UCLA Symp Mol Cell Biol; New Ser 21:253-72 1984. Unique Identifier : AIDSLINE ICDB/86622808
Purtilo DT; Harada S; Meuwissen H; Lipscomb H; Ochs H; Sonnabend J; Manolov G; Manolova Y; Depts. of Pathology and Lab. Medicine, Univ. of Nebraska Medical; Center, 42nd and Dewey Avenue, Omaha, NE 68105
Epstein-Barr virus (EBV)-induced disease is reviewed with respect to selected studies performed on patients with immune deficiency, salient clinical and pathological features of some of the diseases, and methods for documenting infection by Epstein-Barr virus (EBV) (serology, cell-mediated immune studies, detection of
With the number of reported cases exceeding 15,000 as of December 1, 1985, the acquired immunodeficiency syndrome (AIDS) continues to spread with alarming frequency. Over 100 cases per week are reported to the Centers for Disease Control. PAs and other clinicians face a formidable task of keeping up with continual upd
Hunsmann G; Schneider J; Bayer H; Jurkiewicz E; Yamamoto N
Primate lymphotropic retroviruses (PLRV) have been isolated from man and various species of Old World monkeys. The human isolates adult T-cell leukemia virus (ATLV) or human T-cell leukemia virus (HTLV-I) are endemic among Japanese in the south-west of the country as well as Africans in both Africa and America. In the
The past 5 years have witnessed the beginning of a new era in retrovirology, the era of human retroviruses. Within this short period the causes of two fatal human diseases have been defined as due to human retroviruses. In both instances in vitro systems have been developed which mimic the apparent in vivo effects of
The primary structure analysis of the gag gene products of human T-cell leukemia virus (HTLV)-ICR has been nearly completed. A comparison of the amino acid sequences with the published nucleotide sequence of HTLV-IATK established that i) p19 which is known to share antigenic determinants with a protein present in norm
Shimotohno K; Takahashi Y; Shimizu N; Takano M; Miwa M; Sugimura T
The total nucleotide sequence of an infectious clone of human T-cell leukemia virus type II (HTLV-II) provirus was determined. The provirus has 8,952 nucleotides with a long terminal repeat (LTR) at each end. The LTR consists of 341 +/- 1 bases of U3, 248 +/- 1 bases of R, and 201 bases of U5 regions. There are gag, p
Rosenblatt J; Wachsman W; Shimotohno K; Slamon D; Chen IS
The human T-cell leukemia viruses (HTLV) I and II, have been implicated in naturally occurring T-cell malignancies in man. We are engaged in ongoing comparative studies of HTLV-I and HTLV-II in our laboratory. We have isolated a replication-competent clone of HTLV-II, as well as several defective HTLV-II proviruses fr
Gene expression directed by the long terminal repeats of human T-lymphotropic viruses is activated in trans by factors present in virus-infected cells. Trans-activation probably plays a major role in stimulating virus production and may also mediate some of the effects of viral infection on the host cell.
Type I and type II human T-cell leukemia viruses (HTLV) contain in their genomes three structural genes, gag, pol, and env and a putative transforming gene, lor. Using a living cell membrane immunofluorescence assay, antibodies to surface-expressed env gene products of HTLV-MA have been detected in healthy carriers li
Gallo and his coworkers isolated a retrovirus (HTLV) from human cells derived from T-cell leukemia and lymphoma. Hinuma and his coworkers isolated independently a similar virus from a cell line derived from adult T-cell leukemia (ATL) patient. The occurrence of ATL correlates with the formation of antibody to ATL asso
Burny A; Bruck C; Cleuter Y; Couez D; Deschamps J; Ghysdael J; Gregroire D; Kettmann R; Mammerickx M; Marbaix G; et al
Bovine leukemia virus (BLV) has many structural and functional characteristics in common with the human T-lymphotropic viruses (HTLVs). The most striking feature of these retroviruses is the existence of a long open reading frame (LOR) located at the 3 side of the provirus between the right end of the 3 side of env
We have compared the sequences of the entire genomes of bovine leukemia virus (BLV) and human T-cell leukemia virus type I (HTLV-I). Both the gag and pol genes show overall strong homologies between the two retroviruses, indicating their close evolutionary relationship. However, a surface glycoprotein portion of the e
Seiki M; Watanabe T; Komuro A; Miyoshi I; Hayami M; Yoshida M
Human T-cell leukemia virus type I (HTLV-I) is exogenous for human transmission by viral infection and was shown to be a causative agent of adult T-cell leukemia (ATL) in man. Monkeys of several species were found to have antibodies reactive with HTLV-I antigens and thus infection with HTLV-I like retroviruses was sus
Waldmann TA; Leonard WJ; Depper JM; Kronke M; Goldman CK; Oh T; Greene WC
Interleukin-2 ( IL-2 ) is a lymphokine synthesized by some T cells following activation. Resting T cells do not express IL-2 receptors but receptors are rapidly expressed on T cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antige
Sugamura K; Fujii M; Sakitani M; Kobayashi N; Nakai S; Hatanaka M; Hinuma Y
The first half of this report describes direct evidence for the interleukin 2 receptor (IL-2R)-inducing ability of human T-cell leukemia/lymphoma virus (HTLV). When an Epstein-Barr virus (EBV)-transformed human B-cell line, LCL-Kan was infected with HTLV or transfected with plasmid DNA containing defective HTLV genome
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immunodeficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4+ (helper/inducer) T-cells. Moreover, the virus is cytopathic for these cells.
