Characterization of simian retrovirus genome related to human T-cell leukemia virus type I. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Characterization of simian retrovirus genome related to human T-cell leukemia virus type I.

Princess Takamatsu Symp. 1984;15:241-9. Unique Identifier : AIDSLINE MED/86111565
Seiki M; Watanabe T; Komuro A; Miyoshi I; Hayami M; Yoshida M

Abstract: Human T-cell leukemia virus type I (HTLV-I) is exogenous for human transmission by viral infection and was shown to be a causative agent of adult T-cell leukemia (ATL) in man. Monkeys of several species were found to have antibodies reactive with HTLV-I antigens and thus infection with HTLV-I like retroviruses was suspected. The retroviruses in several species of monkeys were characterized by Southern hybridization, molecular cloning and sequencing. These monkey retroviruses, tentatively called simian T-cell leukemia viruses (STLV), have a genome structure of LTR-gag-pol-env-pX-LTR and are highly homologous with HTLV-I in all regions. A DNA clone of the STLV was isolated from a pig-tailed monkey and the nucleotide sequence was determined. The STLV showed 90% homology in the nucleotide sequence with that of HTLV-I in env-pX-LTR region. This highly homologous sequence indicates that the STLV is a member of the HTLV family but apparently different from HTLV-I. This result excluded the possibility of recent interspecies viral transmission from monkeys to humans, and suggested that STLV can be useful as an animal model in studies on HTLV-I transmission and leukemogenesis in humans. Supporting this suggestion, an African green monkey which was naturally infected with STLV was found to have developed T-cell leukemia that was very similar to human ATL.
Keywords: Animal Cell Line Cercopithecus aethiops/MICROBIOLOGY *Genes, Viral Haplorhini/*MICROBIOLOGY Human HTLV-BLV Viruses/*GENETICS Repetitive Sequences, Nucleic Acid Retroviridae/*GENETICS Sequence Homology, Nucleic Acid JOURNAL ARTICLE REVIEW

KWDanimalcelllinecercopithecusaethiops/microbiologyKWDgenes,viralhaplorhini/KWDmicrobiologyhumanhtlv-blvviruses/KWDgeneticsrepetitivesequences,nucleicacidretroviridae/KWDgeneticssequencehomology,nucleicacidjournalarticlereview
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M8650228

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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