THE USE OF IMMUNOCYTOCHEMICAL TECHNIQUES IN THE DIAGNOSIS OF LYMPHORETICULAR PROLIFERATIONS

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

THE USE OF IMMUNOCYTOCHEMICAL TECHNIQUES IN THE DIAGNOSIS OF LYMPHORETICULAR PROLIFERATIONS

Dev Oncol; 34:141-73 1985. Unique Identifier : AIDSLINE ICDB/86626483
Giraldo AA; Meis JM; Dept. of Pathology, St. John Hosp., Detroit, MI 48236

Abstract: Experience with the use of immunological techniques (immunofluorescence, immunoperoxidase, rosette) in 405 cases of lymphoreticular proliferations is described. The cases involved studies carried out on cell suspensions of solid tissues (lymph nodes, gastric lymphomas) and studies carried out on markers on lymphoid cells of various body fluids (pleural effusion, cerebrospinal fluid (CSF)) and of peripheral blood and bone marrow. Indications, findings, and interpretation are included for the following: normal peripheral blood; peripheral bloods of patients (pts) with benign and malignant conditions (eg, lymphopenia, autoimmune diseases, congenital immunodeficiency, chronic lymphocytic leukemia, acute lymphoblastic leukemia (ALL), and poorly-differentiated lymphocytic lymphoma); bone marrows of normal subjects, ALL pts, and other pts; pleural effusions and CSFs of pts with benign and malignant conditions; and studies in solid tissues (lymph nodes from pts with benign or reactive proliferations, with non-Hodgkin's lymphomas of B cell type, with non-Hodgkin's lymphoma of T cell type, with Hodgkin's lymphoma, or with metastatic tumor of non-lymphoid origin; solid tissues of non-nodal origin, including benign and malignant mediastinal, pelvic, and other tissues). This review shows the value of immunologic evaluation of B and T cell markers in the diagnostic immunopathology laboratory. Development of new monoclonal antibodies and instrumentation continually expands the types of neoplasms that can be diagnosed. (14 Refs)

Keywords: Acquired Immunodeficiency Syndrome/DIAGNOSIS B-Lymphocytes/IMMUNOLOGY Bone Marrow Examination/METHODS Fluorescent Antibody Technique Human Immunoenzyme Techniques Immunoglobulins, Surface/ANALYSIS *Immunologic Techniques Lymph Nodes/PATHOLOGY Lymphoma/DIAGNOSIS/PATHOLOGY Lymphoma, Diffuse/DIAGNOSIS/PATHOLOGY Lymphoma, Large-Cell/DIAGNOSIS/PATHOLOGY Lymphoproliferative Disorders/*DIAGNOSIS/PATHOLOGY Pleural Effusion/PATHOLOGY Reference Values Specimen Handling T-Lymphocytes/IMMUNOLOGY MEETING PAPER

861130
M86B0234

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