Glendale, Calif. : Audio-Video Digest Foundation & University of California, San Francisco, c1984 1 videocassette (39 min.) : sd., col. ; 3/4 in. + 1 guide (Postgraduate course for the primary care physician) Unique Identifier : AIDSLINE AV/8600828A
Glendale, Calif. : Audio-Video Digest Foundation & University of California, San Francisco, c1984 1 videocassette (50 min.) : sd., col. with b&w ; 3/4 in. + 1 guide (Postgraduate course for the primary care physician) Unique Identifier : AIDSLINE AV/8600834A
Dev Oncol; 33:53-64 1985. Unique Identifier : AIDSLINE ICDB/86621677
Wachsman W; Gasson JC; Golde DW; Chen IS; Dept. of Medicine, UCLA Sch. of Medicine, Los Angeles, CA
Human T-cell leukemia virus (HTLV) is a type C retrovirus associated with some adult T-cell leukemias and lymphomas. Evidence for a causal relationship between HTLV and HTLV-associated leukemia/lymphoma is strong; however, the mechanism of HTLV-induced leukemogenesis is unknown. The majority of HTLV isolates, termed H
Health Prog. 1986 May;67(4):34-7. Unique Identifier : AIDSLINE AHA/86224256
Cox JM
Caring for patients with AIDS presents an emotional and ethical challenge for care givers. Not only do AIDS patients have great medical needs but they also must cope with the attitudes of a society that has stigmatized them. Stigma complicates the health care decisions that must be made, since many patients with AIDS
Health Prog. 1986 May;67(4):38-40. Unique Identifier : AIDSLINE AHA/86224257
Johnson ME
When Michael Jones was admitted to the hospital with AIDS, he was quite alone. Always a private person, with few personal friends, he had isolated himself from those around him after his diagnosis. Although Michael had long felt alienated from religion, daily visits from a hospital chaplain proved enjoyable and helpfu
Health Prog. 1986 May;67(4):41-7. Unique Identifier : AIDSLINE AHA/86224258
Tibesar LJ
AIDS is unique in that it is terminal, transmissible, and surrounded by stigma. AIDS patients are often ostracized by those close to them and frequently they are alienated from religion. The pastoral care giver must provide a special ministry to AIDS patients, a ministry in which he or she accompanies the patient on a
Acquired immunodeficiency syndrome (AIDS) can be cause for apprehension not only among the public but among medical workers faced with the care of AIDS patients. Transmission, in some ways, appears similar to that of hepatitis B; consequently, similar precautions are indicated: prohibition on recapping needles, attent
Health Prog. 1986 May;67(4):30-3. Unique Identifier : AIDSLINE AHA/86224255
Gamble SW
Health care organizations must work toward public policy that addresses the cost of treating AIDS patients. One approach to the funding of AIDS medical care--although the evolving nature of the disease s treatment may make it difficult--would be to assign a diagnosis-related group weight to AIDS. Other possible mechan
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) announces the availability of a special program announcement for Research Grants on Alcohol and Immunology including Acquired Immunodeficiency Syndrome (AIDS). These awards will be to support research grants to study the role of heavy alcohol consumption i
Health Prog. 1986 May;67(4):48-52. Unique Identifier : AIDSLINE AHA/86224259
Kadzielski MA
In the future, health care providers will not be able to avoid the legal problems that the AIDS epidemic presents. They can find guidance in the long-standing legal principles of privacy and confidentiality and of fair employment. Many laws contain confidentiality principles that focus on the right of patients to dete
Appel B; Muller RN; Collard M; Moens E; Mortelmans L; Martin JJ; Lowenthal A
From a series of 117 neurological patients presenting a pathological periventricular white matter signal on NMR, the authors discuss the differential diagnosis possibilities based on the configuration of the lesions, on their localization in the brain, and on the calculated apparent T2 (T2**) values achieved with the
