THE FAMILY OF HUMAN T-CELL LEUKEMIA VIRUSES AND THEIR ROLE IN THE CAUSE OF T-CELL LEUKEMIA AND AIDS

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

THE FAMILY OF HUMAN T-CELL LEUKEMIA VIRUSES AND THEIR ROLE IN THE CAUSE OF T-CELL LEUKEMIA AND AIDS

Dev Oncol; 28:191-205 1985. Unique Identifier : AIDSLINE ICDB/86621735
Gallo RC; Shaw G; Hahn B; Wong-Staal F; Popovic M; Schupbach J; Sarngadharan MG; Arya S; Salahuddin SZ; Reitz MS Jr; Lab. of Tumor Cell Biology, Developmental Therapeutics Program,; Div. of Cancer Treatment, NCI, Bethesda, MD 20205

Abstract: The family of human T-cell leukemia viruses (HTLV) and their etiological role in adult T-cell leukemia and acquired immunodeficiency syndrome are discussed and HTLV genomic structure and transforming properties and mechanisms are described. The term HTLV has been used to designate the members of a family of three highly distinct, but related, virus groups, HTLV-I, II, and III, which infect and have major effects on OKT4+ T cells. HTLV-I is highly associated with adult T-cell leukemia and its identification helped establish ATLL as a distinct worldwide clinicopathologic entity. Its biology in vitro appears to mimic at least some of its activity in vivo, and provides in many respects a model system for the disease. Infection in vitro results in cell transformation, loss of immune function, and in some instances selective T-cell death. HTLV-II, brings about many of the same changes in infected T cells as HTLV-I, but presently is not associated with any disease. HTLV-III seems highly likely to be the cause of AIDS. It is found in the overwhelming majority of AIDS and pre-AIDS patients, and its cytopathic effect in vitro against OKT4+ cells mimics what occurs in vivo in AIDS. (53 Refs)

Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Adult Base Sequence Cell Transformation, Neoplastic Cell Transformation, Viral DNA, Viral/GENETICS Human HTLV-BLV Viruses/GENETICS/ULTRASTRUCTURE Leukemia/*MICROBIOLOGY Microscopy, Electron Retroviridae Infections/*MICROBIOLOGY RNA, Viral/GENETICS T-Lymphocytes/MICROBIOLOGY Viral Proteins/GENETICS MEETING PAPER

861130
M86B0253

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .