinal vessels, an AIDS-related ocular manifestation. Both patients had antibodies to HTLV-III and although they presented with herpes zoster ophthalmicus, they d
Int J Neurosci. 1986 Nov;30(4):249-54. Unique Identifier : AIDSLINE MED/87082578
Faulstich ME
The Acquired Immune Deficiency Syndrome (AIDS) has been associated with a series of central nervous system (CNS) complications, including focal and nonfocal neurological indications. Overall, the most common form of CNS dysfunction is diffuse cerebral atrophy pathologically characterized by neuronal loss, glial nodule
Burg G; Klepzig K; Kaudewitz P; Wolff H; Braun-Falco O
A survey is given on 23 patients (10 of our own, 13 reported in personal communications and in the literature) suffering from lymphoproliferative diseases and treated with acyclovir (ACV). In 5 patients (3 of 18 with cutaneous T-cell lymphomas, 2 of 5 with lymphomatoid papulosis
Serum samples from 27 patients infected with human T-cell lymphotropic virus type III (14 with acquired immune deficiency syndrome [AIDS] and 13 with AIDS-related complex) were examined for antibodies to viral proteins by the Western blot method and with four different commercial solid-phase enzyme-linked immunosorben
A micromethod for assaying the reverse transcriptase enzyme of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus in cocultures of clinical specimens for viral isolation was developed and compared with the macromethod in use. Ultracentrifuged, pelleted, and solubilized viral culture supernatants
The RNA-dependent DNA polymerase (RDDP) of human immunodeficiency virus (HIV) was purified from sucrose density gradient-banded virus by four successive procedures: anion exchange chromatography, cation exchange chromatography, affinity chromatography on oligo(dT)-cellulose and adsorption chromatography on hydroxyapat
JAMA. 1987 Jan 16;257(3):321-5. Unique Identifier : AIDSLINE MED/87087005
Winkelstein W Jr; Lyman DM; Padian N; Grant R; Samuel M; Wiley JA; Anderson RE; Lang W; Riggs J; Levy JA
The San Francisco Men s Health Study is a prospective study of the epidemiology and natural history of the acquired immunodeficiency syndrome in a cohort of 1034 single men, 25 to 54 years of age, recruited by multistage probability sampling. At entry, June 1984 through January 1985, the seropositivity rate for human
By analogy to other retroviruses, the major envelope glycoprotein, gp120, of human T-lymphotropic virus type III (HTLV-III) is a probable target for neutralizing antibody. This antigen has been purified from H9 cells chronically infected with the HTLV-IIIB prototype strain. Several goats immunized with the gp120 produ
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9759-63. Unique Identifier : AIDSLINE MED/87092327
Gendelman HE; Phelps W; Feigenbaum L; Ostrove JM; Adachi A; Howley PM; Khoury G; Ginsberg HS; Martin MA
To investigate whether DNA viruses can augment gene expression of the human immunodeficiency virus (HIV), cotransfection experiments were carried out in which a recombinant plasmid containing the HIV long terminal repeat (LTR) linked to the chloramphenicol acetyltransferase (CAT) gene was transfected into cultured cel
An unusual pattern of nephrocalcinosis associated with Mycobacterium avium-intracellulare infection and asymmetrically involving the renal cortex and medulla in a patient with acquired immunodeficiency syndrome (AIDS) is reported. This pattern, partial nephrocalcinosis, differs from the increased parenchymal echogenic
Pneumocystis carinii and Toxoplasma gondii are the commonest protozoans causing infections in patients with acquired immunodeficiency syndrome (AIDS). P. carinii is almost exclusively a pulmonary pathogen and caused the commonest serious infection experienced by AIDS patients. The clinical findings are those of progre
Cryptosporidium is a newly recognized human pathogen associated with severe enteritis and, perhaps, cholecystitis in immunocompromised patients, particularly those with the acquired immunodeficiency syndrome, and significant, though self-limited, diarrheal illness in the immunocompetent host. As more physicians look f
Serious infections caused by the Mycobacterium avium complex (MAC) have been increasingly recognized over the last three decades. However, the epidemic of the acquired immunodeficiency syndrome (AIDS) has increased interest in these infections. Disseminated mycobacterial disease is common in patients with AIDS, and MA
