Nakahara memorial lecture. Human T-cell leukemia virus type I: molecular biology and its implications in adult T-cell leukemia. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Nakahara memorial lecture. Human T-cell leukemia virus type I: molecular biology and its implications in adult T-cell leukemia.

Princess Takamatsu Symp. 1984;15:39-47. Unique Identifier : AIDSLINE MED/86111575
Yoshida M; Kiyokawa T; Watanabe T; Hattori S; Fujisawa J; Seiki M

Abstract: Isolation and characterization of the human T-cell leukemia virus (HTLV) type I was carried out from patients with adult T-cell leukemia (ATL). Total nucleotide sequence of the provirus genome was determined and the HTLV was distinguished from other retroviruses by a unique gene pX and also by its extremely long R sequence in the long terminal repeat (LTR). HTLV was demonstrated to be a causative agent of ATL by monoclonal integration of the proviruses in ATL cells. However, nonspecific provirus integration in ATL cells disproved the direct insertional activation of a specific cellular onc gene, eventually suggesting that a transacting viral function was involved in the leukemogenesis. A gene product of the unique gene pX and trans-activation of the transcription by the product was identified. This pX gene function might explain the leukemogenesis in ATL. The mass-production of the env gene products and their identified function provided information useful for developing the systems for diagnosis and prevention of HTLV infection and ATL.
Keywords: DNA, Viral/ANALYSIS Genes, Viral Human HTLV-BLV Viruses/*GENETICS/PATHOGENICITY Leukemia/*ETIOLOGY Repetitive Sequences, Nucleic Acid Support, Non-U.S. Gov't T-Lymphocytes Viral Proteins/BIOSYNTHESIS/PHYSIOLOGY JOURNAL ARTICLE REVIEW

KWDdna,viral/analysisgenes,viralhumanhtlv-blvviruses/KWDgenetics/pathogenicityleukemia/KWDetiologyrepetitivesequences,nucleicacidsupport,non-uKWDsKWDgov'tt-lymphocytesviralproteins/biosynthesis/physiologyjournalarticlereview
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M8650219

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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