[Disseminated cryptococcosis in 2 AIDS patients. A contribution to cryptococcosis diagnosis in AIDS] NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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[Disseminated cryptococcosis in 2 AIDS patients. A contribution to cryptococcosis diagnosis in AIDS]

Dtsch Med Wochenschr. 1986 Jul 4;111(27):1061-5. Unique Identifier : AIDSLINE MED/86247149
Staib F; Rogler G; Prufer-Kramer L; Seibold M; Eichenlaub D; Pohle HD

Abstract: In two AIDS patients (homosexual men) microscopical demonstration of Cryptococcus neoformans in samples obtained by puncture of the liver (n = 1) and additionally of the spleen (n = 1) led to the diagnosis of systemic cryptococcosis. Using the India ink method capsulated Cryptococcus neoformans cells could also be detected in cerebrospinal fluid (CSF) and urine. Concomitant culture of the fungus from tracheal secretion, CSF, urine and faeces confirmed the diagnosis of a disseminated infection; the identification and germ count of C. neoformans was achieved by means of the differential-selective medium Guizotia-abyssinica-creatinine agar. The C. neoformans antigen titres in serum and CSF corresponded to the stage of the mycosis as detected by microscopy and culture. After a six-week course of treatment with amphotericin B and flucytosine (Ancotil), the fungus could no longer be isolated from the materials examined in one patient. Mycological monitoring aiming at the detection of C. neoformans in the tracheal secretions by means of the mentioned differential-selective medium is therefore recommended as a prophylactic measure in AIDS patients and persons at risk.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY Adult Amphotericin B/THERAPEUTIC USE Case Report Cryptococcosis/*DIAGNOSIS/DRUG THERAPY English Abstract Flucytosine/THERAPEUTIC USE Human Male JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosis/drugtherapyadultamphotericinb/therapeuticusecasereportcryptococcosis/KWDdiagnosis/drugtherapyenglishabstractflucytosine/therapeuticusehumanmalejournalarticle
861030
M86A0277

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