The current epidemic of acquired immunodeficiency syndrome (AIDS) poses a major threat to our population. Urgently needed are both a vaccine to prevent infection with the etiologic retrovirus, human immunodeficiency virus (HIV), and safe, effective antiviral agents to treat those individuals already infected. The eluc
Ann Intern Med. 1987 Feb;106(2):257-74. Unique Identifier : AIDSLINE MED/87098293
Fahey JL; Sarna G; Gale RP; Seeger R
Three therapeutic areas of clinical immunology that have seen active development recently are immunopharmacology of immunosuppressive drugs; clinical use of the alpha-, beta-, and gamma-interferons and interleukin-2; and monoclonal antibody applications in marrow transplantation and antitumor therapy. Understanding of
Because of recent advances in instrumentation, immunological reagents, and methods for measuring a variety of cell constituents and functions, there has been increasing interest in clinical applications of flow cytometry. Several commercially available flow cytometers and a growing list of monoclonal antibodies make i
Suramin is a potent inhibitor of the reverse transcriptase (RNA-directed DNA polymerase) of retroviruses, including the HTLV-III/LAV (human T-cell lymphotropic virus type III/lymphadenopathy-associated virus) reverse transcriptase. Although suramin is far from specific as a reverse transcriptase inhibitor and known to
Biochem Biophys Res Commun. 1986 Nov 26;141(1):33-8. Unique Identifier : AIDSLINE MED/87100132
Blough HA; Pauwels R; De Clercq E; Cogniaux J; Sprecher-Goldberger S; Thiry L
The glycosylation inhibitors 2-deoxy-D-glucose (2-dGlc) and, to a lesser extent, beta-hydroxynorvaline blocked the formation of syncytia in HIV (LAV/HTLV-III)-infected cells. Using monospecific polyclonal antibodies against recombinant envelope proteins gp110 and gp41 or monoclonal antibodies against env gp110, we cou
To facilitate discourse and improve the formulation of policy, a clear distinction should be made between financially catastrophic and high-cost health care expenditures. I propose that financially catastrophic be used to describe cases whose expenditures are large relative to ability to pay (e.g., when out-of-pocket
Among the many factors contributing to the rise in health care costs, recent attention has concentrated on the supply side. Demand factors have generally been neglected or misunderstood. Developments discussed in this paper include: growing public skepticism toward new therapies and drugs; increasing emphasis on patie
Seventy-five homosexual men with lymphadenopathy syndrome (LAS) for three months or more and antibody against the human immunodeficiency virus were enrolled in a prospective study in Atlanta in 1982 and 1983. Fourteen developed the acquired immunodeficiency syndrome (AIDS) three to 38 months after enrollment in the st
Three homosexual male patients with biopsy-proved Kaposi s sarcoma were classified as having the acquired immune deficiency syndrome (AIDS) by Centers for Disease Control criteria when first seen in 1983 and 1984. These patients, however, differed from most patients with AIDS and Kaposi s sarcoma in having normal CD4
Biochemistry. 1986 Oct 21;25(21):6711-5. Unique Identifier : AIDSLINE MED/87076613
Eide B; Gierschik P; Spiegel A
Rabbits immunized with ADP-ribose chemically conjugated to carrier proteins developed antibodies reactive against guanine nucleotide binding proteins (G proteins) that had been mono-ADP-ribosylated by bacterial toxins. Antibody reactivity on immunoblots was strictly dependent on incubation of substrate proteins with b
Accessory cells and/or soluble factors, together with interleukin 2 (IL2), are required for the proliferation and differentiation of phytohemagglutinin (PHA)-activated T lymphocytes. Human T-lymphotropic virus, type I (HTLV-I), a human retrovirus isolated from patients with adult T cell leukemia, can transform T cells
Allan JS; Coligan JE; Lee TH; Barin F; Kanki PJ; M'Boup S; McLane MF; Groopman JE; Essex M
The present studies were initiated to define the coding region of a 34 kilodalton (kd) protein (p34) frequently observed with antibodies from HTLV-III/LAV-infected people by immunoblotting and radioimmunoprecipitation (RIP) techniques. We have directly mapped this viral protein to the pol gene of HTLV-III/LAV by radio
De Paoli P; Reitano M; Battistin S; Martelli P; Villalata D; Bergamo F; Tirelli U; Carbone A; Diodato S; Bosio R; et al
The prolonged generalized lymphadenopathy syndrome (PGL) has been considered a prodromal condition to the Acquired immunodeficiency syndrome (AIDS), but the clinical, virological and immunological characteristics of patients who will develop AIDS are not known. We report on the immunological profile of intravenous dru
Morishima Y; Ohya K; Morishima T; Nishikawa K; Fukuda T
Adult T cell leukaemia associated antibody (ATLA-Ab) positive people who were considered to be adult T cell leukaemia virus (ATLV) carriers were found in 0.75% of the adult population in the non-endemic area of Nagoya, Japan . Immunological studies on these people revealed that T lym
Murray JL; Bywaters DW; Reuben JM; Mansell PW; Hersh EM
The purine metabolic enzymes adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5 nucleotidase (5NT) have been shown to be important for normal lymphocyte maturation. Abnormalities of these enzymes have been associated with hereditary as well as acquired immunodeficiency states. Enzyme activity was
Isoprinosine and Imuthiol are non mitogenic immunomodulators active on T cell differentiation. In ARC patients, they modulate the circulating T cell receptor complex in terms of OKT4+ phenotype induction. This effect is not responsible for any expansion of the target population but for a partial inhibition of in vitro
EMBO J. 1986 Nov;5(11):2883-8. Unique Identifier : AIDSLINE MED/87080273
Inoue J; Seiki M; Taniguchi T; Tsuru S; Yoshida M
Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL). A viral product, p40x, encoded by the pX sequence of HTLV-1 is a trans-acting transcriptional activator of the long terminal repeat (LTR) and has been suspected of involvement in leukemogenesis, activating the cellular ge
FEBS Lett. 1986 Dec 15;209(2):187-90. Unique Identifier : AIDSLINE MED/87080757
Inoue J; Seiki M; Yoshida M
The human T-cell leukemia virus type-1 (HTLV-1) contains a unique pX region, which encodes the gene products p40 chi, p27 chi-III and p21 chi-III. p40 chi is required for transcriptional trans-activation, whereas p27 chi-III and p21 chi-III have no such function. Transfection of pX expression plasmids containing diffe
FEBS Lett. 1986 Dec 15;209(2):289-94. Unique Identifier : AIDSLINE MED/87080776
Shima H; Takano M; Shimotohno K; Miwa M
Human T-cell leukemia virus type II (HTLV-II) isolated from a T-cell variant of hairy cell leukemia contains gag, pol and env genes as well as a fourth gene termed X, which can code three major open reading frames Xa, Xb and Xc. Proteins with molecular masses of 26 kDa (p26Xb) and 24 kDa (p24Xb) encoded by the Xb open
Int J Cancer. 1986 Dec 15;38(6):859-65. Unique Identifier : AIDSLINE MED/87082363
Matsuda S; Nakao Y; Ohigashi H; Koshimizu K; Ito Y
The addition to culture dishes of 10-50 ng/ml of the essential diterpene ester of Sapium sebiferum, 12-O-hexadecanoylphorbol-13-acetate (HPA), increased colony formation of normal peripheral blood lymphocytes co-cultured with gamma-irradiated HTLV-I-producing HUT 102 cells. The cells in the stimulated colonies showed
Schinazi RF; del Bene V; Scott RT; Dudley-Thorpe JB
Several different genital and non-genital HSV isolates were obtained from a patient with an acquired immune deficiency of unknown aetiology. The patient was initially treated with topical acyclovir (ACV) and later with topical and intravenous ACV. In spite of treatment with anti
Sera from 526 old-world primates representing 50 different species were screened by ELISA for antibodies to human T-lymphotropic viruses I and III, and simian retrovirus type 1 (SRV-1). About one-fourth of the sera were positive by ELISA. There was a tendency, however, for the same sera to be positive for all three hu
Infection with human immunodeficiency virus (HIV, previously known as HTLV-III/LAV) documented by a sensitive, specific immunoblotting (western blot) technique is described in 14 children with symptoms of AIDS or AIDS-related complex. For serodiagnosis of HIV infection, immunoblots blocked with milk were more sensitiv
A case is reported of a patient with sudden onset, generalized toothache accompanied with a numb chin and lower lip. A thorough oral examination was negative. A complete medical evaluation revealed a positive HTLV-III antibody titer and acute lymphoblastic leukemia (Burkitt s-type). An unexplained trigeminal neuropath
Shah NP; Wachsman W; Cann AJ; Souza L; Slamon DJ; Chen IS
The mechanism of cellular transformation by the human T-cell leukemia viruses (HTLVs) is thought to involve a novel retrovirus gene known as chi. The chi gene is essential for HTLV replication and acts by enhancing transcription from the viral long terminal repeat. By using the HTLV type I and II chi gene-coding regio
Nature. 1986 Dec 18-31;324(6098):691-5. Unique Identifier : AIDSLINE GENBANK/M15390