Southeast Asian J Trop Med Public Health. 1985 Dec;16(4):517-20. Unique Identifier : AIDSLINE MED/86235655
Wangroongsarb Y; Weniger BG; Wasi C; Traisupa A; Kunasol P; Rojanapithayakorn W; Fucharoen S
Antibody to the human T-lymphotropic virus, type III/lymphadenopathy-associated virus (HTLV-III/LAV) by ELISA test was detected in one (1%) of 101 male homosexual prostitutes (confidence limit 95%:0.03-5.4%, in two (2%) of 100 thalassemia patients, and in none (C.L. 95%:0-3.6%) of 100 female prostitutes, 99 parenteral
A case of Kaposi s sarcoma of a digit in a patient with acquired immune deficiency syndrome (AIDS) is described. The patient had what appeared to be a chronic paronychia. The paronychia tissue was excised and biopsy findings showed Kaposi s sarcoma. Kaposi s sarcoma is a multicentric, malignant, vascular tumor compose
Yokota M; Jing HX; Takagi S; Tsunekawa A; Koide M; Iwase M; Tsuzuki M; Yoshida R; Sotobata I
Multistage bicycle ergometer exercise testings with Frank vectorcardiogram and M-mode echocardiogram were performed on 12 patients with effort angina pectoris. The left atrial and left ventricular end-diastolic volume (LAV and LVEDV) were calculated as a cube of the left atrial and left ventricular end-diastolic dimen
Radionuclide brain scintigraphy and computed tomography (CT) demonstrated cerebral lesions in two patients with acquired immunodeficiency disease syndrome (AIDS) complicated by opportunistic infection of the brain. In the detection of these cerebral lesions, [99mTc]DTPA radionuclide scintigraphy was as reliable as CT.
The ultrastructural morphology of Kaposi s sarcoma of the oral mucosa in patients with acquired immune deficiency syndrome (AIDS) was examined electron-microscopically. Neoplastic spindle cells and vascular endothelial tumor cells are frequently involved in the phagocytosis of extravasated erythrocytes. Pericytes, fib
Tertian G; Derycke M; Delfraissy JF; Laurian Y; Tchernia G
We describe three patients with chronic autoimmune thrombocytopenia who exhibited transient remission during viral infection (varicella, hepatitis B, and influenza virus pneumopathy). In two patients, a male homosexual and an hemophiliac, thrombocytopenia was associated with AIDS-related complex. The third patient had
These reports indicate that we have just begun to tap the potential uses of IGIV in the prevention and therapy of pediatric disease. The ability to give large amounts of immunoglobulin intravenously repeatedly and in a safe fashion allows us to achieve and maintain very high levels of antibody. These high antibody lev
Marinelli DL; Albelda SM; Williams TM; Kern JA; Iozzo RV; Miller WT
The medical records, radiographs, and pathologic specimens of ten patients with the diagnoses of nontuberculous mycobacterial infection and acquired immunodeficiency syndrome (AIDS) were examined. The radiographic findings of alveolar or nodular infiltrates and adenopathy were relatively nonspecific but in most cases
Rhodococcus (formerly Corynebacterium) equi, a common animal pathogen, can cause a slowly evolving pneumonia in humans, particularly immunocompromised people. The authors describe two patients; one with acquired immunodeficiency syndrome. On chest radiographs, R. equi produces chronic, localized pulmonary opacities th
Am J Med Sci. 1986 Jul;292(1):44-6. Unique Identifier : AIDSLINE MED/86239326
Little BJ; Spivak JL; Quinn TC; Mann RB
A patient with the acquired immune deficiency syndrome (AIDS) and the lymphadenopathic variant of Kaposi s sarcoma developed skin, gastrointestinal and pulmonary lesions. A cellular specimen was obtained on bone marrow aspiration, but the bone marrow biopsy revealed dense reticulin fibrosis with slit-like spaces and e
Am J Psychiatry. 1986 Jun;143(6):777-8. Unique Identifier : AIDSLINE MED/86239743
Rundell JR; Wise MG; Ursano RJ
Psychiatric disorders related to acquired immune deficiency syndrome (AIDS) can take various and complex forms. The authors present cases of AIDS patients in whom paranoia, organic brain syndrome, depression, or suicidal ideation was present.
