Angio-proliferative lesions in a homosexual boar with features resembling Kaposi's sarcoma. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Angio-proliferative lesions in a homosexual boar with features resembling Kaposi's sarcoma.

AIDS Res. 1983-84;1(1):13-30. Unique Identifier : AIDSLINE MED/86242442
Prakash C; Cole CR; Sharma HM; Murray FA; Kooner DS; Hughes JH; Blakeslee JR Jr; Penn GM

Abstract: Clinical, biopsy and necropsy studies of a homosexual boar revealed angio-proliferative lesions in the skin of the thigh, scrotum and the inguinal lymph node. Angiofibromas were identified in the dermis and subcutis of the thorax and mandible. The avidin-biotin-peroxidase complex technique demonstrated Factor VIII-related antigen as a marker for the neoplastic endothelial cells of the tumors. This boar also showed weight loss and lymphopenia. Explants of tumors were maintained in cultures for 22 passages and cultured cells produced tumors when injected subcutaneously into nude mice. No viral antigen was detected in the cultured tumor cells. Similarities and differences between the lesions in the boar and human Kaposi's sarcoma are discussed.
Keywords: Animal Cells, Cultured Dermatofibroma/PATHOLOGY/*VETERINARY Hemangiosarcoma/PATHOLOGY/*VETERINARY Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Sarcoma, Kaposi's/*PATHOLOGY *Sex Behavior, Animal Skin/PATHOLOGY Skin Neoplasms/PATHOLOGY/*VETERINARY Support, U.S. Gov't, P.H.S. Swine Swine Diseases/*PATHOLOGY Transplantation, Heterologous JOURNAL ARTICLE

KWDanimalcells,cultureddermatofibroma/pathology/KWDveterinaryhemangiosarcoma/pathology/KWDveterinarymalemicemice,inbredbalbcmice,nudeneoplasmtransplantationsarcoma,kaposi's/KWDpathologyKWDsexbehavior,animalskin/pathologyskinneoplasms/pathology/KWDveterinarysupport,uKWDsKWDgov't,pKWDhKWDsKWDswineswinediseases/KWDpathologytransplantation,heterologousjournalarticle
861030
M86A0298

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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