More than 400 entries to literature for books, newspapers, periodicals, and the gay press, as well as nontechnical articles from scientific and health journals. Clinical citations were excluded. Chronological arrangement ranging from 1981-1983. Miscellaneous appendixes contain lists of organizations, services, and new
New Horiz Oncol; 3:33-44 1984. Unique Identifier : AIDSLINE ICDB/86621773
Weiss RA; Inst. of Cancer Res., Royal Cancer Hosp., Chester Beatty Lab.,; London, England
Several viruses can cause cancer in man and animals. These viruses probably induce malignancy by different mechanisms, and interact with different environmental and host cofactors. Malignant disease is a rare result of infection and may occur many years after initial infection. In many cases the viral genome, or a par
Dev Oncol; 28:1-409 1985. Unique Identifier : AIDSLINE ICDB/86621720
Anonymous; No affiliation given
This volume presents the proceedings of the International Conference on RNA Tumor Viruses in Human Cancer, held in Denver, Colorado on 10-14 June 1984. A section on molecular genetics of the RNA tumor viruses includes papers dealing with the following topics: the myc genetic element, viral and cellular fos gene, P21 r
Investigations of the characteristics of the sis oncogene, originally isolated from simian sarcoma virus (SSV), are reviewed. The results of analyses to determine the nucleotide sequence, identify the SSV transforming protein, and characterize the relationship between the SSV transforming protein and human platelet-de
Dev Oncol; 28:191-205 1985. Unique Identifier : AIDSLINE ICDB/86621735
Gallo RC; Shaw G; Hahn B; Wong-Staal F; Popovic M; Schupbach J; Sarngadharan MG; Arya S; Salahuddin SZ; Reitz MS Jr; Lab. of Tumor Cell Biology, Developmental Therapeutics Program,; Div. of Cancer Treatment, NCI, Bethesda, MD 20205
The family of human T-cell leukemia viruses (HTLV) and their etiological role in adult T-cell leukemia and acquired immunodeficiency syndrome are discussed and HTLV genomic structure and transforming properties and mechanisms are described. The term HTLV has been used to designate the members of a family of three high
The main characteristics of lymphadenopathy associated virus (LAV) are summarized and the relationship of this virus to acquired immune deficiency syndrome (AIDS) is discussed. LAV1 was isolated from lymph node tissue of a French homosexual with lymphadenopathy syndrome (LAS). LAV is similar to human T-cell leukemia v
Dev Oncol; 28:218-31 1985. Unique Identifier : AIDSLINE ICDB/86621737
Essex M; Dept. of Microbiology, Harvard Sch. of Public Health, Boston, MA; 02115
Human T-cell leukemia virus (HTLV) biology is reviewed, including transmission and distribution of HTLVs, immunogenicity of HTLV proteins, and the association of HTLV and acquired immune deficiency syndrome (AIDS). Induction of both leukemias and immunosuppression by retroviruses has been most thoroughly documented in
Dev Oncol; 28:232-9 1985. Unique Identifier : AIDSLINE ICDB/86621738
Francis DP; Cabradilla CD; Feorino PM; Kalyanaraman VS; Div. of Viral Diseases, Center for Infectious Disease, Centers; for Disease Control, Atlanta, GA 30333
Epidemiological and other evidence that lymphadenopathy-associated virus (LAV) is the etiologic agent in acquired immune deficiency syndrome (AIDS) is reviewed. Criteria that are addressed are: presence of markers of infection in virtually all AIDS patients (pts), prevalence of antibody in groups at risk of AIDS, infe
Dev Oncol; 28:240-6 1985. Unique Identifier : AIDSLINE ICDB/86621739
de The G; Faculty of Medicine Alexis Carrel, Rue G. Paradin 69372 Lyon,; France
Human viruses with oncogenic properties are compared from an epidemiological viewpoint and results from the author s sero-epidemiologic studies on human T-cell leukemia virus (HTLV)-I are presented. Genetic, epidemiologic, co-factor, and associated-disease characteristics of the HTLV family, hepatitis B virus, Epstein
Dev Oncol; 28:247-53 1985. Unique Identifier : AIDSLINE ICDB/86621740
Srivastava BI; Koga M; Roswell Park Memorial Inst., Buffalo, NY 14263
Patients (pts) with mycosis fungiodes/Sezary syndrome (MF/SS) or various leukemias/lymphomas were examined for the presence of human T-cell leukemia virus (HTLV) antibodies. HTLV antibodies in serum/plasma and HTLV p-19 antigen expression by cells were assessed in 108 subjects. About 25% of pts with MF/SS and 10% (ELI
Dev Oncol; 28:254-66 1985. Unique Identifier : AIDSLINE ICDB/86621741
Kirkpatrick CH; Davis KC; Horsburgh CR Jr; Rickmann PE; Cohn DL; Penley K; Judson FN; Dobozin BS; Conrad D. Stephenson Lab. for Res. in Immunology, Dept. of; Medicine, Natl. Jewish Hosp. and Res. Center/NAC, Denver, CO; 80206
Preliminary results are described of a prospective study of immune functions of persons whose lifestyle or medical histories make them at risk for development of the acquired immune deficiency syndrome (AIDS). Participants in the study included asymptomatic homosexual men (61), homosexual men with generalized lymphade
Dev Oncol; 28:267-88 1985. Unique Identifier : AIDSLINE ICDB/86621742
Hoover EA; Dept. of Pathology, College of Veterinary Medicine and Biological; Science, Colorado State Univ., Fort Collins, CO 80523
Characteristics of feline leukemia virus (FeLV) infection and the disease progression are reviewed under the following headings: transmission of FeLV, FeLV strain- and age-related resistance, early FeLV-target cell interactions and resultant virus-host relationships, preleukemic changes, aplastic anemia, feline acquir
Dev Oncol; 28:289-305 1985. Unique Identifier : AIDSLINE ICDB/86621743
Hardy WD Jr; Lab. of Veterinary Oncology, Memorial Sloan Kettering Cancer; Center, New York, NY 10021
Virology, epidemiology, immunology, and disease states associated with feline leukemia virus (FeLV) and feline sarcoma viruses (FeSVs) are reviewed. FeLV replicates in rapidly dividing cells and can produce proliferative and degenerative diseases. The fate of the FeLV-exposed cat depends on its immune response to the
Dev Oncol; 28:332-7 1985. Unique Identifier : AIDSLINE ICDB/86621746
Gardner MB; Dept. of Pathology, Univ. of California, Davis, CA 95817
Evidence for a retroviral etiology of Simian acquired immune deficiency syndrome (SAIDS) is reviewed and the human and monkey syndrome, and their respective retroviruses, are compared. Several epidemiologic, virologic, and serologic findings support a retroviral etiology for SAIDS. Both SAIDS and AIDS are infectious,
Dev Oncol; 28:338-53 1985. Unique Identifier : AIDSLINE ICDB/86621747
Hunter E; Barker CS; Bradac J; Chatterjee S; Desrosiers R; Wills JW; Univ. of Alabama, Lab. for Special Cancer Res., Birmingham, AL; 35294
Molecular studies of the D-type retroviruses are reviewed, including protein biosynthesis, comparative studies of retrovirus nucleic acids, and properties of D-type retroviruses associated with Simian acquired immune deficiency syndrome (SAIDS). D-type retroviruses have been isolated from Old World monkeys (Mason-
Biomarkers, Genetics, and Cancer. Anton-Guirgis H, Lynch HT, eds. New York, Van Nostrand Reinhold Company, p. 81-152, 1985.. Unique Identifier : AIDSLINE ICDB/86622764
Lynch HT; Schuelke GS; Danes BS; Lynch JF; Dept. of Preventive Medicine and Public Health, Creighton Univ.; Sch. of Medicine, Omaha, NE 68178
Cancer liability can be depicted operationally as a combination of genetic susceptibility and environmental exposure. Identification of hereditary influences may be best approached through family studies wherein pedigree analysis may aid in their delineation. Selected facets of human cancer genetics are discussed unde
Eukaryotic recombinant expression vector systems have facilitated the large scale synthesis of cloned gene products, as well as dramatically enhancing our understanding of gene regulation and polypeptide processing. The expression of cloned genes in eukaryotic cells has been demonstrated for a wide variety of viral re
Dev Oncol; 31:1-207 1985. Unique Identifier : AIDSLINE ICDB/86624698
Anonymous; No affiliation given
This book consists of the proceedings of a symposium on lymphoproliferative diseases, held at the University of Southern California, Los Angeles, November 16-17, 1984. The articles are divided into four sections, namely, pathobiology, epidemiology, diagnosis, and clinical aspects. Those included in the first section h
Dev Oncol; 31:72-85 1985. Unique Identifier : AIDSLINE ICDB/86624705
Tajima K; Tominaga S; Aichi Cancer Center, Chikusa-Ku, Nagoya, Japan
Clinico-pathological and epidemiological findings of adult T-cell leukemia/lymphoma (ATLL) in Japan are reviewed, and the epidemiological aspects of the relationship between human T-cell leukemia virus (HTLV) infection and the ATLL manifestation in the Kyushu district are discussed.
Dev Oncol; 31:171-90 1985. Unique Identifier : AIDSLINE ICDB/86624711
Meyer PR; Osborn KG; USC-Dept. of Pathology, 2025 Zonal Avenue, Los Angeles, CA 90033
The acquired immune deficiency syndrome (AIDS) in man and that in the Rhesus-Macaque monkey are discussed under the following headings: AIDS in the human; AIDS in the simian (SAIDS); pathogenesis (lymph node findings in monkey and man); early changes in SAIDS; follicular hyperplasia; lymphocyte depletion; summary of l
Dev Oncol; 31:191-203 1985. Unique Identifier : AIDSLINE ICDB/86624712
Levine AM; Gill P; Meyer P; Rasheed S; USC-Division of Hematology, 2025 Zonal Avenue, Los Angeles, CA; 90033
Acquired immunodeficiency syndrome (AIDS) has been defined operationally by the Center for Disease Control (CDC) as the development of opportunistic infections and/or Kaposi s sarcoma in an individual who is not at risk for these disorders. Persistent, generalized lymphadenopathy (PGL) has been defined by the CDC as t
DNA Probes. New Technologies in their Development and Application. September 23, 1985, London, 1985.. Unique Identifier : AIDSLINE ICDB/86624767
Anonymous; No affiliation given
Proceedings from a seminar on new technologies in the development and application of DNA probes, held September 23, 1985, in London, are presented under the following headings: use of DNA probes for diagnosis of infectious diseases; diagnosis of infectious disease using DNA probes: advantages, limitations, and potenti
Theories and Models in Cellular Transformation. Santi L, Zardi L, eds. New York, Academic Press, p. 85-100, 1985.. Unique Identifier : AIDSLINE ICDB/86626470
Recent results obtained using acutely transforming animal retroviruses as tools to detect, isolate, and analyze the c-onc gene in human DNA and to clarify growth and/or differentiation abnormalities in leukemias and lymphomas are discussed. In addition, explorations into the role of animal chronic leukemia viruses in
Dev Oncol; 34:141-73 1985. Unique Identifier : AIDSLINE ICDB/86626483
Giraldo AA; Meis JM; Dept. of Pathology, St. John Hosp., Detroit, MI 48236
Experience with the use of immunological techniques (immunofluorescence, immunoperoxidase, rosette) in 405 cases of lymphoreticular proliferations is described. The cases involved studies carried out on cell suspensions of solid tissues (lymph nodes, gastric lymphomas) and studies carried out on markers on lymphoid ce
Medicaid is currently providing necessary services to approximately 40 percent of AIDS sufferers who have no other sources of payment and met eligibility requirements of the program. For those AIDS patients, states can exercise current Medicaid Program flexibility in adopting innovative delivery systems to provide hig
Since the Acquired Immune Deficiency Syndrome (AIDS) was first recognized in 1981 it has become a subject of increasing clinical importance. Patients with AIDS and related conditions often present with symptoms and signs in the head and neck region. This paper presents the experience of a joint consultation service ru
Using the polyethylene glycol (PEG) precipitation technique, circulating immune complexes were demonstrated in 88% of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related disorders. The finding of immune complexes in these individuals was confirmed by using a second assay, the commercially availab
Malignant lymphoma of the heart was found at autopsy of two homosexual men with acquired immune deficiency syndrome (AIDS). Both patients had symptoms and signs of cardiac dysfunction, and it is likely that the immediate cause of their deaths was related to the cardiac tumors. In both cases, there was lymphomatous inv
A pleomorphic bacterium exhibiting both acid-fast rod forms and non-acid-fast coccal forms, and identified as Mycobacterium avium-intracellulare was cultured from a facial lesion diagnosed as immunoblastic sarcoma. The patient was a 36 year-old homosexual man who died of the acquired immune deficiency syndrome (AIDS).
