Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
MOLECULAR COMPARISONS OF THE D-TYPE RETROVIRUSES
Dev Oncol; 28:338-53 1985. Unique Identifier : AIDSLINE ICDB/86621747 Hunter E; Barker CS; Bradac J; Chatterjee S; Desrosiers R; Wills JW; Univ. of Alabama, Lab. for Special Cancer Res., Birmingham, AL; 35294
Abstract:
Molecular studies of the D-type retroviruses are reviewed, including protein biosynthesis, comparative studies of retrovirus nucleic acids, and properties of D-type retroviruses associated with Simian acquired immune deficiency syndrome (SAIDS). D-type retroviruses have been isolated from Old World monkeys (Mason-Pfizer monkey virus (M-PMV), X-381, FTP-1, SAIDS-D/NE, SAIDS-D/CA, SAIDS-D/W, Po-1-Lu), New World monkeys (squirrel monkey retrovirus), and man ('HeLa' isolates). Characteristics of D-type retroviruses are the following: (1) bud from the cell membrane with complete nucleoid, (2) assemble intracytoplasmic A-type particles, (3) have extracellular particles with nucleoid, but lacking prominent surface projections, (4) have a density of 1.16 in sucrose/1.21 in CsCl, (5) possess Mg++-dependent reverse transcriptase, and (6) induce cell-to-cell fusion of normal cells. Molecular weights of the individual structural polypeptides of the various retroviruses differ, but the functional domains are invariably located in the same relative positions on the precursor protein, and are arranged in the order: NH2-membrane-associated protein-phosphoprotein (RNA binding)-major capsid protein-ribonucleoprotein-COOH. Comparisons of the D-type viral proteins at the molecular level generally are supported by their antigenic relationships. SAIDS-D viral isolates have properties that clearly place them within the D-type retrovirus groups, as follows: (1) assembly of intracytoplasmic A-type particles, (2) preference for Mg over Mn by reverse transcriptase, (3) fusion of human lymphoid cells with normal rhesus cells, (4) antigenic identity between major core protein p27 and M-PMV, and (5) nucleic acid homology with M-PMV and langur virus. D-type Simian viruses share important characteristics with human T-cell leukemia virus (HTLV)-III/lymphadenopathy-associated virus, including Mg preference of their reverse transcriptase, cylindrically shaped cores of mature particles, and the ability to cause cell-to-cell fusion of human and/or primate cells. (47 Refs)
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Animal Base Sequence DNA, Viral/ANALYSIS Genes, Viral Glycoproteins/ANALYSIS Human Macaca Peptides/ANALYSIS Retroviridae/*ANALYSIS/GENETICS Retroviridae Proteins/ANALYSIS Viral Envelope Proteins/ANALYSIS Viral Proteins/*ANALYSIS/GENETICS MEETING PAPER
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Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
