HUMAN RETROVIRUS IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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HUMAN RETROVIRUS IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)

Dev Oncol; 28:232-9 1985. Unique Identifier : AIDSLINE ICDB/86621738
Francis DP; Cabradilla CD; Feorino PM; Kalyanaraman VS; Div. of Viral Diseases, Center for Infectious Disease, Centers; for Disease Control, Atlanta, GA 30333

Abstract: Epidemiological and other evidence that lymphadenopathy-associated virus (LAV) is the etiologic agent in acquired immune deficiency syndrome (AIDS) is reviewed. Criteria that are addressed are: presence of markers of infection in virtually all AIDS patients (pts), prevalence of antibody in groups at risk of AIDS, infection with virus prior to onset of AIDS, successful experimental infection, and overall biological sense of the LAV/AIDS relationship. Evidence on all these points suggests that LAV is the etiologic agent of AIDS. Remaining questions include the similarity of LAV and human T-cell leukemia virus (HTLV)-III; they appear to be the same virus, but more comparison is necessary. More studies are necessary to complete our understanding of the etiologic association and more details of the virus's natural history are needed to determine why some pts develop severe disease and others do not. In addition, the geographical source of LAV remains to be determined. (15 Refs)
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Antibodies, Viral/ANALYSIS Homosexuality Human HTLV-BLV Viruses/IMMUNOLOGY/ISOLATION & PURIF Retroviridae/IMMUNOLOGY Retroviridae Infections/IMMUNOLOGY/*MICROBIOLOGY Risk MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/immunology/KWDmicrobiologyantibodies,viral/analysishomosexualityhumanhtlv-blvviruses/immunology/isolation&purifretroviridae/immunologyretroviridaeinfections/immunology/KWDmicrobiologyriskmeetingpaper
861130
M86B0250

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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