Transmission of ATLV (HTLV-I) through blood transfusion. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Transmission of ATLV (HTLV-I) through blood transfusion.

Princess Takamatsu Symp. 1984;15:129-35. Unique Identifier : AIDSLINE MED/86111553
Okochi K; Sato H

Abstract: In a follow-up of blood recipients, antibodies against adult T-cell leukemia antigen (anti-ATLA) were found in those who had received blood preparations containing cells. Detection of lymphocytes carrying viral antigen of ATLV (human T-cell leukemia virus type I (HTLV-I) ) in seroconverted recipients and the appearance of the viral antigen in cord blood lymphocytes co-cultured with a T-cell clone of a seroconverted recipient strongly suggested that the virus was transmitted through blood transfusion. Screening of blood donors by testing their antibodies against the virus is necessary to prevent future transmission through transfusion, and should be done even if such transmission does not result in the development of adult T-cell leukemia.
Keywords: Adult Antibodies, Viral/ANALYSIS Blood Donors Blood Transfusion/*ADVERSE EFFECTS Female Follow-Up Studies Human HTLV-BLV Viruses/IMMUNOLOGY Leukemia/*TRANSMISSION Lymphocytes/MICROBIOLOGY Male Middle Age Retroviridae Infections/*TRANSMISSION Retroviridae Proteins/ANALYSIS JOURNAL ARTICLE

KWDadultantibodies,viral/analysisblooddonorsbloodtransfusion/KWDadverseeffectsfemalefollow-upstudieshumanhtlv-blvviruses/immunologyleukemia/KWDtransmissionlymphocytes/microbiologymalemiddleageretroviridaeinfections/KWDtransmissionretroviridaeproteins/analysisjournalarticle
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M8650215

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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