FELINE LEUKEMIA AND SARCOMA VIRUSES NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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FELINE LEUKEMIA AND SARCOMA VIRUSES

Dev Oncol; 28:289-305 1985. Unique Identifier : AIDSLINE ICDB/86621743
Hardy WD Jr; Lab. of Veterinary Oncology, Memorial Sloan Kettering Cancer; Center, New York, NY 10021

Abstract: Virology, epidemiology, immunology, and disease states associated with feline leukemia virus (FeLV) and feline sarcoma viruses (FeSVs) are reviewed. FeLV replicates in rapidly dividing cells and can produce proliferative and degenerative diseases. The fate of the FeLV-exposed cat depends on its immune response to the viral gp70, virus neutralizing antibody and to the FeLV-induced tumor-specific feline oncornavirus associated cell membrane antigen. The most frequent clinical consequence of FeLV infection is severe immunosuppression. The cat genome contains 8 to 12 discrete copies of endogenous FeLV-related sequences arranged in a non-tandem fashion. Although there is no clear association of any of the three subgroups of FeLV with any specific disease, one strain of FeLV has induced mainly thymic lymphosarcomas (LSAs) and several isolates of another subgroup have induced erythroid hypoplasia. Defective FeLV proviruses containing the myc oncogene have been found in the DNA of 8 of 58 pet cats with FeLV-positive thymic LSAs. It is not clear, however, what, if any, relationship these defective myc-containing proviruses have to the etiology of feline LSAs. FeSVs are replication defective acute transforming retroviruses that possess oncogenes acquired through recombination of the FeLV genome with cellular c-onc genes. FeSVs induce neoplasms in a short latent period and transform cells of various species in vitro. To date there are 10 well characterized isolates; seven oncogenes have been transduced by FeSVs. (77 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Animal Base Sequence Cats DNA, Viral/GENETICS Leukemia Virus, Feline/GENETICS Leukemia, Experimental/*MICROBIOLOGY Oncogenes Recombination, Genetic Sarcoma Virus, Feline/GENETICS Tumor Virus Infections/*MICROBIOLOGY Virus Activation MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/microbiologyanimalbasesequencecatsdna,viral/geneticsleukemiavirus,feline/geneticsleukemia,experimental/KWDmicrobiologyoncogenesrecombination,geneticsarcomavirus,feline/geneticstumorvirusinfections/KWDmicrobiologyvirusactivationmeetingpaper
861130
M86B0245

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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