De Maubeuge J; Ledoux M; Feremans W; Zissis G; Goens J; Andre J; Gourdain JM; Menu R; De Wit S; Cran S; et al
A 34-year-old African patient with AIDS developed a new form of oral leucoplakia closely resembling the hairy leucoplakia described by Greenspan in male homosexuals in the San Francisco area. A herpes-like virus was seen on ultrastructural analysis with electron microscopy. This case supplies further evidence suggesti
The corticotectal influences of somatosensory cortex were investigated by using reversible deactivation of cortex by cooling. More than half of the somatosensory superior colliculus (SC) cells studied exhibited a response depression (often not apparent qualitatively) or an elimination of responses to somatosensory sti
Ferritin has been linked to a variety of immunosuppressive effects on cell-mediated immunity. Therefore, serum ferritin was measured by radioimmunoassay in patients with acquired immune deficiency syndrome (AIDS), AIDS-related complex (ARC) and healthy heterosexual men. 13 of 15 patients with AIDS and 4 of 15 with ARC
We report a case of secondary Kaposi s sarcoma of the penis and the acquired immune deficiency syndrome. Recognition of the penile lesion as being secondary Kaposi s sarcoma is paramount, since the clinical course appears to be dependent upon systemic disease. Local therapy is reserved for palliation upon disease recu
Med Clin North Am. 1986 Sep;70(5):967-86. Unique Identifier : AIDSLINE MED/86283669
Levin S; Goodman LJ; Fuhrer J
The processes presented here do not represent an all-inclusive list of fulminant infectious diseases. Some of the more common acute, overwhelming infections of the central nervous system and lungs are covered elsewhere in this issue. We have selected less common, potentially catastrophic syndromes that might be recogn
Three tectal afferent-fiber systems were experimentally labeled in the cat to learn how their distributions within the superior colliculus were related to the prominent compartments of high acetylcholinesterase activity found in the intermediate gray layer. Presumptive somatic sensory afferents were labeled by injecti
By 30th September 1985, 21 countries were taking part in a network of AIDS surveillance in Europe. The data collected by each country are centralized in one of the WHO Collaborating Centres on AIDS, located in Paris ( France ). The cases reported are analysed according to sex, age, d
A study about mortality by AIDS had been undertaken since July 1st 1983, in the Service of Information on Medical causes of Death (INSERM SC8), which is in charge of developing mortality statistics in France . From July 1st 1983 to September 30th 1985, 243 deaths due to AIDS were re
Stat Med. 1986 May-Jun;5(3):271-9. Unique Identifier : AIDSLINE MED/86288907
Grimson RC; Groshen S
In investigating an epidemic or outbreak of a disease in which patient contact (appropriately defined) is hypothesized to be a factor, investigators may ask patients to provide names of people with whom they have had contact. This paper provides statistical methods for assessing whether or not the number of named cont
This article deals with the physician s fear of contagion using AIDS as a paradigm. It deals with this in four ways: it examines the concepts of duty, fear and courage in their medical setting; it deals with the historical aspects of the problem; it analyzes the role of social contract and professionalism; and it deve
The ultrastructural morphology of both the classical and the AIDS-associated forms of Kaposi s sarcoma was examined electron-microscopically. Tubuloreticular structures were found only in the AIDS-associated form of Kaposi s sarcoma, and not in the classical variant of the tumor. Moreover, the tubuloreticular structur
Ann Allergy. 1986 Aug;57(2):95-102. Unique Identifier : AIDSLINE MED/86293841
Wolcott DL
Acquired immune deficiency syndrome is now an epidemic in the United States . Multiple factors contribute to the high degree of psychosocial stress experienced by those with HTLV-III infection, regardless of their current clinical status. Family members, friends, and health care profess
This survey among 1 000 french male homosexuals and bisexuals (July-August 1985) shows the reactions to AIDS in the still largest risk group. The survey reveals the diversity of social and sexual lifestyles. Gays perceive AIDS as a health threat, but also as a social threat eventually leading to discrimination. Ambiva
Lerche NW; Osborn KG; Marx PA; Prahalada S; Maul DH; Lowenstine LJ; Munn RJ; Bryant ML; Henrickson RV; Arthur LO; et al
Simian acquired immune deficiency syndrome (SAIDS) type D retrovirus (SRV) was isolated from saliva, urine, and peripheral blood mononuclear cells of a 6-year-old healthy rhesus monkey (Macaca mulatta) seronegative for antibodies to human T-lymphotropic virus (HTLV) type I, HTLV type III, and simian T-lymphotropic vir
Ashraf SJ; Arya SC; Arendrup M; Krogsgaard K; Parande CM; Orskov B; Ageel AR
Serum samples from 608 residents of Saudi Arabia were examined for the presence of hepatitis B, delta and HTLV-III virus markers. The HBsAg carrier rate was 17% and the prevalence of all hepatitis B virus markers was 55%. Males betw
The primary etiologic agent of the acquired immune deficiency syndrome (AIDS) is a human T-lymphotropic retrovirus (the AIDS virus). However, the pathogenesis of this virus suggests that other cofactors may contribute to the development of clinically overt disease. The hepatitis B virus (HBV) has been implicated as a
A young Hong Kong Chinese male patient with fever of unknown origin is presented. The diagnosis of acquired immunodeficiency syndrome was made only 5 months after the onset of his illness. The lack of awareness of the syndrome might
Int J Cancer. 1986 Aug 15;38(2):259-64. Unique Identifier : AIDSLINE MED/86277016
Chany C; Cerutti I
Immune stimulators such as Corynebacterium parvum (CP) are useful for antitumoral and antiviral therapy. However, the immune trigger cannot be reactivated without adversely affecting the disease. We have tried to amplify the results yielded by a single injection of CP by using either interleukin-2 (IL2) or aspartate s
J Immunol. 1986 Aug 15;137(4):1157-63. Unique Identifier : AIDSLINE MED/86279639
Bonavida B; Katz J; Gottlieb M
Peripheral blood from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) exhibits poor NK activity in the 51Cr-release assay. The present studies were undertaken to investigate the mechanism underlying the observed defective NK cytotoxic activity. On the basis of our studies on the m
Monoclonal antibody BE2 recognizes an antigen found on malignant T4+ lymphocytes from cutaneous T-cell lymphoma patients (CTCL). Normal peripheral blood lymphocytes do not express detectable levels of BE2 antigen. Forty-eight percent of patients with the acquired immunodeficiency syndrome (AIDS) had lymphocyte populat
We reviewed the notes of the first 11 patients with AIDS managed by the infectious disease unit, Auckland Hospital, who all presented during 1985. All were homosexual males: none had other recognised risk factors: ten had travelled beyond New Zealand . Five were diagnosed at Auc
Schweiz Med Wochenschr. 1986 Jun 28;116(26):873-80. Unique Identifier : AIDSLINE MED/86289297
Roux-Lombard P; Aladjem D; Balavoine JF; Chofflon M; Despont JP; Hirschel B; Jeannet M; Kapanci Y; Toccanier MF; Wilhelm JA; et al
In two groups of subjects at risk for acquired immune deficiency syndrome (AIDS), homosexual males and intravenous drug users with persistent generalized lymphadenopathy, humoral and cell-mediated immunity were compared. A small group of patients with definite AIDS were also studied. It was found that levels of immuno
Ann Pathol. 1986;6(2):85-98. Unique Identifier : AIDSLINE MED/86269256
Audouin J; Diebold J
The stimulation of the cellular and humoral immune reactions is described, as well as the different cellular types implicated (B and T lymphocytes, their subsets and derived cells, and mononuclear cells of the phagocytic system). The classification of these various cells, using immunolabeling the back-up cells and the
Infectious complications are the most common cause of death in patients with acquired immunodeficiency syndrome (AIDS). Opportunistic infections associated with defects in both T and B lymphocyte function have been observed. Invasive infections, including those secondary to procedures both in and out of the hospital,
It is evident that cyclosporine A is a potent immunosuppressive agent and may become immensely valuable in the treatment of cutaneous disease. The extent of its application and efficacy is speculative, as neither the pathogenesis of many of the diseases, nor the mechanism of action of cyclosporine is fully understood.
Br Med J (Clin Res Ed). 1986 Jun 28;292(6537):1727-9. Unique Identifier : AIDSLINE MED/86270842
Marasca G; McEvoy M
An analysis of the lengths of survival of patients with the acquired immune deficiency syndrome presenting with different opportunistic diseases was performed using epidemiological data routinely collected at the PHLS Communicable Disease Surveillance Centre. The overall crude case fatality rate was 55.4% (93/168). Th
Br Med J (Clin Res Ed). 1986 Jul 19;293(6540):161-2. Unique Identifier : AIDSLINE MED/86270915
Goldman M; Liesnard C; Vanherweghem JL; Dolle N; Toussaint C; Sprecher S; Cogniaux J; Thiry L
Patients and members of staff from a haemodialysis unit were tested for markers of infection with human T cell lymphotropic virus type III (HTLV-III), the virus associated with the acquired immune deficiency syndrome (AIDS). An enzyme linked immunosorbent assay showed eight of 100 patients to have antibodies to HTLV-I
Freeman CR; Shustik C; Brisson ML; Meagher-Villemure K; Dylewski I
Between 1960 and 1983, 19 patients with primary malignant lymphoma of the central nervous system (CNS) were seen at McGill University Hospitals. The diagnosis was made at autopsy in 3 patients, and by biopsy in 16. Results of treatment were poor. All four patient who underwent surgery alone died within 2 months of dia
Gorski A; Gjerset GF; Martin PJ; Counts RB; Hansen JA
B-Cell function was evaluated in a group of 43 patients with factor VIII or factor IX deficiency. Thirty had been treated primarily with cryoprecipitate and 13 with concentrates of factor VIII or IX. Serum immunoglobulin G levels were found to be diffusely elevated; however, the absolute number of mature B cells in pe
Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi s sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and P
Immunofluorescence and immunogold techniques yielded similar results when used to determine the T lymphocyte subsets (T4 and T8 positive cells) in patients with AIDS or AIDS-related complex and in healthy homosexual men seropositive for HTLV III/LAV antibody. In these pathological situations, the advantages of immunog
Five of 22 hemophiliacs who were seropositive for human T cell leukemia virus III (HTLV III) and manifested severe impairment of immune parameters (both in vivo and in vitro) similar to those observed in patients with clinical symptoms of acquired immune deficiency syndrome (AIDS) were chosen for this study. Profound
Epidemic Kaposi s sarcoma, a neoplasm associated with AIDS, is rapidly becoming common in the United States and Europe. The pathogenesis of this form of Kaposi s sarcoma has not yet been fully understood, but epidemiological clues point to the possibility that an infectious agent (in a
Since the acquired immunodeficiency syndrome (AIDS) is characterized by opportunistic infections and malignancies indicative of a profound suppression in cell-mediated immunity, we investigated the antibody-dependent cell-mediated cytotoxicity (ADCC) of peripheral blood mononuclear cells of patients with AIDS against
A homosexual man developed staphylococcal scalded skin syndrome associated with a Staphylococcus aureus septicemia. We discuss the role of prednisone, renal insufficiency, and immunosuppression as predisposing factors to staphylococcal scalded skin syndrome in adults. In particular, our study of the patient s immune f
Seven patients of Haitian and Central African origin were investigated for interstitial pneumonitis and unexplained chronic lymphadenopathy. A study of broncho-alveolar lavage fluid showed no opportunistic micro-organisms and disclosed a high alveolar lymphocyte count with more than 80% T8+ cells. In 3 patients, open
We have studied 26 patients presenting with a symmetrical papular or papulovesicular acrolocated eruption of more than 10 days duration. Mean age at onset was 2 years (range 10 months to 5.75 years). Lymphadenopathy was noted in eight cases, and hepatomegaly in one case. In 12 cases, histopathology and direct immunofl
Sera collected 13 years ago from 592 residents of the Republic of Liberia have been tested for antibodies to LAV polypeptides. 7 sera were positive by ELISA using two commercially available test kits whereas immunoblotting did not confirm antibodies specific for LAV.