Wong-Staal F; Hahn BH; Shaw GM; Arya SK; Harper M; Gonda M; Gilden R; Ratner L; Starcich B; Okamoto T; et al
A T-lymphotropic retrovirus with cytopathic but not immortalizing activity has been isolated repeatedly from patients with acquired immune deficiency (AIDS) or lymphadenopathy syndrome (LAS) and successfully transmitted to a T-cell line (HT) for continuous production. Seroepidemiology data and the OKT4 tropism and cyt
Before 1980, infectiously transmitted human retroviruses were unknown. Since then three types of human T-lymphotropic viruses (HTLVs) have been discovered and are under intensive study. Further types may well come to light. HTLV-I is etiologically associated with adult T-cell leukemia-lymphoma (ATLL), HTLV-II has been
A retrovirus belonging to the family of human T-cell leukemia/lymphoma virus (HTLV) was isolated from several patients with acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC) and asymptomatic homosexual males at increased risk of developing AIDS. This new virus was designated HTLV-III. A serological
Essex M; Kanki P; Allan J; Barin F; McLane MF; Lee TH; Kitchen L; Homma T; Malone G; Yokota T; et al
There is increasing evidence for the link between members of the human T-lymphotropic virus family and clinically important disease. We used indirect membrane immunofluorescence (IMI) to screen patient and control sera for antibodies to human T-cell leukemia virus (HTLV) specific cell membrane antigens (HTLV-MA) of HT
Montagnier L; Chermann JC; Barre-Sinoussi F; Klatzmann D; Wain-Hobson S; Alizon M; Clavel F; Brun-Vezinet F; Vilmer E; Rouzioux C; et al
Lymphadenopathy associated virus (LAV) is a novel human retrovirus first reported in 1983. It was isolated from the lymph node lymphocytes of a French homosexual patient with generalized hyperplasic lymphadenopathy. Subsequently LAV was isolated from patients with frank acquired immune deficiency syndrome (AIDS) comin
Yoshida M; Kiyokawa T; Watanabe T; Hattori S; Fujisawa J; Seiki M
Isolation and characterization of the human T-cell leukemia virus (HTLV) type I was carried out from patients with adult T-cell leukemia (ATL). Total nucleotide sequence of the provirus genome was determined and the HTLV was distinguished from other retroviruses by a unique gene pX and also by its extremely long R seq
Gibbs WN; Lofters WS; Campbell M; Hanchard B; LaGrenade L; Clark J; Cranston B; Saxinger C; Gallo R; Blattner WA
We had shown previously that the prevalence of human T-cell leukemia/lymphoma virus type I (HTLV-I)-antibody positivity is high in Jamaican non-Hodgkin s lymphoma (NHL) patients and that virus-positive patients have the clinical features and poor prognosis of adult T-cell leukemia/
Blattner WA; Clark JW; Gibbs WN; Williams CK; Nomura A; Mann D; Saxinger C; Robert-Guroff M; Gallo RC
With the discovery of the human retrovirus class, an important turning point in the understanding of the process by which cancer is caused and develops in humans has been achieved. As summarized here, clinical and epidemiologic studies have documented the close association of human T-cell leukemia virus (HTLV-I) to a
Miyoshi I; Yoshimoto S; Fujishita M; Kubonishi I; Taguchi H; Ohtsuki Y
An human T-cell leukemia virus (HTLV)-producing cell line (Ra-1) was established from rabbit lymphocytes by co-cultivation with lethally irradiated MT-2 cells. Ra-1 cells were inoculated intravenously into a Japanese monkey and rabbits. All animals responded with the production of antibodies to HTLV. Lymphocytes from
In a follow-up of blood recipients, antibodies against adult T-cell leukemia antigen (anti-ATLA) were found in those who had received blood preparations containing cells. Detection of lymphocytes carrying viral antigen of ATLV (human T-cell leukemia virus type I (HTLV-I) ) in seroconverted recipients and the appearanc
Hoshino H; Weiss RA; Clapham P; Miwa M; Miyoshi I; Yoshida M; Sugimura T
We tried to transmit human T-cell leukemia virus type I (HTLV-I) into non-lymphoid cells and found that S+L- CCC cat cells were permissive for HTLV-I. Using these HTLV-positive cat cells, vesicular stomatitis virus (VSV) pseudotypes bearing envelope antigens of Japanese isolates of HTLVs were prepared and their reacti
Takatsuki K; Yamaguchi K; Kawano F; Hattori T; Nishimura H; Tsuda H; Sanada I
We screened serum samples from patients with various hematological disorders and healthy individuals for the presence of adult T-cell leukemia/lymphoma associated antigen (anti-ATLA) antibodies. These antibodies were detected not only in all patients with ATL but frequently in those diagnosed as T-cell malignant lymph
We describe studies in 14 black patients with adult T-cell leukemia/lymphoma (ATLL) born in the Caribbean (13) and west Africa (1). Lymphadenopathy, hypercalcemia, and a leukemic blood picture were seen in the majority. The clinical course was short with a median survival of 5 months. Serum antibodies to human T-cell
Shimoyama M; Seki S; Nagai M; Minato K; Kitamura T; Hoshino H; Miwa M; Tobinai K; Nagoshi H; Oosuga T; et al
Abnormally large lymphocytes with Pelger-like nuclear lobulation have been found in peripheral blood of smoldering adult T-cell leukemia-lymphoma (ATL) patients. They are also found in quite low percentage in peripheral blood of healthy HTLV carriers. Therefore, it has become difficult to discriminate smoldering ATL h
Hosp Community Psychiatry. 1985 Dec;36(12):1309-11. Unique Identifier : AIDSLINE MED/86110007
Douglas CJ; Kalman CM; Kalman TP
In a large urban teaching hospital treating many patients with AIDS, 37 medical house officers and 91 registered nurses completed a questionnaire designed to measure attitudes about homosexuality. Mean scores for both physicians and nurses fell in the low-grade homophobic range. No significant differences were found b
The topographical distribution of the cortical afferent connections of the prefrontal cortex (PFC) in adult cats was studied by using the retrograde axonal transport of horseradish peroxidase technique. Small single injections of the enzyme were made in different locations of the PFC, and the areal location and densit
The acquired immune deficiency syndrome (AIDS), is a recently described irreversible dysfunction of cell-mediated immunity in homosexuals, intravenous, drug abusers, and hemophiliacs, with subsequent development of potentially lethal opportunistic infections and/or unusual neoplasms, such as Kaposi s sarcoma. A prospe
Med Trop (Mars). 1985 Oct-Dec;45(4):405-11. Unique Identifier : AIDSLINE MED/86117660
Lesbordes JL; McCormick JB; Beuzit Y; Ramiara JP; Vohito DM; Meunier DM; Georges MC; Gonzalez JP; Georges AJ
AIDS is known in Central African Republic since 1983: 64 recognized cases have been registered. AIDS is of endemic aspect presenting the main following signs: lost of weight (100%), degeneration of the health status (80%), lymphadenopathy (46%), pneumopathy (44%), d
Kleihues P; Lang W; Burger PC; Budka H; Vogt M; Maurer R; Luthy R; Siegenthaler W
Two adult patients with acquired immune deficiency syndrome (AIDS) presented with psycho-organic symptoms produced by an extensive cerebral and cerebellar leukoencephalopathy. Diffuse loss of myelin and axons with reactive astrocytosis and distinctive multinucleated giant cells were prominent in the deep white matter,
A review of 54 cases of AIDS established the ORL manifestations of this constantly fatal disease. Simple infections such as sinusitis, otitis and tonsillitis were frequent and quite typical, but buccopharyngeal herpes and particularly buccopharyngo-esophageal candidosis were widespread affections. The onset of candido
Natural cell-mediated cytotoxicity (CYT) was determined using whole blood samples from 32 patients with the acquired immunodeficiency syndrome (AIDS) and 12 with AIDS-related complexes (ARC) and correlated with the number of putative natural killer cells (NK) bearing surface marker Leu 11a. Mean percent cytotoxicity (
Alloantigen specific primary cytotoxic T lymphocyte (CTL) responses were examined in vitro in 10 patients with AIDS and nine with AIDS-related complex (ARC). The lymphocytes from patients with AIDS and ARC expressed significantly less (P less than 0.01) CTL activity (mean +/- s.d.; 4.7 +/- 9% and 10 +/- 11% respective
Siegel JP; Lane HC; Stocks NI; Quinnan GV Jr; Fauci AS
Intravenous infusions of 250,000 U of lymphocyte-derived or recombinant DNA-derived interleukin-2 ( IL-2 ) were administered to patients with the acquired immunodeficiency syndrome, and sera were obtained for pharmacokinetic studies. A methodology was developed for the d
Hammar SP; Winterbauer RH; Bockus D; Remington F; Friedman S