Two homosexual men presented with primary malignant lymphomas of the anorectum. Each patient presented with a painful mass, diagnosed by biopsy and immunologic cell marker studies. One patient, who had a reversed T4/T8 cell ratio, developed a local relapse of the tumor 11 months after radiotherapy, and Pneumocystis ca
Schweiz Med Wochenschr. 1986 May 17;116(20):674-8. Unique Identifier : AIDSLINE MED/86235405
von Planta M
The practical aspects surrounding taking of the history and physical examination in febrile patients returning from tropical countries are outlined. The differential diagnosis of evocative signs stemming from CNS, myocardium, lung and anemia is explained and the approach to laboratory evaluation is discussed.
We report two cases of peliosis hepatis in patients with acquired immunodeficiency syndrome. Hepatic tissue, obtained by needle biopsy from one patient and at postmortem examination from a second patient, demonstrated lesions grossly and microscopically consistent with previous descriptions of peliosis. Peliotic lesio
Parenteral substance abuse is widespread. Although treatment for opiate dependence and cocaine abuse takes place in specialized programs, abusers frequently present in primary care settings for management of associated health problems. This article reviews the two drugs that are most commonly abused parenterally (hero
A decline in T-cell lymphocyte number is the central characteristic of acquired immune deficiency syndrome (AIDS). The reason for the loss of these cells is not well understood. We investigated the hypothesis that defects in T-cell differentiation contributed to T-cell loss using an in vitro colony assay that measures
Brush biopsies and lung lavages were obtained from 263 individuals with acquired immune deficiency syndrome who collectively had 658 hospitalizations for pneumonia. Chlamydia trachomatis was isolated during three (0.5%) of the episodes, indicating that it was not an important respiratory tract pathogen in this populat
This paper presents clinical, immunological and post-mortem findings in three family members (husband, wife and daughter) who all died in 1976 after having had chronic and recurrent opportunistic infections for many years. In all of them a progressive, presumably acquired T-lymphocyte defect associated with B-lymphocy
Although spontaneous pneumothorax has rarely been reported as a complication of Pneumocystis carinii pneumonia in AIDS patients, recent experience suggests that its frequency is increasing. Seven such cases have been encountered in the past 1 1/2 years, whereas no cases were found in an earlier review at San Francisco
In immunodeficient patients, particularly in those with acquired immune deficiency syndrome, cryptosporidia can cause severe, sometimes life-threatening and protracted diarrhoea. There is no specific antiparasitic therapy available so far. In AIDS patients an immunomodulatory therapy, e.g. with interleukin-2, may poss
Since the Middle Ages, European society has passed through two successive stages in the civilizing process. Each has been attended by profound changes in psychological and social codes. These are examined in relation to a greater concern with health and hygiene in response to four waves of epidemics: leprosy, plague,
Diverse states of immunodeficiency are complicated by the development of various types of cancer. Most striking in nearly every type of immunodeficiency is a high incidence of a neoplasm of the immune system itself, the NHL, which consists of activated pathologic lymphocytes. Morphologically, these are mostly reticulu
The nonocular manifestations of parenteral drug abuse are presented to familiarize the ophthalmologist with this ever growing, medical and psychosocial problem. The ophthalmologist, like other primary care physicians, may be the first professional to encounter these patients whose substance abuse may lead to a wider s
Twenty-one male patients with acquired immune deficiency syndrome (AIDS), 6 male patients with AIDS-related complex (ARC) and 23 controls had a punch biopsy taken from clinically unaffected skin of the buttock. Vertical skin sections were examined by immunofluorescence for in vivo deposits of immunoglobulins (Ig) and
Ann Intern Med. 1986 Jul;105(1):37-44. Unique Identifier : AIDSLINE MED/86240507
Wharton JM; Coleman DL; Wofsy CB; Luce JM; Blumenfeld W; Hadley WK; Ingram-Drake L; Volberding PA; Hopewell PC