Br Med J (Clin Res Ed). 1986 Jul 19;293(6540):162-4. Unique Identifier : AIDSLINE MED/86270916
Kennedy PG; Newsome DA; Hess J; Narayan O; Suresch DL; Green WR; Gallo RC; Polk BF
Paraffin sections of retinal tissue from five patients who died from the acquired immune deficiency syndrome (AIDS) and retinopathy were examined by in situ hybridisation experiments with deoxyribonucleic acid (DNA) labelled with sulphur-35 of lentivirus, human T lymphotropic virus type III/lymphadenopathy associated
Br Med J (Clin Res Ed). 1986 Jul 19;293(6540):168-9. Unique Identifier : AIDSLINE MED/86270918
Cheinsong-Popov R; Tedder RS; O'Connor T; Clayden S; Smith A; Craske J; Weiss R
At the end of 1984 a collaborative survey was carried out to determine the prevalence of infection with human T cell lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) and HTLV-I among 584 recipients of various blood products in Britain at that time. In 204 cases yearly point prevalence figure
Cancer. 1986 Aug 1;58(3):694-8. Unique Identifier : AIDSLINE MED/86271525
Temple JJ; Brammer MG; Andes WA; Covington S; Rangan S
The occurrence of adult T-cell leukemia-lymphoma in two New Orleans patients, one native-born, the other originally from Honduras , is reported. Both exhibited an unusual feature. One patient was diagnosed following an atypical episo
Cancer Res. 1986 Sep;46(9):4756-8. Unique Identifier : AIDSLINE MED/86271770
Srivastava BI; Wong-Staal F; Getchell JP
Antibodies reactive against human T-cell leukemia virus I (HTLV-I) were detected by indirect immunofluorescence assay using MT-2 as target cells, enzyme linked immunosorbent assay screen and competition assay, and Western blot analysis in three sera (one collected in 1979) from a captive gorilla which developed diffus
Cell. 1986 Aug 1;46(3):401-5. Unique Identifier : AIDSLINE MED/86272087
Fujita T; Shibuya H; Ohashi T; Yamanishi K; Taniguchi T
Interleukin-2 ( IL-2 ) is a lymphokine that plays a crucial role in the immune system, especially in the growth control of T lymphocytes. Expression of this lymphokine is restricted to activated T lymphocytes. Here we demonstrate the presence of unique DNA sequences in t
The number of lymphocytes bearing the Leu 2+ or T8+ (suppressor/cytotoxic) phenotype is elevated in asymptomatic homosexual men. By two-color immunofluorescence using paired monoclonal antibodies (alpha-Leu 2 and alpha-Leu 15, alpha-Leu 2 and alpha-Leu 7, alpha-Leu 7 and alpha-Leu 11), we enumerated phenotypic subpopu
Coates RA; Read SE; Fanning MM; Vellend H; Shepherd FA; Johnson JK
This study compared clinical and laboratory parameters in 37 individuals with serologic evidence of exposure to human T-cell lymphotropic virus type 3 (HTLV-III) and generalized lymphadenopathy. Basal levels of the interferon-induced enzyme, 2-5A synthetase were also measured and compared with the clinical parameters.