Clavel F; Guyader M; Guetard D; Salle M; Montagnier L; Alizon M
We recently reported the isolation of a novel retrovirus, the human immune deficiency virus type 2 (HIV-2, previously named LAV-2), from patients with acquired immune deficiency syndrome (AIDS) originating from West Africa. This virus is related to HIV-1, the causative agent of the AIDS epidemic now spreading in Centr
The human immunodeficiency virus, HIV (formerly T-cell lymphotropic virus type III, HTLV-III or lymphadenopathy-associated virus, LAV) is the primary cause of AIDS (acquired immune deficiency syndrome). Patients with AIDS have profound immunosuppression as a result of almost complete absence of the OKT4+ cell populati
To examine the association between MS and anti-human T-cell lymphotropic virus-I (HTLV-I) antibody, we studied serum and CSF antibody to HTLV-I in 27 Japanese MS patients by an indirect immunofluorescence method sensitive and specific enough to detect carriers of HTLV-I. The antibody was detected in 3 of 27 MS patient
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9734-8. Unique Identifier : AIDSLINE MED/87092322
Peterlin BM; Luciw PA; Barr PJ; Walker MD
The genome of human immunodeficiency virus encodes a protein that dramatically elevates amounts of viral proteins. The precise mechanism of this trans-activation remains to be established. It has been reported that trans-activation can occur without major changes in the levels of mRNA. We constructed recombinant plasm
Involvement of the central nervous system in acquired immune deficiency syndrome (AIDS) is usually due to opportunistic infections; these frequently offer a difficult differential diagnostic problem. Imaging methods play an important part in the elucidation of symptoms. CT and MR findings were analysed in 13 patients
Viruses may cause immunosuppression by a variety of mechanisms. This review delineates four categories. First, immunosuppression can result from the direct effects of viral replication on lymphocyte functions. Either all classes of lymphocytes can be affected, as occurs in measles, or the effect can be restricted to a
Trans Ophthalmol Soc U K. 1986;105 ( Pt 5):505-9. Unique Identifier : AIDSLINE MED/87095189
Humphry RC; Parkin JM; Marsh RJ
The ocular findings in 38 patients infected by the Human T Cell Lymphotropic Virus Type III (HTLV III) are reviewed. Twenty patients were suffering from the Acquired Immunodeficiency Syndrome (AIDS) and 18 from the HTLV III related disease Persistent Generalised Lymphadenopathy (PGL). Cotton wool spots were found in t
Niedobitek G; Jautzke G; Schwenk J; Kramer A; Sommer D; Metelmann C; Habermehl KO; Stein H
We have evaluated the autopsies of 11 patients with HTLV III/LAV-infection. The clinical diagnosis was AIDS in 10 cases and AIDS related complex (ARC) in one case. The most common infectious disease was pneumocystis carinii pneumonia, occurring in 5 cases. 3 patients showed evidence of mycobacterial infections and ano
Am Fam Physician. 1987 Jan;35(1):109-18. Unique Identifier : AIDSLINE MED/87096940
Hollerman JJ; Bernstein MA; Beute GH
Of 67 hospitalized AIDS patients, 39 had pulmonary pathology. More than half of these patients died of pulmonary disease. Pneumocystis carinii, cytomegalovirus , Cryptococcus neoformans and Mycobacterium avium-intracellulare were the most common pulmonary pathogens, and Kaposi s sar
Am J Med. 1987 Jan;82(1):151-2. Unique Identifier : AIDSLINE MED/87097359
Teich SA; Tay S; Friedman AH; Schmitterer ME
Conjunctival biopsy from a 39-year-old man with the acquired immune deficiency syndrome revealed the presence of herpes virus particles by electron microscopy. The finding of herpes virus particles in the conjunctiva may be of prognostic significance in documenting the presence of systemic viral infection.
Am J Ophthalmol. 1987 Jan 15;103(1):17-23. Unique Identifier : AIDSLINE MED/87097572
Henry K; Cantrill H; Fletcher C; Chinnock BJ; Balfour HH Jr
A patient with acquired immune deficiency syndrome with bilateral cytomegalovirus retinitis was treated with intravitreal 200-micrograms/0.1-ml doses of ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl]guanine). The ganciclovir serum and intravitreal concentrations were mea
Nara PL; Robey WG; Arthur LO; Gonda MA; Asher DM; Yanagihara R; Gibbs CJ Jr; Gajdusek DC; Fischinger PJ
Re-isolation of virus from HTLV-III B and LAV-infected chimpanzee also yielded a simian foamy virus. This virus, replicated in HTLV-III B and LAV-producing H 9 cells, had identical reverse transcriptase activity and caused similar cytopathic effects in H 9 cells.
