The effect of seminal plasma on macrophage function--a possible contributory factor in sexually transmitted disease. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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The effect of seminal plasma on macrophage function--a possible contributory factor in sexually transmitted disease.

AIDS Res. 1983-84;1(1):45-57. Unique Identifier : AIDSLINE MED/86242444
James K; Harvey J; Bradbury AW; Hargreave TB; Cullen RT

Abstract: The present studies confirm that small doses of human seminal plasma inhibit mitogen induced lymphocyte transformation and experiments in a murine model suggest this effect may be mediated through accessory macrophages. They also reveal that seminal plasma interferes with the attachment, spreading and phagocytic activity of C. parvum elicited murine peritoneal macrophages and the release of reactive oxygen species from zymosan triggered human peripheral blood monocytes and neutrophils. As macrophages are known to programme various aspects of the immune response our results may be relevant to the acquired immune deficiency syndrome (AIDS), the genesis of antisperm antibodies and the response to prostatic and cervical cancer.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY Human Luminescence Lymphocyte Transformation Macrophages/*PHYSIOLOGY Male Semen/*PHYSIOLOGY Sexually Transmitted Diseases/*ETIOLOGY Superoxides/METABOLISM JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiologyhumanluminescencelymphocytetransformationmacrophages/KWDphysiologymalesemen/KWDphysiologysexuallytransmitteddiseases/KWDetiologysuperoxides/metabolismjournalarticle
861030
M86A0297

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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