Colvin BT; Ainsworth M; Machin SJ; Mackie IJ; Smith JK; Winkelman L; Haddon ME
Three patients who have been given intermediate purity NHS heat-treated factor VIII concentrate have been followed prospectively for 7-10 months. None had previously received more than six donor units of blood products containing factor VIII. There were no clinical side effects from concentrate administration, haemost
Sera of 1046 patients undergoing haemodialysis for terminal renal failure or after renal transplantation were tested with the ELISA screening test for anti-LAV/HTLV-III and, if positive, the Western blot and ELAVIA tests. Four patients (0,38%) had true antibodies against LAV/HTLV-III, confirmed by the Western blot and
Dtsch Med Wochenschr. 1986 Aug 1;111(31-32):1175-80. Unique Identifier : AIDSLINE MED/86274146
Brodt HR; Helm EB; Werner A; Joetten A; Bergmann L; Kluver A; Stille W
543 persons in AIDS risk groups were examined for LAV/HTLV-III infection. Antibodies against LAV/HTLV-III were demonstrated in 377, during an observation period of 3 months to 3 years. Patients were divided into 5 groups, according to clinical, serological and immunological criteria. Severity of symptoms and incidence
De Rossi A; Gassa OD; del Mistro A; Faulkner Valle G; Bianchi LC
A seroepidemiological survey has been carried out in the Veneto region to determine the prevalence of HTLV-III and HTLV-I antibodies in subjects at risk for development of AIDS and related conditions. Serum samples were tested by ELISA and, for confirmation, by radioimmunoassay (Western blot), using disrupted virus as
Roux-Lombard P; Aladjem D; Balavoine JF; Chofflon M; Despont JP; Hirschel B; Jeannet M; Kapanci Y; Lang R; Toccanier MF; et al
Persistent generalized lymphadenopathy (PGL) is observed predominantly in subjects at risk of developing AIDS. Twenty-seven individuals belonging to such groups: twelve homosexual males and fifteen intravenous drug users, were investigated for immunological abnormalities with particular attention to monocyte functions
Reinders Folmer SC; Danner SA; Bakker AJ; Lange JM; van Steenwijk RP; Alberts C; van Keulen PH; van der Schoot JB
Fifteen 67Ga lung scans were obtained from 11 men with AIDS to detect opportunistic lung infection. Results were compared with clinical findings, chest radiographs, CO-transfer and transbronchial biopsies or BAL. Clinical symptoms were least helpful in diagnosing pneumonia. Chest radiographs were normal in six of eigh
Fifty four sexual partners of homosexual men with the acquired immune deficiency syndrome (AIDS) were studied, of whom 32 were seropositive and 22 seronegative for human T cell lymphotropic virus type III or lymphadenopathy virus (HTLV-III/LAV) antibody, which showed that repeated exposure by anal intercourse does not
To investigate the asymptomatic shedding of herpes simplex virus (HSV) from women with recurrent genital herpes infection, and to assess whether inapparent shedding could occur, eight such women were examined thrice weekly for one month. At each visit colposcopy was performed an
Three examples are presented to illustrate the importance of retroviruses and associated oncogenes in neoplasms of the immune system. In adult T-cell leukemia/lymphoma the HTLV I-provirus is often integrated in the human genome on chromosome 8 adjacent to the c-myc protooncogene. Cytogenetic studies of Burkitt s lymph
The acquired immunodeficiency syndrome (AIDS) is caused by a retrovirus. LAV/HTLV-III is mainly transmitted by blood and sperm. More than 90% of the newly infected persons belong to four risk groups: male homosexuals, drug addicts, persons with multiple changing sex partners, and bisexuals. Infected individuals carry
This short review deals with the cutaneous manifestations of the acquired immune deficiency syndrome (AIDS), which comprise Kaposi s sarcoma, as an important marker disease for AIDS, as well as various skin infections caused by bacteria, fungi and viruses. In patients at risk of acquiring AIDS, an extensive immunologi
HTLV-I antibodies were found in 10 out of 68 patients with cutaneous T-cell lymphoma (14%). HTLV antibodies were found in the earliest pre-diagnostic stage [Mycosis fungoides I (MF I), histologically non-diagnostic] as well as in the later stages (MF-III), where tumour cells are histologically apparent and the skin le
Infectivity was assayed by infecting human T-lymphocytes, H9, Molt-4, and MT-4 cells with different strains of AIDS viruses (HTLV-III, LAV, ARV, and YU viruses). Human T-lymphotropic virus type-III (HTLV-III), lymphadenopathy-associated virus (LAV), and AIDS-associated retrovirus (ARV) were able to infect all kinds of
The simian sarcoma virus (SSV) oncogene (v-sis) has a high degree of homology to the cellular gene coding for the B peptide of human platelet-derived growth factor (PDGF), a potent fibroblast mitogen. The cellular homolog of v-sis is activated in some mesenchymal human tumors and cell lines derived from them. To deter
Patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) have hyperimmunoglobulinemia and increased numbers of circulating immunoglobulin-secreting cells. In this paper, we studied the basis for this B cell hyperactivity. Limiting dilution studies of B cells from seven patients with ARC a
Fetchick DA; Bertolini DR; Sarin PS; Weintraub ST; Mundy GR; Dunn JF
The human T cell lymphotrophic virus type I (HTLV-I) has recently been identified in a T cell lymphoma associated with hypercalcemia and increased bone turnover. Since increased serum concentrations of 1,25-dihydroxyvitamin D have been reported in this disease, we have examined the capacity of HTLV-I-infected cord blo
J Immunol. 1986 Aug 15;137(4):1115-9. Unique Identifier : AIDSLINE MED/86279632
Suciu-Foca N; Rubinstein P; Rohowsky-Kochan C; Cai J; Popovic M; Gallo RC; King DW
Two alloreactive T cell clones with anti-HLA-DR1 specificity showed significant alterations of cognitive and functional characteristics after infection with human T cell leukemia virus (HTLV-I). Similar to HTLV-I-infected lines derived from immunologically uncommitted lymphocytes, the transformed clones displayed blas
We examined the usefulness of a counterimmunoelectrophoresis (CIE) technique for detecting antibodies to HTLV-III using sera that previously had been assessed for antibodies to HTLV-III by the standard enzyme-linked immunosorbent assay (ELISA). We selected a subset of 53 sera from patients with the acquired immune def
The effect of UV irradiation on HTLV-III was quantitatively studied to evaluate the dosage of UV irradiation which inactivates the virus for sterilization of blood products and for laboratory decontamination. In order to estimate the biologic activity and quantitation of the virus, induction of HTLV-III-specific antig
Adachi A; Gendelman HE; Koenig S; Folks T; Willey R; Rabson A; Martin MA
We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. Upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells. The progeny, infectious virions, were synthesized in mouse, mink, monke
The pol gene from a biologically active clone of the human T-cell lymphotropic virus type III provirus was inserted into a bacterial expression vector. The resulting gene fusion induced the formation of active reverse transcriptase that could be readily detected in extracts of bacterial cells. The activity exhibited t
JAMA. 1986 Aug 15;256(7):869-72. Unique Identifier : AIDSLINE MED/86282075
Francis DP; Feorino PM; McDougal S; Warfield D; Getchell J; Cabradilla C; Tong M; Miller WJ; Schultz LD; Bailey FJ; et al
In the United States , one hepatitis B vaccine (Heptavax-B) has been licensed for the prevention of hepatitis B virus infections. Even though this vaccine has been shown to be highly effective and well tolerated in controlled trials and has been recommended for use in those at risk for
A method is presented for embedding nucleotide sequence data in a simple metric space. Computer graphical examination of spatially-represented sequences permits rapid searches for canonical patterns or interesting structures. Sequence comparisons are facilitated by plots of distance measures for homologous sequences,
Sodroski J; Goh WC; Rosen C; Campbell K; Haseltine WA
Acquired immune deficiency syndrome (AIDS) is characterized by marked depletion of the T4+ helper subset of T cells. The aetiological agent of the disease, the human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV), specifically kills T4+ cells in vitro. Part of this specificity for the
N Z Med J. 1986 Jun 11;99(803):405-7. Unique Identifier : AIDSLINE MED/86285791
Buchanan JG; Goldwater PN; Somerfield SD; Tobias MI
A 47-year-old man developed an acute infectious mononucleosis-like illness with a moderate lymphocytosis and numerous atypical lymphocytes in the peripheral blood. Seroconversion to the AIDS-associated virus occurred between 14 and 20 days following the onset of the acute illness. He was found to have reduction of the
Rogers MF; Ewing EP Jr; Warfield D; Hardy AM; Emery DR; Wolf GC
The number of cases of acquired immunodeficiency syndrome (AIDS) in women is increasing. As of December 30, 1985, 1075 cases in women had been reported to the Centers for Disease Control; 81% of these cases occurred in women of childbearing age (15 to 45 years). The human T-lymphotropic virus type III/lymphadenopathy-
Vogt MW; Ho DD; Bakar SR; Gilbard JP; Schooley RT; Hirsch MS
The human T-lymphotropic retrovirus type III (HTLV-III), the etiological agent of AIDS, has recently been detected in tears, cornea, and conjunctiva, raising the possibility of transmission of HTLV-III via contact lens trial sets used in routine fitting. We evaluated the ability of several contact lens cleaning soluti
Gessain A; Plumelle Y; Sanhadji K; Barin F; Gazzolo L; Constant-Desportes M; Pascaline N; Diebold J; De-The G
Two HTLV-I associated adult T cell leukemia cases were observed in patient from Martinique (French West Indies). These case are similar to the clinical entity, described by Takatsuki in 1977 in Japan
We have isolated retroviruses from six acquired immunodeficiency syndrome (AIDS) and three lymphadenopathy syndrome (LAS) patients by cocultivation of patients lymphocytes with phytohemagglutinin-stimulated normal T cells. In an effort to address the extent to which these viruses have identical genetic information or
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6159-63. Unique Identifier : AIDSLINE MED/86287415
Wang JJ; Steel S; Wisniewolski R; Wang CY
A peptide of 21 amino acids with the sequence Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-I- le-Trp- Gly-Cys - Ser encoded by a segment in the env gene of human T-lymphotropic virus type III (HTLV-III), corresponding to amino acids 586-606 of the precursor envelope glycoprotein, has been synthesize
LAV is the causative agent of AIDS. Its biological properties, assessed in vitro, fully account for the major immunological abnormalities which characterize the disease. LAV is a lentivirus which presents a selective tropism for T4+ lymphocytes, the very cells that are destroyed in AIDS. Its replication is associated
This article reviews some of the epidemiologic aspects of transmission of LAV through transfusion of blood and blood products in the light of data available until late December 1985 in France , Europe and the United States . As of December 1985, blood
Over the past 3 yr we have treated 6 homosexual men (age 22-55 yr) with immune thrombocytopenic purpura. 4 of the 6 have antibody to HTLV-III in their serum, 1 of these patients has the acquired immune deficiency syndrome (AIDS), 1 has AIDS-related-complex (ARC), and a 3rd has persistent generalised lymphadenopathy (P
Science. 1986 Aug 29;233(4767):980-4. Unique Identifier : AIDSLINE MED/86289442
Stevenson M; Volsky B; Hedenskog M; Volsky DJ
Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, has the ability to transform human B lymphocytes. No other cell type has been experimentally transformed by EBV, either by intact virions or naked viral DNA and subgenomic fragments. Two immortalized human T-lymphoblastoid cell lines have now been established b
Schnittman SM; Lane HC; Higgins SE; Folks T; Fauci AS
When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory c
Koenig S; Gendelman HE; Orenstein JM; Dal Canto MC; Pezeshkpour GH; Yungbluth M; Janotta F; Aksamit A; Martin MA; Fauci AS
One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia . By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmi
Tumori. 1986 Jun 30;72(3):219-24. Unique Identifier : AIDSLINE MED/86290643
Faulkner-Valle GP; De Rossi A; Dalla Gassa O; Chieco-Bianchi L
Serum samples which had previously been found positive for LAV/HTLV-III antibodies by the ELISA test and then confirmed by radioimmunoassay (Western blot) were tested for the presence of neutralizing antibodies. No neutralizing activity was found in the sera of a group of patients with the clinical diagnosis of AIDS.
