Infectious transmission of human T-cell leukemia virus to animals. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Infectious transmission of human T-cell leukemia virus to animals.

Princess Takamatsu Symp. 1984;15:121-7. Unique Identifier : AIDSLINE MED/86111552
Miyoshi I; Yoshimoto S; Fujishita M; Kubonishi I; Taguchi H; Ohtsuki Y

Abstract: An human T-cell leukemia virus (HTLV)-producing cell line (Ra-1) was established from rabbit lymphocytes by co-cultivation with lethally irradiated MT-2 cells. Ra-1 cells were inoculated intravenously into a Japanese monkey and rabbits. All animals responded with the production of antibodies to HTLV. Lymphocytes from the seroconverted animals were grown in the presence of T-cell growth factor (TCGF) or co-cultured with lymphocytes from seronegative healthy persons. The TCGF-grown cells, which were chromosomally of the recipient type, expressed HTLV antigens and particles. The co-cultures gave rise to human T-cell lines which also harbored HTLV antigens and particles. Blood transfusion from the infected rabbits resulted in the seroconversion of the recipient rabbits. HTLV-producing lymphoid cell lines were established from some of the transfused rabbits. The recipient origin of these cell lines was determined by chromosome analysis. It was possible to serially transmit HTLV by blood transfusion in rabbits. Thus, these animals offer promise as a laboratory model for HTLV infection.
Keywords: Animal Antibodies, Viral/ANALYSIS Blood Transfusion Human HTLV-BLV Viruses/GROWTH & DEVELOPMENT/IMMUNOLOGY Interleukin-2/PHARMACOLOGY Leukemia/*TRANSMISSION Lymphocytes/MICROBIOLOGY Macaca Male Rabbits Retroviridae Infections/*TRANSMISSION Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW

KWDanimalantibodies,viral/analysisbloodtransfusionhumanhtlv-blvviruses/growth&development/immunologyinterleukin-2/pharmacologyleukemia/KWDtransmissionlymphocytes/microbiologymacacamalerabbitsretroviridaeinfections/KWDtransmissionsupport,non-uKWDsKWDgov'tjournalarticlereview
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M8650216

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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