Forty patients with the acquired immunodeficiency syndrome (AIDS) and their first episodes of Pneumocystis carinii pneumonia were assigned at random to receive either trimethoprim-sulfamethoxazole or pentamidine isethionate. The two groups did not differ significantly in the severity of pulmonary or systemic processes
Activated B cells that spontaneously secrete immunoglobulin are found in homosexual men with AIDS or lymphadenopathy. These cells constitute a very small percentage of peripheral blood lymphocytes (usually less than 1%), making identification of their surface antigens difficult. To identify surface antigens on immunog
Shannon BT; Roach J; Cheek-Luten M; Orosz C; Ruymann FB
Fifty asymptomatic, pediatric hemophiliacs were examined for distribution of T-cell subsets, responsiveness to mitogen stimulation, interleukin-2 production, hypergammaglobulinemia, and the presence of antibody to virus including the human T-lymphotrophic virus type III (HTLV-III). Hemophilia A patients receiving fact
Vilcek J; Klion A; Henriksen-DeStefano D; Zemtsov A; Davidson DM; Davidson M; Friedman-Kien AE; Le J
Production of interferon (IFN)-gamma by peripheral blood leukocytes (PBL) was examined in cultures of unseparated fresh whole blood exposed to phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). The yield of IFN-gamma was measured by a newly developed immunoradiometric assay. Nine of 14 patien
In the context of a clinical phase I/II therapy study with recombinant interleukin-2 (rIL-2), we monitored immunological alterations in four patients with acquired immune deficiency syndrome (AIDS) and three patients with AIDS-related complex (ARC). By determining the surface phenotypes and in vitro functions of perip
In this Fourth Ruth Langton Memorial Lecture, the author highlights some of the major health problems in children, mentally and physically handicapped people, and in the growing numbers of elderly people in society. Nurses roles are discussed. He identifies many major areas of concern and points out that many of the
Patients with the acquired immunodeficiency syndrome (AIDS) are susceptible to a variety of opportunistic pathogens which require intact cellular immunity for control and eradication. We evaluated interleukin 1 and 2 production in 12 homosexual men without AIDS but with evidence of altered cell-mediated immunity and s
Hofmann B; Odum N; Jakobsen BK; Platz P; Ryder LP; Nielsen JO; Gerstoft J; Svejgaard A
The lymphocyte transformation responses to mitogens (phytohaemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM)), allogeneic cells, and the antigen-purified protein derivative (PPD) were studied in six acquired immunodeficiency syndrome (AIDS) patients and in six healthy controls, each of whom was H
Ann Intern Med. 1986 Jul;105(1):45-8. Unique Identifier : AIDSLINE MED/86240508
Leoung GS; Mills J; Hopewell PC; Hughes W; Wofsy C
All patients with the acquired immunodeficiency syndrome and a first episode of Pneumocystis carinii pneumonia seen at the San Francisco General Hospital between November 1984 and April 1985 were evaluated for oral treatment with dapsone (100 mg/d) plus trimethoprim (20 mg/kg body weight X d). All 15 patients who met
Danner SA; Schuurman HJ; Lange JM; Gmelig Meyling FH; Schellekens PT; Huber J; Kater L
Cultured thymic fragments were implanted in one patient with acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and in eight AIDS patients with opportunistic infections (OIs, four patients), Kaposi s sarcoma (KS, two patients), or both (two patients). Thereafter, objective clinical improvement was noted i
Four Ugandan patients (1 women, 3 men) with generalized Kaposi s sarcoma (KS) were seen in the Uganda Cancer Institute between October 1983 and December 1984. They presented with generalized lymphadenopathy, plaques/nodules on the body, general swelling of the head, oral and visceral involvement and respiratory distre
Forty-one cases of T cell lymphoma were identified on the basis of morphology and the expression of two or more T cell antigens with an absence of B cell markers. Mycosis fungoides and lymphoblastic lymphoma were excluded. Marked clinical, morphological, and immunologic diversity was observed. Cutaneous lymphoma was f
Migration-inhibitory factor (MIF) is a lymphokine that acts to localize mononuclear phagocytes (monocytes and macrophages) and perhaps to activate them. Mo cells are a human T cell leukemia virus II-infected T cell line previously shown to secrete large quantities of MIF upon stimulation with phytohemagglutinin and ph
Br Med J (Clin Res Ed). 1986 May 10;292(6530):1231-4. Unique Identifier : AIDSLINE MED/86217012
Goudsmit J; Wolters EC; Bakker M; Smit L; Van der Noordaa J; Hische EA; Tutuarima JA; Van der Helm HJ
De novo synthesis in the central nervous system of IgG antibodies to human T cell lymphotropic virus type III (HTLV-III) (lymphadenopathy associated virus) was shown in seven of 10 seropositive men who had syphilis but not the acquired immune deficiency syndrome (AIDS) or AIDS related complex. None of these men showed
C R Acad Sci III. 1986;302(8):287-92. Unique Identifier : AIDSLINE MED/86217387
Auffray C
HLA class II beta chains contain in their aminoterminal polymorphic domain a highly conserved tetrapeptide (RFDS) also present in protein F encoded by the LAV virus. Homology between this tetrapeptide and the fibronectin cell-attachment site (RGDS) has suggested a role in cell adhesion processes. I propose here that s
Cancer Res. 1986 Jul;46(7):3295-8. Unique Identifier : AIDSLINE MED/86217733
Kronke M; Schlick E; Waldmann TA; Vitetta ES; Greene WC
Adult T-cell leukemia is a progressive disease produced by infection of mature T-cells with the human T-lymphotropic virus-I (HTLV-I). These retrovirus infected T-cells express large numbers of receptors for interleukin 2 (or T-cell growth factor). Due to the presence of these receptors, these leukemic T-cells can be
Cell. 1986 Jun 6;45(5):637-48. Unique Identifier : AIDSLINE GENBANK/M17451
Starcich BR; Hahn BH; Shaw GM; McNeely PD; Modrow S; Wolf H; Parks ES; Parks WP; Josephs SF; Gallo RC; et al
To determine the extent and nature of genetic variation present in independent isolates of HTLV-III/LAV, the nucleotide sequences of the entire envelope gene and parts of gag and pol were determined for two AIDS viruses. The results indicated that variation throughout the viral genome is extensive and that the envelop
B-cell functions were investigated in a well-defined high-risk group for the development of AIDS/AIDS-related complex (ARC). Stimulation of mononuclear cells (MNC) with T-cell-independent polyclonal B-cell activators failed to increase high spontaneous IgG levels observed in vivo and in vitro. The secretion of IgM fol
Ghrayeb J; Kato I; McKinney S; Huang JJ; Chanda PK; Ho DD; Sarangadharan MG; Chang TW; Chang NT
Fragments of human T-cell lymphotropic virus type III (HTLV-III) proviral DNA carrying the gene for the core antigen (gag) was cloned in the plasmid REV. Several of the recombinants direct high levels of synthesis of the antigens. One clone, pG1, produced a hybrid protein containing 13 amino acid residues of the carbo
EMBO J. 1986 Mar;5(3):561-5. Unique Identifier : AIDSLINE MED/86220135
Seiki M; Inoue J; Takeda T; Yoshida M
Human T-cell leukemia virus type I has a unique sequence, pX, between the env gene and the 3 LTR (long terminal repeat). This sequence codes for p40x, which was proposed to trans-activate transcription from the LTR. Recently, we identified novel pX proteins coded by frame III, which mostly overlaps frame IV (x-lor, co
EMBO J. 1986 Apr;5(4):713-8. Unique Identifier : AIDSLINE MED/86220152
Fujisawa J; Seiki M; Sato M; Yoshida M
Human T-cell leukemia virus type I (HTLV-I) contains a unique sequence pX that is located between env and the 3 long terminal repeat (LTR) and codes for three pX proteins, p40 chi, pp27 chi-III and pp21 chi-III. One of these proteins, p40 chi, was previously shown to activate transcription from the LTR in a trans-act
FEBS Lett. 1986 May 12;200(2):327-32. Unique Identifier : AIDSLINE MED/86220768
Chandra A; Gerber T; Kaul S; Wolf C; Demirhan I; Chandra P
The immunological relationship between reverse transcriptases purified from human T-cell lymphotropic viruses (HTLV-I, HTLV-II, HTLV-III) was defined using monoclonal antibodies specific for HTLV-III reverse transcriptase, secreted by a mouse/mouse hybridoma clone (4F8) developed in our laboratory. The viral proteins
Nine pregnant women with the AIDS problem were under treatment and care at the Department of Gynaecology of the University of Berlin at Charlottenburg during 1985. Of these, seven had HTLV-III antibodies only, whereas one woman showed additional clinical signs such as lymphoadenopathy and opportunistic infections; ano
Geroldi D; Arico M; Plebani A; Maccario R; Notarangelo LD; Duse M; Rey F; Barre Sinoussi F; Chermann JC; Burgio GR