A panel of 50 blood group antibodies covering a range of blood group antigens has been tested in the presence of 0.25% beta-propiolactone as a possible means of reducing infectivity of high-risk HTLV III/HBsAg samples. 11/50 (22%) antibodies could not be detected by the indirect antiglobulin test, and 6/40 (15%) were
In a survey on 82,383 blood donor specimens from Hessen, West Germany , the observed percentage of repeatedly positive HTLV-III/LAV antibody ELISA results was 0.2%, but only 0.018% were confirmed by Western blot, immunofluorescence assay or radioimmunoprecipitation assay. These dat
Antilymphocyte, antigranulocyte and antiplatelet alloantibodies, T lymphocyte subsets, expression of HLA-DR antigens on T lymphocytes and NK cell function were determined in 11 homozygous beta-thalassemic children multitransfused ab initio with Erypur-filtered leukocyte-free red cell units (group A) and in 13 similar
To demonstrate the feasibility of using robots in blood banking applications several prototype systems were developed. Activities associated with sample testing and component preparation were examined. In one project, a general-purpose laboratory robot (Zymate Laboratory Automation System, Zymark, Inc., Hopkinton, Mas
The Organon Teknika Vironostika anti-HTLV-III/LAV test was evaluated in three Danish blood banks. The evaluation comprised in total 3,940 consecutive donors. In all three blood banks the tests were carried out exactly according to the manufacturer s instructions, using a low cut-off value defined as (4N + P)/5, where
da Cunha Bang F; Weismann K; Ralfkiaer E; Pallesen G; Lange Wantzin G
Erythema elevatum diutinum (EED) is a chronic disease with symmetrical persistent erythematous nodules and plaques primarily in an acral distribution. EED is often associated with infections, especially of streptococcals. An immunological reaction has been proposed as pathogenetic mechanism. We describe a patient, who
An enzyme immunoassay (EIA), designed to detect antibodies to human T-cell lymphotropic virus type III (HTLV III), was evaluated. The antibody test was found to be highly sensitive; serum from 221 of 223 (99.1%) patients with acquired immune deficiency syndrome (AIDS) was positive for antibodies to HTLV III. In additi
Am J Gastroenterol. 1986 Aug;81(8):714-7. Unique Identifier : AIDSLINE MED/86292910
Elta G; Turnage R; Eckhauser FE; Agha F; Ross S
A 29-yr-old homosexual man with acquired immunodeficiency syndrome presented with watery diarrhea and fever. Upper gastrointestinal endoscopy was performed to obtain duodenal aspirates and biopsies. A 4-cm submucosal mass in the gastric antrum was identified. Subsequent abdominal CT scan confirmed the presence of this
The relationship of T lymphocyte subset abnormalities and the presence of antibodies to the human T lymphotropic virus type III (HTLV-III) was evaluated in 66 adult patients with hemophilia. Positive test results for antibodies to HTLV-III were observed in 62 percent of patients with hemophilia A and 9 percent of pati
A retrovirus, variously named human T-lymphotropic virus type III or lymphadenopathy-associated virus, is now recognized as the etiologic agent of the acquired immunodeficiency syndrome. As of January, 1986, more than 16,000 cases of acquired immunodeficiency syndrome have been reported, and it is estimated that great
Focal crypt epithelial cell degeneration (apoptosis) of the rectum is a characteristic pathologic feature in AIDS. The presence of apoptosis usually implies cell-mediated cytolysis, which would be an unexpected finding in this disease. We investigated the ultrastructural features of apoptosis in rectal biopsies from f
This article presents data obtained by our group in the molecular characterization of the probable agent of the acquired immune deficiency syndrome (AIDS), the lymphadenopathy/AIDS virus (LAV). Molecular cloning and complete nucleotide sequencing of LAV allows a detailed comparison with other AIDS virus isolates, as w
Ann Neurol. 1986 Jul;20(1):98-102. Unique Identifier : AIDSLINE MED/86294297
Rosenberg NL; Hochberg FH; Miller G; Kleinschmidt-DeMasters BK
The study of a patient suggested a relationship between Epstein-Barr virus infection and primary lymphoma of the central nervous system in the acquired immune deficiency syndrome. Deoxyribonucleic acid preparations from tumor tissue contained 30 to 100 copies of Epstein-Barr virus genome per cell when hybridized with
Gan To Kagaku Ryoho. 1986 Aug;13(8):2671-4. Unique Identifier : AIDSLINE MED/86294573
Araki Y; Tamura K; Seita M
A 60-year-old man with adult T cell leukemia had been suffering from intractable hypercalcemia resistant to saline hydration, intravenous administration of furosemide, elcatonin, prednisolone and phosphate, and also hemodialysis. Since there was one report suggesting that bleomycin could act as an anticalcemic agent,
Cancer Res. 1986 Sep;46(9):4458-62. Unique Identifier : AIDSLINE MED/86271720
Shirakawa F; Tanaka Y; Oda S; Chiba S; Suzuki H; Eto S; Yamashita U
The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied in vitro. Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte proliferative respo
Int J Cancer. 1986 Aug 15;38(2):265-74. Unique Identifier : AIDSLINE MED/86277017
Katoh T; Harada T; Morikawa S; Wakutani T
Human T-cell leukemia/lymphoma virus I (HTLV-I) is known to be associated with adult T-cell leukemia/lymphoma (ATL) as an etiological agent. The mechanism of leukemogenesis by HTLV, however, is still obscure. Two hypotheses have been proposed concerning abnormalities in IL
Kashiwagi S; Kajiyama W; Hayashi J; Nomura H; Ikematsu H
Two separate studies were carried out between 1968 and 1984; a total of 2,021 serum samples from healthy subjects were collected in two districts of Okinawa-on Iriomote Island and in Ishigaki City. The first samples were collected in 1970 on Iriomote Island and in 1968 in Ishigaki City. The second samples were collect
Itagaki A; Tsuchie H; Morimoto H; Ito Y; Gomyoda M; Kurimura T
Serological survey for human T-lymphotropic virus type I (HTLV-I) was performed in Shimane Prefecture, Japan , located on the coast of Japan sea. The rates of anti-adult T-cell leukemia-associated antigen-positive sera were 4.2% and 6.9% respectively for males and females. The rate i
Sera obtained from 3,472 persons in Malaysia , Thailand , Philippines and Indonesia were tested for the presence of antibody to adult T-cell leukemia-associated
Serum samples from 460 patients with existing or previous Plasmodium infections, high antimalarial antibody titres, and no apparent risk of exposure to human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) were assayed for HTLV-III/LAV antibody; only 1 sample, from a 21-year-old African w
Daniel V; Opelz G; Schafer A; Schimpf K; Wendler I; Hunsmann G
Of 170 hemophilia patients, 22% had high-titer, 29% had low-titer, and 49% had no antibodies against HTLV-III. The strength of HTLV-III antibodies was correlated significantly with a decreased OKT4/T8 ratio (p less than 0.0005), decreased in vitro response to pokeweed mitogen (p less than 0.025), and elevated serum ne
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