Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
CANCER GENETICS: A SURVEY
Biomarkers, Genetics, and Cancer. Anton-Guirgis H, Lynch HT, eds. New York, Van Nostrand Reinhold Company, p. 81-152, 1985.. Unique Identifier : AIDSLINE ICDB/86622764 Lynch HT; Schuelke GS; Danes BS; Lynch JF; Dept. of Preventive Medicine and Public Health, Creighton Univ.; Sch. of Medicine, Omaha, NE 68178
Abstract:
Cancer liability can be depicted operationally as a combination of genetic susceptibility and environmental exposure. Identification of hereditary influences may be best approached through family studies wherein pedigree analysis may aid in their delineation. Selected facets of human cancer genetics are discussed under the following headings: lung cancer genetics (familial lung cancer clustering; lung cancer and chronic obstructive pulmonary disease; alpha-1-antitrypsin deficiency), breast cancer genetics (genetic heterogeneity in breast cancer; gene linkage; endocrine studies; in vitro hyperdiploidy), colon cancer genetics (in vivo tetraploidy in hereditary colonic cancer; HLA in the cancer family syndrome; cytoskeletal actin in cultured skin fibroblasts; proliferative lesions of colonic epithelial cells; immune competence; additional biomarker findings in cancer family syndrome and hereditary site-specific colorectal cancer), malignant melanoma and other cancer-associated genodermatoses (the familial atypical multiple mole melanoma syndrome), miscellaneous problems (hereditary ovarian carcinoma; hepatocellular carcinoma; Epstein-Barr virus-associated malignancies; human T-cell leukemia/lymphoma virus), and future projections. It is shown in this survey that it is possible to identify patients who are at an exceedingly high risk for development of cancer. In certain settings, such as multiple endocrine neoplasia types II and III, the use of a biomarker (in this case, calcitonin, with pentagastrin stimulation if needed) may aid in the diagnosis of susceptibility to medullary thyroid carcinoma and possible associated pheochromocytoma. Finally, the issue of gene therapy is considered. (225 Refs)
Keywords: Bibliography Breast Neoplasms/GENETICS Carcinoma, Hepatocellular/GENETICS Colonic Neoplasms/GENETICS/IMMUNOLOGY/MORTALITY Colonic Polyps/GENETICS Disease Susceptibility Female Human HLA Antigens/GENETICS HTLV-BLV Viruses Immunocompetence Leukemia/GENETICS Linkage (Genetics) Liver Neoplasms/GENETICS Lung Diseases, Obstructive/GENETICS Lung Neoplasms/GENETICS Male Melanoma/GENETICS Neoplasms/*GENETICS Neoplasms, Multiple Primary/GENETICS/PATHOLOGY Nevus, Pigmented/GENETICS/PATHOLOGY Ovarian Neoplasms/GENETICS Pedigree Phenotype Ploidies Retroviridae Infections/GENETICS Skin/ULTRASTRUCTURE Skin Diseases/GENETICS Skin Neoplasms/GENETICS/PATHOLOGY Space-Time Clustering Syndrome Variation (Genetics) BIBLIOGRAPHY MONOGRAPH REVIEW
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