Fibrosing alveolitis is a usually chronic pulmonary disease affecting middle-aged men and women and causing progressive dyspnea. This review discusses the nosologic, etiologic, immunopathogenic, histologic, immunohistochemical and ultrastructural features of this condition. A hypothesis is presented suggesting microva
Duncan CR; Tani RD; Palmitano JB; Predari S; Aguirre C; Alvarez C
Malignant tumors occur with greater frequency in patients with kidney transplants. Kaposi s sarcoma (KS), a rare vascular neoformation, represents approximately 3% of them. Its uncertain etiology appears to respond to: a chronic antigen stimulation by the transplanted tissue, to a depression of immune responsiveness,
Since December 1980, over 3000 cases of acquired immunodeficiency syndrome (AIDS) have been reported. The charts of 102 patients admitted to the New York University Medical Center with a diagnosis of AIDS were reviewed with particular emphasis on presenting signs, symptoms, and laboratory values. Symptoms tended to be
The computed tomography manifestations of Kaposi s sarcoma in the stomach have not been described. A case of autoimmune deficiency syndrome-related Kaposi s sarcoma with stomach involvement documented on computed tomography is presented.
Gen Hosp Psychiatry. 1986 Jan;8(1):7-10. Unique Identifier : AIDSLINE MED/86109485
Price WA; Forejt J
The acquired immune deficiency syndrome (AIDS) is a diverse disease that can affect all the systems of the human body. Frequently it can present initially as a neurologic or psychiatric illness due in part to the various infectious and neoplastic illnesses often encountered in susceptible individuals. Psychiatrists sh
Persistent, generalized lymphadenopathy (PGL) is considered part of the acquired immunodeficiency syndrome (AIDS)-related complex. The clinical course is usually benign, although some patients may evolve to AIDS. Characteristic features on lymph node biopsy have been described. Recently, large series of PGL have been
This report describes a 28-year-old woman with the acquired immune deficiency syndrome (AIDS) with culture-proven disseminated Mycobacterium avium intracellulare infection. The histopathologic and cytologic features in this case were unique in that these organisms that stained positively with the Ziehl-Neelsen and per
Am J Hematol. 1986 Mar;21(3):243-7. Unique Identifier : AIDSLINE MED/86127286
Goldsweig HG; Grossman R; William D
The office records of two private practices with a preponderance of homosexual patients were reviewed for cases of males with unexplained thrombocytopenia. Twenty-five patients meeting the selection criteria were found. The clinical and laboratory features of these patients were reviewed and compared to those characte
Between 1 January 1981 and 1 December 1984, 34 of 396 patients with the acquired immunodeficiency syndrome (AIDS) developed cryptococcal infections. Twenty-six cases are reviewed. Twenty-two patients had brain or meningeal disease; the others had pulmonary disease (2 patients), pericarditis (1 patient), and antigenemi
Combined tumor syndromes, specifically reticuloendothelial malignancies and Kaposi s sarcoma, have long been recognized. With the recognition of the acquired immunodeficiency syndrome (AIDS), several patients with concurrent non-Hodgkin s lymphoma and Kaposi s sarcoma have been rep
To determine the risk of transmission of human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) to close but nonsexual contacts of patients with the acquired immunodeficiency syndrome (AIDS), we studied the nonsexual household contacts of patients with AIDS or the AIDS-related complex
Hemophiliac patients receiving factor VIII replacement therapy and homosexual subjects are at risk for the acquired immune deficiency syndrome. Immunologic abnormalities, especially depletion of helper T cell populations, have been noted in members of these groups and may parallel their clinical state. We have evaluat
N Engl J Med. 1986 Feb 13;314(7):414-8. Unique Identifier : AIDSLINE MED/86118551
Kreiss JK; Koech D; Plummer FA; Holmes KK; Lightfoote M; Piot P; Ronald AR; Ndinya-Achola JO; D'Costa LJ; Roberts P; et al
The acquired immunodeficiency syndrome (AIDS) is epidemic in Central Africa. To determine the prevalence of AIDS virus infection in East Africa, we studied 90 female prostitutes, 40 men treated at a clinic for sexually transmitted diseases, and 42 medical personnel in Nairobi, Kenya
