Lack of specific cell mediated immunity to cytomegalovirus in people at risk for AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Lack of specific cell mediated immunity to cytomegalovirus in people at risk for AIDS.

AIDS Res. 1983-84;1(2):99-105. Unique Identifier : AIDSLINE MED/86242454
Sirianni MC; Testi R; Bonomo G; Aiuti F; Morrone A

Abstract: Twenty apparently healthy homosexuals from Italy and five patients with lymphadenopathic syndrome (LAS) were studied for specific cell mediated immunity (CMI) to Cytomegalovirus (CMV), by means of the leukocyte migration inhibition test (LMIT). Total circulating T cells and T cell subpopulations were also investigated by the use of specific monoclonal antibodies of the OK series. An inverted OKT4/T8 ratio was also found in about 30% of subjects. CMV was recovered from the urine of three homosexuals and high specific antibody titers were found in all the people studied. In addition we found a lack of specific CMI to CMV in 18 homosexuals and in 3 patients with LAS. We think that CMV can induce a state of immune tolerance in people at risk for AIDS which may contribute to promote the disease.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Antibodies, Monoclonal/DIAGNOSTIC USE Cell Migration Inhibition Cytomegalovirus/*IMMUNOLOGY Cytomegalovirus Infections/IMMUNOLOGY Female Homosexuality Human Immunity, Cellular Leukocyte Count Leukocyte Migration-Inhibitory Factors/BIOSYNTHESIS Leukocytes/IMMUNOLOGY Lymphatic Diseases/IMMUNOLOGY Lymphocytes Male Middle Age Risk T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultantibodies,monoclonal/diagnosticusecellmigrationinhibitioncytomegalovirus/
861030
M86A0293

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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