In order to confirm suspected LAV/HTLV III infection, serological evaluation of patients is of utmost importance. ELISA is currently being employed on a large scale for screening, but like the immunofluorescence assay, it has a variable rate of possible non-specific positivity. On the other hand, the Western Blot (WB)
Int J Cancer. 1986 Jun 15;37(6):911-7. Unique Identifier : AIDSLINE MED/86222793
Nakao Y; Matsuda S; Matsui T; Koizumi T; Katakami Y; Fujita T; Ito Y
To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated
There was 100% agreement between enzyme immunoassay (EIA) ( Abbott Laboratories ), Western blot, and indirect immunofluorescence (IF) when these three methods were used to measure antibody to the acquired immune deficiency syndrome (AIDS) virus in sera from 142 high-risk individuals
Techniques presently available for detection of human T-cell lymphotropic virus type III (HTLV-III) antigens and antibodies are laborious or relatively nonsensitive. We adapted anticomplementary immunofluorescence (ACIF) for these purposes. In HTLV-III-infected cells, specific ACIF was demonstrated by a diffuse speckl
22 homosexual or narcotic addict patients at risk for acquired immunodeficiency syndrome (AIDS) or with AIDS, were studied for the presence of antiimmunoglobulin antibodies and circulating immune complexes (20 were thrombocytopenic, 6 had AIDS). Circulating immune complex levels were 10-fold higher than levels in norm
We explored the possibility that normal human monocytes can be infected with the retrovirus human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). The T4 antigen, believed to be the receptor for HTLV-III/LAV binding to CD4 cells, is found on monocytes at low levels. Anti-T4A, which recogn
The human T-cell lymphotropic virus type III (HTLV-III/LAV) is a retrovirus associated with acquired immune deficiency syndrome. The region on the viral genome that is necessary for trans-activation of the HTLV-III/LAV long terminal repeat called tatIII has previously been determined to lie between nucleotides 5365 an
JAMA. 1986 Jun 20;255(23):3255-9. Unique Identifier : AIDSLINE MED/86227910
Mann JM; Francis H; Quinn T; Asila PK; Bosenge N; Nzilambi N; Bila K; Tamfum M; Ruti K; Piot P; et al
Surveillance for acquired immunodeficiency syndrome (AIDS) in Kinshasa, Zaire , was initiated in July 1984, using a modified version of the case definition developed by the Centers for Disease Control. During the first eight months, 332 patients met all clinical and laboratory crit
An increase in total urinary neopterin was observed in 12 of 13 patients with acquired immunodeficiency syndrome (AIDS), seven of 13 patients with lymphadenopathy, one of six healthy homosexual males, seven of ten adult patients with staphylococcal pneumonia, 11 of 12 children with viral infections, four of seven chil
Chosa T; Hattori T; Matsuoka M; Yamaguchi K; Yamamoto S; Takatsuki K
Antibodies against human T-cell lymphotropic virus type I (HTLV-I) in the sera from 60 patients with adult T-cell leukemia and 21 carriers who were suspected of having HTLV-I infection were investigated by indirect immunofluorescence assay (IFA), enzyme-linked immunosorbent assay (ELISA), membrane immunofluorescence a
Med J Aust. 1986 May 12;144(10):545-7. Unique Identifier : AIDSLINE MED/86230235
Biggs B; Newton-John HF
An acute febrile illness with mouth ulcers and a skin rash was observed in a 37-year-old homosexual man. Acute human T-lymphotropic virus type III (HTLV-III) infection was suspected. The clinical features were documented prospectively, and striking changes in circulating T lymphocytes were demonstrated shortly after t
Evidence is provided for the existence of a seventh gene in the genome of human T-lymphotropic virus type III/lymphadenopathy-associated virus. The gene is necessary for replication and acts post-transcriptionally to relieve negative regulation of the messenger RNA for the virion capsid and envelope proteins. These ob
Nature. 1986 May 22-28;321(6068):435-7. Unique Identifier : AIDSLINE MED/86230867
Murphey-Corb M; Martin LN; Rangan SR; Baskin GB; Gormus BJ; Wolf RH; Andes WA; West M; Montelaro RC
Acquired immune deficiency syndrome (AIDS) has become a worldwide epidemic, so the development of vaccines and antiviral agents effective against the causative agent, human T-lymphotropic virus type III (HTLV-III), is vital. This work would be greatly simplified if a suitable animal model could be developed. Here we r
