Natural history of the AIDS related complex in hemophilia--relationships to Epstein Barr virus. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Natural history of the AIDS related complex in hemophilia--relationships to Epstein Barr virus.

AIDS Res. 1983-84;1(3):197-209. Unique Identifier : AIDSLINE MED/86242458
Gervais F; Tsoukas C; Fuks A; Shuster J

Abstract: Several cases of hemophiliacs with AIDS have been reported. These case reports have prompted studies of asymptomatic healthy hemophiliacs. During these studies, we found four hemophiliacs who presented a distinct clinical syndrome identical to the lymphadenopathy syndrome in homosexuals which has been considered a prodrome to AIDS. Our results demonstrated that the AIDS related complex in hemophiliacs is characterized by recurrent herpes viral infections. Furthermore, the clinical and laboratory data in these patients suggest that this syndrome does not inexorably lead to AIDS, and may be a manifestation of a group of disorders in which AIDS represents one end of the spectrum.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY Adult Antigens, Viral/ANALYSIS Case Report Disease Susceptibility Factor VIII/ADMINISTRATION & DOSAGE Hemophilia/*COMPLICATIONS/IMMUNOLOGY/THERAPY Herpesviridae Infections/*COMPLICATIONS/IMMUNOLOGY Herpesvirus 4, Human/IMMUNOLOGY/*PATHOGENICITY Human Immunity, Cellular Lymphatic Diseases/*ETIOLOGY/IMMUNOLOGY Lymphocyte Transformation Male Middle Age Recurrence Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiology/immunologyadultantigens,viral/analysiscasereportdiseasesusceptibilityfactorviii/administration&dosagehemophilia/KWDcomplications/immunology/therapyherpesviridaeinfections/KWDcomplications/immunologyherpesvirus4,human/immunology/KWDpathogenicityhumanimmunity,cellularlymphaticdiseases/KWDetiology/immunologylymphocytetransformationmalemiddleagerecurrencesupport,non-uKWDsKWDgov'tjournalarticle
861030
M86A0292

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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