Human retrovirus-induced IL-2 receptors and their possible role in transduction of continuous cell growth signal. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Human retrovirus-induced IL-2 receptors and their possible role in transduction of continuous cell growth signal.

Princess Takamatsu Symp. 1984;15:269-76. Unique Identifier : AIDSLINE MED/86111568
Sugamura K; Fujii M; Sakitani M; Kobayashi N; Nakai S; Hatanaka M; Hinuma Y

Abstract: The first half of this report describes direct evidence for the interleukin 2 receptor (IL-2R)-inducing ability of human T-cell leukemia/lymphoma virus (HTLV). When an Epstein-Barr virus (EBV)-transformed human B-cell line, LCL-Kan was infected with HTLV or transfected with plasmid DNA containing defective HTLV genome (long terminal repeat (LTR)-gag-pX-LTR), LCL-Kan cells were altered to express IL-2R which was indistinguishable from that of normal activated T cells. The second half of this paper reports that IL-2 could inhibit proliferation of HTLV-carrying T-cell lines which were spontaneously immortalized from IL-2-dependent cells or peripheral blood cells containing ATL leukemia cells. These results suggest that expression of IL-2R may be induced by HTLV in HTLV-transformed cells, where the IL-2R plays an important role in transduction of continuous cell growth signal.
Keywords: Cell Division Cell Line Cell Transformation, Neoplastic Genes, Viral Human HTLV-BLV Viruses/GENETICS/*PATHOGENICITY Receptors, Cell Surface/ANALYSIS Receptors, Immunologic/*BIOSYNTHESIS/PHYSIOLOGY Support, Non-U.S. Gov't T-Lymphocytes JOURNAL ARTICLE

KWDcelldivisioncelllinecelltransformation,neoplasticgenes,viralhumanhtlv-blvviruses/genetics/KWDpathogenicityreceptors,cellsurface/analysisreceptors,immunologic/KWDbiosynthesis/physiologysupport,non-uKWDsKWDgov'tt-lymphocytesjournalarticle
860530
M8650226

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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