Epstein-Barr virus and chronic lymphadenomegaly in male homosexuals with acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Epstein-Barr virus and chronic lymphadenomegaly in male homosexuals with acquired immunodeficiency syndrome (AIDS).

AIDS Res. 1983-84;1(1):59-82. Unique Identifier : AIDSLINE MED/86242445
Lipscomb H; Tatsumi E; Harada S; Yetz J; Davis J; Bechtold T; Volsky DJ; Kuszynski C; Purtilo DT; Sonnabend J; et al

Abstract: Male homosexuals at risk for developing AIDS frequently exhibit chronic lymphadenomegaly (LAD). They are at high risk for developing malignant B cell lymphomas. A study of Epstein-Barr virus (EBV) revealed marked abnormalities in these patients. One hundred percent of the patients were seropositive. The patients with most severe acquired immune deficiency disorders manifested a decreased number of circulating B cells with EBV receptors and decreased lymphocyte transformation. Patients often showed defective memory T cell cytotoxic responses to autologous EBV infection in vitro. Three of five lymph node specimens contain significant EBV genome copies to suggest a significant etiologic role. In addition, a Burkitt-like lymphoma carried EBV genome. Although all of the men were seropositive for EBV, reactivation patterns were not as common as anticipated. Given the presence of EBV genome in the lymph nodes of the patients who lack anti-early antigen (EA) antibodies indicative of reactivation, we suggest that reliance on serology to indicate EBV involvement is insufficient for assessing the patient. The detection of a t(8;14) transposition in the monoclonal mu kappa Burkitt-like lymphoma containing EBV genome supports the view that cytogenetic transposition is a mechanism in lymphomagenesis.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY/*MICROBIOLOGY Antibodies, Viral/ANALYSIS Chromosome Aberrations Chronic Disease DNA, Viral/ANALYSIS Genes, Viral Herpesvirus 4, Human/GENETICS/*PATHOGENICITY *Homosexuality Human Immunoglobulins/ANALYSIS Lymphatic Diseases/ETIOLOGY/*MICROBIOLOGY Lymphoma/ETIOLOGY Male Nucleic Acid Hybridization Receptors, Virus/ANALYSIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiology/KWDmicrobiologyantibodies,viral/analysischromosomeaberrationschronicdiseasedna,viral/analysisgenes,viralherpesvirus4,human/genetics/KWDpathogenicityKWDhomosexualityhumanimmunoglobulins/analysislymphaticdiseases/etiology/KWDmicrobiologylymphoma/etiologymalenucleicacidhybridizationreceptors,virus/analysissupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
861030
M86A0296

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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