We studied three patients with acquired immune deficiency syndrome (AIDS) and progressive polyradiculopathy. Postmortem examination of one patient disclosed extensive necrosis, inflammatory infiltrates, and focal vasculitis of spinal roots. Typical cytomegaloviral (
The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were u
Proc Natl Acad Sci U S A. 1986 Jun;83(11):4035-9. Unique Identifier : AIDSLINE MED/86233368
Koeffler HP; Miller C; Nicolson MA; Ranyard J; Bosselman RA
We examined synthesis of the cellular phosphoprotein p53 in fresh bone marrow or peripheral blood cells from normal donors and from patients with leukemia, preleukemia, or other hematopoietic disorders. Lysates of cells labeled with [35S]methionine were immunoprecipitated with monoclonal antibodies to p53, and the imm
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4143-6. Unique Identifier : AIDSLINE MED/86233388
Zamecnik PC; Goodchild J; Taguchi Y; Sarin PS
The possibility of using oligodeoxynucleotides complementary to viral RNA or proviral DNA to inhibit the replication of human T-cell lymphotropic virus type III (HTLV-III) [the etiological agent of acquired immunodeficiency syndrome (AIDS)] in cultured human cells was addressed by studying the association of 32P-label
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4297-301. Unique Identifier : AIDSLINE MED/86233417
De Rossi A; Franchini G; Aldovini A; Del Mistro A; Chieco-Bianchi L; Gallo RC; Wong-Staal F
We isolated six human T-cell lymphotropic virus type I (HTLV-I)-transformed T-cell clones carrying the phenotypic markers of helper and suppressor T cells. Five of the transformed T-cell clones produced infectious HTLV-I, but one (clone 55) contained a defective provirus and was therefore not competent for viral repli
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4524-8. Unique Identifier : AIDSLINE MED/86233459
Shimoyama M; Kagami Y; Shimotohno K; Miwa M; Minato K; Tobinai K; Suemasu K; Sugimura T
We describe five patients with adult T-cell leukemia/lymphoma (ATL) with neither integration of human T-cell leukemia virus type I (HTLV-I) into their leukemia cells nor anti-HTLV-I antibody in their sera. These findings indicate that HTLV-I may not have been involved in leukemogenesis in these patients. The clinicohe
Science. 1986 Jun 20;232(4757):1548-53. Unique Identifier : AIDSLINE GENBANK/M12507
Hahn BH; Shaw GM; Taylor ME; Redfield RR; Markham PD; Salahuddin SZ; Wong-Staal F; Gallo RC; Parks ES; Parks WP
In a study of genetic variation in the AIDS virus, HTLV-III/LAV, sequential virus isolates from persistently infected individuals were examined by Southern blot genomic analysis, molecular cloning, and nucleotide sequencing. Four to six virus isolates were obtained from each of three individuals over a 1-year or 2-yea
Sex Transm Dis. 1986 Apr-Jun;13(2):111-3. Unique Identifier : AIDSLINE MED/86235927
Nemeth A; Bygdeman S; Sandstrom E; Biberfeld G
An eight-year-old child from Zaire died in Sweden in 1982 after a clinical course compatible with the acquired immunodeficiency syndrome (AIDS). In 1975, at the age of 5 months, the infant had an acute viral infection with a rash; this illness
Unheated human serum does not lyse the AIDS-associated retrovirus (ARV), change the density of the virus, or suppress its ability to infect human peripheral mononuclear cells. The results indicate that ARV and the human oncovirus HTLV-I, unlike other animal retroviruses, are resistant to the effect of human serum. The
Z Geburtshilfe Perinatol. 1986 Mar-Apr;190(2):65-8. Unique Identifier : AIDSLINE MED/86237596
Muller JE; Distler W; von Kries R; Wahn V
In the past the acquired immune deficiency syndrome (AIDS) could be mainly observed in homosexual and drug addicted persons. But at present one has to deal with this problem in obstetrics as well. In this paper a report is given on the late pregnancy and delivery in a heroin addicted gravida with positive HTLV III ant
Z Hautkr. 1986 May 1;61(9):626-8, 633-4. Unique Identifier : AIDSLINE MED/86237634
Meigel W; Kern P; Dietrich M
The disseminated form of Kaposi s sarcoma (KS) is an important cutaneous manifestation of acquired immune deficiency syndrome (AIDS). Since 1983, we observed 5 patients suffering from this rare multifocal cancer associated with AIDS. We report on clinical picture, histopathologic changes, and immunologic parameters.