Cancer Res. 1987 Jan 1;47(1):269-74. Unique Identifier : AIDSLINE MED/87077968
Tsujimoto H; Noda Y; Ishikawa K; Nakamura H; Fukasawa M; Sakakibara I; Sasagawa A; Honjo S; Hayami M
Proviral integration of a simian retrovirus highly homologous to human T-cell leukemia virus type I was examined in cellular DNAs extracted from primary peripheral blood lymphocytes of 31 adult African green monkeys (Cercopithecus aethiops) that were seropositive for simian T-cell leukemia virus type I (STLV-I). Among
A classification of malignant lymphomas has been formulated to identify distinct clinical groups of patients for future therapeutic trials. The unifying concept of primary cutaneous lymphomas as of either T- or B-cell origin does not conflict with the Working Formulation but encompasses its categories. This classifica
Cutaneous T-cell lymphoma is a malignant disease whose behavior reflects its T-cell lineage. The biologic characteristics of the disease are understandable when viewed from a perspective of normal T-cell-skin interactions. Thus, it is of no surprise that this malignancy of helper T lymphocytes usually demonstrates a r
This article has provided an introduction to and a brief overview of recent developments in the investigation of retroviruses and their role in animal and human neoplasia. The sheer volume of new information concerning this subject is nearly overwhelming. We can only hope that this knowledge will eventually lead to ma
The distinctive clinical features and natural history of mycosis fungoides, an epidermotropic variant of cutaneous T-cell lymphoma, are presented. These findings are compared with certain non-mycosis fungoides T-cell lymphomas that occasionally occur in the skin. Clinical staging and evaluation of patients with cutane
The presence of antibody to human T-cell leukaemia virus (HLTV-I) has been assessed in 2,143 men and women who represent 83% of all adults aged 35 to 69 years resident in a defined urban community in Trinidad . Individuals of African
Int J Cancer. 1986 Dec 15;38(6):809-13. Unique Identifier : AIDSLINE MED/87082355
Fleming AF; Maharajan R; Abraham M; Kulkarni AG; Bhusnurmath SR; Okpara RA; Williams E; Akinsete I; Schneider J; Bayer H; et al
Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria , in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin s lymphoma , one of 12 with Burkitt s lymphoma an
Cynomolgus monkeys and squirrel monkeys were inoculated with autologous lymphoid cell lines immortalized by and producing human T-cell leukemia virus type-I (HTLV-I) in order to serve as an animal model of adult T-cell leukemia (ATL). The autologous cell lines were established from peripheral blood mononuclear cells (
A bibliography of leukaemias in Africa is presented from 1904 to 1985. The literature is listed chronologically and is classified geographically (north, south, east and west Africa) and by leukaemia type. The epidemiology of leukaemias in Africa is discussed briefly, especially as to the rarity of acute lymphoblastic
Sanada I; Nakada K; Furugen S; Kumagai E; Yamaguchi K; Yoshida M; Takatsuki K
A cytogenetic study was performed on peripheral blood cells from a patient with smoldering adult T-cell leukemia (ATL). Four types of primary abnormal clones were found upon examination of a large number of karyotypically analysed cells cultured with and without phytohemagglutinin (PHA). However, human T-cell leukemia
Hori T; Uchiyama T; Umadome H; Tamori S; Tsudo M; Araki K; Uchino H
We studied cell proliferation and interleukin-2 ( IL-2 ) receptor upregulation mediated by exogenous IL-2 in leukemic cells from adult T-cell leukemia (ATL) patients to characterize some aspects of abnormal IL-2 receptor expression in ATL. Leukemic cells from 7 ATL patie
The classification of non-Hodgkin s lymphomas (NHLs) is an important factor in treatment. Most clinical protocols divide these tumors into two broad categories--indolent, or low-grade, and aggressive, or high-grade. Patients with low-grade NHLs usually have a relatively long survival, with or without the use of aggres
Gan To Kagaku Ryoho. 1987 Jan;14(1):188-91. Unique Identifier : AIDSLINE MED/87098833
Ogawa T; Naito K; Yamada K
A 58-year-old man, born in Nagasaki prefecture, was admitted to our hospital because of anorexia and general fatigue on November 22, 1984. Hepatosplenomegaly was found without skin eruption. The blood examination on admission revealed leukocytosis (50,800/microliter) and atypical lymphocytes with hyperlobulated nuclei
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