Acquired immunodeficiency syndrome (AIDS) has become a major public health problem in the United States . Current projections, based on seroepidemiologic data, suggest a large increase in the number of cases over the next several years. Pneumocystis carinii pneumonia is the most common
Am J Ophthalmol. 1986 Feb 15;101(2):153-5. Unique Identifier : AIDSLINE MED/86127565
Sandor EV; Millman A; Croxson TS; Mildvan D
In a prospective investigation of 54 consecutive cases of herpes zoster ophthalmicus, conducted over a two-year period, immunologic evaluations included enumeration of T lymphocyte subsets and serum immunoglobulin levels. Herpes zoster ophthalmicus occurred with frequent ocular complications in a subgroup of adults di
Pitchenik AE; Ganjei P; Torres A; Evans DA; Rubin E; Baier H
The diagnostic utility of sputum examination in patients with Pneumocystis carinii pneumonia secondary to the acquired immunodeficiency syndrome (AIDS) has so far not been determined. Sputum was induced in 43 patients with AIDS or suspected AIDS just prior to fiberoptic bronchoscopy, scheduled because of an unexplaine
Five weeks before the development of acquired immunodeficiency syndrome (AIDS), a 38-yr-old homosexual man had symptomatic gastroenteritis that resolved without antibiotic treatment. His stool culture was positive for Salmonella typhimurium at that time. The patient subsequently developed Pneumocystis carinii pneumoni
The authors investigated by immunofluorescence the thymic epithelium from AIDS patients, using several structural and functional markers of this tissue. In AIDS thymus, the epithelial reticular pattern was lost; and instead, clusters of round or spindle-shaped cells (assessed by their keratin content) were found. In a
Minerva Med. 1986 Jan 14;77(1-2):1-5. Unique Identifier : AIDSLINE MED/86119266
Ferraris R; Nahum M; Ruffo A
The complex diagnostic procedure involved in a case of splenic abscess in a young drug addict as a result of septicaemia caused by streptococcus fascalis is described and discussed with an examination of the criteria in support of a more aggressive approach to the removal of septic foci in such patients with AIDS. It
Ann Intern Med. 1986 Feb;104(2):175-80. Unique Identifier : AIDSLINE MED/86128591
Cohen AJ; Philips TM; Kessler CM
Abnormal coagulation profiles were identified in ten patients with the acquired immunodeficiency syndrome (AIDS) associated with opportunistic infections and malignancies. Activated partial thromboplastin times were elevated in all patients; three of seven had elevated prothrombin times. All patients had lupus-type an
Lymphokines have been known to be part of the immune system during almost the last three decades; within the last decade the information on their production, biochemical and biological characteristics has grown immensely. Their study has contributed significantly in the understanding of the physiological aspects of th
Daugharty H; Chorba TL; Personette DW; Savoca KV; MacDonald V
Acquired immunodeficiency syndrome (AIDS), lymphadenopathy syndrome (LAS), and immune thrombocytopenic purpura (ITP) specimens were tested by an enzyme-linked immunosorbent assay (ELISA) for immunoglobulin (Ig) bound to platelets. All specimen evaluations were performed with General Diagnostic s newly developed kit pr
Enteric infections are common in homosexual men. We have characterized the phenotypic distribution of small intestinal mononuclear cells among healthy homosexual men, homosexual men with lymphadenopathy syndrome, homosexual men with acquired immunodeficiency syndrome (AIDS), and a group of healthy heterosexual men. To
Schuurman HJ; Kluin PM; Gmelig Meijling FH; Van Unnik JA; Kater L
Blood lymphocytes and lymph nodes from three patients with acquired immunodeficiency syndrome (AIDS) and two cases with AIDS-related complex (ARC) were studied during the course of the disease. The lymph node histomorphology could be grossly categorized into three stages: follicle hyperplasia, follicle degeneration an
Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A gene
Mannhalter JW; Zlabinger GJ; Ahmad R; Zielinski CC; Schramm W; Eibl MM
In search of a functional immunological defect in patients with hemophilia A, we investigated the early phase of the immune response and found a deficiency in the monocyte-T cell interaction after in vitro exposure to a bacterial antigen. T-cell proliferation in response to Escherichia coli-pulsed autologous monocytes
