Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
PRIMATE RETROVIRUSES AND AIDS
Dev Oncol; 28:332-7 1985. Unique Identifier : AIDSLINE ICDB/86621746 Gardner MB; Dept. of Pathology, Univ. of California, Davis, CA 95817
Abstract:
Evidence for a retroviral etiology of Simian acquired immune deficiency syndrome (SAIDS) is reviewed and the human and monkey syndrome, and their respective retroviruses, are compared. Several epidemiologic, virologic, and serologic findings support a retroviral etiology for SAIDS. Both SAIDS and AIDS are infectious, exhibit similar epidemiologic, immunologic, and pathologic features, and are apparently caused by exogenous retroviruses. The opportunistic infections and tumors in both syndromes are alike with the exception that Pneumocystis carinii and disseminated Kaposi's sarcoma are much less common in SAIDS. Victims of both syndromes exhibit a severe impairment of cellular and humoral immune function; in SAIDS this takes the form of a severe depletion of both T and B cells without the early reversal of the helper-suppressor cell ratio or polyclonal hypergammopathy as often seen in prodromal AIDS. The SAIDS retrovirus isolates are morphologically indistinguishable from human T-cell lymphotropic retrovirus (HTLV)-III and lymphadenopathy associated virus (LAV) in that the extracellular particles have a similar type D structure. The monkey and human viruses are unrelated antigenically: human sera reactive with major core protein p25 of LAV fail to react with the major core protein p27 of the SAIDS virus. The SAIDS type D family viruses may be the macaque counterpart of human HTLV-III/LAV retroviruses, but the AIDS agents are unique to each species. The retroviruses responsible for AIDS in monkeys and humans may have had a common origin based upon their morphology, Mg++-dependent reverse transcriptase activity, and cytopathic effect on lymphoid cells. However, compared to the HTLV family, the SAIDS virus has a much broader cell tropism, and is not restricted to T4 helper cells. (21 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Animal Haplorhini HTLV-BLV Viruses/ISOLATION & PURIF Retroviridae/ISOLATION & PURIF Retroviridae Infections/*MICROBIOLOGY T-Lymphocytes, Helper-Inducer/MICROBIOLOGY MEETING PAPER
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