Haratake J; Horie A; Oda S; Chiba S; Kobori K; Sato H
Twelve autopsied cases with adult T-cell leukemia (ATL) were reviewed clinicopathologically. The prognosis of three cases who had suffered from severe cutaneous lesions was much better than that of the other nine cases with no or negligible cutaneous lesions. The surface marker of leukemic cells from six cases was ord
Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the for
Monozygotic twin girls discordant for acquired immunodeficiency syndrome were born to parents with antibodies to human T-cell lymphotropic virus type III. One twin had clinical evidence of the syndrome with tests positive for antibody, whereas the other at the age of 3 years was clinically, serologically, and virologi
Ann Intern Med. 1986 Jul;105(1):32-7. Unique Identifier : AIDSLINE MED/86240506
Levine AM; Gill PS; Cohen J; Hawkins JG; Formenti SC; Aguilar S; Meyer PR; Krailo M; Parker J; Rasheed S
The human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) requires reverse transcriptase for viral replication. We treated 12 patients who had acquired immunodeficiency syndrome and active HTLV-III/LAV viremia with suramin, a potent competitive inhibitor of reverse transcriptase, in six w
Blanche S; Fischer A; Le Deist F; Bremard-Oury C; Debre M; Montagnier L; Griscelli C
The clinical and immunologic abnormalities of 7 infants with Lymphadenopathy Associated Virus (LAV) infection are reported. Indicative immune changes, positive anti-LAV serologic test and/or virus isolation led to the diagnosis. In a case with a particularly severe form of the disease, whose mother died from AIDS, ser
Heat treatment at 60 degrees C for 10 h in solution (pasteurization) was introduced into the manufacturing process of factor VIII concentrate (Haemate P) in order to considerably reduce the risk of transmission of human pathogenic viruses to haemophiliacs. The results of experimental and clinical studies with regard t
Int J Cancer. 1986 Jun 15;37(6):843-7. Unique Identifier : AIDSLINE MED/86222783
Kotani S; Yoshimoto S; Yamato K; Fujishita M; Yamashita M; Ohtsuki Y; Taguchi H; Miyoshi I
Human T-cell leukemia virus type I (HTLV-I) was serially transmitted for 5 passages from rabbit to rabbit by blood transfusion. The virus could be transmitted with 20 ml of whole blood or washed blood cell suspension (fresh or stored for 1-2 weeks at 4 degrees C) but not with cell-free plasma from seroconverted rabbit
A review is presented of functional studies performed with the expanded T cells in Sezary syndrome, T-cell chronic lymphocytic leukemia (T-CLL), T-prolymphocytic leukemia (T-PLL), adult T-cell leukemia lymphoma (ATLL), T-cell acute lymphoblastic leukemia (T-ALL) and T gamma lymphocytosis. The immunological and clinica
Abuse of drugs, including some used clinically and others with no legal or clinical use, can cause ocular injury and disease. Ocular manifestations of drug abuse may be due to the substances themselves, to invasive methods of administration, or to injury suffered during states of altered consciousness. Grouping the dr
Unpublished brief: Available from the American Medical Association, 535 North Dearborn St., Chicago, Ill. 60610, 1985 Oct 11 21 p Unique Identifier : AIDSLINE KIE/20610
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