Hosp Community Psychiatry. 1986 Feb;37(2):135-42. Unique Identifier : AIDSLINE MED/86110033
Perry S; Jacobsen P
Psychiatric symptoms among patients with acquired immune deficiency syndrome (AIDS) may be functional reactions to contracting a fatal and stigmatizing disease or may be secondary to malignancies and opportunistic infections in the central nervous system (CNS). More recent evidence indicates that HTLV-III, the virus t
The distribution of the conventional lymphoid cell markers on T lymphocytes and the principal panels of monoclonal antibodies used to recognize distinctive T-lymphocyte-associated differentiation antigens are discussed. These reagents have been used to probe the early and late stages of T-cell differentiation, and a h
In normal blood, there appears to be two similar but different subsets of T-lymphocytes present: (1) the cerebriform or convoluted Sezary-syndrome Lutzner cell, which may give rise to cutaneous T-cell lymphoma; (2) the polypetaloid or lobated acute T-cell lymphoma/leukemia (ATLL) cell, which may give rise to ATLL. Bot
J Immunol. 1986 Feb 15;136(4):1322-8. Unique Identifier : AIDSLINE MED/86113412
Lee JC; Rebar L; Young P; Ruscetti FW; Hanna N; Poste G
Culture supernatants of several human T cell leukemia cell lines were screened for macrophage-activating activity (MAF) as defined by induction of tumoricidal activity against human melanoma cells in a 72-hr assay. Two cell lines, MT-2 and C10/MJ2, were found to produce high levels of MAF activity constitutively, but
A murine monoclonal antibody (MAb), named C.V.K., was produced after immunization with highly purified and sonicated lymphadenopathy-associated virus (LAV). No monoclonal antibody was observed with intact virus used as immunogen. C.V.K. MAb recognizes an epitope present on the precursor gag protein of 55 kilodaltons.
To maximize safety in the setting of an increasing number of requests for flow cytometric analysis of specimens potentially contaminated with the AIDS retrovirus, we evaluated some commonly used fixatives for their ability to inactivate the infectious potential of the virus. We found that both formaldehyde (0.37% v/v)
Jarrett RF; Mitsuya H; Mann DL; Cossman J; Broder S; Reitz MS
We studied the configuration and expression of the gene encoding the beta chain of the T cell receptor (TCR beta) in cell lines and primary tumor cells infected by the human T cell leukemia/lymphoma (lymphotrophic) virus type I (HTLV-I). Most of the cell lines and all the primary tumor cells showed rearrangement of th
The level of synthesis of viral proteins and heterologous proteins under the control of long terminal repeat sequences of human T-lymphotropic virus type III (HTLV-III or LAV) increases dramatically in cells that constitutively express the HTLV-III trans-activator protein. Increased levels of protein synthesis occur w
Minerva Med. 1986 Jan 14;77(1-2):7-11. Unique Identifier : AIDSLINE MED/86119273
Valentini F; Ferrara MC; Pagani C; Rascio L
The Authors, after a review of the latest reports on ethiology, pathology and clinical aspects of acquired immunodeficiency syndrome (AIDS) and of linphadenopathyc syndrome (LAS or pre-AIDS), describe a case of pre-AIDS syndrome in a heroin addict characterized by typical symptoms, histological, serological and immuno
Proc Natl Acad Sci U S A. 1986 Feb;83(3):772-6. Unique Identifier : AIDSLINE MED/86121022
Harper ME; Marselle LM; Gallo RC; Wong-Staal F
By using in situ hybridization methodology, we have directly examined primary lymph node and peripheral blood from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex for the presence of human T-lymphotropic virus type III (HTLV-III) viral RNA. Mononuclear cell preparations were hybridized
Frager DH; Frager JD; Brandt LJ; Wolf EL; Rand LG; Klein RS; Beneventano TC
The radiologic features were examined in a retrospective review of 25 patients with gastrointestinal complications of acquired immunodeficiency syndrome (AIDS). Factors of risk for AIDS present in these patients included homosexuality (n = 10), intravenous drug abuse (n = 7), multiple blood transfusions (n = 1), and u
The epidemiological, immunological and early virological observations on the acquired immune deficiency syndrome (AIDS) suggested that an agent was involved which was sexually, parenterally and perinatally transmitted and perhaps tropic for T helper lymphocytes. A new subgroup of human T lymphotropic retroviruses have
