HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy.

AIDS Res. 1984-85;1(6):447-54. Unique Identifier : AIDSLINE MED/86242475
Epstein LG; Sharer LR; Cho ES; Myenhofer M; Navia B; Price RW

Abstract: It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY Adult Astrocytes/CYTOLOGY/ULTRASTRUCTURE Brain/MICROBIOLOGY/*ULTRASTRUCTURE Brain Diseases/*ETIOLOGY Case Report Child Human HTLV-BLV Viruses/ANALYSIS/*ULTRASTRUCTURE Macrophages/CYTOLOGY/ULTRASTRUCTURE Male Microscopy, Electron Retroviridae/ANALYSIS/*ULTRASTRUCTURE Retroviridae Infections/COMPLICATIONS Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiologyadultastrocytes/cytology/ultrastructurebrain/microbiology/KWDultrastructurebraindiseases/KWDetiologycasereportchildhumanhtlv-blvviruses/analysis/KWDultrastructuremacrophages/cytology/ultrastructuremalemicroscopy,electronretroviridae/analysis/KWDultrastructureretroviridaeinfections/complicationssupport,non-uKWDsKWDgov'tjournalarticle
861030
M86A0286

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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