HTLV-II AND HUMAN LEUKEMIA NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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HTLV-II AND HUMAN LEUKEMIA

Dev Oncol; 33:53-64 1985. Unique Identifier : AIDSLINE ICDB/86621677
Wachsman W; Gasson JC; Golde DW; Chen IS; Dept. of Medicine, UCLA Sch. of Medicine, Los Angeles, CA

Abstract: Human T-cell leukemia virus (HTLV) is a type C retrovirus associated with some adult T-cell leukemias and lymphomas. Evidence for a causal relationship between HTLV and HTLV-associated leukemia/lymphoma is strong; however, the mechanism of HTLV-induced leukemogenesis is unknown. The majority of HTLV isolates, termed HTLV-I, are identical by nucleic acid hybridization and immunologic cross-reactivity. The current state of knowledge of HTLVII, a related virus, is summarized under the following headings: identification of HTLV-II; clinical perspective; molecular cloning of HTLV-II; biological properties of HTLV-II; and HTLV-II and leukemogenesis (functions of the long terminal repeat (LTR), oncogenes and HTLV-II-induced transformation, the pX region). HTLV-I and HTLV-II are the two major types of lymphotropic retrovirus that is epidemiologically associated with human T-lymphocyte malignancy. Molecular cloning of HTLV-II has revealed significant sequence differences between HTLV-II and HTLV-I; however, general structural features including proviral size, gene arrangement, and the presence of the pX region at the 3' end, are conserved. Sequence analysis of the LTRs from HTLV-II and HTLV-I shows little overall homology but does reveal the conservation of short sequences important for proviral integration, reverse transcription, and transcriptional regulation. The mechanism of HTLV-II-induced leukemic transformation is unknown, but indirect evidence suggests that the pX gene region is important to the process. (30 Refs)
Keywords: Base Sequence Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Cloning, Molecular DNA, Viral/GENETICS Human HTLV-BLV Viruses/GENETICS Leukemia/*MICROBIOLOGY Lymphocytes/MICROBIOLOGY Oncogenes Retroviridae Infections/*MICROBIOLOGY Viral Proteins/GENETICS Virus Replication MEETING PAPER

KWDbasesequencecelllinecelltransformation,neoplasticcelltransformation,viralcloning,moleculardna,viral/geneticshumanhtlv-blvviruses/geneticsleukemia/KWDmicrobiologylymphocytes/microbiologyoncogenesretroviridaeinfections/KWDmicrobiologyviralproteins/geneticsvirusreplicationmeetingpaper
860930
M8690242

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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