Schweiz Med Wochenschr. 1985 Dec 7;115(49):1777-8. Unique Identifier : AIDSLINE MED/86122733
Vogt M; Luthy R; Ferber T; Ledergerber B; Schupbach J; Tauber M; Siegenthaler W
Sera of 100 healthy homosexual men were tested for antibodies to AIDS virus HTLV-III. Significant differences were found between 45 seropositive and 55 seronegative men, such as a higher number of sexual partners per year, more contacts with AIDS patients, positive serological markers for syphilis, and reduced skin re
Science. 1986 Feb 7;231(4738):589-94. Unique Identifier : AIDSLINE GENBANK/M14855
Stephens RM; Casey JW; Rice NR
Comparison of HTLV-III, the putative AIDS virus, with other related viruses, may help to reveal more about the origin of AIDS in humans. In this study, the nucleotide sequence of the gag and pol genes of an equine infectious anemia virus (EIAV) proviral DNA clone was determined. The sequence was compared with that of
Science. 1986 Feb 7;231(4738):600-2. Unique Identifier : AIDSLINE MED/86122876
Folks T; Powell DM; Lightfoote MM; Benn S; Martin MA; Fauci AS
When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor ca
Science. 1986 Feb 21;231(4740):850-3. Unique Identifier : AIDSLINE MED/86122904
Zagury D; Bernard J; Leonard R; Cheynier R; Feldman M; Sarin PS; Gallo RC
Long-term cultures were established of HTLV-III-infected T4 cells from patients with the acquired immune deficiency syndrome (AIDS) and of T4 cells from normal donors after infection of the cells in vitro. By initially reducing the number of cells per milliliter of culture medium it was possible to grow the infected c
Science. 1986 Feb 28;231(4741):992-5. Unique Identifier : AIDSLINE MED/86122914
Goedert JJ; Biggar RJ; Weiss SH; Eyster ME; Melbye M; Wilson S; Ginzburg HM; Grossman RJ; DiGioia RA; Sanchez WC; et al
The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral drug users, and hem
Science. 1986 Mar 14;231(4743):1289-91. Unique Identifier : AIDSLINE GENBANK/K03455
di Marzo Veronese F; Copeland TD; DeVico AL; Rahman R; Oroszlan S; Gallo RC; Sarngadharan MG
Approximately 80 percent of all human sera that react with antigens of HTLV-III, the etiologic agent of the acquired immune deficiency syndrome (AIDS), recognize protein bands at 66 and 51 kilodaltons. A mouse hybridoma was produced that was specific to these proteins. Repeated cloning of the hybridoma did not separat
Thromb Haemost. 1985 Oct 30;54(3):665-8. Unique Identifier : AIDSLINE MED/86123589
Rodeghiero F; Castaman GC; Chisesi T; De Rossi A; Dalla Gassa O; Del Mistro A; Dini E; Castronovo S; Pornaro E; Chieco-Bianchi L
A 1-year follow-up study of the T-cell subset abnormalities was carried out in 16 severe haemophilia A patients, treated on demand with an average amount of 500 U/kg/yr of factor VIII concentrate (group A) and in 15 mild haemophiliacs or von Willebrand patients treated only sporadically with less than 3000 U of factor
15,680 volunteer blood donors were screened by enzyme-linked immunosorbent assay (EIA) for antibodies to human T-lymphotropic virus Type III (HTLV-III). On at least two of three determinations, 0.37 percent were found to be reactive. When the first 38 of these samples were sent for repeat EIA and Western blot, the EIA
Z Hautkr. 1985 Dec 1;60(23):1872-7. Unique Identifier : AIDSLINE MED/86125258
Gross G
The relationship between virus infections of the skin and mucosae and the development of malignant tumors is discussed. Guided by seroepidemiological data, virus infections with herpes simplex have been associated with the development of cervical carcinoma, genomes specific for HSV, however, have only occasionally bee
Many of the genes that are likely participants in the pathogenesis of human neoplasia have been identified. The major classes of events that activate these genes in tumors have also been described. We expect that continuing research on the function of oncogenes will greatly inform our understanding of fundamental grow
A 66-year old acquired immunodeficiency syndrome (AIDS) patient presented with cutaneous lesions suspicious for Kaposi s sarcoma. Biopsies disclosed granulomatous infiltrates with acid-fast bacilli and cytomegalovirus inclusions within macrophages and endothelial cells in one biops
Am J Epidemiol. 1986 Feb;123(2):308-15. Unique Identifier : AIDSLINE MED/86127253
