Laboratory investigation of pediatric acquired immunodeficiency syndrome.

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Laboratory investigation of pediatric acquired immunodeficiency syndrome.

Clin Immunol Immunopathol. 1986 Jul;40(1):122-7. Unique Identifier : AIDSLINE MED/86245744
Ammann AJ; Levy J

Abstract: Unique laboratory abnormalities, found in pediatric patients with clinical features of immunodeficiency, led to the original observation that a syndrome of acquired immunodeficiency (AIDS) was also occurring in pediatric populations. Initial observations which demonstrated the nonspecific findings of polyclonal hypergammaglobulinemia and T-cell deficiency were followed by confirmatory findings when testing for the AIDS retrovirus became available. In the pediatric population availability of antibody testing and viral isolation became critical in differentiating primary immunodeficiency disorders which involved both the B- and T-cell systems from AIDS associated with retrovirus infection. At this time based upon clinical, epidemiologic, immunologic, and serologic studies, the syndrome of pediatric AIDS can be distinguished from other primary and secondary pediatric immunodeficiency disorders.

Keywords: Acquired Immunodeficiency Syndrome/DIAGNOSIS/EPIDEMIOLOGY/ *IMMUNOLOGY Adolescence Antibodies, Viral/ANALYSIS B-Lymphocytes/IMMUNOLOGY Child Child, Preschool Diagnosis, Differential Human HTLV-BLV Viruses/IMMUNOLOGY Immunity, Cellular Infant Monocytes/IMMUNOLOGY Phagocytosis T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE REVIEW

861030
M86A0128

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