Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
CONTRIBUTIONS OF MODERN BIOLOGY TO MEDICINE. NEW APPROACHES IN PATHOGENESIS, DIAGNOSIS AND THERAPY IN IMMUNOLOGICAL AND HAEMATOLOGICAL DISORDERS
Serono Symp Publ Raven Press; 17:1-249 1985. Unique Identifier : AIDSLINE ICDB/86622144 Anonymous; No affiliation given
Abstract:
Contributions of modern biology to medicine, as discussed by various investigators who attended a Serono International Symposium, are organized in this book under different section headings. The immune response in health and disease is discussed under the following titles: molecular organization of humoral immunity: novel features of immunoglobulin gene expression and possible implications for oncogenesis; on the complexity of interferon-mediated natural killer (NK) regulation; biological role of major transplantation antigens in T cell self-recognition: possible consequences in clinical medicine; T cell subsets and their functions in primary immunodeficiencies; and non-infectious cofactors in the etiology of acquired immune deficiency syndrome (AIDS). Titles in the section on biological response modifiers are as follows: thymosin peptides: modulation of host defense by neuroendocrine circuits; growth factors: their production by antigen-activated T cell clones and their use for the in vitro analysis of human T cells and B cells; cloning, expression, and characterization of human interferon-beta, interferon-gamma, and interleukin 2 (IL2) genes; interferons as activators of gene expression: induction of messenger RNAs (mRNAs) specifying major histocompatibility complex antigens, (2'-5')(A)n synthetases, and proteins of unknown function; and IL2 in human immunodeficiency states: partial correction of T cell proliferation in vitro and in vivo by highly purified human lymphocyte IL2. Globinopathies are discussed under the following headings: pathogenesis of abnormal globin mRNA metabolism in beta-thalassemias; and regulation of fetal hemoglobin synthesis. The molecular and cellular pathogenesis, and etiology of malignant diseases are described under the following headings: the role of retroviruses and onc genes in some human leukemias and lymphomas; and alterations in the NK-cell population: phenotypic heterogeneity of granular lymphocytes in lymphoproliferative disorders. Diagnostic markers and new approaches to therapy are detailed under the following headings: differentiation antigens and lymphopoiesis; application of surface markers in the diagnosis of leukemia; differentiation of pre-B and pre-T leukemic cell lines by phorbol ester; definition and analysis of human cancer antigens with mouse and human monoclonal antibodies; and growth and differentiation factors in therapy: regulation of hematopoiesis and the normalization of leukemic cells.
Keywords: *Medicine *Molecular Biology MONOGRAPH
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