Sirianni MC; Rossi P; Moroni M; Romagnani S; Lazzarin A; Carbonari M; Scarpati B; Mariani M; Manconi PE; Del Giacco GS; et al
An epidemiologic survey of the distribution of lymphoadenopathy syndrome in six Italian cities and its correlation with human T-lymphotropic retrovirus III (HTLV-III) is reported. Serum samples of nine patients with acquired immune deficiency syndrome (AIDS) were tested, 180 from patients with lymphoadenopathy and 349
Corneoscleral donor tissue from a donor with a positive serum antibody to HTLV-III but without the overt clinical signs of the acquired immune deficiency syndrome (AIDS) was cultured for the presence of the human T-cell leukemia/lymphotropic virus type III (HTLV-III). The virus was isolated from the two corneal specim
A cohort of 215 asymptomatic homosexually active men from a Boston community health center are being prospectively followed to assess the natural history of the human T-lymphotropic virus type III (HTLV-III) infection. To determine if certain asymptomatic persons who are HTLV-III antibody negative may be viremic, an a
Fibrin glue has become an indispensable tool in salvaging operations of the parenchymatous organs of the abdomen, in vascular and ophthalmic plastic surgery as well as neurosurgery. Currently available glues contain clotting factors from human plasma and thus carry the potential risk of transmitting viral infections l
Cancer. 1986 Feb 15;57(4):732-6. Unique Identifier : AIDSLINE MED/86105679
Okawa H; Takase K; Takagi S; Yata J; Matsumoto M; Matsumoto T
Research was carried out on neoplastic T-cells taken from 10 cases of Japanese adult T-cell leukemia (ATL) in regard to their immunoregulatory activity on pokeweed mitogen (PWM)-driven immunoglobulin (Ig) production and their differentiation antigens. ATL cells were reactive with OKT3, OKT4 and OKT11 in most cases; ho
Iwanaga M; Takada K; Fujiwara S; Osato T; Mikuni C; Maekawa I; Miyazaki T; Akahonai Y; Kwon KW; Sekiguchi S
Sera and peripheral blood lymphocytes in 40 clinical cases of adult T-cell leukemia (ATL) and 66 cases of mature T-cell malignancies in Hokkaido district, the most northern part of Japan , were examined for the infection with ATL virus (ATLV). All of the 40 ATL patients (100%) had an
Kwon KW; Yano M; Sekiguchi S; Iwanaga M; Fujiwara S; Osato T; Higuchi M
In order to investigate the spread of adult T-cell leukemia (ATL) virus in the inhabitants of ATL-non-endemic Hokkaido, we surveyed the antibodies to ATL-associated antigen (ATLA) in 29516 healthy individuals by indirect immunofluorescence test using MT-1 for target cell. Of the healthy inhabitants, only 219 individua
Iwanaga M; Fujiwara S; Osato T; Mikuni C; Maekawa I; Miyazaki T
Family members of non-endemic Hokkaido patients with adult T-cell leukemia (ATL) were assessed for the prevalence of ATL virus (ATLV) infection. Immunofluorescence test showed that 53 (39.8%) of 133 healthy family members of 23 ATL patients were positive for antibodies of ATLV-associated antigen (ATLA). When seroposit
In 1982 only two cases of acquired immune deficiency syndrome (AIDS) and one case of persistent generalized lymphadenopathy (PGL) were diagnosed at St Stephen s hospital in central London. By 31 July 1985, the numbers of cases with these conditions had increased to 41 and 185 respectively and a total of approximately
Several assays are in preparation for the diagnosis of cytomegalovirus infection in acquired immune deficiency syndrome and other immunocompromised patients. In particular, ELISA and DNA probes look to be particularly promising for testing body fluids and tissue sections respective
Unified procedures to control those infections that are transmitted by inoculation of blood are recommended. These should be applied to patients with overt acquired immune deficiency syndrome, persistent generalized lymphadenopathy or hepatitis B, those with serological evidence of infection by HTLV III or hepatitis B
Since the first discovery of HTLVIII 2 years ago, there have been remarkable advances in the molecular characterization of the virus, our understanding of its replication and the development of serological tests. But a great deal remains to be elucidated about the natural history of viral transmission and of the spect
This information is designed to support, not replace, the relationship that exists between you and your doctor.