Kaposi's sarcoma: immunoperoxidase staining for cytomegalovirus. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Kaposi's sarcoma: immunoperoxidase staining for cytomegalovirus.

AIDS Res. 1983-84;1(2):121-5. Unique Identifier : AIDSLINE MED/86242448
Civantos J; Penneys N; Ziegels-Weissman J

Abstract: An immunoperoxidase technique was used to test for cytomegalovirus (CMV) proteins in lesions of Kaposi's sarcoma from 19 patients with acquired immune deficiency syndrome (AIDS) and 3 patients without AIDS. CMV proteins could not be detected in any of the cases of Kaposi's sarcoma. Thus, while CMV genetic material may be present in these cells, the virus is not actively directing the synthesis of proteins. This eliminates reactivation of latent CMV in tumor tissue, or late infection of Kaposi's sarcoma cells as explanations for the elevated antibody titers to CMV and other evidence of CMV infection in patients with Kaposi's sarcoma. However, the possibility remains that exposure to CMV occurs as a primary event in the development of Kaposi's sarcoma. These findings indicate that, as in Kaposi's sarcoma of the elderly, the virus is inactive in Kaposi's sarcoma cells of patients with AIDS, and there is no difference between the two lesions in immunoperoxidase staining for CMV proteins.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Antibodies, Monoclonal/DIAGNOSTIC USE Antigens, Viral/*IMMUNOLOGY Cytomegalovirus/*IMMUNOLOGY Cytomegalovirus Infections/*IMMUNOLOGY Human Immunoenzyme Techniques Sarcoma, Kaposi's/IMMUNOLOGY/*MICROBIOLOGY Viral Proteins/*ANALYSIS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDmicrobiologyantibodies,monoclonal/diagnosticuseantigens,viral/KWDimmunologycytomegalovirus/KWDimmunologycytomegalovirusinfections/KWDimmunologyhumanimmunoenzymetechniquessarcoma,kaposi's/immunology/KWDmicrobiologyviralproteins/KWDanalysisjournalarticle
861030
M86A0294

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .