Alteration of immune response induced by chronic intrarectal insemination in rabbits. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Alteration of immune response induced by chronic intrarectal insemination in rabbits.

AIDS Res. 1983-84;1(5):309-26. Unique Identifier : AIDSLINE MED/86242462
Wicher V; Wicher K; Albini B

Abstract: Three groups of adult male Nya:(FG) rabbits were treated intrarectally, 3 times a week for 7 months, with 1 ml of fresh homologous semen, 20 ml of colonic enema, or 20 ml of enema followed by 1 ml of previously frozen semen. A control group was untreated. The results of several in vitro tests of humoral and cellular response showed that chronic intrarectal insemination leads to an abrogation of the immune response, expressed differently in the two groups of rabbits receiving semen. A consistently depressed blastogenic stimulation in response to T-cell mitogens was observed only in the animals receiving fresh semen. Neither group produced antilymphocyte antibodies. Anti-seminal-fluid and antispermatozoa antibodies were detected after 3 months of treatment in two animals receiving enema and semen and one animal receiving fresh semen. Circulating immune complexes were detected after 2 months of treatment in animals receiving enema and semen. These immune complexes contained predominantly IgM and were specific for seminal antigens. Assay of the cellular response to a T-cell-dependent antigen showed, in the animals receiving enema and semen, a pronounced decrease in the indirect IgA and IgG plaque-forming cells response with practically no effect on the IgM response. These results, taken together with those of the preceding paper, suggest that in intrarectally inseminated rabbits the functional capabilities of the immune system may deteriorate without histologic or morphologic changes in the anorectal mucosa of relevant lymphoid tissues.
Keywords: Animal Antibodies/IMMUNOLOGY *Antibody Formation Antigen-Antibody Complex/ANALYSIS/IMMUNOLOGY Colon *Enema Enzyme-Linked Immunosorbent Assay IgM/ANALYSIS Immunity, Cellular *Insemination Kinetics Lymphocyte Transformation/DRUG EFFECTS Lymphocytes/IMMUNOLOGY Male Rabbits/BLOOD/*IMMUNOLOGY Spermatozoa/IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDanimalantibodies/immunologyKWDantibodyformationantigen-antibodycomplex/analysis/immunologycolonKWDenemaenzyme-linkedimmunosorbentassayigm/analysisimmunity,cellularKWDinseminationkineticslymphocytetransformation/drugeffectslymphocytes/immunologymalerabbits/blood/KWDimmunologyspermatozoa/immunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
861030
M86A0317

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .